苹果手机怎么下载tokenpocket|bca法测蛋白浓度

作者：苹果手机怎么下载tokenpocket

2024-03-08 19:06:17

如何使用BCA进行蛋白浓度测定 - 知乎

如何使用BCA进行蛋白浓度测定 - 知乎切换模式写文章登录/注册如何使用BCA进行蛋白浓度测定爱分享的Leo博士中山大学医学博士实验原理BCA法基于双缩脲原理，碱性条件下蛋白质将Cu2+还原成Cu+，BCA鳌合Cu+作为显色剂，产生蓝紫色并在562nm有吸收峰，单价Cu+与蛋白质呈剂量相关性。可以根据待测蛋白在562nm处的吸光度计算待测蛋白浓度。1. 蛋白标准品的准备 a. 取0.8ml蛋白标准配制液加入到一管蛋白标准(20mg BSA)中，充分溶解后配制成25mg/ml的蛋白标准溶液。配制后可立即使用，也可以-20ºC长期保存。 b. 取适量25mg/ml蛋白标准，稀释至终浓度为0.5mg/ml。例如取20µl 25mg/ml蛋白标准，加入980µl稀释液即可配制成 0.5mg/ml蛋白标准。蛋白样品在什么溶液中，标准品也宜用什么溶液稀释。但是为了简便起见，也可以用0.9% NaCl或PBS 稀释标准品。稀释后的0.5mg/ml蛋白标准可以-20ºC长期保存。 2. BCA工作液配制根据样品数量，按50体积BCA试剂A加1体积BCA试剂B(50:1)配制适量BCA工作液，充分混匀。例如5ml BCA试剂A加100µl BCA试剂B，混匀，配制成5.1ml BCA工作液。BCA工作液室温24小时内稳定。 3. 蛋白浓度测定 a. 将标准品按0、1、2、4、8、12、16、20µl加到96孔板的标准品孔中，加标准品稀释液补足到20µl，相当于标准品浓度分别为0、0.025、0.05、0.1、0.2、0.3、0.4、0.5mg/ml。b. 加适当体积样品到96孔板的样品孔中。如果样品不足20µl，需加标准品稀释液补足到20µl。请注意记录样品体积。 c. 各孔加入200µl BCA工作液，37ºC放置20-30分钟。注: 也可以室温放置2小时，或60ºC放置30分钟。BCA法测定蛋白浓度时，颜色会随着时间的延长不断加深。并且显色反应会因温度升高而加快。如果浓度较低，适合在较高温度孵育，或适当延长孵育时间。 d. 用酶标仪测定A562，或540-595nm之间的其他波长的吸光度。 e. 根据标准曲线和使用的样品体积计算出样品的蛋白浓度。是否每次测定时都需要做标准曲线？建议每次测定时都做标准曲线。因为BCA法测定时颜色会随着时间的延长不断加深，并且显色反应的速度和温度有关，所以除非精确控制显色反应的时间和温度，否则如需精确测定宜每次都做标准曲线。SCI方法写作实验太常规了，通常都是一笔带过的。发布于 2021-12-28 15:32生物化学分子生物学化学赞同 12115 条评论分享喜欢收藏申请

点成分享 | 蛋白质浓度测定之BCA法 - 知乎

点成分享 | 蛋白质浓度测定之BCA法 - 知乎切换模式写文章登录/注册点成分享 | 蛋白质浓度测定之BCA法点成生物专注分享生物科技领域产品和解决方案蛋白质浓度的测定是常见的生物实验之一。本文介绍的是使用BCA法（二辛可酸法或二喹啉甲酸法）进行蛋白质浓度的测定。BCA分子式1 实验原理BCA是一种稳定的碱性水溶性复合物。在碱性条件下，蛋白质可以将BCA试剂中的二价铜离子Cu2+还原成一价铜离子Cu+，接着还原出来的Cu+与BCA试剂螯合形成紫蓝色络合物，该络合物在562nm处有强烈的光吸收，且蛋白质浓度和其吸光度在一定范围内（如50-2000μg/ml浓度）是具有良好的线性关系的，因此可以通过制作蛋白质浓度与其在562nm处的吸光度的标准曲线，根据待测蛋白的吸光度对照标准曲线就可计算待测蛋白浓度。原理图：第一步反应：第二步反应：2 实验步骤1、实验器材可调分光光度计、恒温水浴箱、移液器、移液管、试管若干2、实验试剂(1) 试剂A：含1%BCA二钠盐、2%无水碳酸钠、0.16%酒石酸钠、0.4%氢氧化钠、0.95%碳酸氢钠,将上述液体混合后调pH到11.25。(2) 试剂B: 4%硫酸铜溶液。(3) BCA工作液：将试剂A和试剂B先分别摇晃混匀，然后按照50:1的比例配置BCA工作液，之后再充分混匀并在24小时内使用。(4) 蛋白质标准液：可选用牛血清白蛋白（BSA）作为标准蛋白。准确称取150mg牛血清白蛋白,溶于100mL蒸馏水中,即得1.5mg/mL的蛋白质标准液。之后还可以分别吸取不同容量的标准液并与蒸馏水混合稀释成不同浓度的蛋白质标准液。(5) 待测样品。3、实验操作（1）选取7支洁净试管，其中5支标号1-5号管，其他2支分别标签空白管和待测管。按照下表用移液器准确移取相应的标准蛋白溶液或待测样品、蒸馏水和BCA工作液于试管中。注意：稀释后的标准蛋白溶液或待测样品与BCA工作液混合比例应为1:20。（2）将上述各试管混匀后置于恒温水浴锅中37℃保温30分钟；（3）然后吸取各试管中的溶液于比色皿中并用分光光度计的562nm波长比色测定吸光度值；（4）以蛋白质含量或者浓度为横坐标，吸光度值为纵坐标绘制标准曲线；（5）将测得的待测蛋白吸光度值代入标准曲线，就可计算得出蛋白质含量或者蛋白质浓度。操作过程示意图：3 方法优缺点优点：（1）此方法被广泛选用，操作简便、准确，灵敏度高，试剂稳定性好；（2）不易受一般浓度去污剂影响，抗干扰能力强；（3）检测不同蛋白质分子的变异系数也远小于考玛斯亮蓝法；（4）在20-2000μg/mL浓度大范围内具有良好的线性关系。缺点：（1）可能会受螯合剂和高浓度还原剂的影响；（2）需要30分钟或者更长时间的恒温水浴孵育。发布于 2022-12-20 17:09・IP 属地陕西蛋白质赞同 12添加评论分享喜欢收藏申请

BCA法测蛋白浓度，标曲绘制，上样量计算（3种方法） - 知乎

BCA法测蛋白浓度，标曲绘制，上样量计算（3种方法） - 知乎切换模式写文章登录/注册BCA法测蛋白浓度，标曲绘制，上样量计算（3种方法）亚卡达力biuBCA 法测蛋白浓度标取的绘制上样量的计算分为三种方法，大家选择适合自己的方法，或者是你们科室的师哥师姐用哪种方法，你就去按哪种方法去做。试剂盒里有 BCA 染液 A 和B，我们需要 50: 1 按照说明书避光进行配置。标准蛋白 BSA 一般常用的就是1毫克每千克，或者是 0. 5 毫克每千克。运用到我们的 96 孔板，每一个黑色的框就是我们的一个孔，里面包含了我们需要加的所有的液体，比如第二个孔，我们就需要加一体积的标准蛋白 BSA 以及 19 体积的 PBS 和 200 体积的BCA。因为 BCA 是需要闭光保存的，所以我们一般是最后加入 200ul 的BCA。加样的时候需要注意先加多液体，再加少液体，这样可以最大限度地减少我们的加上的误差。就比如第二孔，我们就先加 19 的PPS，或者是去离子水、纯水以及1体积的BSA。第八个第七个孔先加 16 体积的 BSA 和 4 体积的PBS。如果有气泡，最简单容易的方法就是用10u的针头去弄破，或者你比较放心的话，直接在下一步干烘箱 37 度静置或者是摇床， 30 分钟之后，它的气泡或许会自动地就破了。再用酶标仪在 562 纳米处检测它的 OD 值，第一行是标准蛋白的 OD 值。我们得到的下面这三个是我加样品，是我以一个样品为例做的三个复孔，它的 OD 值是第二行。先做标准曲线，把标取列出来，把标准蛋白的 o d 值列出来，列到了这里。还有一列是我们需要计算的标准浓度，运用公式： c = m / v。刚刚上的标准蛋白为 1 千克每毫升，我们就用 1 千克每毫升去乘以我们的上样体积，上映的体积有1，2，4，8，12，乘以对应的就可以。这样就可以算出我们的标准蛋白它的质量，之后再除以总体积。那这里的总体积是不算 BCA 的，只是算我们的 PBS 以及我们加入标准蛋白 BSA 的体积。它的总体积就是20，所以我们再除以20，就得到了我们每一个孔它的标准浓度是多少。选择这两列，插入散点图，散点图，任意一个点，我们右键添加趋势线-显示公式-显示 r 的平方值，我们的标曲就绘制出来了R 的平方要大于 0. 99，当然越大越好。我们之后利用标曲去计算蛋白浓度，就是用我们样品它的 OD 值，也就是 y 减去 0. 1911，再除以 1. 9131，得到了我们的蛋白浓度。但是我们这个蛋白浓度我们是被稀释了，因为我们还加入了PBS，所以我们需要再乘以它的体积，就是我们得到的实际蛋白浓度，再计算出三个复孔的平均值，那后面这两个是我假设我还有其他三个样品，我随便列出来的一些数据，这样方便后面给大家演示上样体积的计算。第一种方法是定体积，如果你还没有确定你的上样量是 50 微克， 30 微克还是多少，我们先按照你不同的上样量来分别的计算一下。这里用到的是我第一个样品浓度的平均值 12. 05。那假如你想要上 15 微克，此时你的总体积已经确定了是20，我们选择的是 5 × loading buffer，那就需要上总体积的 1/ 5，所以先用 20 / 5 就等于4。我们要加入 loading buffer 的量就是4ul，样品的体积就用 c =m/v，那 c平均浓度是 12. 05 ，m是我们的 15 ug，就得到了我们需要的样品。再用 20 减去 loading buffer，减去我们样品的体积，就得到我们再需要补充ddH2O，它的体积是多少,那 30 微克、 50 微克、 80 微克的时候，以此类推。那假如你已经知道了你要上 30 微克，第一行是我们样品浓度，同样，因为你要上的是 20 ul，所以你的 loading buffer 就是4，你要上的样品质量就是你确定的 30ug ，再除以你的浓度，再用总体积减去 5 × loading buffer，减去你的样品体积，就得到了你需要补充ddH2O的体积第二种方法我们也是先来介绍，就是假如你要上 15 ug， 30 ug、 50 ug、 80 ug的时候的方法。先计算你加入 5 × loading buffer 之后，你样品的浓度是多少，我们这里是要加入总体积 1/ 5 的 5 × loading buffer。所以说你有4体积的样品以及1体积的 loading buffer 构成了你的总体积，那么这 5 份里面的你的样品的质量是多少，就是用 4 体积的样品乘以你上面得到了样品的浓度，就是你这 5 份里面样品的质量，之后再除以 5 份的体积，就是以上样它的样品浓度。所以这里就是用 15 乘以 4 份体积，再除以 5 份体积或30 乘以 4 体积，再除以 5 体积再来算总体积，就是你样品的量，除以你刚刚算得的浓度就是总体积 5 × loading buffer =总体积/ 5。现在已经确定了你要上的量是 30 微克，第一行是你 BCA 得到的浓度来算你加入 loading buffer 之后浓度是多少，还是用刚才的方法× 4 / 5 之后算总的体积，用 30 微克除以刚刚算得的加入 loading buffer 浓度loading buffer 的量就是总体积，再除以5。不过像你这样的话，如果每次都只配一次上样的体积的话，它会比较麻烦，所以你可以一次你配个稍微多一点，但也不要太多，因为蛋白你总拿出来加样的话，它也容易降解。比如第一次你就可以配个 10 份来用。第三种方法就是既定了浓度又定了体积，虽然说计算上有一点点麻烦，但是在你上样的时候会简单很多。第一行是我们的浓度，第二层蛋白原液体积就需要你在之前提样的时候在抽取你离心得到的上清，你要注意上清的体积是多少，假如你是 450 差不多，你就是用 200 的枪头，最后一次用可以用 100 的枪头，之后你吸了一半发现它没有了，这样你就旋转你的枪头排出它的气泡。等将它的气泡全部排出，你看看上面枪头的数字是多少，就是你抽取剩余液体它的体积。你想要说将你这部分的上样的浓度全部调整为 5 微克每微升，因为你经过 BCA 浓度测定，你肯定是发现它们的浓度都大于 5 ug/ul，它的最小的浓度跟 5 ug/ul接近。我们是把所有的浓度全都往最小浓度方向上去调整，我们肯定要稀释，那稀释就需要加入我们的裂解液，怎么去计算，就是将我们蛋白原液的体积乘以我们的浓度得到蛋白的量，再除以你调整后的浓度5 微克每微升，得到总体积。我们再减去蛋白原液的体积，就知道我们需要添加的列解液的体积是多少了。它就是一个 c 等于 m 比 v 这样的公式来反复的去计算调整，那它调整后的总体积就是蛋白原液的体积，再加上需要添加裂解液的体积,加 5×的 loading buffer，就是在总体积里面加上总体积 1/ 4 的 loading buffer。不知道这个地方大家可不可以想明白，因为你加入的 loading buffer 它已经是一份儿的体积了，所以你蛋白的体积就要是 4 份之后，你这一份的loading buffer加入到 4 份的蛋白里面，混合成5体积，loading buffer就是混合后体积的 1/ 5，所以这里加 loading buffer 的体积就是你混合前蛋白体积的 1/ 4。你加入 loading buffer 之后的浓度是多少，就跟我们上一个计算方法有一点类似，也是要先从乘以 4 份的体积得到它的量，再除以 5 份的体积就是它的浓度。如果按 20 微克蛋白量计算的话，就是用它的质量 20 比上浓度4，你的上样体积就是5。因为你把所有的样品浓度全都调齐了，都调成了4，那你的上样体积它就都是5，你上样也会更容易一点。编辑于 2023-10-14 16:18・IP 属地辽宁蛋白质组学蛋白质赞同 372 条评论分享喜欢收藏申请

【实验技巧】BCA 法蛋白定量 - 实验方法 - 丁香通

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首页实验方法蛋白质技术蛋白质含量测定【实验技巧】BCA 法蛋白定量

【实验技巧】BCA 法蛋白定量

来源： &英文特</a&>

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BCA 蛋白定量法是实验室常用的蛋白质定量方法。Invent 所有蛋白提取试剂盒提取的蛋白均可使用 BCA 法进行定量！那么今天小编就手把手的教大家该如何用 BCA 来定量！

BCA 法原理

碱性条件下，蛋白将 Cu2+还原为 Cu+，Cu+与 BCA 试剂相互作用形成紫色的络合物，该水溶性的复合物在 562nm 处显示强烈的吸光性，吸光度和蛋白浓度在广泛范围内有良好的线性关系，因此根据吸光值可以推算出蛋白浓度。

实验操作具体步骤

1. 梯度稀释牛血清白蛋白（BSA）标准品（具体操作按试剂盒中说明操作）

2. 制备 BCA 工作液（具体操作按说明书进行）

3. 将各个稀释浓度的蛋白质标准品和待测蛋白质样品加入到微孔板或试管中，分别加入 BCA 工作液（比例参照试剂盒说明书）混匀。

4. 密封后，37℃ 保温 30-60 min

5. 冷却到室温，以空白为对照，测量样品在 562nm 或该波长附近的吸光值

6. 将各个标准品和待测蛋白质样品在 562nm 处的吸光值减去空白标准品在 562nm 处的平均吸光值。

浓度计算步骤

1. 输入相对应的标准曲线值和相应的蛋白样品值。（图中所示均为举例说明，具体数据参照自己的实验结果）选定标准曲线的 OD 值和标准品蛋白浓度。

2. 点击表头上的插入-图表-XY 散点图，点击确定。

3. 完成后会弹出一个图表，点击图表里面的散点，右键添加趋势曲线。

4. 完成后弹出设置趋势线格式，点击选勾最底下显示公式（E）以及显示 R 平方值。则在图表标题中显示出公式和 R2 值来。一般 R2 值越接近 1 代表你的标准曲线做得越好，根据标准曲线带入的样品 OD 值测出的蛋白浓度也越准确。R2 值越接近 1 越好，一般要求为 0.99 几左右。

5. 将样品 OD 值代入标准曲线的公式中，推导即得到待测样品蛋白的浓度。以 C1 蛋白样品 OD 值为例，按照图中模式代入公式，点击 enter 即为终结果。

图片来源：均为英文特公司制作，版权归英文特所属！

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chengxue727

为什么同一批次提取蛋白跑出的条带不一致做这个实验的时，我同一批次提取的蛋白，胶跑出的条带都不一致，这是什么原因呢？ 43 评论

jianchi20

WB 敷牛奶需要的时间 Western Blot 实验时敷牛奶大概多久?一定要过夜吗 42 评论

grass010

WB发光结果异常我做WB也不算是新手，自己觉得整个过程也没有什么明显的问题，可是最后发光的时候内参整个是晕开的，分子还连成了一条线，之前没出现过这种情况，所以想请大家帮忙分析下，是胶的问题，蛋白的问题，还是什么别的，谢啦！ 28 评论

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Home›Life Sciences›Protein Biology›Protein Assays and Analysis›Protein Assays›BCA Assay and Lowry AssaysBCA Assay and Lowry AssaysSee Navigation‹Protein AssaysFluorescent Protein Assays

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Copper-based total protein quantification

The BCA Protein Assay is a popular method for colorimetric detection and quantitation of total protein. Pierce BCA Protein Assays have a unique advantage over the Coomassie dye–based assays (Bradford)–they are compatible with samples that contain up to 5% surfactants (detergents), and are affected much less by protein compositional differences, providing greater protein-to-protein uniformity.For added ease of use, BCA protein assays with dilution-free protein standards reduces assay setup time by up to 80%. Dilution-Free protein standards are a set of prediluted standards packaged in a multichannel pipette compatible format which allows you to easily transfer a full dilution series to your microplate at once.Selection guide Technical handbookOn this page:Choose the right BCA assay for your sampleBCA assay principlesDilution-Free BCA protein assaysAdvantages of BCA assaysBCA protein assay protocolsRelated content:Bradford assays

Choose the right BCA protein assay for your sample

BCA assaysLowry assaysOrderingDocuments Pierce Dilution-Free Rapid Gold BCA Protein AssayPierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsPierce BCA Protein Assay - Reducing Agent CompatibleMicro BCA Protein AssayAssay range: (sample volume)20–10,000 µg (10 µL)20–2,000 µg/mL (25 µL)125–2,000 µg/mL (9 µL)2–40 µg/mL (150 µL) or 0.5–20 µg/mL (500 µL)Incubation time and temperature5 min at RT30 min at 37°C45 min at 37°C60 min at 60°CTotal assay time10 min45 min115 min130 minAbsorbance480 nm562 nm562 nm562 nmCompatible reagentsDetergentsDetergentsDetergents/reducing agents (e.g. DTT)DetergentsIncompatible reagentsReducing agents; chelatorsReducing agents; chelatorsChelatorsReducing agents; chelatorsUniformityLess protein: protein variation than Bradford assaysLess protein: protein variation than Bradford assaysSignificantly less (14–23%) protein: protein variation than Bradford assaysLess protein: protein variation than Bradford assaysDilution-free protein standardsYesYesNoNoCat. No.A55860 (500 mL)A55861 (250 mL)A55862 (20 mL)A55864 (1000 mL)A55865 (500 mL) Related BCA Kits:23225 (1000 mL)23227 (500 mL)23250 (275 mL/kit)23252 (microplate)23235 (500 mL/kit)Related product: Pierce Dilution Free BSA Protein Standards, Multichannel Pipette Compatible, 0.125–2 mg/mLRelated product: Pierce Dilution-Free BSA Protein Standards, Multichannel Pipette Compatible, 0.125–10 mg/mLBCA kits overviewDilution-Free Rapid Gold BCA Protein Assay – green to yellow (A480 nm), 2-component, precise, detergent compatible assay to measure total protein vs. protein standard in 5 minutes at room temperatureBCA Protein Assay with Dilution-Free BSA Protein Standards – green-to-purple (A562 nm), 2-component, precise, detergent-compatible assay reagent to measure total protein concentration vs. protein standard in 30 minutes at 37°C.BCA Protein Assay - Reducing Agent Compatible – reducing agent–compatible version of our BCA Reagent Kit to measure protein concentration in samples containing DTT or BME thiol-reductants.Micro BCA Protein Assay – special 3-component version of our BCA Reagent Kit to measure total protein concentration of dilute protein solutions (0.5 to 20 μg/mL).Effortless, Fast, AccurateSelect BCA assays now include Dilution-Free BSA Protein Standards which are a set of 7 prediluted BSA standards, uniquely designed for multichannel pipette compatibility.Pierce Dilution-Free standards allow you to eliminate time-consuming and tedious dilutions when generating your standard curve and are calibrated by direct comparison to purified BSA from the National Institute of Standards and Technology (NIST) to help ensure accurate standard curve generation.

BCA assay principles

Chemistry of BCA-based protein assaysThe Pierce BCA Protein Assays combines the well-known reduction of Cu2+ to Cu+ by protein in an alkaline medium (also known as the biuret reaction) with the highly sensitive and selective colorimetric detection of the cuprous cation (Cu+) by bicinchoninic acid (BCA).Figure 1. The first step is the chelation of copper with protein in an alkaline environment to form a blue-colored complex. In this reaction, peptides containing three or more amino acid residues form a colored chelate complex with cupric ions in an alkaline environment containing sodium potassium tartrate.Single amino acids and dipeptides are unaffected in the biuret reaction, but tripeptides and larger polypeptides or proteins will react to produce the light blue-to-violet complex that absorbs light at 540 nm. One cupric ion forms a colored coordination complex with four to six nearby peptides bonds. The intensity of the color produced is proportional to the number of peptide bonds participating in the reaction.Figure 2. In the second step, BCA reagent, a highly sensitive and selective colorimetric detection reagent, reacts with the cuprous cation (Cu+) that was formed in the first step and produces a purple-color.The BCA-copper complex is water-soluble and exhibits a strong linear absorbance at 562 nm with increasing protein concentrations. The purple color may be measured at any wavelength between 550 and 570 nm with minimal (less than 10%) loss of signal. The signal induced by the BCA reagent is approximately 100 times more sensitive (lower limit of detection) than the signal using the biuret reagent.Pierce Dilution-Free Rapid Gold BCA protein assay uses the same copper reduction method as traditional BCA assay with a unique copper chelator. In the second step of the color development reaction, the Pierce Dilution-Free Rapid Gold BCA chelator reacts with the reduced (cuprous) cation (Cu+) that was formed in step one to produce an intensely gold-colored reaction product. The copper complex exhibits a strong linear absorbance at 480 nm with increasing protein concentrations.

Dilution-free BCA protein assays

Dilution-free BSA protein standards are available separately or as part of other BCA protein assays. Compared to the Bradford Assay or Pierce BCA Protein assay kit, the Dilution-Free Rapid Gold BCA Protein Assay reduces assay setup by up to 80% by eliminating the need to dilute samples and standards. Additionally, it only requires a 5-minute, room temperature incubation. The dilution-free BSA protein standards are also available in the BCA Protein Assay Kit with Dilution-Free BSA Protein Standards.Figure 3. The Pierce Dilution-Free Rapid Gold BCA Assay reduces setup time by up to 80% compared to other protein assays. The assays were conducted following the manufacturer’s protocols in a microplate format. Five cell lysates and five pure proteins were prepared to give a total of ten samples. Standard curves for the BCA and Bradford assays were generated through serial dilution of 2 mg/mL bovine serum albumin (BSA) standard. The standard curve for the Pierce Dilution-Free Rapid Gold BCA Assay was generated using Pierce Dilution-Free BSA Protein Standards (included with the kit) packaged in a multichannel pipette-friendly tube strip. Four of the ten samples were expected to have a starting concentration of >2 mg/mL, which necessitated a sample dilution step for the BCA and Bradford assays, whereas samples were not required to be diluted for the Dilution-Free Rapid Gold BCA Assay. Samples were then mixed with working reagent from each assay and incubated according to the manufacturer’s instructions.

Advantages of BCA assays

BCA protein quantificationOne of the major advantages of the BCA assay is that it produces a linear response curve. This response curve allows accurate determination of unknown protein concentrations and provides a higher dynamic range than other standard assays.Figure 4. Pierce Dilution-Free Rapid Gold BCA Protein Assay generates a linear standard curve across a wide dynamic range (0–10 mg/mL). Standard curves were produced for the Pierce Dilution-Free Rapid Gold BCA Protein Assay and the Quick Start Bradford Protein Assay (Bio-Rad) with purified BSA in 0.9% saline (0–10 mg/mL). Both assays were conducted using the manufacturer’s protocols in a microplate format. Absorbance readings were taken using the Thermo Scientific Varioskan LUX Multimode Microplate Reader.

BCA assay accuracy

Another major advantage of BCA protein assays is the accuracy as shown through low protein-to-protein variation. Proteins are diverse in their composition and structure, and with some assays, the proteins’ differences in amino acid sequence, isoelectric point (pI), secondary structure, and side chains or prosthetic groups result in variation in the colorimetric response. Since BCA chemistries develop a color response in proportion to the number of peptide bonds present, they are less affected by these differences when compared to dye-binding assays (e.g. Bradford Assays) and therefore exhibit less protein-to-protein variation.Figure 5. Protein quantification results of the Pierce Dilution-Free Rapid Gold BCA Protein Assay and the Quick Start Bradford Protein Assay compared to samples of known concentration. Both assays were conducted in a microplate format, according to the respective manufacturers’ protocols. For the Bradford assay, 5 μL of sample was added to 250 μL of the Bradford working reagent and incubated at room temperature for 5 minutes. For the Dilution-Free Rapid Gold BCA Protein Assay, 10 μL of sample was added to 200 μL of Dilution-Free Rapid Gold BCA working reagent and incubated at room temperature for 5 minutes. Known concentrations of protein samples were based on manufacturers’ indicated concentrations and were confirmed by absorbance at 280 nm.

BCA protein assay protocols

BCA Protein Assay with Dilution-Free BSA Protein StandardsThe Pierce BCA Protein Assay can be performed using two different formats based upon the dynamic range needed to detect the protein concentration of an unknown sample. This BCA assay detects protein concentrations from 20–2,000 μg/mL using a two-component system: Reagent A, a carbonate buffer containing BCA reagent, and Reagent B, a cupric sulfate solution, which are combined to make an apple green–colored working solution that turns purple after 30 minutes at 37°C in the presence of protein. Since the color reaction is not a true endpoint reaction, considerable protocol flexibility is allowed with the Pierce BCA Protein Assay. By increasing the incubation temperature, the sensitivity of the assay can be increased. When using the enhanced tube protocol (i.e., incubating at 60°C for 30 minutes), the working range for the assay shifts to 5–250 μg/mL, facilitating detection of more dilute samples.Figure 6. BCA Protein Assay Kit with Dilution-Free BSA Protein Standards, multichannel pipe compatible protocol.Dilution-Free Rapid Gold BCA Protein Assay Kit protocolThe Dilution-Free Rapid Gold BCA Protein Assay provides the high sensitivity and linearity associated with the BCA assay but performed within a fraction of the time. Simply mix the BCA working solution, add samples and dilution-free standards to your microplate, incubate for 5 minutes at room temperature, and read the absorbance.Figure 7. Dilution-Free Rapid Gold BCA Protein Assay Kit protocol.Modified Lowry Protein Assay KitAssay range: microplate (sample volume)10 to 1,500 µg/mL (40 µL)Assay range: cuvette (sample volume)1–1,500 µg/mL (200 µL)Incubation time and temperature10 and 30 min at RTTotal assay time110 minAbsorbance750 nmCompatible reagentsSDS (up to 1%)Incompatible reagentsReducing reagents, Chelators, detergents, tris, tricine, glycerolUniformityLess protein:protein variation than Coomassie dye methodsProduct size530 mL/kitCat. No.23240Related product: Pierce Dilution Free BSA Protein Standards, Multichannel Pipette Compatible, 2 mg/mLLowry assay principlesThe Pierce Modified Lowry Protein Assay is based on the colorimetric method introduced by Oliver H. Lowry in 1951. The Pierce modified assay replaces two of the assay’s traditional unstable reagents with a single, more stable one.Chemistry of the Pierce Modified Lowry AssayThe Pierce Modified Lowry Protein Assay is an enhanced biuret assay involving copper-chelation chemistry. Although the mechanism of color formation for the Pierce Modified Lowry Protein Assay is similar to that of the Pierce BCA Protein Assay, there are several significant differences between the two. While the precise mechanism for color formation using the Pierce Modified Lowry Protein Assay is not completely understood, it is known that the reaction occurs as two distinct steps. First, protein reacts with alkaline cupric sulfate in the presence of tartrate during a 10-minute incubation at room temperature. During this incubation, a tetradentate copper complex forms from four peptide bonds and one atom of copper, which is light blue in color (this is the “biuret reaction”). Following the incubation, the Folin phenol reagent is added. It is believed that the color enhancement occurs when the tetradentate copper complex transfers electrons to the phosphomolybdic–phosphotungstic acid complex (the Folin phenol reagent). The reduced phosphomolybdic–phosphotungstic acid complex produced by this reaction is intensely blue in color.Figure 8. Reaction schematic for the Pierce Modified Lowry Protein Assay Kit.Figure 9. Pierce Modified Lowry Protein Assay protocolA55860, A55861, A55862, A55864, A55865,23221,23228,23223,23222,23224,23225,23227,2323023250,2325223235,23231,23232,2323423240A55863, A56979,23209, 23208, 23212, 23213Manuals & protocolsUser Guide: Pierce Dilution-Free Rapid Gold BCA Protein Assay KitUser Guide: Pierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsUser Guide: Pierce BCA Protein Assay Kit − Reducing Agent CompatibleUser Guide: Micro BCA Protein Assay KitUser Guide: Modified Lowry Protein Assay KitApplication & technical guidesTechnical handbook: Protein AssaysTech Tip: Determine acceptable wavelengths for measuring protein assaysTech Tip: Eliminate interfering substances from samples for BCA Protein AssayTech Tip: How to use a protein assay standard curveTech Tip: Protein assay compatibility tableOther literatureLiberate yourself with Pierce Dilution-Free protein assays

BCA assays

Pierce Dilution-Free Rapid Gold BCA Protein AssayPierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsPierce BCA Protein Assay - Reducing Agent CompatibleMicro BCA Protein AssayAssay range: (sample volume)20–10,000 µg (10 µL)20–2,000 µg/mL (25 µL)125–2,000 µg/mL (9 µL)2–40 µg/mL (150 µL) or 0.5–20 µg/mL (500 µL)Incubation time and temperature5 min at RT30 min at 37°C45 min at 37°C60 min at 60°CTotal assay time10 min45 min115 min130 minAbsorbance480 nm562 nm562 nm562 nmCompatible reagentsDetergentsDetergentsDetergents/reducing agents (e.g. DTT)DetergentsIncompatible reagentsReducing agents; chelatorsReducing agents; chelatorsChelatorsReducing agents; chelatorsUniformityLess protein: protein variation than Bradford assaysLess protein: protein variation than Bradford assaysSignificantly less (14–23%) protein: protein variation than Bradford assaysLess protein: protein variation than Bradford assaysDilution-free protein standardsYesYesNoNoCat. No.A55860 (500 mL)A55861 (250 mL)A55862 (20 mL)A55864 (1000 mL)A55865 (500 mL) Related BCA Kits:23225 (1000 mL)23227 (500 mL)23250 (275 mL/kit)23252 (microplate)23235 (500 mL/kit)Related product: Pierce Dilution Free BSA Protein Standards, Multichannel Pipette Compatible, 0.125–2 mg/mLRelated product: Pierce Dilution-Free BSA Protein Standards, Multichannel Pipette Compatible, 0.125–10 mg/mLBCA kits overviewDilution-Free Rapid Gold BCA Protein Assay – green to yellow (A480 nm), 2-component, precise, detergent compatible assay to measure total protein vs. protein standard in 5 minutes at room temperatureBCA Protein Assay with Dilution-Free BSA Protein Standards – green-to-purple (A562 nm), 2-component, precise, detergent-compatible assay reagent to measure total protein concentration vs. protein standard in 30 minutes at 37°C.BCA Protein Assay - Reducing Agent Compatible – reducing agent–compatible version of our BCA Reagent Kit to measure protein concentration in samples containing DTT or BME thiol-reductants.Micro BCA Protein Assay – special 3-component version of our BCA Reagent Kit to measure total protein concentration of dilute protein solutions (0.5 to 20 μg/mL).Effortless, Fast, AccurateSelect BCA assays now include Dilution-Free BSA Protein Standards which are a set of 7 prediluted BSA standards, uniquely designed for multichannel pipette compatibility.Pierce Dilution-Free standards allow you to eliminate time-consuming and tedious dilutions when generating your standard curve and are calibrated by direct comparison to purified BSA from the National Institute of Standards and Technology (NIST) to help ensure accurate standard curve generation.

BCA assay principles

Dilution-free BCA protein assays

Advantages of BCA assays

BCA assay accuracy

BCA protein assay protocols

Lowry assays

Modified Lowry Protein Assay KitAssay range: microplate (sample volume)10 to 1,500 µg/mL (40 µL)Assay range: cuvette (sample volume)1–1,500 µg/mL (200 µL)Incubation time and temperature10 and 30 min at RTTotal assay time110 minAbsorbance750 nmCompatible reagentsSDS (up to 1%)Incompatible reagentsReducing reagents, Chelators, detergents, tris, tricine, glycerolUniformityLess protein:protein variation than Coomassie dye methodsProduct size530 mL/kitCat. No.23240Related product: Pierce Dilution Free BSA Protein Standards, Multichannel Pipette Compatible, 2 mg/mLLowry assay principlesThe Pierce Modified Lowry Protein Assay is based on the colorimetric method introduced by Oliver H. Lowry in 1951. The Pierce modified assay replaces two of the assay’s traditional unstable reagents with a single, more stable one.Chemistry of the Pierce Modified Lowry AssayThe Pierce Modified Lowry Protein Assay is an enhanced biuret assay involving copper-chelation chemistry. Although the mechanism of color formation for the Pierce Modified Lowry Protein Assay is similar to that of the Pierce BCA Protein Assay, there are several significant differences between the two. While the precise mechanism for color formation using the Pierce Modified Lowry Protein Assay is not completely understood, it is known that the reaction occurs as two distinct steps. First, protein reacts with alkaline cupric sulfate in the presence of tartrate during a 10-minute incubation at room temperature. During this incubation, a tetradentate copper complex forms from four peptide bonds and one atom of copper, which is light blue in color (this is the “biuret reaction”). Following the incubation, the Folin phenol reagent is added. It is believed that the color enhancement occurs when the tetradentate copper complex transfers electrons to the phosphomolybdic–phosphotungstic acid complex (the Folin phenol reagent). The reduced phosphomolybdic–phosphotungstic acid complex produced by this reaction is intensely blue in color.Figure 8. Reaction schematic for the Pierce Modified Lowry Protein Assay Kit.Figure 9. Pierce Modified Lowry Protein Assay protocol

Ordering

A55860, A55861, A55862, A55864, A55865,23221,23228,23223,23222,23224,23225,23227,2323023250,2325223235,23231,23232,2323423240A55863, A56979,23209, 23208, 23212, 23213

Documents

Manuals & protocolsUser Guide: Pierce Dilution-Free Rapid Gold BCA Protein Assay KitUser Guide: Pierce BCA Protein Assay Kit with Dilution-Free BSA Protein StandardsUser Guide: Pierce BCA Protein Assay Kit − Reducing Agent CompatibleUser Guide: Micro BCA Protein Assay KitUser Guide: Modified Lowry Protein Assay KitApplication & technical guidesTechnical handbook: Protein AssaysTech Tip: Determine acceptable wavelengths for measuring protein assaysTech Tip: Eliminate interfering substances from samples for BCA Protein AssayTech Tip: How to use a protein assay standard curveTech Tip: Protein assay compatibility tableOther literatureLiberate yourself with Pierce Dilution-Free protein assays

Resources

Pierce Protein methods – an encyclopedia of articles about protein analysisOverview of Protein AssaysChemistry of Protein AssaysProtein Assay Data AnalysisProtein assay technical guide – tools and reagents for improved quantitation of total or specific proteins.Protein assay compatibility table – summarizes compatible substances for several popular protein assays.Protein Analysis Learning Center – resources for different protein analysis techniquesProtein Biology Application Notes – journal-style articles based on research applications and proof-of-concept experimentsLiberate yourself with Pierce Dilution-Free protein assaysFor Research Use Only. Not for use in diagnostic procedures.

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BCA蛋白浓度检测_百度百科

白浓度检测_百度百科网页新闻贴吧知道网盘图片视频地图文库资讯采购百科百度首页登录注册进入词条全站搜索帮助首页秒懂百科特色百科知识专题加入百科百科团队权威合作下载百科APP个人中心BCA蛋白浓度检测播报讨论上传视频检测实验收藏查看我的收藏0有用+10BCA蛋白浓度检测是一个实验，是根据吸光值可以推算出蛋白浓度.碱性条件下，蛋白将Cu2+还原为Cu+， Cu+与BCA试剂形成紫颜色的络合物，两分子BCA螯合一个Cu+。将该水溶性复合物在562nm处的吸收值，与标准曲线对比，即可计算待测蛋白的浓度。常用浓度的去垢剂SDS，Triton X-100，Tween不影响检测结果，但受螯合剂(EDTA，EGTA)、还原剂（DTT，巯基乙醇）和脂类的影响。实验中，若发现样品稀释液或裂解液本身背景值较高，可试用Bradford蛋白浓度测定试剂盒。中文名BCA蛋白浓度检测外文名BCA assay实验试剂BCA试剂，标准蛋白质溶液实验操作绘制标准曲线试验方法根据吸光值可以推算出蛋白浓度。目录1简介2实验试剂3实验操作简介播报编辑二价铜离子在碱性的条件下，可以被蛋白质还原成一价铜离子，一价铜离子和独特的BCA　Solution　A（含有BCA）相互作用产生敏感的颜色反应。两分子的BCA螯合一个铜离子，形成紫色的反应复合物。该水溶性的复合物在562nm处显示强烈的吸光性，吸光度和蛋白浓度在广泛范围内有良好的线性关系，因此根据吸光值可以推算出蛋白浓度。测定方法：实验试剂播报编辑(1) BCA试剂的配制① 试剂A，1L：分别称取10g BCA (1%)，20g Na2CO3·H2O(2%)，1.6g Na2C4H4O6·2H2O(0.16%)，4g NaOH (0.4%) ，9.5g NaHCO3(0.95%) ，加水至1L，用NaOH或固体NaHCO3调节pH值至11.25。②试剂B，50ml：取2g CuSO4·5H2O (4%)，加蒸馏水至50ml。③BCA试剂：取50份试剂A与1份试剂B混合均匀。此试剂可稳定一周。(2)标准蛋白质溶液：称取0.5g牛血清白蛋白，溶于蒸馏水中并定容至100ml，制成5mg/ml的溶液。用时稀释十倍。实验操作播报编辑绘制标准曲线：取96孔酶标板，按下表加入试剂。管号12345678标准蛋白溶液（μl）蒸馏水（μl）BCA试剂（μl）蛋白质浓度（mg/ml）02020001192000.0252182000.054162000.18122000.21282000.31642000.42002000.5上述试剂加完后，准确吸取20μl样品溶液于酶标孔中，加入BCA试剂200μl，轻摇，于37℃保温30-60min，冷却至室温后，以空白为对照，在酶标仪上562nm处比色，以牛血清白蛋白含量为横坐标，以吸光值为纵坐标，绘制标准曲线。以标准曲线空白为对照，根据样品的吸光值从标准曲线上查出样品的蛋白质含量。新手上路成长任务编辑入门编辑规则本人编辑我有疑问内容质疑在线客服官方贴吧意见反馈投诉建议举报不良信息未通过词条申诉投诉侵权信息封禁查询与解封©2024 Baidu 使用百度前必读 | 百科协议 | 隐私政策 | 百度百科合作平台 | 京ICP证030173号京公网安备110000020000

常见的BCA法检测蛋白定量 - 分子生物 - 综合其他 - 小木虫论坛-学术科研互动平台

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小木虫论坛-学术科研互动平台 » 生物医药区 » 分子生物 » 综合其他 » 常见的BCA法检测蛋白定量

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常见的BCA法检测蛋白定量

在蛋白质比色定量试验中，最常用的方法是二喹啉甲酸（Bicinchoninic acid，BCA）法蛋白定量。那么为什么我们要选择用BCA法？BCA法是Lowry测定法的一种改进方法，与Lowery法相比，BCA蛋白测定方法操作更简单，试剂及其形成的颜色复合物稳定性更好，几乎没有干扰物质的影响，灵敏度高（微量检测可达到0.5μg/ml），应用更加灵活。与Bradford法相比，BCA法的显著优点是不受去垢剂的影响。

BCA法蛋白定量的原理是什么？

大多数蛋白样品可通过比色测定法定量，在典型的蛋白测定中，化学试剂加入到蛋白样品溶液里产生颜色变化，这一变化可由分光光度计或酶标仪检测，并与已知浓度的蛋白标准曲线作比较。BCA法是在碱性环境下蛋白质与Cu2+络合并将Cu2+还原成Cu1+，BCA与Cu1+结合形成稳定的紫蓝色复合物，在562 nM处有高的光吸收值并与蛋白质浓度成正比，据此可测定蛋白质浓度。

BCA法蛋白定量是如何操作的？

先将solution A 摇晃混匀，根据样品数量，按50体积solution A加1体积solution B试剂（50:1）配制成BCA工作液，充分混匀。BCA工作液在24小时内稳定。

稀释标准品：蛋白质标准品（5mg/ml BSA，-20℃保存）用生理盐水或PBS稀释成2000ug/ml，1000 ug/ml，500 ug/ml，250 ug/ml，125 ug/ml，62.5 ug/ml，31.25 ug/ml，15.625 ug/ml八个浓度的蛋白标准溶液。（大家根据实验室的标准品的浓度合理设计制作标准曲线的浓度）

样本的制备：蛋白质样品用细胞总蛋白提取试剂提取总蛋白。

取步骤2中的20ul蛋白标准品和待测样品至96孔板中。

在各孔中加入200微升BCA工作液，这时使用加样枪轻柔吹打，将其中液体混匀，这时请注意，尽量小一点力气轻柔一点，不要弄出很多气泡，这样会影响读数，然后再37℃室内放置30-60min。将液体冷却至室温，在酶标仪上测定562nm（或540-590nm之间）的波长的吸光值，最后可根据标准曲线计算出蛋白质的浓度，为样品蛋白质定量。

MDL进行的BCA法蛋白定量的实验视频

浓度计算步骤

输入相对应的标准曲线值和相应的蛋白样品值，一般是8个点。

然后将上面数据做图表（XY 散点图），点击图表里面的散点，右键添加趋势曲线。

然后弹出设置趋势线格式，点击选勾最底下显示公式（E）以及显示R平方值。则在图表标题中显示出公式和R2值来。一般 R2值越接近1代表你的标准曲线做得越好，根据标准曲线带入的样品OD值测出的蛋白浓度也越准确。R2值越接近1越好，一般要求为0.99几左右。

将样品OD值代入标准曲线的公式中，即得到待测样品蛋白的浓度。

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碧云天-P0010-BCA蛋白浓度测定试剂盒(增强型)

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Mitochondrial dysfunction as an early event in the process of apoptosis induced by woodfordin I in human leukemia K562 cells.

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Dual effects of cycloheximide on U937 apoptosis induced by its combination with VP-16.

Biol Pharm Bull

2004 Jul;27(7):1075-80.

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A protein delivery system: biodegradable alginate-chitosan-poly(lactic-co-glycolic acid)composite microspheres.

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Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria.

Cancer Lett

2005;224:229–41.

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30. Liu MJ, Wang Z, Ju Y, Wong RN, Wu QY.

Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis.

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2005 Jan;55(1):79-90.

(IF 2.967)

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TatPTD can introduce HBV targeted ribonuclease into hepatocytes.

世界华人消化杂志

2005 Apr 15;13(8):958-962.

32. Zhao Y, Guan H, Liu SF, Wu RC, Wang Z.

Overexpression of QM induces cell differentiation and mineralization in MC3T3-E1.

Biol Pharm Bull

2005 Aug;28(8):1371-6.

(IF 1.863)

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Influence of the Numbers of Octapeptide Repeats within N2terminus of Recombinant Human PrP Proteins on the Protease Resistance af ter Interacting with Metal Ions and the Binding Abil ity with Tau Protein.

J VIROL

2005 Sep;21(5):376-83.

(IF 4.501)

34. Zhang LF, Peng SQ, Wang S.

Influence of lead (Pb2+) on the reactions of in vitro cultured rat aorta to 5-hydroxytryptamine.

Toxicol Lett

2005 Oct 15;159(1):71-82.

(IF 3.569)

35. Ma JF, Guo JK, Peng LW, Chen CY, Zhang LX.

Decrease of photosystem II photochemistry in Arabidopsis ppt1 mutant is dependent on leaf age.

J Integr Plant Biol

2006; 48(12):1409-14.

(IF 4.885)

36. Huang YY, Deng JY, Gu J, Zhang ZP, Maxwell A, Bi LJ, Chen YY, Zhou YF, Yu ZN, Zhang XE.

The key DNA-binding residues in the C-terminal domain of Mycobacterium tuberculosis DNA gyrase A subunit (GyrA).

Nucleic Acids Res

2006;34(19):5650-9.

(IF 11.501)

37. Wu ZQ, Li M, Chen J, Chi ZQ, Liu JG.

Involvement of cAMP/cAMP-dependent protein kinase signaling pathway in regulation of Na+,K+-ATPase upon activation of opioid receptors by morphine.

Mol Pharmacol

2006 Mar;69(3):866-76.

(IF 3.664)

38. Yi ZC, Liu YZ, Li HX, Yin Y, Zhuang FY, Fan YB, Wang Z.

Tellimagrandin I enhances gap junctional communication and attenuates the tumor phenotype of human cervical carcinoma HeLa cells in vitro.

Cancer Lett

2006 Oct 8;242(1):77-87.

(IF 7.36)

39. Jun Hong, Dongmei Xua, Peijun Gong, Hanwen Suna, Li Dong, Side Yao.

Covalent binding of α-chymotrypsin on the magnetic nanogels covered by amino groups.

J MOL CATAL B-ENZYM

2007;45:84–90.

(IF 2.269)

40. Jun Hong, Dongmei Xua, Peijun Gong, Hanwen Suna, Li Dong, Side Yao.

Covalent binding of -chymotrypsin on the magnetic nanogels covered by amino groups.

J MOL CATAL B-ENZYM

2007;45:84–90.

(IF 2.269)

41. Huang JW, Tian LX, Du ZY, Yang HJ, Liu YJ.

Effects of dietary thiamin on the physiological status of the grouper Epinephelus coioides.

Fish Physiol Biochem

2007;33:167–72.

(IF 2.242)

42. Cheng BQ, Jiang B, Bao J.

Construction and expression of ga lectin2 3 shRNA recombinant vector and its effect on prolifera tion ra te of colorecta l cancer lovo cells.

第四军医大学学报

2007;28(11):1014-7.

43. Wang YC, Zou QM, Mao XH, Guo G, Xie QH.

A prelim inary non2clin ica l study of Helicobacter pylori m icrospheres vacc ine.

《中国新药杂志》

2007;16(7):539-543.

44. Wang M, Long AH, Liu CH, Ji G.

Effect of Qinggan Huoxue recipe and its separated recipe on ERK signal ing pathway in Kupffer cell mediated by LPS.

HIN J INTEGR MED

2007;17(5):277-280.

(IF 1.346)

45. Ji G, Wang M, Long AH, Liu CH.

Regulative Effects of"Qinggan Huoxue Recipe" and Its Separated Recipes on Kupffer Cells Mediated by LPS.

shanghai journal of traditional chinese medicine

2007 Jan;41(1):18-21.

46. Li JL, Yan ZP, Chen XH, Wang YJ, Sun M, Shi YX, Wang CB.

Inh ib ition of Polypeptide from Chlamys fa rreri on UVA2Induced Apoptosis of HaCaT Cells Depending on p38MAPK Pa thway and Ca spase23.

中国药科大学学报

2007 Jan ;42(2):116-120.

47. Wu ZQ, Chen J, Chi ZQ, Liu JG.

Involvement of dopamine system in regulation of Na+,K+-ATPase in the striatum upon activation of opioid receptors by morphine.

Mol Pharmacol

2007 Feb;71(2):519-30.

(IF 3.664)

48. Gao J, Zhao YN, Jiang QW.

Investigation of Asymptomatic Infection of Echovirus 30 in Population of Shanghai.

Journal of the virus

2007 March;23(2):121-124.

49. Zhang LF, Peng SQ, Wang S, Li BL, Han G, Dong YS.

Direct effects of lead (Pb2+) on the relaxation of in vitro cultured rat aorta to acetylcholine.

Toxicol Lett

2007 Apr 25;170(2):104-10.

(IF 3.569)

50. Deng XQ, Chen LL, Li NX.

The expression of SIRT1 in nonalcoholic fatty liver disease induced by high-fat diet in rats.

Liver Int

2007 Jun;27(5):708-15.

(IF 5.175)

51. Gao MQ, Guo SB, Chen XH, Du W, Wang CB.

Molecular mechanisms of polypeptide from Chlamys farreri protecting HaCaT cells from apoptosis induced by UVA plus UVB.

Acta Pharmacol Sin

2007 Jul;28(7):1007-14.

(IF 5.064)

52. Dong S, Li C, Wu P, Tsien JZ, Hu Y.

Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice.

Eur J Neurosci

2007 Jul;26(1):101-12.

(IF 3.115)

53. Wang Q, Liang C, Song J, Chen X.

HA2 from the Helicoverpa armigera nucleopolyhedrovirus: a WASP-related protein that activates Arp2/3-induced actin filament formation.

Virus Res

2007 Jul;127(1):81-7.

(IF 2.934)

54. Wang YC, Zou QM, Ren JM, Guo G, Xie QH, Liu j.

Study of the microspheres technology of Helicobacter pylori whole cell protein encapsulated by chitosan2alginate.

Journal of Chongqing Medical University 重庆医科大学学报

2007 July;36(13):1285-1287.

55. Li JL, Liu N, Chen XH, Sun M, Wang CB.

Inhibition of UVA-induced apoptotic signaling pathway by polypeptide from Chlamys farreri in human HaCaT keratinocytes.

RADIAT ENVIRON BIOPH

2007 Aug;46(3):263-8.

(IF 1.321)

56. Yuan QL, Yang CX, Xu P, Gao XQ, Deng L, Chen P, Sun ZL, Chen QY.

Neuroprotective effects of ginsenoside Rb1 on transient cerebral ischemia in rats.

Brain Res

2007 Sep 5;1167:1-12.

(IF 2.733)

57. Chen YR, Nie SD, Shan W, Jiang DJ, Shi RZ, Zhou Z, Guo R, Zhang Z, Li YJ.

Decrease in endogenous CGRP release in nitroglycerin tolerance: role of ALDH-2.

Eur J Pharmacol

2007 Sep 24;571(1):44-50.

(IF 3.263)

58. Zong-Chun Yi, Hong Wang, Guang-Yao Zhang, Bing Xia.

Downregulation of connexin 43 in nasopharyngeal carcinoma cells is related to promoter methylation.

Oral Oncol

2007 Oct;43(9):898-904.

(IF 3.979)

59. Wang ZL, Li JL, Wang CB.

The role of tumor necrosis factor rela ted apoptosis induc ing ligand and Polypeptide from Chlam ys fa rreri in UVA2induced apoptosis in HaCaT cells.

《中国药理学通报》

2007 Oct;23(10):1375-9.

60. Zhang Y, Zhen DX, Ren TL, Wang DP.

The Character istics Effects of Ga tifloxac in on L iverM icrosome Cytochrome P450 in Rats.

pharm j chin pla

2007 Dec;23(6):404-407.

61. Pan YQ, Ding D, Li DX, Chen SQ.

Expression and bioactivity analysis of Staphylococcal enterotoxin M and N.

PROTEIN EXPRES PURIF

2007 Dec;56(2):286-92.

(IF 1.513)

62. Nie H, Li Z, Lukas RJ, Shen Y, Song L, Wang X, Yin M.

Construction of SH-EP1-alpha4beta2-hAPP695 Cell Line and Effects of Nicotinic Agonists on beta-amyloid in the Cells.

Cell Mol Neurobiol

2008 Jan;28(1):103-12.

(IF 3.606)

63. Zhang DW, Cheng Y, Wang NL, Zhang JC, Yang MS, Yao XS.

Effects of total flavonoids and flavonol glycosides from Epimedium koreanum Nakai on the proliferation and differentiation of primary osteoblasts.

Phytomedicine

2008 Jan;15(1-2):55-61.

(IF 4.268)

64. Zhang H, Deng JY, Bi LJ, Zhou YF, Zhang ZP, Zhang CG, Zhang Y, Zhang XE.

Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase.

FEBS J

2008 Feb;275(4):753-62.

(IF 4.392)

65. Liu C, Wang Q, Guo H, Xia M, Yuan Q, Hu Y, Zhu H, Hou M, Ma J, Tang Z, Ling W.

Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine.

J Nutr

2008 Feb;138(2):311-5.

(IF 4.281)

66. Zhang GG, Bai YP, Chen MF, Shi RZ, Jiang DJ, Fu QM, Tan GS, Li YJ.

Asymmetric dimethylarginine induces TNF-alpha production via ROS/NF-kappaB dependent pathway in human monocytic cells and the inhibitory effect of reinioside C.

VASC PHARMACOL

2008 Feb-Mar;48(2-3):115-21.

(IF 4.152)

67. Yu S, Geng J, Zhou P, Wang J, Feng A, Chen X, Tong H, Hu J.

Application of a new hybrid organic-inorganic monolithic column for efficient deoxyribonucleic acid purification.

Anal Chim Acta

2008 Mar 24;611(2):173-81.

(IF 5.977)

68. Yu S, Geng J, Zhou P, Wang J, Chen X, Hu J.

New hydroxyapatite monolithic column for DNA extraction and its application in the purification of Bacillus subtilis crude lysate.

J Chromatogr A

2008 Mar 7;1183(1-2):29-37.

(IF 4.049)

69. Wang Y, Peng KM, Li JL, Song H, Li SH, Wei L, Wang JX.

Ultrastructure and melatonin 1a receptor distribution in the ovaries of African ostrich chicks.

Cytotechnology

2008 Mar;56(3):187-95.

(IF 1.777)

70. Zhang GG, Shi RZ, Jiang DJ, Chen YR, Jia-Chen, Tang ZY, Bai YP, Xiao HB, Li YJ.

Involvement of the endothelial DDAH/ADMA pathway in nitroglycerin tolerance: the role of ALDH-2.

Life Sci

2008 Mar 26;82(13-14):699-707.

(IF 3.647)

71. Li J, Liu W, Ding S, Xu W, Guan Y, Zhang JH, Sun X.

Hyperbaric oxygen preconditioning induces tolerance against brain ischemia-reperfusion injury by upregulation of antioxidant enzymes in rats.

Brain Res

2008 May 19;1210:223-9.

(IF 2.733)

72. Fu Y, Zhang Z, Zhang G, Liu Y, Cao Y, Yu J, Hu J, Yin X.

Adenovirus-mediated gene transfer of tissue factor pathway inhibitor induces apoptosis in vascular smooth muscle cells.

Apoptosis

2008 May;13(5):634-40.

(IF 4.543)

73. Tian B, Wang Z, Zhao Y, Wang D, Li Y, Ma L, Li X, Li J, Xiao N, Tian J, Rodriguez R.

Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model.

Cancer Lett

2008 Jun 18;264(2):299-308.

(IF 7.36)

74. Gao F, Wu DQ, Hu YH, Jin GX, Li GD, Sun TW, Li FJ.

In vitro cultivation of islet-like cell clusters from human umbilical cord blood-derived mesenchymal stem cells.

Transl Res

2008 Jun;151(6):293-302.

(IF 5.411)

75. He X, Zhang Z, Zhang H, Zhao Y, Chai Z.

Neurotoxicological evaluation of long-term lanthanum chloride exposure in rats.

Toxicol Sci

2008 Jun;103(2):354-61.

(IF 3.703)

76. Wan F, You J, Sun Y, Zhang XG, Cui FD, Du YZ, Yuan H, Hu FQ.

Studies on PEG-modified SLNs loading vinorelbine bitartrate (I): preparation and evaluation in vitro.

INT J PHARMACOL

2008 Jul 9;359(1-2):104-10.

(IF 0.692)

77. An R, Dong C, Lei Y, Han L, Li P, Chen J, Wang G, Shi Q, Gao C, Jiang H, Zhou W, Han J, Chu Y, Dong X.

PrP mutants with different numbers of octarepeat sequences are more susceptible to the oxidative stress.

SCI CHINA LIFE SCI

2008 Jul;51(7):630-9.

(IF 4.611)

78. Tian SL, Wang XY, Ding GH.

Repeated electro-acupuncture attenuates chronic visceral hypersensitivity and spinal cord NMDA receptor phosphorylation in a rat irritable bowel syndrome model.

Life Sci

2008 Aug 29;83(9-10):356-63.

(IF 3.647)

79. Chen M, Li Y, Yang T, Wang Y, Bai Y, Xie X.

ADMA induces monocyte adhesion via activation of chemokine receptors in cultured THP-1 cells.

Cytokine

2008 Aug;43(2):149-59.

(IF 2.952)

80. Wei Y, Weng D, Li F, Zou X, Young DO, Ji J, Shen P.

Involvement of JNK regulation in oxidative stress-mediated murine liver injury by microcystin-LR.

Apoptosis

2008 Aug;13(8):1031-42.

(IF 4.543)

81. Hu X, Zhou J, Zhang N, Tan H, Gao C.

Preparation and properties of an injectable scaffold of poly(lactic-co-glycolic acid) microparticles/chitosan hydrogel.

J MECH BEHAV BIOMED

2008 Oct;1(4):352-9.

(IF 3.372)

82. Zhu M, Gu F, Shi J, Hu J, Hu Y, Zhao Z.

Increased oxidative stress and astrogliosis responses in conditional double-knockout mice of Alzheimer-like presenilin-1 and presenilin-2.

FREE RADICAL BIO MED

2008 Nov 15;45(10):1493-9.

(IF 6.17)

83. Sun J, Wu Y, Wang J, Ma F, Liu X, Li Q.

Novel translationally controlled tumor protein homologue in the buccal gland secretion of Lampetra japonica.

Biochimie

2008 Nov-Dec;90(11-12):1760-8.

(IF 3.413)

84. Yi Q, Wen X, Li L, He B, Nie Y, Yao Wu Y, Zhang Z, Gu Z.

The chiral effects on the responses of osteoblastic cells to the polymeric substrates.

European Polymer Journal

2009;45:1970–8.

(IF 3.621)

85. ZHANG ZY, LIU XJ, LIU T, YAN L, WANG YJ, WANG CB.

Polypeptide from Chlamys farreri inhibits UVB-induced apoptosis of HaCaT cells via iNOS/NO and HSP90.

Chinese Journal of Oceanology and Limnology

2009;27(3):594-9.

(IF 0.741)

86. WU T, NAN KH, CHEN JD, JIN D, JIANG S, ZHAO PR, XU JC, DU H, ZHANG XQ, LI JW, PEI GX.

A new bone repair scaffold combined with chitosan/hydroxyapatite and sustained releasing icariin.

CHINESE SCI BULL

2009; 54(17):2953-2961.

(IF 1.649)

87. Liu XJ, Wang WC, Wang HJ, Zhang LL, Liu LQ, Wang YJ, Wang CB.

A polypeptide from Chlamys farreri inhibits UVB-induced HaCaT cells apoptosis via the Apaf-1/caspase-9 and Smac/XIAP signaling pathway.

Chinese Journal of Oceanology and Limnology

2009;27(3):587-93.

(IF 0.741)

88. Jin-qiao S, Bin S, Wen-hao Z, Yi Y.

Basic fibroblast growth factor stimulates the proliferation and differentiation of neural stem cells in neonatal rats after ischemic brain injury.

BRAIN DEV-JPN

2009;31(5):331-40.

(IF 1.504)

89. Yuan Q, Li PD, Li BH, Yang XZ, Xu SB, Liu XH, Zhou FX, Zhang WJ.

Differential IL-4/Stat6 activities correlate with differential expression of regulatory genes SOCS-1, SHP-1, and PP2A in colon cancer cells.

J CANCER RES CLIN

2009 Jan;135(1):131-40.

(IF 3.656)

90. Li W, Liu Y, Zhang JW, Ai CZ, Xiang N, Liu HX, Yang L.

Anti-androgen-independent prostate cancer effects of ginsenoside metabolites in vitro: mechanism and possible structure-activity relationship investigation.

Arch Pharm Res

2009 Jan;32(1):49-57.

(IF 2.934)

91. Wang YL, Wang CY, Zhang BJ, Zhang ZZ.

Shenfu injection suppresses apoptosis by regulation of Bcl-2 and caspase-3 during hypoxia/reoxygenation in neonatal rat cardiomyocytes in vitro.

Mol Biol Rep

2009 Feb;36(2):365-70.

(IF 1.402)

92. Liu XS, Jiang J, Jiao XY, Wu YE, Lin JH, Cai YM.

Lycorine induces apoptosis and down-regulation of Mcl-1 in human leukemia cells.

Cancer Lett

2009 Feb 8;274(1):16-24.

(IF 7.36)

93. Gao R, Wang J, Shen Y, Lei M, Wang Z.

Functional expression of voltage-gated sodium channels Nav1.5 in human breast caner cell line MDA-MB-231.

J HUAZHONG U SCI-MED

2009 Feb;29(1):64-7.

(IF 1.151)

94. Liu X, Zhang Z, Li P, Zhu L, Wang Y, Wang C.

Polypeptide from Chlamys farreri modulates UVB-induced activation of NF-kappaB signaling pathway and protection HaCaT cells from apoptosis.

REGUL PEPTIDES

2009 Feb 25;153(1-3):49-55.

(IF 1.813)

95. Jin D, Ojcius DM, Sun D, Dong H, Luo Y, Mao Y, Yan J.

Leptospira interrogans induces apoptosis in macrophages via caspase-8- and caspase-3-dependent pathways.

Infect Immun

2009 Feb;77(2):799-809.

(IF 3.201)

96. Kang Y, Hu M, Zhu Y, Gao X, Wang MW.

Antioxidative effect of the herbal remedy Qin Huo Yi Hao and its active component tetramethylpyrazine on high glucose-treated endothelial cells.

Life Sci

2009 Mar 27;84(13-14):428-36.

(IF 3.647)

97. Xu J, Wang S, Lin Y, Cao L, Wang R, Chi Z.

Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats.

Neurosci Lett

2009 Mar 27;453(1):58-61.

(IF 2.274)

98. Jia H, Qi X, Fang S, Jin Y, Han X, Wang Y, Wang A, Zhou H.

Carnosine inhibits high glucose-induced mesangial cell proliferation through mediating cell cycle progression.

REGUL PEPTIDES

2009 Apr 10;154(1-3):69-76.

(IF 1.813)

99. Zhang LF, Peng SQ, Wang S.

Decreased aortic contractile reaction to 5-hydroxytryptamine in rats with long-term hypertension induced by lead (Pb(2+)) exposure.

Toxicol Lett

2009 Apr 25;186(2):78-83.

(IF 3.569)

100. Dong C, Wang Y, Zhu YZ.

Asymmetric synthesis and biological evaluation of Danshensu derivatives as anti-myocardial ischemia drug candidates.

BIOORG MED CHEM LETT

2009 May 1;17(9):3499-507.

(IF 2.572)

101. Xiao X, Liu A, Wen H, Tian Y, Ni J, Liu G.

Expression and localization of transcription factor Ets-1 in the rat ovary during the estrous cycle and pregnancy.

Fertil Steril

2009 May;91(5 Suppl):1998-2005.

(IF 6.312)

102. Cheng B, Song J, Zou Y, Wang Q, Lei Y, Zhu C, Hu C.

Responses of vascular smooth muscle cells to estrogen are dependent on balance between ERK and p38 MAPK pathway activities.

Int J Cardiol

2009 May 29;134(3):356-65.

(IF 3.229)

103. Chen MF, Li YJ, Yang TL, Lou B, Xie XM.

Losartan inhibits monocytic adhesion induced by ADMA via downregulation of chemokine receptors in monocytes.

Eur J Clin Pharmacol

2009 May;65(5):457-64.

(IF 2.641)

104. Zhang DL, Chen YQ, Jiang X, Ji TT, Mei B.

Oxidative damage increased in presenilin1/presenilin2 conditional double knockout mice.

Neurosci Bull

2009 Jun;25(3):131-7.

(IF 4.326)

105. Wang XD, Meng MX, Gao LB, Liu T, Xu Q, Zeng S.

Permeation of astilbin and taxifolin in Caco-2 cell and their effects on the P-gp.

INT J PHARMACOL

2009 Aug 13;378(1-2):1-8.

(IF 0.692)

106. Chen B, Gao XQ, Yang CX, Tan SK, Sun ZL, Yan NH, Pang YG, Yuan M, Chen GJ, Xu GT, Zhang K, Yuan QL.

Neuroprotective effect of grafting GDNF gene-modified neural stem cells on cerebral ischemia in rats.

Brain Res

2009 Aug 11;1284:1-11.

(IF 2.733)

107. Ding D, Huang P, Sun H, Xue Q, Pan Y, Chen S.

Identification of protein components and quantitative immunoassay for SEC2 in staphylococcin injection.

J PHARMACEUT BIOMED

2009 Aug 15;50(1):79-85.

(IF 3.209)

108. Liu X, Shi S, Ye J, Liu L, Sun M, Wang C.

Effect of polypeptide from Chlamys farreri on UVB-induced ROS/NF-kappaB/COX-2 activation and apoptosis in HaCaT cells.

J PHOTOCH PHOTOBIO B

2009 Aug 3;96(2):109-16.

(IF 4.383)

109. Zhang Z, Wang Q, Li P, Zhou Y, Li S, Yi W, Chen A, Kong P, Hu C.

Overexpression of the Interferon regulatory factor 4-binding protein in human colorectal cancer and its clinical significance.

Cancer Epidemiol

2009 Aug;33(2):130-6.

(IF 2.179)

110. Ma K, Hu M, Qi Y, Qiu L, Jin Y, Yu J, Li B.

Structure-transfection activity relationships with glucocorticoid-polyethyl-enimine conjugate nuclear gene delivery systems.

Biomaterials

2009 Aug;30(22):3780-9.

(IF 10.317)

111. Liao Z, Huang C, Zhou F, Xiong J, Bao J, Zhang H, Sun W, Xie C, Zhou Y.

Radiation enhances suicide gene therapy in radioresistant laryngeal squamous cell carcinoma via activation of a tumor-specific promoter.

Cancer Lett

2009 Sep 28;283(1):20-8.

(IF 7.36)

112. Feng B, Huang CG, Chen RH, Guo YW, Jiao BH.

2'-Epi-2'-O-acetylthevetin B induces apoptosis partly via Ca(2+)-mediated mitochondrial pathway in human hepatocellular carcinoma HepG2 cells.

Cell Biol Int

2009 Sep;33(9):918-25.

(IF 2.571)

113. Ye Y, Hu SJ, Li L.

Inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced hypertrophic responses in rat neonatal cardiomyocytes: involvement of the RhoA/Rho kinase pathway.

FEBS Lett

2009 Sep 17;583(18):2997-3003.

(IF 3.057)

114. Shi GS, Ren LF, Wang LZ, Lin HS, Wang SB, Tong YQ.

H2O2/HCl and heat-treated Ti-6Al-4V stimulates pre-osteoblast proliferation and differentiation.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod

2009 Sep;108(3):368-75.

(IF 0.27)

115. Chen Y, Wang J, Yao Y, Yuan W, Kong M, Lin Y, Geng D, Nie R.

CRP regulates the expression and activity of tissue factor as well as tissue factor pathway inhibitor via NF-kappaB and ERK 1/2 MAPK pathway.

FEBS Lett

2009 Sep 3;583(17):2811-8.

(IF 3.057)

116. Chen WL, Qian Y, Meng WF, Pang JY, Lin YC, Guan YY, Chen SP, Liu J, Pei Z, Wang GL.

A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro.

Biochem Pharmacol

2009 Oct 15;78(8):941-50.

(IF 4.96)

117. Ma K, Hu MX, Qi Y, Zou JH, Qiu LY, Jin Y, Ying XY, Sun HY.

PAMAM-triamcinolone acetonide conjugate as a nucleus-targeting gene carrier for enhanced transfer activity.

Biomaterials

2009 Oct;30(30):6109-18.

(IF 10.317)

118. Hua W, Jiang J, Rong X, Wu R, Qiu H, Zhang Y, Chen Q.

The dual role of the cystathionine gamma-lyase/hydrogen sulfide pathway in CVB3-induced myocarditis in mice.

BIOCHEM BIOPH RES CO

2009 Oct 23;388(3):595-600.

(IF 2.985)

119. Lin Y, Chen Y, Yang X, Xu D, Liang S.

Proteome analysis of a single zebrafish embryo using three different digestion strategies coupled with liquid chromatography-tandem mass spectrometry.

Anal Biochem

2009 Nov 15;394(2):177-85.

(IF 2.877)

120. Xu Y, Ge R, Du J, Xin H, Yi T, Sheng J, Wang Y, Ling C.

Corosolic acid induces apoptosis through mitochondrial pathway and caspase activation in human cervix adenocarcinoma HeLa cells.

Cancer Lett

2009 Nov 1;284(2):229-37.

(IF 7.36)

121. Li H, Zhang L, Huang Q.

Differential expression of mitogen-activated protein kinase signaling pathway in the hippocampus of rats exposed to chronic unpredictable stress.

Behav Brain Res

2009 Dec 14;205(1):32-7.

(IF 2.977)

122. Gong HS, Meng XC, Wang H.

Plantaricin MG active against Gram-negative bacteria produced by Lactobacillus plantarum KLDS1.0391 isolated from"Jiaoke", a traditional fermented cream from China.

Food Control

2010;21:89–96.

(IF 4.258)

123. Li F, Gong QH, Wu Q, Lu YF, Shi JS.

Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats.

PHARMACOL BIOCHEM BE

2010;96(3):301-5.

(IF 2.519)

124. Li H, Fong C, Chen Y, Cai G, Yang M.

beta2- and beta3-, but not beta1-adrenergic receptors are involved in osteogenesis of mouse mesenchymal stem cells via cAMP/PKA signaling.

Arch Biochem Biophys

2010 15;496(2):77-83.

(IF 3.391)

125. Han J, Zhou YP, Jiang YZ, He YT, Mei F.

Postnatal development of interstitial cells of Cajal in mouse colon in response to Kit signal blockade with Imatinib (Glivec).

Acta Histochem

2010;112(3):215-21.

(IF 2.107)

126. Feng B, Guo YW, Huang CG, Li L, Chen RH, Jiao BH.

2'-epi-2'-O-Acetylthevetin B extracted from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.

CHEM-BIOL INTERACT

2010;183(1):142-53.

(IF 3.723)

127. Qin XL, Bi HC, Wang XD, Li JL, Wang Y, Xue XP, Chen X, Wang CX, Xu le J, Wang YT, Huang M.

Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506).

INT J PHARMACOL

2010;389(1-2):114-21.

(IF 0.692)

128. Lin Y, Xu J, Cao L, Han Y, Gao J, Xie N, Zhao X, Jiang H, Chi Z.

Mitochondrial base excision repair pathway failed to respond to status epilepticus induced by pilocarpine.

Neurosci Lett

2010;474(1):22-5.

(IF 2.274)

129. Li Q, Wu D, Zhang L, Zhang Y.

Effects of galantamine on β-amyloid release and beta-site cleaving enzyme 1 expression in differentiated human neuroblastoma SH-SY5Y cells.

Exp Gerontol

2010;45(11):842-7.

(IF 3.376)

130. Li GG, Liang XF, Xie Q, Li G, Yu Y, Lai K.

Gene structure, recombinant expression and functional characterization of grass carp leptin.

GEN COMP ENDOCR

2010;166(1):117-27.

(IF 2.426)

131. Zhao L, Wang X, Chang Q, Xu J, Huang Y, Guo Q, Zhang S, Wang W, Chen X, Wang J.

Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis.

Eur J Pharmacol

2010;627(1-3):304-12.

(IF 3.263)

132. He F, Zhang F, Yang G, Wang X, Zhao S.

Enhanced initial proliferation and differentiation of MC3T3-E1 cells on HF/HNO3 solution treated nanostructural titanium surface.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod

2010;110(4):e13-22.

(IF 0.27)

133. Yan J, Sun XB, Wang HQ, Zhao H, Zhao XY, Xu YX, Guo JC, Zhu CQ.

Chronic restraint stress alters the expression and distribution of phosphorylated tau and MAP2 in cortex and hippocampus of rat brain.

Brain Res

2010;1347:132-41.

(IF 2.733)

134. Song XZ, Xu JQ, Wang T, Liu FH.

Traditional Chinese medicine decoction enhances growth performance and intestinal glucose absorption in heat stressed pigs by up-regulating the expressions of SGLT1 and GLUT2 mRNA.

Livestock Science

2010;128:75–81.

(IF 1.376)

135. Yuan H, Zhang W, Du YZ, Hu FQ.

Ternary nanoparticles of anionic lipid nanoparticles/protamine/DNA for gene delivery.

INT J PHARMACOL

2010;392(1-2):224-31.

(IF 0.692)

136. Yu Q, Zhao Z, Sun J, Guo W, Fu J, Burnstock G, He C, Xiang Z.

Expression of P2X6 receptors in the enteric nervous system of the rat gastrointestinal tract.

Histochem Cell Biol

2010;133(2):177-88.

(IF 3.418)

137. Hu H, Zhang Y, Zou M, Yang S, Liang XQ.

Expression of TRF1, TRF2, TIN2, TERT, KU70, and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric cancer.

J CANCER RES CLIN

2010;136(9):1407-14.

(IF 3.656)

138. Ding XL, Wang YH, Ning LP, Zhang Y, Ge HY, Jiang H, Wang R, Yue SW.

Involvement of TRPV4-NO-cGMP-PKG pathways in the development of thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats.

Behav Brain Res

2010;208(1):194-201.

(IF 2.977)

139. Huang LH, Hu JQ, Tao WQ, Li YH, Li GM, Xie PY, Liu XS, Jiang J.

Gossypol inhibits phosphorylation of Bcl-2 in human leukemia HL-60 cells.

Eur J Pharmacol

2010;645(1-3):9-13.

(IF 3.263)

140. Sun J, Sha B, Zhou W, Yang Y.

VEGF-mediated angiogenesis stimulates neural stem cell proliferation and differentiation in the premature brain.

BIOCHEM BIOPH RES CO

2010;394(1):146-52.

(IF 2.985)

141. Mao Z, Wan L, Hu L, Ma L, Gao C.

Tat peptide mediated cellular uptake of SiO2 submicron particles.

COLLOID SURFACE B

2010;75(2):432-40.

(IF 4.389)

142. Liu PS, Chen Q, Wu SS, Shen J, Lin SC.

Surface modification of cellulose membranes with zwitterionic polymers for resistance to protein adsorption and platelet adhesion.

Journal of Membrane Science

2010;350:387–94.

(IF 7.015)

143. Cao BY, Yang YP, Luo WF, Mao CJ, Han R, Sun X, Cheng J, Liu CF.

Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway.

J Ethnopharmacol

2010;131(1):122-9.

(IF 3.69)

144. Liu J, Wang A, Li L, Huang Y, Xue P, Hao A.

Oxidative stress mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus.

SEIZURE-EUR J EPILEP

2010;19(3):165-72.

(IF 2.522)

145. Wu W, Yan C, Gan T, Chen Z, Lu X, Duerksen-Hughes PJ, Zhu X, Yang J.

Nuclear proteome analysis of cisplatin-treated HeLa cells.

MUTAT RES-REV MUTAT

2010;691(1-2):1-8.

(IF 5.803)

146. Zhou CL, Yu XJ, Chen LM, Jiang H, Li CY.

Corticotropin-releasing hormone attenuates vascular endothelial growth factor release from human HaCaT keratinocytes.

REGUL PEPTIDES

2010 Feb 25;160(1-3):115-20.

(IF 1.813)

147. Chen S, Chen Y, Hu C, Jing H, Cao Y, Liu X.

Association of clinicopathological features with UbcH10 expression in colorectal cancer.

J CANCER RES CLIN

2010 Mar;136(3):419-26.

(IF 3.656)

148. Sun J, Zhou W, Sha B, Yang Y.

Ischemia induced neural stem cell proliferation and differentiation in neonatal rat involved vascular endothelial growth factor and transforming growth factor-beta pathways.

BRAIN DEV-JPN

2010 Mar;32(3):191-200.

(IF 1.504)

149. Wu GJ, Zhou LZ, Wang KW, Chen F, Sun Y, Duan YR, Zhu YJ, Gu HC.

Hydroxylapatite nanorods: An efficient and promising carrier for gene transfection.

J COLLOID INTERF SCI

2010 May 15;345(2):427-32.

(IF 7.489)

150. Wang YX, Xu XY, Su WL, Wang Q, Zhu WX, Chen F, Jin G, Liu YJ, Li YD, Sun YP, Gao WC, Ruan CP.

Activation and Clinical Significance of p38 MAPK Signaling Pathway in Patients With Severe Trauma.

J Surg Res

2010 Jun 1;161(1):119-25.

(IF 1.841)

151. Yuan D, Pan Y, Zhang J, Shao C.

Role of nuclear factor-kappaB and P53 in radioadaptive response in Chang live cells.

MUTAT RES-REV MUTAT

2010 Jun 1;688(1-2):66-71.

(IF 5.803)

152. Zhang JC, Liu CL, Li YP, Sun J, Wang P, Di KQ, Chen H, Zhao YY .

Effect of yttrium ion on the proliferation, differentiation and mineralization function of primary mouse osteoblasts in vitro.

Journal Of Rare Earths

2010 Jun;28(3):466-470.

(IF 2.846)

153. Sun H, Li QW, Lv XY, Ai JZ, Yang QT, Duan JJ, Bian GH, Xiao Y, Wang YD, Zhang Z, Liu YH, Tan RZ, Yang Y, Wei YQ, Zhou Q.

MicroRNA-17 post-transcriptionally regulates polycystic kidney disease-2 gene and promotes cell proliferation.

Mol Biol Rep

2010 Jul;37(6):2951-8.

(IF 1.402)

154. Zhu J, Zhang L, Jin X, Han X, Sun C, Yan J.

beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway.

Mol Biol Rep

2010 Jul;37(6):2653-63.

(IF 1.402)

155. Wang S, Lv X, Zhang K, Lin T, Liu X, Yuan J, Dai Y, Li N.

Knockdown of the prion gene expression by RNA interference in bovine fibroblast cells.

Mol Biol Rep

2010 Oct;37(7):3193-8.

(IF 1.402)

156. Deng X, Cheng J, Zhang Y, Li N, Chen L.

Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats.

Acta Diabetol

2010 Dec;47(1):177-85.

(IF 3.418)

157. Wu J, Song R, Song W, Li Y, Zhang Q, Chen Y, Fu Y, Fang W, Wang J, Zhong Z, Ling H, Zhang L, Zhang F

Chlorpromazine protects against apoptosis induced by exogenous stimuli in the developing ratbrain.

PLoS One

2011;6(7):e21966.

(IF 2.74)

158. Huang Z, Song L, Wang C, Liu JQ, Chen C.

Hypoxia-ischemia upregulates TRAIL and TRAIL receptors in the immature rat brain.

DEV NEUROSCI-BASEL

2011;33(6):519-30.

(IF 3.041)

159. Wang S, Zhang J, Jiang T, Zheng L, Wang Z, Zhang J, Yu P.

Protective effect of Coenzyme Q(10) against oxidative damage in human lens epithelial cells by novel ocular drug carriers.

INT J PHARMACOL

2011;33(6):519-30.

(IF 0.692)

160. Lu J, Wang C, Zhou Z, Zhang Y, Cao T, Shi C, Chen Z, Chen L, Cai C, Fan X.

Immunogenicity and protective efficacy against murine tuberculosis ofa prime-boost regimenwith BCG and a DNA vaccine expressing ESAT-6 and Ag85A fusion protein.

CLIN DEV IMMUNOL

2011;2011:617892.

(IF 3.603)

161. Wang M, Yang J, Zhou Z, Qiu L, Wang L, Zhang H, Gao Y, Wang X, Zhang L, Zhao J, Song L

A primitive Toll-like receptor signaling pathway in mollusk Zhikong scallop Chlamys farreri.

Dev Comp Immunol

2011 Apr;35(4):511-20.

(IF 3.192)

162. Nie HZ, Li ZQ, Yan QX, Wang ZJ, Zhao WJ, Guo LC, Yin M.

Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-α4β2 nAChR-APP695 cells.

Neurochem Res

2011 May;36(5):904-12.

(IF 3.038)

163. Chen Z, Liu S, Sumida T, Sun S, Wei Y, Liu M, Dong Z, Zhang F, Hamakawa H, Wei F.

Silencing Id-1 with RNA Interference Inhibits Adenoid Cystic Carcinoma in Mice.

J Surg Res

2011 Jul;169(1):57-66.

(IF 1.841)

164. Cao B, Aa J, Wang G, Wu X, Liu L, Li M, Shi J, Wang X, Zhao C, Zheng T, Guo S, Duan J.

GC-TOFMS analysis of metabolites in adherent MDCK cells and a novel strategy for identifyingintracellular metabolic markers for use as cell amount indicators in data normalization.

Anal Bioanal Chem

2011 Jul;400(9):2983-93.

(IF 3.637)

165. Cao X, Yang M, Wei RC, Zeng Y, Gu JF, Huang WD, Yang DQ, Li HL, Ding M, Wei N, Zhang KJ, Xu B, Liu XR, Qian QJ, Liu XY.

Cancer targeting Gene-Viro-Therapy of liver carcinoma by dual-regulated oncolytic adenovirusarmed with TRAIL gene.

Gene Ther

2011 Aug;18(8):765-77.

(IF 4.128)

166. Hao D, Huang X, Zhen HY, Chen YC, Liu LJ, Wang XM, Wang ZY.

ER-a36 participate growth inhibiting which induced by Tamoxifen in gastric cancer cell line BGC823

Human Health and Biomedical Engineering (HHBE)

2011 Aug:1062-5.

167. Liu C, Guo W, Shi X, Kaium MA, Gu X, Zhu YZ.

Leonurine-cysteine analog conjugates as a new class of multifunctional anti-myocardial ischemia agent.

Eur J Med Chem

2011 Sep;46(9):3996-4009.

(IF 5.572)

168. Luo J, Xu Y, Zhu Q, Zhao F, Zhang Y, Peng X, Wang W, Wang X.

Expression pattern of Mical-1 in the temporal neocortex of patients with intractable temporalepilepsy and pilocarpine-induced rat model.

Synapse

2011 Nov;65(11):1213-21.

(IF 2.318)

169. Zhao L, Yang R, Cheng L, Wang M, Jiang Y, Wang S.

LPS-Induced Epithelial-Mesenchymal Transition of Intrahepatic Biliary Epithelial Cells.

J Surg Res

2011 Dec;171(2):819-25.

(IF 1.841)

170. Su TF, Zhang LH, Peng M, Wu CH, Pan W, Tian B, Shi J, Pan HL, Li M.

Cannabinoid CB2 receptors contribute to upregulation of β-endorphin in inflamed skin tissues byelectroacupuncture.

Mol Pain

2011 Dec 19;7:98.

(IF 2.696)

171. Ding M, Cao X, Xu HN, Fan JK, Huang HL, Yang DQ, Li YH, Wang J, Li R, Liu XY.

Prostate cancer-specific and potent antitumor effect of a DD3-controlled oncolytic virus harboring the PTEN gene.

PLoS One

2012;7(4):e35153.

(IF 2.74)

172. Guo E, He Q, Liu S, Tian L, Sheng Z, Peng Q, Guan J, Shi M, Li K, Gilbert LI, Wang J, Cao Y, Li S.

MET is required for the maximal action of 20-hydroxyecdysone during Bombyx metamorphosis.

PLoS One

2012;7(12):e53256.

(IF 2.74)

173. Liu Y, Yin B, Zhang C, Zhou L, Fan J.

Hsa-let-7a functions as a tumor suppressor in renal cell carcinoma cell lines by targeting c-myc.

BIOCHEM BIOPH RES CO

2012 Jan 6;417(1):371-5.

(IF 2.985)

174. Qiu T, Zhu HC, Liu XH, Dong WC, Weng XD, Hu CH, Kuang YL, Gao RH, Dan C, Tao T.

Lentiviral-mediated shRNA against RelB induces the generation of tolerogenic dendritic cells.

Int Immunopharmacol

2012 Mar;12(3):501-9.

(IF 3.943)

175. Xu JN, Chen JP, Chen DL.

Serodiagnosis efficacy and immunogenicity of the fusion protein of Mycobacterium tuberculosiscomposed of the 10-kilodalton culture filtrate protein, ESAT-6, and the extracellular domainfragment of PPE68.

Clin Vaccine Immunol

2012 Apr;19(4):536-44.

(IF 3.233)

176. Du Z, Yang Y, Hu Y, Sun Y, Zhang S, Peng W, Zhong Y, Huang X, Kong W.

A long-term high-fat diet increases oxidative stress, mitochondrial damage and apoptosis in theinner ear of D-galactose-induced aging rats.

HEARING RES

2012 May;287(1-2):15-24.

(IF 3.693)

177. Shi G, Chen X, Wang H, Wang S, Guo X, Zhang X.

Activity of sitafloxacin against extracellular and intracellular Staphylococcus aureus in vitro and invivo: comparison with levofloxacin and moxifloxacin.

J ANTIBIOT

2012 May;65(5):229-36.

(IF 2.668)

178. Xu JN, Yang ZW, Chen JP, Chen DL, Wang T, Liu MJ, Zhang L, Yang BB.

Protective immunity against Legionnaires' disease in an A/J mouse model using a DNA vaccinecomposed of an outer membrane protein (29 kDa) and the pilE fusion protein.

DIAGN MICR INFEC DIS

2012 May;73(1):9-15.

(IF 2.499)

179. Su TF, Zhao YQ, Zhang LH, Peng M, Wu CH, Pei L, Tian B, Zhang J, Shi J, Pan HL, Li M.

Electroacupuncture reduces the expression of proinflammatory cytokines in inflamed skin tissuesthrough activation of cannabinoid CB2 receptors.

Eur J Pain

2012 May;16(5):624-35.

(IF 3.492)

180. Zhang M, Dang L, Guo F, Wang X, Zhao W, Zhao R.

Coenzyme Q(10) enhances dermal elastin expression, inhibits IL-1α production and melanin synthesis in vitro.

INT J COSMETIC SCI

2012 Jun;34(3):273-9.

(IF 1.673)

181. Ding F, Shao ZW, Yang SH, Wu Q, Gao F, Xiong LM.

Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells.

Apoptosis

2012 Jun;17(6):579-90.

(IF 4.543)

182. Jin Y, Sui HJ, Dong Y, Ding Q, Qu WH, Yu SX, Jin YX.

Atorvastatin enhances neurite outgrowth in cortical neurons in vitro via up-regulating theAkt/mTOR and Akt/GSK-3β signaling pathways.

Acta Pharmacol Sin

2012 Jul;33(7):861-72.

(IF 5.064)

183. Luo J, Zeng K, Zhang C, Fang M, Zhang X, Zhu Q, Wang L, Wang W, Wang X, Chen G.

Down-Regulation of CRMP-1 in Patients with Epilepsy and a Rat Model.

Neurochem Res

2012 Jul;37(7):1381-91.

(IF 3.038)

184. Zhang D, Jin T, Xu YQ, Lu YF, Wu Q, Zhang YK, Liu J.

Diurnal-and sex-related difference of metallothionein expression in mice.

J Circadian Rhythms

2012 Jul 24;10(1):5.

(IF 2.31)

185. Mao J, Duan S, Song A, Cai Q, Deng X, Yang X.

Macroporous and Nanofribrous Poly (Lactide-co-Glycolide)(50/50) Scaffolds Via Phase Separation Combined with Particle-Leaching.

MAT SCI ENG C-MATER

2012 Aug 1;32(6):1407-1414.

(IF 5.88)

186. Du Z, Hu Y, Yang Y, Sun Y, Zhang S, Zhou T, Zeng L, Zhang W, Huang X, Kong W, Zhang H.

NADPH oxidase-dependent oxidative stress and mitochondrial damage in hippocampus of D-galactose-inducedaging rats.

J HUAZHONG U SCI-MED

2012 Aug;32(4):466-72.

(IF 1.151)

187. Wang F, Zhao XQ, Liu JN, Wang ZH, Wang XL, Hou XY, Liu R, Gao F, Zhang MX, Zhang Y, Bu PL.

Antagonist of microRNA-21 improves balloon injury-induced rat iliac artery remodeling by regulating proliferation and apoptosis of adventitial fibroblasts and myofibroblasts.

J Cell Biochem

2012 Sep;113(9):2989-3001.

(IF 4.237)

188. Zhou J, Shang J, Ping F, Zhao G.

Alcohol extract from Vernonia anthelmintica (L.) willd seed enhances melanin synthesis through activation of the p38 MAPK signaling pathway in B16F10 cells and primary melanocytes.

J Ethnopharmacol

2012 Sep 28;143(2):639-47.

(IF 3.69)

189. Huang H, Xiao T, He L, Ji H, Liu XY.

Interferon-β-armed oncolytic adenovirus induces both apoptosis and necroptosis in cancer cells.

ACTA BIOCH BIOPH SIN

2012 Sep;44(9):737-45.

(IF 2.836)

190. Xu Z, Zhang C, Zhang Y, Yang X.

Europium complexes as novel indicators of paracellular diffusion.

Chem Biodivers

2012 Sep;9(9):1916-22.

(IF 2.039)

191. Du G, Ye L, Zhang G, Dong Q, Liu K, Tian J.

Human IL18-IL2 fusion protein as a potential antitumor reagent by enhancing NK cell cytotoxicityand IFN-γ production.

J CANCER RES CLIN

2012 Oct;138(10):1727-36.

(IF 3.656)

192. Zhang YP, Sun P, Zhang XR, Yang WL.

In vitro gastric cancer cell imaging using near-infrared quantum dot-conjugated CC49.

Oncol Lett

2012 Nov;4(5):996-1002.

(IF 2.311)

193. Gao Y, Zhang RR, Li JH, Ren M, Ren ZX, Shi JH, Pan QZ, Ren SP.

Radix Astragali lowers kidney oxidative stress in diabetic rats treated with insulin.

Endocrine

2012 Dec;42(3):592-8.

(IF 3.235)

194. He Y, Cai G, Ni Y, Li Y, Zong H, He L.

siRNA-mediated knockdown of two tyrosinase genes from Schistosoma japonicum cultured in vitro.

Exp Parasitol

2012 Dec;132(4):394-402.

(IF 1.69)

195. Ye J, Yang T, Guo H, Tang Y, Deng F, Li Y, Xing Y, Yang L, Yang K.

Wnt10b promotes differentiation of mouse hair follicle melanocytes.

Int J Med Sci

2013;10(6):691-8.

(IF 2.523)

196. Liu Y, Wang DK, Jiang DZ, Qin X, Xie ZD, Wang QK, Liu M, Chen LM.

Cloning and functional characterization of novel variants and tissue-specific expression of alternative amino andcarboxyl termini of products of slc4a10.

PLoS One

2013;8(2):e55974.

(IF 2.74)

197. Feng J, Tang Y, Xu Y, Sun Q, Liao F, Han D.

Substrate stiffness influences the outcome of antitumor drug screening in vitro.

CLIN HEMORHEOL MICRO

2013 ;55(1):121-31.

(IF 1.741)

198. Liu C, Guo W, Maerz S, Gu X, Zhu Y.

3,5-Dimethoxy-4-(3-(2-carbonyl-ethyldisulfanyl)-propionyl)-benzoic acid 4-guanidino-butyl ester: a novel twin drug that prevents primary cardiac myocytes from hypoxia-induced apoptosis.

Eur J Pharmacol

2013 Jan 30;700(1-3):118-26.

(IF 3.263)

199. Wang G, Han B, Zhou H, Wu L, Wang Y, Jia G, Lv J, Cheng Z, Pan S, Liu J, Zhou Y, Sun B.

Inhibition of hydrogen sulfide synthesis provides protection for severe acute pancreatitis rats via apoptosispathway.

Apoptosis

2013 Jan;18(1):28-42.

(IF 4.543)

200. Liu Z, Zhang J, Huang X, Huang L, Li S, Wang Z.

Magnesium sulfate inhibits the secretion of high mobility group box 1 from lipopolysaccharide-activated RAW264.7 macrophages in vitro.

J Surg Res

2013 Jan;179(1):e189-195.

(IF 1.841)

201. Wu XR, Sha JJ, Liu DM, Chen YH, Yang GL, Zhang J, Chen YY, Bo JJ, Huang YR.

High expression of P53-induced Ring-h2 protein is associated with poor prognosis in clear cell renal cellcarcinoma.

EJSO-EUR J SURG ONC

2013 Jan;39(1):100-6.

(IF 3.959)

202. Wang Y, Fang J, Huang S, Chen L, Fan G, Wang C.

The chronic effects of low lead level on the expressions of Nrf2 and Mrp1 of the testes in the rats.

ENVIRON TOXICOL CHEM

2013 Jan;35(1):109-16.

(IF 3.152)

203. Yang F, Wang J, Hou J, Guo H, Liu C.

Bone regeneration using cell-mediated responsive degradable PEG-based scaffolds incorporating with rhBMP-2.

Biomaterials

2013 Feb;34(5):1514-28.

(IF 10.317)

204. Wang Z, Yan J, Zheng Q, Wang Z, Li J, Zhang X, Zhang S.

Effects of biodegradable Mg-6Zn alloy extracts on cell cycle of intestinal epithelial cells.

J Biomater Appl

2013 Feb;27(6):739-47.

(IF 2.22)

205. Li S, Tian H, Yue W, Li L, Gao C, Si L, Li W, Hu W, Qi L, Lu M.

Down-regulation of MTA1 protein leads to the inhibition of migration, invasion, and angiogenesis of non-small-celllung cancer cell line.

ACTA BIOCH BIOPH SIN

2013 Feb;45(2):115-22.

(IF 2.836)

206. Yang D, Li L, Liu H, Wu L, Luo Z, Li H, Zheng S, Gao H, Chu Y, Sun Y, Liu J, Jia L.

Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth ofliver cancer cells.

Cell Death Differ

2013 Feb;20(2):235-47.

(IF 10.717)

207. Zhou J, Shang J, Song J, Ping F.

Interleukin-18 augments growth ability of primary human melanocytes by PTEN inactivation through the AKT/NF-κB pathway.

INT J BIOCHEM CELL B

2013 Feb;45(2):308-16.

(IF 3.673)

208. Miao CG, Huang C, Huang Y, Yang YY, He X, Zhang L, Lv XW, Jin Y, Li J.

MeCP2 modulates the canonical Wnt pathway activation by targeting SFRP4 in rheumatoid arthritis fibroblast-likesynoviocytes in rats.

Cell Signal

2013 Mar;25(3):598-608.

(IF 3.968)

209. Liu Z, Chang Y, Zhang J, Huang X, Jiang J, Li S, Wang Z.

Magnesium deficiency promotes secretion of high-mobility group box 1 protein fromlipopolysaccharide-activated macrophages in vitro.

J Surg Res

2013 Apr;180(2):310-6.

(IF 1.841)

210. Wu J, Yang J, Liu Q, Wu S, Ma H, Cai Y.

Lanthanum induced primary neuronal apoptosis through mitochondrial dysfunction modulated by Ca2+ and Bcl-2 family.

Biol Trace Elem Res

2013 Apr;152(1):125-34.

(IF 2.639)

211. Li L, Ma Y.

Effect of fatty acids on the β-oxidation system and thioesterase of Lactococcus lactis subspecies lactis.

J Dairy Sci

2013 Apr;96(4):2003-10.

(IF 3.333)

212. Ren M, Yang S, Li J, Hu Y, Ren Z, Ren S.

Ginkgo biloba L.extract enhances the effectiveness of syngeneic bone marrow mesenchymal stem cells in lowering blood glucose levels and reversing oxidative stress.

Endocrine

2013 Apr;43(2):360-9.

(IF 3.235)

213. Qu J, Li J, Chen K, Qin D, Li K, Sheng Y, Zou C, Wang S, Huang A, Tang H.

Hepatitis B virus regulation of Raf1 promoter activity through activation of transcription factor AP-2α.

Arch Virol

2013 Apr;158(4):887-94.

(IF 2.243)

214. Cen J, Liu L, Li MS, He L, Wang LJ, Liu YQ, Liu M, Ji BS.

Alteration in P-glycoprotein at the blood-brain barrier in the early period of MCAO in rats.

J Pharm Pharmacol

2013 May;65(5):665-72.

(IF 2.571)

215. Chang Y, Huang X, Liu Z, Han G, Huang L, Xiong YC, Wang Z.

Dexmedetomidine inhibits the secretion of high mobility group box 1 from lipopolysaccharide-activated macrophages in vitro.

J Surg Res

2013 May;181(2):308-14.

(IF 1.841)

216. Jiang L, Zhang X, Zheng X, Ru A, Ni X, Wu Y, Tian N, Huang Y, Xue E, Wang X, Xu H.

Apoptosis, senescence, and autophagy in rat nucleus pulposus cells: Implications for diabetic intervertebral discdegeneration.

J Orthop Res

2013 May;31(5):692-702.

(IF 2.728)

217. Wang T, Huang Y, Zhang M, Wang L, Wang Y, Zhang L, Dong W, Chang P, Wang Z, Chen X, Tao L.

[Gly14]-Humanin offers neuroprotection through glycogen synthase kinase-3β inhibition in a mouse model ofintracerebral hemorrhage.

Behav Brain Res

2013 Jun 15;247:132-9.

(IF 2.977)

218. Xie W, Lin B, Zhou Z, Lu G, Lun J, Xia C, Li S, Hu Z.

Characterization of a novel β-agarase from an agar-degrading bacterium Catenovulumsp.X3.

APPL MICROBIOL BIOT

2013 Jun;97(11):4907-15.

(IF 3.53)

219. Wang M, Wang L, Zhou Z, Gao Y, Wang L, Shi X, Gai Y, Mu C, Song L.

The molecular characterization of a catalase from Chinese mitten crab Eriocheir sinensis.

Int J Immunogenet

2013 Jun;40(3):230-40.

(IF 1.13)

220. Zhang Y, Huang L, Bi H, Cui Y, Li J, Wang X, Qin X, Chen J, Huang M.

Study of the upregulation of the activity of cytochrome P450 3A isoforms by Astragalus injectionand Astragalus granules in rats and in cells.

EUR J DRUG METAB PH

2013 Jun;38(2):105-113.

(IF 1.913)

221. Sun L, Zhao M, Yu XJ, Wang H, He X, Liu JK, Zang WJ.

Cardioprotection by acetylcholine: a novel mechanism via mitochondrial biogenesis and function involving the PGC-1α pathway.

J Cell Physiol

2013 Jun;228(6):1238-48.

(IF 5.546)

222. Li X, Zhang J, Chen Z, Yang L, Xing X, Ma X, Yang Z.

Both PI3K- and mTOR-Signaling Pathways Take Part in CVB3-Induced Apoptosis of HeLa Cells.

DNA Cell Biol

2013 Jul;32(7):359-70.

(IF 3.191)

223. Jiang G, Cao Q, Li J, Zhang Y, Liu X, Wang Z, Guo F, Chen Y, Chen Y, Chen G, Wang X.

Altered expression of vesicular monoamine transporter 2 in epileptic patients and experimental rats.

Synapse

2013 Jul;67(7):415-26.

(IF 2.318)

224. Lin Z, Zhang Y, Li C, Qian H.

Purification antibody by thiophilic magnetic sorbent modified with 2-mercapto-1-methylimidazol.

COLLOID SURFACE B

2013 Aug 1;108:72-9.

(IF 4.389)

225. Wang F, Xu H, Yuan L, Ma S, Wang Y, Duan X, Duan J, Xiang Z, Xia Q.

An optimized sericin-1 expression system for mass-producing recombinant proteins in the middle silk glands oftransgenic silkworms.

Transgenic Res

2013 Oct;22(5):925-938.

(IF 1.856)

226. Li H, Jin G, Zhu P, Zou L, Shi J, Yi X, Zhang X, Tian M, Qin J.

Upregulation of Lhx8 increase VAChT expression and ACh release in neuronal cell line SHSY5Y.

Neurosci Lett

2014 Jan 24;559:184-8.

(IF 2.274)

227. Xiao X, Yu S, Li S, Wu J, Ma R, Cao H, Zhu Y, Feng J.

Exosomes: decreased sensitivity of lung cancer A549 cells to cisplatin.

PLoS One

2014 Feb 21;9(2):e89534.

(IF 2.74)

228. Liu Z, Zhang J, Wu L, Liu J, Zhang M.

Overexpression of GNAO1 correlates with poor prognosis in patients with gastric cancer and plays a role in gastric cancer cell proliferation and apoptosis.

Int J Mol Med

2014 Mar;33(3):589-96.

(IF 3.098)

229. Liu L, Wang P, Liu X, He D, Liang C, Yu Y.

Exogenous NAD+ supplementation protects H9c2 cardiac myoblasts against hypoxia/reoxygenation injury viaSirt1-p53 pathway.

FUND CLIN PHARMACOL

2014 Apr;28(2):180-189.

(IF 2.754)

230. Sheng Y, Ding S, Chen K, Chen J, Wang S, Zou C, Zhang J, Cao Y, Huang A, Tang H.

Functional analysis of miR-101-3p and Rap1b involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis.

Biochem Cell Biol

2014 Apr;92(2):152-62.

(IF 2.46)

231. Liu X, Gao Y, Yao H, Zhou L, Pei J, Sun L, Wang J, Sun D.

p38 and extracellular signal-regulated kinases activations have opposite effects on primary-cultured rat cerebellar granule neurons exposed to sodium arsenite.

J BIOCHEM MOL TOXIC

2014 Apr;28(4):143-8.

(IF 3.606)

232. Wang Y, Chen Z, Zhang Y, Fang S, Zeng Q.

Mitochondrial biogenesis of astrocytes is increased under experimental septic conditions.

CHINESE MED J-PEKING

2014 May;127(10):1837-42.

(IF 1.585)

233. Jin P, Wu H, Xu G, Zheng L, Zhao J.

Epigallocatechin-3-gallate (EGCG) as a pro-osteogenic agent to enhance osteogenic differentiation of mesenchymal stem cells from human bone marrow: an in vitro study.

Cell Tissue Res

2014 May;356(2):381-90.

(IF 4.044)

234. Shi Q, Cao J, Fang L, Zhao H, Liu Z, Ran J, Zheng X, Li X, Zhou Y, Ge D, Zhang H, Wang L, Ran Y, Fu J.

Geniposide suppresses LPS-induced nitric oxide, PGE2 and inflammatory cytokine by downregulating NF-κB, MAPK and AP-1 signaling pathways in macrophages.

Int Immunopharmacol

2014 Jun;20(2):298-306.

(IF 3.943)

235. Zhang LL, Sui HJ, Liang B, Wang HM, Qu WH, Yu SX, Jin Y.

Atorvastatin prevents amyloid-β peptide oligomer-induced synaptotoxicity and memory dysfunction in rats through a p38 MAPK-dependent pathway.

Acta Pharmacol Sin

2014 Jun;35(6):716-26.

(IF 5.064)

236. Liu L, Li T, Tan J, Fu J, Guo Q, Ji H, Zhang Y.

NG as a novel nitric oxide donor induces apoptosis by increasing reactive oxygen species and inhibiting mitochondrial function in MGC803 cells.

Int Immunopharmacol

2014 Aug 16;23(1):27-36.

(IF 3.943)

237. Wang X, Zou F, Deng H, Fu Z, Li Y, Wu L, Wang Z, Liu L.

Characterization of sphere forming cells with stem like properties from the gastric cancer cell lines MKN45 and SGC7901.

Mol Med Rep

2014 Dec;10(6):2937-41.

(IF 2.1)

238. Zuo T, Cao L, Sun X, Li X, Wu J, Lu S, Xue C, Tang Q.

Dietary squid ink polysaccharide could enhance SIgA secretion in chemotherapeutic mice.

Food Funct

2014 Dec;5(12):3189-3196.

(IF 4.171)

239. Yu C, Zhou Z, Wang J, Sun J, Liu W, Sun Y, Kong B, Yang H, Yang S.

In depth analysis of apoptosis induced by silica coated manganese oxide nanoparticles in vitro.

J Hazard Mater

2015;283:519-28.

(IF 9.038)

240. Shi Q, Cheng L, Liu Z, Hu K, Ran J, Ge D, Fu J.

The p38 MAPK inhibitor SB203580 differentially modulates LPS-induced interleukin 6 expression in macrophages.

Cent Eur J Immunol

2015;40(3):276-82.

(IF 1.415)

241. Yi X, Cai Y, Li W.

Isoflurane Damages the Developing Brain of Mice and Induces Subsequent Learning and Memory Deficits through FASL-FAS Signaling.

Biomed Res Int

2015;2015:315872.

(IF 2.276)

242. Jiang H, Xia Q, Xin S, Lun Y, Song J, Tang D, Liu X, Ren J, Duan Z, Zhang J.

Abnormal Epigenetic Modifications in Peripheral T Cells from Patients with Abdominal Aortic Aneurysm AreCorrelated with Disease Development.

J Vasc Res

2015;52(6):404-13.

(IF 1.725)

243. Yu L, Xie J, Xin N, Wang Z.

Panax notoginseng saponins promote wound repair of anterior cruciate ligament through phosphorylation of PI3K, AKT and ERK.

INT J CLIN EXP PATHO

2015 Jan 1;8(1):441-9.

(IF 0.252)

244. Yang S, Zheng J, Xiao X, Xu T, Tang W, Zhu H, Yang L, Zheng S, Dong K, Zhou G, Wang Y.

SOX2 promotes tumorigenicity and inhibits the differentiation of I-type neuroblastoma cells.

Int J Oncol

2015 Jan;46(1):317-23.

(IF 3.899)

245. Hao Z, Yang J, Wang C, Li Y, Zhang Y, Dong X, Zhou L, Liu J, Zhang Y, Qian J.

MicroRNA-7 inhibits metastasis and invasion through targeting focal adhesion kinase in cervical cancer.

Int J Clin Exp Med

2015 Jan 15;8(1):480-7.

(IF 0.166)

246. Du Z, Yang Q, Liu L, Li S, Zhao J, Hu J, Liu C, Qian D, Gao C.

NADPH oxidase 2-dependent oxidative stress, mitochondrial damage and apoptosis in the ventral cochlear nucleus of D-galactose-induced aging rats.

Neuroscience

2015 Feb 12;286:281-92.

(IF 3.056)

247. Xiao WJ, Ma T, Ge C, Xia WJ, Mao Y, Sun RB, Yu XY, Aa JY, Wang GJ.

Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextromethorphan in HepG2 cells.

Acta Pharmacol Sin

2015 Feb;36(2):259-67.

(IF 5.064)

248. Yu D, Li M, Tian Y, Liu J, Shang J.

Luteolin inhibits ROS-activated MAPK pathway in myocardial ischemia/reperfusion injury.

Life Sci

2015 Feb 1;122:15-25.

(IF 3.647)

249. Zhou J, Wang Z, Li Q, Liu F, Du Y, Yuan H, Hu F, Wei Y, You J.

Hybridized doxorubicin-Au nanospheres exhibit enhanced near-infrared surface plasmon absorption for photothermal therapy applications.

Nanoscale

2015 Mar 19;7(13):5869-83.

(IF 6.895)

250. Ren A, Qiu Y, Cui H, Fu G.

Inhibition of H3K9 methyltransferase G9a induces autophagy and apoptosis in oral squamous cell carcinoma.

BIOCHEM BIOPH RES CO

2015 Mar 27;459(1):10-7.

(IF 2.985)

251. Wang F, Meng Y, Zhang Y, Zhao G, Zheng X, Xiao Q, Yu Y.

Ketamine reduces lipopolysaccharide-induced high-mobility group box-1 through heme oxygenase-1 and nuclear factor erythroid 2-related factor 2/ p38 mitogen-activated protein kinase.

J Surg Res

2015 Apr;194(2):599-613.

(IF 1.841)

252. Yu S, Hou D, Chen P, Zhang Q, Lv B, Ma Y, Liu F, Liu H, Song EJ, Yang D, Liu J.

Adenosine induces apoptosis through TNFR1/RIPK1/P38 axis in colon cancer cells.

BIOCHEM BIOPH RES CO

2015 May 8;460(3):759-65.

(IF 2.985)

253. Zhang B, He P, Lu Y, Bian X, Yang X, Fu X, Wu Y, Li D.

HSF1 Relieves Amyloid-β-Induced Cardiomyocytes Apoptosis.

Cell Biochem Biophys

2015 Jun;72(2):579-87.

(IF 2.073)

254. Jia K, Zhang Y, Ma W, Zhang X, Sun Q.

Effect of interleukin-17 on receptor-interacting protein 4 expression and keratinocyte proliferation.

Exp Ther Med

2015 Jul;10(1):374-378.

(IF 1.785)

255. Guo X, Shang J, Deng Y, Yuan X, Zhu D, Liu H.

Alterations in left ventricular function during intermittent hypoxia: Possible involvement of O-GlcNAc protein and MAPK signaling.

Int J Mol Med

2015 Jul;36(1):150-8.

(IF 3.098)

256. Miao CG, Shi WJ, Xiong YY, Yu H, Zhang XL, Qin MS, Du CL, Song TW, Zhang B, Li J.

MicroRNA-663 activates the canonical Wnt signaling through the adenomatous polyposis coli suppression.

Immunol Lett

2015 Jul;166(1):45-54.

(IF 3.276)

257. Zhang Y, Wu S, Song S, Lv J, Feng C, Lin X.

Preparation and characterization of a stable BHK-21 cell line constitutively expressing the Schmallenberg virus nucleocapsid protein.

MOL CELL PROBE

2015 Aug;29(4):244-53.

(IF 1.951)

258. Wang C, Wu X, Shen F, Li Y, Zhang Y, Yu D.

Shlnc-EC6 regulates murine erythroid enucleation by Rac1-PIP5K pathway.

Dev Growth Differ

2015 Aug;57(6):466-73.

(IF 1.723)

259. Zhang F, Yang F, Zhao H, An Y.

Curcumin alleviates lung injury in diabetic rats by inhibiting NF-κB pathway.

CLIN EXP PHARMACOL P

2015 Sep;42(9):956-63.

(IF 2.092)

260. Wang Y, Jiang Y, Ma N, Sang B, Hu X, Cong X, Liu Z.

Overexpression of Hiwi Inhibits the Growth and Migration of Chronic Myeloid Leukemia Cells.

Cell Biochem Biophys

2015 Sep;73(1):117-24.

(IF 2.073)

261. Wang Y, Jiang Y, Bian C, Dong Y, Ma C, Hu X, Liu Z.

Overexpression of Hiwi Inhibits the Cell Growth of Chronic Myeloid Leukemia K562 Cells and Enhances Their Chemosensitivity to Daunomycin.

Cell Biochem Biophys

2015 Sep;73(1):129-35.

(IF 2.073)

262. Wang H, Qi J, Li L, Wu T, Wang Y, Wang X, Ning Q.

Inhibitory effects of Chikusetsusaponin IVa on lipopolysaccharide-induced pro-inflammatory responses in THP-1 cells.

INT J IMMUNOPATH PH

2015 Sep;28(3):308-17.

(IF 2.209)

263. Miao CG, Qin D, Du CL, Ye H, Shi WJ, Xiong YY, Zhang XL, Yu H, Dou JF, Ma ST, Qin MS, Liu HZ, Fang YX, Zhou GL, Chen JZ, He X, Huang C, Huang Y, Zhang B, Song TW, Li J.

DNMT1 activates the canonical Wnt signaling in rheumatoid arthritis model rats via a crucial functional crosstalk between miR-152 and the DNMT, MeCP2.

Int Immunopharmacol

2015 Sep;28(1):344-53.

(IF 3.943)

264. Wu J, Cheng M, Liu Q, Yang J, Wu S, Lu X, Jin C, Ma H, Cai Y.

Protective Role of tert-Butylhydroquinone Against Sodium Fluoride-Induced Oxidative Stress and Apoptosis in PC12 Cells.

Cell Mol Neurobiol

2015 Oct;35(7):1017-25.

(IF 3.606)

265. Wang G, Kang N, Gong H, Luo Y, Bai C, Chen Y, Ji X, Huang C, Dong Q.

Upregulation of uncoupling protein Ucp2 through acute cold exposure increases post-thaw sperm quality in zebrafish.

Cryobiology

2015 Dec;17(3):646-71.

(IF 2.283)

266. Chen L, Mao F, Kirumba GC, Jiang C, Manefield M, He Y.

Changes in metabolites, antioxidant system, and gene expression in Microcystis aeruginosa under sodium chloride stress.

ECOTOX ENVIRON SAFE

2015 Dec;122:126-35.

(IF 4.872)

267. Chen D, Tao X, Wang Y, Tian F, Wei Y, Chen G, Shen H, Wang Z, Yu Z, Li H, Chen G.

Curcumin accelerates reendothelialization and ameliorates intimal hyperplasia in balloon-injured rat carotid artery via the upregulation of endothelial cell autophagy.

Int J Mol Med

2015 Dec;36(6):1563-71.

(IF 3.098)

268. Wang W, Zeng L, Wang ZM, Zhang S, Rong XF, Li RH.

Ginsenoside Rb1 inhibits matrix metalloproteinase 13 through down-regulating Notch signaling pathway in osteoarthritis.

EXP BIOL MED

2015 Dec;240(12):1614-21.

(IF 3.139)

269. Li L, Yang C, Liu X, Yang S, Ye S, Jia J, Liu W, Zhang Y.

Elevated expression of microRNA-30b in osteoarthritis and its role in ERG regulation of chondrocyte.

Biomed Pharmacother

2015 Dec;76:94-9.

(IF 4.545)

270. Wang D, Wang Y, Xu S, Wang F, Wang B, Han K, Sun D, Li L.

Epigallocatechin-3-gallate Protects against Hydrogen Peroxide-Induced Inhibition of OsteogenicDifferentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells.

Stem Cells Int

2016;2016:7532798.

(IF 3.869)

271. Zhang L, Zhao X, Wang F, Lin Q, Wang W.

Effects of Morinda officinalis Polysaccharide on Experimental Varicocele Rats.

EVID-BASED COMPL ALT

2016;2016:5365291.

(IF 1.813)

272. Yan X, Liu J, Wu H, Liu Y, Zheng S, Zhang C, Yang C.

Impact of miR-208 and its Target Gene Nemo-Like Kinase on the Protective Effect of Ginsenoside Rb1 inHypoxia/Ischemia Injuried Cardiomyocytes.

CELL PHYSIOL BIOCHEM

2016;39(3):1187-95.

(IF 5.5)

273. Kang X, Yang Y, Jiao Y, Song H, Song L, Xiong D, Wu L, Pan Z, Jiao X.

HA1-2-fljB Vaccine Induces Immune Responses against Pandemic Swine-Origin H1N1 Influenza Virus inMice.

J MOL MICROB BIOTECH

2016;26(6):422-432.

(IF 0.803)

274. Yuan Y, Li D, Li H, Wang L, Tian G, Dong Y.

YAP overexpression promotes the epithelial-mesenchymal transition and chemoresistance in pancreatic cancer cells.

Mol Med Rep

2016 Jan;13(1):237-42.

(IF 2.1)

275. Cheng S, Liang X, Wang Y, Jiang Z, Liu Y, Hou W, Li S, Zhang J, Wang Z.

The circadian Clock gene regulates acrosin activity of sperm through serine protease inhibitor A3K.

EXP BIOL MED

2016 Jan;241(2):205-15.

(IF 3.139)

276. Liu J, Tang X, Wang Y, Zang Y, Zhou B.

A Zostera marina manganese superoxide dismutase gene involved in the responses to temperature stress.

Gene

2016 Jan 10;575(2 Pt 3):718-24.

(IF 2.984)

277. Wu ZB, Cai L, Lin SJ, Leng ZG, Guo YH, Yang WL, Chu YW, Yang SH, Zhao WG.

Heat Shock Protein 47 Promotes Glioma Angiogenesis.

Brain Pathol

2016 Jan;26(1):31-42.

(IF 5.568)

278. Ding W, Tong Y, Zhang X, Pan M, Chen S.

Study of Arsenic Sulfide in Solid Tumor Cells Reveals Regulation of Nuclear Factors of Activated T-cells byPML and p53.

SCI REP-UK

2016 Jan 22;6:19793.

(IF 3.998)

279. Yuan Y, Li D, Li H, Wang L, Tian G, Dong Y.

YAP overexpression promotes the epithelial-mesenchymal transition and chemoresistance in pancreaticcancer cells.

Mol Med Rep

2016 Jan;13(1):237-42.

(IF 2.1)

280. Chen Y, Jiang T, Shi L, He K.

hcrcn81 promotes cell proliferation through Wnt signaling pathway in colorectal cancer.

Med Oncol

2016 Jan;33(1):3.

(IF 2.834)

281. Sheng Y, Wang H, Liu D, Zhang C, Deng Y, Yang F, Zhang T, Zhang C.

Methylation of tumor suppressor gene CDH13 and SHP1 promoters and their epigenetic regulation by theUHRF1/PRMT5 complex in endometrial carcinoma.

Gynecol Oncol

2016 Jan;140(1):145-51.

(IF 4.623)

282. Yang J, Ma Q, Zhang Y, Wang X, Zhang G, Ma Z.

Molecular cloning and functional analysis of GbRVd, a gene in Gossypium barbadense that plays animportant role in conferring resistance to Verticillium wilt.

Gene

2016 Jan 10;575(2 Pt 3):687-94.

(IF 2.984)

283. Zhou Y, Yang Q, Xu H, Zhang J, Deng H, Gao H, Yang J, Zhao D, Liu F.

miRNA-221-3p Enhances the Secretion of Interleukin-4 in Mast Cells through the Phosphatase and TensinHomolog/p38/Nuclear Factor-kappaB Pathway.

PLoS One

2016 Feb 22;11(2):e0148821.

(IF 2.74)

284. Zhou L, Jiang L, Xu M, Liu Q, Gao N, Li P, Liu EH.

Miltirone exhibits antileukemic activity by ROS-mediated endoplasmic reticulum stress and mitochondrialdysfunction pathways.

SCI REP-UK

2016 Feb 5;6:20585.

(IF 3.998)

285. Gong Y, Li H, Li Y.

Effects of Bacillus subtilis on Epithelial Tight Junctions of Mice with Inflammatory Bowel Disease.

J INTERF CYTOK RES

2016 Feb;36(2):75-85.

(IF 2.032)

286. Li Y, Zhu J, Liu Y, Chen X, Lei S, Li L, Jiang B, Tan L, Yu S, Zhao Y.

Glycogen Synthase Kinase 3β Influences Injury Following Cerebral Ischemia/Reperfusion in Rats.

Int J Biol Sci

2016 Feb 29;12(5):518-31.

(IF 4.858)

287. Ma WY, Jia K, Zhang Y.

IL-17 promotes keratinocyte proliferation via the downregulation of C/EBPα.

Exp Ther Med

2016 Feb;11(2):631-636.

(IF 1.785)

288. Tang Y, Lu S, Gan X, Liu F, Zhang Y, Luo C, Pan Y, Hong L, Gan R.

Expression of LMP and EBNA genes in Epstein-Barr virus-associated lymphomas in Hu-PBL/SCID mice.

Oncol Rep

2016 Feb;35(2):905-11.

(IF 3.417)

289. Ma J. Wang Z, Liu C, Shen H, Chen Z, Yin J, Zuo G, Duan X, Li H, Chen G.

Pramipexole-Induced Hypothermia Reduces Early Brain Injury via PI3K/AKT/GSK3β pathway inSubarachnoid Hemorrhage rats.

SCI REP-UK

2016 Mar 30;6:23817.

(IF 3.998)

290. Wang W, Wang X, Chen L, Zhang Y, Xu Z, Liu J, Jiang G, Li J, Zhang X, Wang K, Wang J, Chen G, Luo J.

The microRNA miR-124 suppresses seizure activity and regulates CREB1 activity.

Expert Rev Mol Med

2016 Mar 21;18:e4.

(IF 3.875)

291. Ma Y, Wang H, Yan D, Wei Y, Cao Y, Yi P, Zhang H, Deng Z, Dai J, Liu X, Luo J, Zhang Z, Sun S, Guo H.

Magnetic Resonance Imaging Revealed Splenic Targeting of Canine Parvovirus Capsid Protein VP2.

SCI REP-UK

2016 Mar 21;6:23392.

(IF 3.998)

292. Liu L, Wang D, Wang J, Wang S.

The Nitric Oxide Prodrug JS-K Induces Ca2+ -Mediated Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells.

J BIOCHEM MOL TOXIC

2016 Apr;30(4):192-9.

(IF 3.606)

293. Dan Yue, Zhang Y, Cheng L, Ma J, Xi Y, Yang L, Su C, Shao B, Huang A, Xiang R, Cheng P.

Hepatitis B virus X protein (HBx)-induced abnormalities of nucleic acid metabolism revealed by (1)H-NMR-based metabonomics.

SCI REP-UK

2016 Apr 14;6:24430.

(IF 3.998)

294. Shang J, Yao Y, Fan X, Shangguan L, Li J, Liu H, Zhou Y.

miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53-p21and p16-pRB pathways.

BBA-BIOMEMBRANES

2016 Apr;1863(4):520-32.

(IF 3.411)

295. Song Zh, Tong G, Xiao K, Jiao le F, Ke Y, Hu Ch.

L-cysteine protects intestinal integrity, attenuates intestinal inflammation and oxidant stress, andmodulates NF-κB and Nrf2 pathways in weaned piglets after LPS challenge.

INNATE IMMUN-LONDON

2016 Apr;22(3):152-61.

(IF 2.298)

296. Ye H, Wu Q, Guo M, Wu K, Lv Y, Yu F, Liu Y, Gao X, Zhu Y, Cui L, Liang N, Yun T, Li L, Zheng X.

Growth inhibition effects of ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid on colorectal

Mol Med Rep

2016 Apr;13(4):3525-32.

(IF 2.1)

297. Tian W, Xiong J, Zhu S, Xu D, Shen H, Deng Y.

mTOR signaling pathway is inhibited downstream of the cyclophilin D-mediated mitochondrial permeabilitytransition in honokiol-triggered regulated necrosis.

Mol Med Rep

2016 Apr;13(4):3227-35.

(IF 2.1)

298. Zhang B, Qiangba Y, Shang P, Lu Y, Yang Y, Wang Z, Zhang H.

Gene expression of vascular endothelial growth factor A and hypoxic adaptation in Tibetan pig.

J ANIM SCI BIOTECHNO

2016 Apr 2;7:21.

(IF 4.167)

299. Jiang X, Chen HQ, Cui ZH, Yin L, Zhang WL, Liu WB, Han F, Ao L, Cao J, Liu JY.

Low-dose and combined effects of oral exposure to bisphenol A and diethylstilbestrol on the malereproductive system in adult Sprague-Dawley rats.

ENVIRON TOXICOL CHEM

2016 Apr;43:94-102.

(IF 3.152)

300. Shi H, Xu J, Zhao R, Wu H, Gu L, Chen Y.

FGF2 regulates proliferation, migration, and invasion of ECA109 cells through PI3K/Akt signalling pathwayin vitro.

Cell Biol Int

2016 May;40(5):524-33.

(IF 2.571)

301. Xie X, Han M, Zhang L, Liu L, Gu Z, Yang M, Yang H.

Effects of Mycobacterium tuberculosis ESAT6-CFP10 Protein on Cell Viability and Production of Nitric Oxidein Alveolar Macrophages.

JUNDISHAPUR J MICROB

2016 May 30;9(6):e33264.

(IF 0.593)

302. Shen SH, Yu N, Xu H, Liu XY, Tan GW, Wang ZX.

Inhibition of Human Glioma Cell Proliferation Caused by Knockdown of Utrophin Using a Lentivirus-Mediated System.

CANCER BIOTHER RADIO

2016 May;31(4):133-8.

(IF 2.314)

303. Zhang C, Wang Z, Zhao J, Li Q, Huang C, Zhu L, Lu D.

Neuroprotective Effect of Lutein on NMDA-Induced Retinal Ganglion Cell Injury in Rat Retina.

Cell Mol Neurobiol

2016 May;36(4):531-40.

(IF 3.606)

304. Wu X, Qi X, Lu Y, Lin C, Yuan Y, Zhu Q, Yin Q, Li W, Li Y, Bian H.

Liguzinediol protects against cardiac fibrosis in rats in vivo and in vitro.

Biomed Pharmacother

2016 May;80:260-7.

(IF 4.545)

305. Zhang B, Shang P, Qiangba Y, Xu A, Wang Z, Zhang H.

The association of NR1H3 gene with lipid deposition in the pig.

Lipids Health Dis

2016 May 26;15:99.

(IF 2.906)

306. Yin J, Li H, Meng C, Chen D, Chen Z, Wang Y, Wang Z, Chen G.

Inhibitory effects of omega-3 fatty acids on early brain injury after subarachnoid hemorrhage in rats:Possible involvement of G protein-coupled receptor 120/β-arrestin2/TGF-β activated kinase-1 bindingprotein-1 signaling pathway.

INT J BIOCHEM CELL B

2016 Jun;75:11-22.

(IF 3.673)

307. Shi Z, Wu D, Tang R, Li X, Chen R, Xue S, Zhang C, Sun X.

Silencing of HMGA2 promotes apoptosis and inhibits migration and invasion of prostate cancer cells.

J BIOSCI BIOENG

2016 Jun;41(2):229-36.

(IF 2.366)

308. Zhu Y, 2 Cui H, Xia Y, Gan H1.

RIPK3-Mediated Necroptosis and Apoptosis Contributes to Renal Tubular Cell Progressive Loss andChronic Kidney Disease Progression in Rats.

PLoS One

2016 Jun 9;11(6):e0156729.

(IF 2.74)

309. Shen X, Ma L, Dong W, Wu Q, Gao Y, Luo C, Zhang M, Chen X, Tao L.

Autophagy regulates intracerebral hemorrhage induced neural damage via apoptosis and NF-κB pathway.

Neurochem Int

2016 Jun;96:100-12.

(IF 3.881)

310. Ye MH, Nan YL, Ding MM, Hu JB, Liu Q, Wei WH, Yang SM.

Effects of dietary tannic acid on the growth, hepatic gene expression, and antioxidant enzyme activity inBrandt's voles (Microtus brandti).

COMP BIOCHEM PHYS B

2016 Jun-Jul;196-197:19-26.

(IF 2.219)

311. Sun L, Dong Y, Zhao J, Yin Y, Zheng Y.

The CLC-2 Chloride Channel Modulates ECM Synthesis, Differentiation, and Migration of HumanConjunctival Fibroblasts via the PI3K/Akt Signaling Pathway.

Int J Mol Sci

2016 Jun 9;17(6). pii: E910.

(IF 4.556)

312. He M, Wang M, Huang Y, Peng W, Zheng Z, Xia N, Xu J, Tian D.

The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADDand RIP1.

SCI REP-UK

2016 Jun 8;6:27597.

(IF 3.998)

313. Cai L, Leng ZG, Guo YH, Lin SJ, Wu ZR, Su ZP, Lu JL, Wei LF, Zhuge QC, Jin K, Wu ZB.

Dopamine agonist resistance-related endocan promotes angiogenesis and cells viability of prolactinomas.

Endocrine

2016 Jun;52(3):641-51.

(IF 3.235)

314. Zhu MY, Lin D, Liu J, Mo HY.

Artesunate interfere in modulation of Foxp3 expression in synovial cells in collagen-induced arthritis rats.

Chin J Integr Med

2016 Jun 28.[Epub ahead of print]

(IF 1.545)

315. Gao H, Deng H, Xu H, Yang Q, Zhou Y, Zhang J, Zhao D, Liu F.

MicroRNA-223 promotes mast cell apoptosis by targeting the insulin-like growth factor 1 receptor.

Exp Ther Med

2016 Jun;11(6):2171-2176.

(IF 1.785)

316. Zhang H, Song Y, Li Z, Zhang T, Zeng L.

Evaluation of breviscapine on prevention of experimentally induced abdominal adhesions in rats.

Am J Surg

2016 Jun;211(6):1143-52.

(IF 2.125)

317. Geng F, Huang X, Ma M.

Hen Egg White Ovomacroglobulin Promotes Fibroblast Migration via Mediating Cell Adhesion and Cytoskeleton.

J SCI FOOD AGR

2016 Jul;96(9):3188-94.

(IF 2.614)

318. Xue F, Zhu L, Meng QW, Wang L, Chen XS, Zhao YB, Xing Y, Wang XY, Cai L.

FAT10 is associated with the malignancy and drug resistance of non-small-cell lung cancer.

ONCOTARGETS THER

2016 Jul 19;9:4397-409.

(IF 3.337)

319. Wang Y, Mei X, Yuan J, Lai X, Xu D.

Taurine zinc solid dispersions enhance bile-incubated L02 cell viability and improve liver function byinhibiting ERK2 and JNK phosphorylation during cholestasis.

Toxicology

2016 Jul 29;366-367:10-9.

(IF 4.099)

320. Liu Z, Ma C, Shen J, Wang D, Hao J, Hu Z.

SDF 1/CXCR4 axis induces apoptosis of human degenerative nucleus pulposus cells via the NF κBpathway.

Mol Med Rep

2016 Jul;14(1):783-9.

(IF 2.1)

321. Ma L, Shen X, Gao Y, Wu Q, Ji M, Luo C, Zhang M, Wang T, Chen X, Tao L.

Blocking B7-1/CD28 Pathway Diminished Long-Range Brain Damage by Regulating the Immune andInflammatory Responses in a Mouse Model of Intracerebral Hemorrhage.

Neurochem Res

2016 Jul;41(7):1673-83.

(IF 3.038)

322. Gao Y, Ma L, Luo CL, Wang T, Zhang MY, Shen X, Meng HH, Ji MM, Wang ZF, Chen XP, Tao LY.

IL-33 Exerts Neuroprotective Effect in Mice Intracerebral Hemorrhage Model Through SuppressingInflammation/Apoptotic/Autophagic Pathway.

Mol Neurobiol

2016 Jul 12. [Epub ahead of print]

(IF 4.5)

323. Wu F, Shi W, Zhou G, Yao H, Xu C, Xiao W, Wu J, Wu X.

Ginkgolide B functions as a determinant constituent of Ginkgolides in alleviating lipopolysaccharide-induced lung injury.

Biomed Pharmacother

2016 Jul;81:71-8.

(IF 4.545)

324. Zhang Q, Zhao Y, Xu Y, Chen Z, Liu N, Ke C, Liu B, Wu W.

Sodium ferulate and n-butylidenephthalate combined with bone marrow stromal cells (BMSCs) improve thetherapeutic effects of angiogenesis and neurogenesis after rat focal cerebral ischemia.

J Transl Med

2016 Jul 28;14(1):223.

(IF 4.124)

325. Gao F, Zhang LH, Su TF, Li L, Zhou R, Peng M, Wu CH, Yuan XC, Sun N, Meng XF, Tian B, Shi J, Pan HL, Li M.

Signaling Mechanism of Cannabinoid Receptor-2 Activation-Induced β-Endorphin Release.

Mol Neurobiol

2016 Aug;53(6):3616-25.

(IF 4.5)

326. Liang Y, Ji J, Lin Y, He Y, Liu J.

The Ganglioside GM-1 Inhibits Bupivacaine-Induced Neurotoxicity in Mouse Neuroblastoma Neuro2a Cells.

Cell Biochem Funct

2016 Aug;34(6):455-62.

(IF 2.632)

327. Cui Y, Duan X, Li H, Dang B, Yin J, Wang Y, Gao A, Yu Z, Chen G.

Hydrogen Sulfide Ameliorates Early Brain Injury Following Subarachnoid Hemorrhage in Rats.

Mol Neurobiol

2016 Aug;53(6):3646-57.

(IF 4.5)

328. Yu J, Qiu Y, Yang J, Bian S, Chen G, Deng M, Kang H, Huang L.

DNMT1-PPARγ pathway in macrophages regulates chronic inflammation and atherosclerosis developmentin mice.

SCI REP-UK

2016 Aug 17;6:30053.

(IF 3.998)

329. Wang C, Zhang Y, Zhan Y, Luo C, Li Y, Qiu D, Mu D, Duan H, Zhou K, Hua Y.

The effect of 17α-ethynylestradiol induced intrahepatic cholestasis of pregnancy on placental P-glycoprotein in mice: Implications in the individualized transplacental digoxin treatment for fetal heartfailure.

Placenta

2016 Aug;44:91-7.

(IF 3.177)

330. Guo C, Yang L, Luo J, Zhang C, Xia Y, Ma T, Kong L.

Sophoraflavanone G from Sophora alopecuroides inhibits lipopolysaccharide-induced inflammation inRAW264.7 cells by targeting PI3K/Akt, JAK/STAT and Nrf2/HO-1 pathways.

Int Immunopharmacol

2016 Sep;38:349-56.

(IF 3.943)

331. Xu Y, Xiang J, Zhao H, Liang H, Huang J, Li Y, Pan J, Zhou H, Zhang X, Wang JH, Liu Z, Wang J.

Human amniotic fluid stem cells labeled with up-conversion nanoparticles for imaging-monitored repairingof acute lung injury.

Biomaterials

2016 Sep;100:91-100.

(IF 10.317)

332. Wang C, Duan X, Sun X, Liu Z, Sun P, Yang X, Sun H, Liu K, Meng Q.

Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholicsteatohepatitis in mice.

Food Funct

2016 Sep 14;7(9):3716-23.

(IF 4.171)

333. Meng Q, Shao L, Luo X, Mu Y, Xu W, Gao L, Xu H, Cui Y.

Expressions of VEGF-A and VEGFR-2 in placentae from GDM pregnancies.

REPROD BIOL ENDOCRIN

2016 Sep 20;14(1):61.

(IF 3.235)

334. Shen M, Fan D, Zang Y, Chen Y, Zhu K, Cai Z, Liu Y, Sun X, Liu J, Gong J.

Neuroprotective effects of methane-rich saline on experimental acute carbon monoxide toxicity.

J Neurol Sci

2016 Oct 15;369:361-7.

(IF 3.115)

335. Deheng C, Kailiang Z, Weidong W, Haiming J, Daoliang X, Ningyu C, Huazi X.

Salidroside Promotes Random Skin Flap Survival in Rats by Enhancing Angiogenesis and InhibitingApoptosis.

J Reconstr Microsurg

2016 Oct;32(8):580-586.

(IF 1.841)

336. Zhang K, Zhu X, Lu Y.

Effect of Mild Heating on Human Lens Epithelial Cells: A Possible Model of Lens Aging.

SCI REP-UK

2016 Oct 11;6:33917.

(IF 3.998)

337. Ge H, Yu A, Chen J, Yuan J, Yin Y, Duanmu W, Tan L, Yang Y, Lan C, Chen W, Feng H, Hu R.

Poly-L-ornithine enhances migration of neural stem/progenitor cells via promoting α-Actinin 4 binding toactin filaments.

SCI REP-UK

2016 Nov 22;6:37681.

(IF 3.998)

338. Hu YB, Zou Y, Huang Y, Zhang YF, Lourenco GF, Chen SD, Halliday GM, Wang G, Ren RJ.

ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances AutophagosomeFormation But not Autophagic Aβ Clearance.

Front Cell Neurosci

2016 Nov 2;10:253.

(IF 3.921)

339. He P, Zhang A, Zhou S, Zhang F, Linhardt RJ, Sun P.

Structural elucidation of polysaccharide containing 3-O-methyl galactose from fruiting bodies of Pleurotuscitrinopileatus.

CARBOHYD RES

2016 Nov 3;434:72-76.

(IF 1.841)

340. Zhang T, Wu Y, Fang Z, Yan Q, Zhang S, Sun R, Khaliq J, Li Y.

Low expression of RBMS3 and SFRP1 are associated with poor prognosis in patients with gastric cancer.

Am J Cancer Res

2016 Nov 1;6(11):2679-2689.

(IF 5.177)

341. Wu K, Guo C, Lu X, Wu X, Pan H, Su M.

Impact of perinatal exposure to acetaminophen on hepatocellular metabolic function in offspring.

Am J Transl Res

2016 Dec 15;8(12):5646-5652.

(IF 3.375)

342. Kang X, Wang J, Jiao Y, Tang P, Song L, Xiong D, Yin Y, Pan Z, Jiao X.

Expression of recombinant Newcastle disease virus F protein in Pichia pastoris and its immunogenicityusing flagellin as the adjuvant.

PROTEIN EXPRES PURIF

2016 Dec;128:73-80.

(IF 1.513)

343. Wu Y, Zhao D, Zhuang J, Zhang F, Xu C.

Caspase-8 and Caspase-9 Functioned Differently at Different Stages of the Cyclic Stretch-InducedApoptosis in Human Periodontal Ligament Cells.

PLoS One

2016 Dec 12;11(12):e0168268.

(IF 2.74)

344. Cao B, Liu N, Wang W.

High glucose prevents osteogenic differentiation of mesenchymal stem cells via lncRNA AK028326/CXCL13pathway.

Biomed Pharmacother

2016 Dec;84:544-551.

(IF 4.545)

345. Yan Z, Xingfen W, Wei R, Jun Y, Zhiying M.

Island Cotton Enhanced Disease Susceptibility 1 Gene Encoding a Lipase-Like Protein Plays a Crucial Role in Response to Verticillium dahliae by Regulating the SA Level and H2O2 Accumulation.

Front Plant Sci

2016 Dec 15;7:1830.

(IF 4.402)

346. Zhang P, Li Y, Du Y, Li G, Wang L, Zhou F.

Resveratrol Ameliorated Vascular Calcification by Regulating Sirt-1 and Nrf2.

TRANSPL P

2016 Dec;48(10):3378-3386.

(IF 0.784)

347. Wen Z, Wu C, Cui F, Zhang H, Mei B, Shen M.

The role of osmolality in saline fluid nebulization after tracheostomy: time for changing?

BMC Pulm Med

2016 Dec 9;16(1):179.

(IF 2.813)

348. Bi Z, Zhu Y, Chen Z, Li C, Wang Y, Wang G, Liu G.

Induction of a robust immunity response against novel duck reovirus in ducklings using a subunit vaccineof sigma C protein.

SCI REP-UK

2016 Dec 15;6:39092.

(IF 3.998)

349. Yan T, Yu X, Sun X, Meng D, Jia JM.

A new steroidal saponin, furotrilliumoside from Trillium tschonoskii inhibits lipopolysaccharide-inducedinflammation in Raw264.7 cells by targeting PI3K/Akt, MARK and Nrf2/HO-1 pathways.

Fitoterapia

2016 Dec;115:37-45.

(IF 2.527)

350. Guo C, Yang L, Wan CX, Xia YZ, Zhang C, Chen MH, Wang ZD, Li ZR, Li XM, Geng YD, Kong LY.

Anti-neuroinflammatory effect of Sophoraflavanone G from Sophora alopecuroides in LPS-activated BV2 microglia by MAPK, JAK/STAT and Nrf2/HO-1 signaling pathways.

Phytomedicine

2016 Dec 1;23(13):1629-1637.

(IF 4.268)

351. Liu Y, Zhi D, Li M, Liu D, Wang X, Wu Z, Zhang Z, Fei D, Li Y, Zhu H, Xie Q, Yang H, Li H.

Shengmai Formula suppressed over-activated Ras/MAPK pathway in C. elegans by opening mitochondrial permeability transition pore via regulating cyclophilin D.

SCI REP-UK

2016 Dec 16;6:38934.

(IF 3.998)

352. Chen Z, Liu S, Sun W, Chen L, Yoo D, Li F, Ren S, Guo L, Cong X, Li J, Zhou S, Wu J, Du Y, Wang J.

Nuclear export signal of PRRSV NSP1α is necessary for type I IFN inhibition.

Virology

2016 Dec;499:278-287.

(IF 2.819)

353. Kang L, Yang C, Yin H, Zhao K, Liu W, Hua W, Wang K, Song Y, Tu J, Li S, Luo R, Zhang Y.

MicroRNA-15b silencing inhibits IL-1β-induced extracellular matrix degradation by targeting SMAD3 inhuman nucleus pulposus cells.

Biotechnol Lett

2016 Dec 30.doi: 10.1007/s10529-016-2280-3. [Epub ahead of print]

(IF 1.977)

354. Huang Y, Zhou M, Li C, Chen Y, Fang W, Xu G, Shi X.

Picroside II protects against sepsis via suppressing inflammation in mice.

Am J Transl Res

2016 Dec 15;8(12):5519-5531.

(IF 3.375)

355. Zhao W, Peng F, Shu M, Liu H, Hou X, Wang X, Ye J, Zhao B, Wang K, Zhong C, Xue L, Gao M, Liu Y, Zhao S.

Isogambogenic Acid Inhibits the Growth of Glioma Through Activation of the AMPK-mTOR Pathway.

CELL PHYSIOL BIOCHEM

2017;44(4):1381-1395.

(IF 5.5)

356. Zhang YH, He K, Shi G.

Effects of MicroRNA-499 On the Inflammatory Damage of Endothelial Cells During Coronary Artery Disease Via the Targeting of PDCD4 Through the NF-Κβ/TNF-α Signaling Pathway.

CELL PHYSIOL BIOCHEM

2017;44(1):110-124.

(IF 5.5)

357. Wu X, Zhu H, Yan J, Khan M, Yu X.

Santamarine Inhibits NF-κB Activation and Induces Mitochondrial Apoptosis in A549 Lung Adenocarcinoma Cells via Oxidative Stress.

Biomed Res Int

2017;2017:4734127.

(IF 2.276)

358. Ding L, Zang L, Zhang Y, Zhang Y, Wang X, Ai W, Ding N, Wang H.

Joint toxicity of fluoroquinolone and tetracycline antibiotics to zebrafish (Danio rerio) based on biochemical biomarkers and histopathological observation.

J Toxicol Sci

2017;42(3):267-280.

(IF 1.737)

359. Xu X, Zhang H, Wang K, Tu T, Jiang Y.

Protective Effect of Edaravone against Carbon Monoxide Induced Apoptosis in Rat Primary Cultured Astrocytes.

Biochemistry Research International

2017;2017:5839762.

360. Wang L, Liu WZ, Pei LY, Ke YS, Cui J, Li SC.

Garidisan: Improving the Quality of Ulcer Healing in Rats with Ulcerative Colitis.

EVID-BASED COMPL ALT

2017;2017:8721257.

(IF 1.813)

361. Gao JM, Meng XW, Zhang J, Chen WR, Xia F, Peng K, Ji FH.

Dexmedetomidine Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury by Suppressing TLR4-MyD88-NF-κB Signaling.

Biomed Res Int

2017;2017:1674613.

(IF 2.276)

362. Wang Q, You T, Fan H, Wang Y, Chu T, Poncz M, Zhu L.

Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis.

Platelets

2017 Jan;28(1):82-89.

(IF 3.378)

363. Zhou W, Xu G, Wang Y, Xu Z, Liu X, Xu X, Ren G, Tian K.

Oxidative stress induced autophagy in cancer associated fibroblast enhances proliferation and metabolism of colorectal cancer cells.

Cell Cycle

2017 Jan 2;16(1):73-81.

(IF 3.699)

364. Zhao P, Guo Y, Zhang W, Chai H, Xing H, Xing M.

Neurotoxicity induced by arsenic in Gallus Gallus: Regulation of oxidative stress and heat shock protein response.

Chemosphere

2017 Jan;166:238-245.

(IF 5.778)

365. Xu X, Yan Q, Wang Y, Dong X.

NTN4 is associated with breast cancer metastasis via regulation of EMT-related biomarkers.

Oncol Rep

2017 Jan;37(1):449-457.

(IF 3.417)

366. Cui L, Li Z, Chang X, Cong G, Hao L.

Quercetin attenuates vascular calcification by inhibiting oxidative stress and mitochondrial fission.

VASC PHARMACOL

2017 Jan;88:21-29.

(IF 4.152)

367. Yang J, Yao Y, Wang L, Yang C, Wang F, Guo J, Wang Z, Yang Z, Ming D.

Gastrin-releasing peptide facilitates glutamatergic transmission in the hippocampus and effectively prevents vascular dementia induced cognitive and synaptic plasticity deficits.

Exp Neurol

2017 Jan;287(Pt 1):75-83.

(IF 4.691)

368. Jia M, Wu C, Gao F, Xiang H, Sun N, Peng P, Li J, Yuan X, Li H, Meng X, Tian B, Shi J, Li M.

Activation of NLRP3 inflammasome in peripheral nerve contributes to paclitaxel-induced neuropathic pain.

Mol Pain

2017 Jan-Dec;13:1744806917719804.

(IF 2.696)

369. Yuan XC, Wu CH, Gao F, Li HP, Xiang HC, Zhu H, Pan XL, Lin LX, Liu YS, Yu W, Tian B, Meng XF, Li M.

Activation and expression of μ-calpain in dorsal root contributes to RTX-induced mechanical allodynia.

Mol Pain

2017 Jan-Dec;13:1744806917719169.

(IF 2.696)

370. Su L, Zhang Y, He K, Wei S, Pei H, Wang Q, Yang D, Yang Y.

Activation of transient receptor potential vanilloid 1 accelerates re-endothelialization and inhibits neointimalformation after vascular injury.

J Vasc Surg

2017 Jan;65(1):197-205.e2.

(IF 3.405)

371. Huang L, Zhou B, Wu H, Zheng L, Zhao J.

Effect of apatite formation of biphasic calcium phosphate ceramic (BCP) on osteoblastogenesis usingsimulated body fluid (SBF) with or without bovine serum albumin (BSA).

MAT SCI ENG C-MATER

2017 Jan 1;70(Pt 2):955-961.

(IF 5.88)

372. Li SW, Sun X, He Y, Guo Y, Zhao HJ, Hou ZJ, Xing MW.

Assessment of arsenic trioxide in the heart of Gallus gallus: alterations of oxidative damage parameters,inflammatory cytokines, and cardiac enzymes.

ENVIRON SCI POLLUT R

2017 Jan 4. doi: 10.1007/s11356-016-8223-7. [Epub ahead of print]

(IF 3.056)

373. Mehmood T, Maryam A, Zhang H, Li Y, Khan M, Ma T.

Deoxyelephantopin induces apoptosis in HepG2 cells via oxidative stress, NF-κB inhibition andmitochondrial dysfunction.

Biofactors

2017 Jan 2;43(1):63-72

(IF 4.734)

374. Duan H, Wang C, Zhou K, Wang T, Li Y, Qiu D, Li Q, Zhang Y, Hua Y.

The effect of histone deacetylase inhibition on the expression of P-glycoprotein in human placentaltrophoblast cell lines.

Placenta

2017 Jan;49:37-47.

(IF 3.177)

375. Zhao P, Guo Y, Zhang W, Chai H, Xing H, Xing M.

Neurotoxicity induced by arsenic in Gallus Gallus: Regulation of oxidative stress and heat shock proteinresponse.

Chemosphere

2017 Jan;166:238-245.

(IF 5.778)

376. He PF, He L, Zhang AQ, Wang XL, Qu L, Sun PL.

Structure and chain conformation of a neutral polysaccharide from sclerotia of Polyporus umbellatus.

CARBOHYD POLYM

2017 Jan 2;155:61-67.

(IF 7.182)

377. Li SL, Yan J, Zhang YQ, Zhen CL, Liu MY, Jin J, Gao JL, Xiao XL, Shen X, Tai Y, Hu N, Zhang XZ, Sun ZJ, Dong DL.

Niclosamide ethanolamine inhibits artery constriction.

Pharmacol Res

2017 Jan;115:78-86.

(IF 5.893)

378. Lin J, Jing L, Zhu H, Dong FS.

Fundamental research on the action mechanism of the 800 nm semiconductor laser on skin blackheads and coarse pores.

Exp Ther Med

2017 Jan;13(1):235-241.

(IF 1.785)

379. Wang X, Tang P, Guo F, Zhang M, Chen Y, Yan Y, Tian Z, Xu P, Zhang L, Zhang L, Zhang L.

RhoA regulates Activin B-induced stress fiber formation and migration of bone marrow-derived mesenchymal stromal cell through distinct signaling.

BBA-BIOMEMBRANES

2017 Jan;1861(1 Pt A):3011-3018.

(IF 3.411)

380. Shen J, Xu S, Zhou H, Liu H, Jiang W, Hao J, Hu Z.

IL-1β induces apoptosis and autophagy via mitochondria pathway in human degenerative nucleus pulposus cells.

SCI REP-UK

2017 Jan 25;7:41067.

(IF 3.998)

381. Lian YJ, Gong H, Wu TY, Su WJ, Zhang Y, Yang YY, Peng W, Zhang T, Zhou JR, Jiang CL, Wang YX.

Ds-HMGB1 and fr-HMGB induce depressive behavior through neuroinflammation in contrast to nonoxid-HMGB1.

Brain Behav Immun

2017 Jan;59:322-332.

(IF 6.633)

382. Du C, Guo Y, Cheng Y, Han M, Zhang W, Qian H.

Torulene and torularhodin, protects human prostate stromal cells from hydrogen peroxide-induced oxidative stress damage through the regulation of Bcl-2/Bax mediated apoptosis.

FREE RADICAL RES

2017 Feb;51(2):113-123.

(IF 2.839)

383. Du P, Zhao J, Wang J, Liu Y, Ren H, Patel R, Hu C, Zhang W, Huang G.

Sine Oculis Homeobox Homolog 1 Regulates Mitochondrial Apoptosis Pathway Via Caspase-7 In Gastric Cancer Cells.

J Cancer

2017 Feb 25;8(4):636-645.

(IF 3.565)

384. Li SW, Sun X, He Y, Guo Y, Zhao HJ, Hou ZJ, Xing MW.

Assessment of arsenic trioxide in the heart of Gallus gallus: alterations of oxidative damage parameters, inflammatory cytokines, and cardiac enzymes.

ENVIRON SCI POLLUT R

2017 Feb;24(6):5781-5790.

(IF 3.056)

385. Li R, Ma L, Huang H, Ou S, Yuan J, Xu T, Yu X, Liu X, Yang J, Chen Y, Peng X.

Altered Expression of CXCL13 and CXCR5 in Intractable Temporal Lobe Epilepsy Patients and Pilocarpine-Induced Epileptic Rats.

Neurochem Res

2017 Feb;42(2):526-540.

(IF 3.038)

386. Kang H, Liu J, Sun A, Liu X, Fan Y, Deng X.

Vascular smooth muscle cell glycocalyx mediates shear stress-induced contractile responses via a Rho kinase (ROCK)-myosin light chain phosphatase (MLCP) pathway.

SCI REP-UK

2017 Feb 13;7:42092.

(IF 3.998)

387. He L, Xiao D, Feng J, Yao C, Tang L.

Induction of apoptosis of liver cancer cells by nanosecond pulsed electric fields (nsPEFs).

Med Oncol

2017 Feb;34(2):24.

(IF 2.834)

388. Yang H, Gu ZT, Li L, Maegele M, Zhou BY, Li F, Zhao M, Zhao KS.

SIRT1 plays a neuroprotective role in traumatic brain injury in rats via inhibiting the p38 MAPK pathway.

Acta Pharmacol Sin

2017 Feb;38(2):168-181.

(IF 5.064)

389. Ji J, Zeng XN, Cao LL, Zhang L, Zhao Z, Yang DD, Sun XL.

PPARβ/δ activation protects against corticosterone-induced ER stress in astrocytes by inhibiting the CpGhypermethylation of microRNA-181a.

Neuropharmacology

2017 Feb;113(Pt A):396-406.

(IF 4.431)

390. Wang X, Ge QM, Bian F, Dong Y, Huang CM.

Inhibition of TLR4 protects rat islets against lipopolysaccharide-induced dysfunction.

Mol Med Rep

2017 Feb;15(2):805-812.

(IF 2.1)

391. Zhang H, Zhai L, Wang T, Li S, Guo Y.

Picroside II Exerts a Neuroprotective Effect by Inhibiting the Mitochondria Cytochrome C SignalPathwayFollowing Ischemia Reperfusion Injury in Rats.

J Mol Neurosci

2017 Feb;61(2):267-278.

(IF 2.678)

392. Zhang WF, Xiong YW, Zhu TT, Xiong AZ, Bao HH, Cheng XS.

MicroRNA let-7g inhibited hypoxia-induced proliferation of PASMCs via G0/G1 cell cycle arrest by targeting c-myc.

Life Sci

2017 Feb 1;170:9-15.

(IF 3.647)

393. Yan YH, Li SH, Li HY, Lin Y, Yang JX.

Osthole Protects Bone Marrow-Derived Neural Stem Cells from Oxidative Damage through PI3K/Akt-1 Pathway.

Neurochem Res

2017 Feb;42(2):398-405.

(IF 3.038)

394. Huang H, Zhang X, Huang Z, Zhang Y, Zhou Z.

Geniposide reverses multidrug resistance in vitro and in vivo by inhibiting the efflux function and expression of P-glycoprotein.

Exp Ther Med

2017 Feb;13(2):437-442.

(IF 1.785)

395. Yu M, Xu X, Jiang N, Wei W, Li F, He L, Luo X.

Dehydropachymic acid decreases bafilomycin A1 induced β-Amyloid accumulation in PC12 cells.

J Ethnopharmacol

2017 Feb 23;198:167-173.

(IF 3.69)

396. Zhang Y, Zhang L, Sun H, Lv Q, Qiu C, Che X, Liu Z, Jiang J.

Forkhead transcription factor 1 inhibits endometrial cancer cell proliferation via sterol regulatory element-binding protein 1.

Oncol Lett

2017 Feb;13(2):731-737.

(IF 2.311)

397. Cao Y, Wang X, Li S, Wang H, Yu L, Wang P.

The Effects of l-Carnitine Against Cyclophosphamide-Induced Injuries in Mouse Testis.

BASIC CLIN PHARMACOL

2017 Feb;120(2):152-158.

(IF 2.651)

398. Shen P, Hou S, Zhu M, Zhao M, Ouyang Y, Feng J.

Cortical spreading depression preconditioning mediates neuroprotection against ischemic stroke by inducing AMP-activated protein kinase-dependent autophagy in a rat cerebral ischemic/reperfusion injury model.

J Neurochem

2017 Mar;140(5):799-813.

(IF 4.066)

399. Zhang L, Li Z, Feng D, Shen H, Tian X, Li H, Wang Z, Chen G.

Involvement of Nox2 and Nox4 NADPH oxidases in early brain injury after subarachnoid hemorrhage.

FREE RADICAL RES

2017 Mar;51(3):316-328.

(IF 2.839)

400. La X, Zhang L, Li Z, Yang P, Wang Y.

Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells.

ONCOTARGET

2017 Mar 28;8(13):20909-20924.

(IF 5.168)

401. Zhou H, Wu W, Zhang Y, He H, Yuan Z, Zhu Z, Zhao Z.

Selective preservation of cholinergic MeCP2 rescues specific Rett-syndrome-like phenotypes in MeCP2stop mice.

Behav Brain Res

2017 Mar 30;322(Pt A):51-59.

(IF 2.977)

402. Li YY, Xiang Y, Zhang S, Wang Y, Yang J, Liu W, Xue FT.

Thioredoxin-2 protects against oxygen-glucose deprivation/reperfusion injury by inhibiting autophagy and apoptosis in H9c2 cardiomyocytes.

Am J Transl Res

2017 Mar 15;9(3):1471-1482. eCollection 2017.

(IF 3.375)

403. Kang L, Hu J, Weng Y, Jia J, Zhang Y.

Sirtuin 6 prevents matrix degradation through inhibition of the NF-κB pathway in intervertebral disc degeneration.

Exp Cell Res

2017 Mar 15;352(2):322-332.

(IF 3.383)

404. Duan T, Sun W, Zhang M, Ge J, He Y, Zhang J, Zheng Y, Yang W, Shen HM, Yang J, Zhu X, Yu P.

Dietary restriction protects against diethylnitrosamine-induced hepatocellular tumorigenesis by restoring the disturbed gene expression profile.

SCI REP-UK

2017 Mar 6;7:43745.

(IF 3.998)

405. Yang F, Shi L, Liang T, Ji L, Zhang G, Shen Y, Zhu F, Xu L.

Anti-tumor effect of evodiamine by inducing Akt-mediated apoptosis in hepatocellular carcinoma.

BIOCHEM BIOPH RES CO

2017 Mar 25;485(1):54-61.

(IF 2.985)

406. Gong J, Shen S, Yang Y, Qin S, Huang L, Zhang H, Chen L, Chen Y, Li S, She S, Yang M, Ren H, Hu H.

Inhibition of FASN suppresses migration, invasion and growth in hepatoma carcinoma cells by deregulating the HIF-1α/IGFBP1 pathway.

Int J Oncol

2017 Mar;50(3):883-892.

(IF 3.899)

407. Su WJ, Zhang Y, Chen Y, Gong H, Lian YJ, Peng W, Liu YZ, Wang YX, You ZL, Feng SJ, Zong Y, Lu GC, Jiang CL.

NLRP3 gene knockout blocks NF-κB and MAPK signaling pathway in CUMS-induced depression mouse model.

Behav Brain Res

2017 Mar 30;322(Pt A):1-8.

(IF 2.977)

408. Shen H, Liu C, Zhang D, Yao X, Zhang K, Li H, Chen G.

Role for RIP1 in mediating necroptosis in experimental intracerebral hemorrhage model both in vivo and in vitro.

Cell Death Dis

2017 Mar 2;8(3):e2641.

(IF 6.304)

409. Chen L, Gao B, Fang M, Li J, Mi X, Xu X, Wang W, Gu J, Tang B, Zhang Y, Wang Z, Zhan A, Chen G, Wang X.

Lentiviral Vector-Induced Overexpression of RGMa in the Hippocampus Suppresses Seizures and Mossy Fiber Sprouting.

Mol Neurobiol

2017 Mar;54(2):1379-1391.

(IF 4.5)

410. Wang C, Wang Z, Zhou J, Liu S, Wu C, Huang C, Ding Y.

TUC.338 promotes invasion and metastasis in colorectal cancer.

Int J Cancer

2017 Mar 15;140(6):1457-1464.

(IF 5.145)

411. Guo Q.

Changes in mitochondrial function during EMT induced by TGFβ-1 in pancreatic cancer.

Oncol Lett

2017 Mar;13(3):1575-1580.

(IF 2.311)

412. Ge H, Zhang F, Duan P, Zhu N, Zhang J, Ye F, Shan D, Chen H, Lu X, Zhu C, Ge R, Lin Z.

Mitochondrial Uncoupling Protein 2 in human cumulus cells is associated with regulating autophagy and apoptosis, maintaining gap junction integrity and progesterone synthesis.

Mol Cell Endocrinol

2017 Mar 5;443:128-137.

(IF 3.871)

413. Deng L, Jiang L, Lin X, Tseng KF, Lu Z, Wang X.

Luteolin, a novel p90 ribosomal S6 kinase inhibitor, suppresses proliferation and migration in leukemia cells.

Oncol Lett

2017 Mar;13(3):1370-1378.

(IF 2.311)

414. Zhang Y, Dong C, Yang S, Wu J, Xiao K, Huang Y, Li X.

Alkalescent nanotube films on a titanium-based implant: A novel approach to enhance biocompatibility.

MAT SCI ENG C-MATER

2017 Mar 1;72:464-471.

(IF 5.88)

415. Chen Z, Wang Q.

Activation of PPARγ by baicalin attenuates pulmonary hypertension in an infant rat model by suppressing HMGB1/RAGE signaling.

FEBS Open Bio

2017 Mar 8;7(4):477-484.

(IF 2.231)

416. Zhai L, Liu M, Wang T, Zhang H, Li S, Guo Y.

Picroside II protects the blood-brain barrier by inhibiting the oxidative signaling pathway in cerebral ischemia-reperfusion injury.

PLoS One

2017 Apr 7;12(4):e0174414.

(IF 2.74)

417. Liu F, Wang G, Wang X, Che Z, Dong W, Guo X, Wang Z, Chen P, Hou D, Zhang Q, Zhang W, Pan Y, Yang D, Liu H.

Targeting high Aurora kinases expression as an innovative therapy for hepatocellular carcinoma.

ONCOTARGET

2017 Apr 25;8(17):27953-27965.

(IF 5.168)

418. Kang L, Yang C, Yin H, Zhao K, Liu W, Hua W, Wang K, Song Y, Tu J, Li S, Luo R, Zhang Y.

MicroRNA-15b silencing inhibits IL-1β-induced extracellular matrix degradation by targeting SMAD3 in human nucleus pulposus cells.

Biotechnol Lett

2017 Apr;39(4):623-632.

(IF 1.977)

419. Xin P, Li C, Zheng Y, Peng Q, Xiao H, Huang Y, Zhu X.

Efficacy of the dual PI3K and mTOR inhibitor NVP-BEZ235 in combination with imatinib mesylate against chronic myelogenous leukemia cell lines.

DRUG DES DEV THER

2017 Apr 3;11:1115-1126.

(IF 3.216)

420. Liu J, Song G, Lin X, Pang X, Meng T.

Upregulated unique long 16 binding protein 1 detected in preeclamptic placenta affects human extravillous trophoblast cell line (HTR-8/SVneo) invasion by modulating the function of uterine natural killer cells.

Exp Ther Med

2017 Apr;13(4):1447-1455.

(IF 1.785)

421. Qiu M, Liang Z, Chen L, Tan G, Liu L, Wang K, Chen H, Liu J.

MicroRNA-200c suppresses cell growth and metastasis by targeting Bmi-1 and E2F3 in renal cancer cells.

Exp Ther Med

2017 Apr;13(4):1329-1336.

(IF 1.785)

422. Hou X, Yang C, Zhang L, Hu T, Sun D, Cao H, Yang F, Guo G, Gong C, Zhang X, Tong A, Li R, Zheng Y.

Killing colon cancer cells through PCD pathways by a novel hyaluronic acid-modified shell-core nanoparticle loaded with RIP3 in combination with chloroquine.

Biomaterials

2017 Apr;124:195-210.

(IF 10.317)

423. Geng Y, Mi J, Gao H, Jia H, Wang W.

Spatiotemporal expression of Wnt3a during striated muscle complex development in rat embryos with ethylenethiourea-induced anorectal malformations.

Mol Med Rep

2017 Apr;15(4):1601-1606.

(IF 2.1)

424. Ma J, Li R, Wang H, Li D, Wang X, Zhang Y, Zhen W, Duan H, Yan G, Li Y.

Transcriptomics Analyses Reveal Wheat Responses to Drought Stress during Reproductive Stages under Field Conditions.

Front Plant Sci

2017 Apr 21;8:592.

(IF 4.402)

425. Li RJ, Gao CY, Guo C, Zhou MM, Luo J, Kong LY.

The Anti-inflammatory Activities of Two Major Withanolides from Physalis minima Via Acting on NF-κB,STAT3, and HO-1 in LPS-Stimulated RAW264.7 Cells.

Inflammation

2017 Apr;40(2):401-413.

(IF 3.212)

426. Li RJ, Gao CY, Guo C, Zhou MM, Luo J, Kong LY.

The Anti-inflammatory Activities of Two Major With anolides from Physalis minima Via Acting on NF-κB,STAT3, and HO-1 in LPS-Stimulated RAW264.7 Cells.

Inflammation

2017 Apr;40(2):401-413.

(IF 3.212)

427. Zan J, Liu S, Sun DN, Mo KK, Yan Y, Liu J, Hu BL, Gu JY, Liao M, Zhou JY.

Rabies Virus Infection Induces Microtubule Depolymerization to Facilitate Viral RNA Synthesis by Upregulating HDAC6.

FRONT CELL INFECT MI

2017 Apr 26;7:146.

(IF 4.123)

428. Qi Y, Ruan J, Wang M, Dai Y, Zhou Q, Gui S, Zhang S, Wang Y.

Effects of hyperbaric oxygen treatment on gastric cancer cell line SGC7901.

Biomed Rep.

2017 Apr;6(4):475-479.

429. Han Y, Wu JZ, Shen JZ, Chen L, He T, Jin MW, Liu H.

Pentamethylquercetin induces adipose browning and exerts beneficial effects in 3T3-L1 adipocytes and high-fat diet-fed mice.

SCI REP-UK

2017 Apr 25;7(1):1123.

(IF 3.998)

430. Zhou Q, Deng Q, Hu B, Wang YJ, Chen JL, Cui JJ, Cao S, Song HN.

Ultrasound combined with targeted cationic microbubble-mediated angiogenesis gene transfection improves ischemic heart function.

Exp Ther Med

2017 May;13(5):2293-2303.

(IF 1.785)

431. Zhang J, Zhang Z, Bao J, Yu Z, Cai M, Li X, Wu T, Xiang J, Cai D.

Jia-Jian-Di-Huang-Yin-Zi decoction reduces apoptosis induced by both mitochondrial and endoplasmic reticulum caspase12 pathways in the mouse model of Parkinson's disease.

J Ethnopharmacol

2017 May 5;203:69-79.

(IF 3.69)

432. Chen S, Lv X, Hu B, Shao Z, Wang B, Ma K, Lin H, Cui M.

RIPK1/RIPK3/MLKL-mediated necroptosis contributes to compression-induced rat nucleus pulposus cells death.

Apoptosis

2017 May;22(5):626-638.

(IF 4.543)

433. Xu Z, Diao Z, Liu R, Liu W.

Molecular mechanism of smurf2 in regulating the expression of SnoN in diabetic nephropathy.

Mol Med Rep

2017 May;15(5):2560-2566.

(IF 2.1)

434. Li Z, Gu J, Liu J, Zhu Q, Lu H, Lu Y, Rao J, Lu L, Wang X.

Chitinase 3-like-1 deficient donor splenocytes accentuated the pathogenesis of acute graft-versus-host diseases through regulating T cell expansion and type I inflammation.

Int Immunopharmacol

2017 May;46:201-209.

(IF 3.943)

435. Huang H, Wang J, Zhang J, Luo Z, Li D, Qiu X, Peng Y, Xu Z, Xu P, Xu Z.

Nitrobenzylthioinosine mimics adenosine to attenuate the epileptiform discharge of hippocampal neurons from epileptic rats.

ONCOTARGET

2017 May 30;8(22):35573-35582.

(IF 5.168)

436. Lu Z, Xiao Y, Liu X, Zhang Z, Xiao F, Bi Y.

Matrine reduces the proliferation of A549 cells via the p53/p21/PCNA/eIF4E signaling pathway.

Mol Med Rep

2017 May;15(5):2415-2422.

(IF 2.1)

437. Li BY, Gao YH, Pei JR, Yang YM, Zhang W, Sun DJ.

ClC-7/Ostm1 contribute to the ability of tea polyphenols to maintain bone homeostasis in C57BL/6 mice, protecting against fluorosis.

Int J Mol Med

2017 May;39(5):1155-1163.

(IF 3.098)

438. Han T, Shu T, Dong S, Li P, Li W, Liu D, Qi R, Zhang S, Zhang L.

Chemokine-like factor-like MARVEL transmembrane domain-containing 3 expression is associated with a favorable prognosis in esophageal squamous cell carcinoma.

Oncol Lett

2017 May;13(5):2982-2988.

(IF 2.311)

439. Li X, Wu Y, Zhang W, Gong J, Cheng Y.

Pre-conditioning with tanshinone IIA attenuates the ischemia/reperfusion injury caused by liver grafts via regulation of HMGB1 in rat Kupffer cells.

Biomed Pharmacother

2017 May;89:1392-1400.

(IF 4.545)

440. Liu Y, Zhang W, Wu X, Gong J.

Foxo3a-dependent Bim transcription protects mice from a high fat diet via inhibition of activation of the NLRP3 inflammasome by facilitating autophagy flux in Kupffer cells.

ONCOTARGET

2017 May 23;8(21):34258-34267.

(IF 5.168)

441. Qiao J, Rong L, Wang Z, Zhang M.

Involvement of Akt/GSK3β/CREB signaling pathway on chronic omethoate induced depressive-like behavior and improvement effects of combined lithium chloride and astaxanthin treatment.

Neurosci Lett

2017 May 10;649:55-61.

(IF 2.274)

442. Guo T, Lin Q, Li X, Nie Y, Wang L, Shi L, Xu W, Hu T, Guo T, Luo F.

Octacosanol Attenuates Inflammation in Both RAW264.7 Macrophages and a Mouse Model of Colitis.

J AGR FOOD CHEM

2017 May 10;65(18):3647-3658.

(IF 4.192)

443. Sun X, He Y, Guo Y, Li S, Zhao H, Wang Y, Zhang J, Xing M.

Arsenic affects inflammatory cytokine expression in Gallus gallus brain tissues.

BMC Vet Res

2017 Jun 5;13(1):157.

(IF 1.835)

444. Li GJ, Zhao GQ, Yang JP, Zhou YC, Yang KY, Lei YJ, Huang YC.

Effect of miR-1244 on cisplatin-treated non-small cell lung cancer via MEF2D expression.

Oncol Rep

2017 Jun;37(6):3475-3483.

(IF 3.417)

445. Cao L, Huang B, Fu X, Yang J, Lin Y, Lin F.

Effects of tanshinone IIA on the regulation of renal proximal tubular fibrosis.

Mol Med Rep

2017 Jun;15(6):4247-4252.

(IF 2.1)

446. Chen L, Ran Q, Xiang Y, Xiang L, Chen L, Li F, Wu J, Wu C, Li Z.

Co-Activation of PKC-δ by CRIF1 Modulates Oxidative Stress in Bone Marrow Multipotent Mesenchymal Stromal Cells after Irradiation by Phosphorylating NRF2 Ser40.

Theranostics

2017 Jun 25;7(10):2634-2648.

(IF 8.579)

447. Chen Y, Fang L, Li G, Zhang J, Li C, Ma M, Guan C, Bai F, Lyu J, Meng QH.

Synergistic inhibition of colon cancer growth by the combination of methylglyoxal and silencing of glyoxalase I mediated by the STAT1 pathway.

ONCOTARGET

2017 Jun 22;8(33):54838-54857.

(IF 5.168)

448. Xu X, Xia L, Chen W, Huang Q.

Detoxification of hexavalent chromate by growing Paecilomyces lilacinus XLA.

Environ Pollut

2017 Jun;225:47-54.

(IF 6.792)

449. Duan HY, Ma D, Zhou KY, Wang T, Zhang Y, Li YF, Wu JL, Hua YM, Wang C.

Effect of Histone Deacetylase Inhibition on the Expression of Multidrug Resistance-associated Protein 2 in a Human Placental Trophoblast Cell Line.

CHINESE MED J-PEKING

2017 Jun 5;130(11):1352-1360.

(IF 1.585)

450. Yang Y, Wang Y, Kong Y, Zhang X, Bai L.

The effects of different frequency treadmill exercise on lipoxin A4 and articular cartilage degeneration in an experimental model of monosodium iodoacetate-induced osteoarthritis in rats.

PLoS One

2017 Jun 8;12(6):e0179162.

(IF 2.74)

451. Song C, Xue L.

Roles of the μ-opioid receptor and its related signaling pathways in the pathogenesis of premenstrual syndrome liver-qi stagnation.

Exp Ther Med

2017 Jun;13(6):3130-3136.

(IF 1.785)

452. Xie J, Shen S, Chen R, Xu J, Dong K, Huang J, Lu Q, Zhu W, Ma T, Jia L, Cai H, Zhu T.

Synthesis, characterization and antitumor activity of Ln(III) complexes with hydrazone Schiff base derived from 2-acetylpyridine and isonicotinohydrazone.

Oncol Lett

2017 Jun;13(6):4413-4419.

(IF 2.311)

453. Wu J, Gao L, Shang L, Wang G, Wei N, Chu T, Chen S, Zhang Y, Huang J, Wang J, Lin R.

Ecdysterones from Rhaponticum carthamoides (Willd.) Iljin reduce hippocampal excitotoxic cell loss and upregulate mTOR signaling in rats.

Fitoterapia

2017 Jun;119:158-167.

(IF 2.527)

454. An HM, Lin C, Gu C, Chen JJ, Sun WX, Jin M, Zhang TL, Qiu MF, Hu B.

Di-Huang-Yi-Zhi herbal formula attenuates amyloid-β-induced neurotoxicity in PC12 cells.

Exp Ther Med

2017 Jun;13(6):3003-3008.

(IF 1.785)

455. Zhao D, Lv C, Liu G, Mi Y, Zhang C.

Effect of estrogen on chick primordial follicle development and activation.

Cell Biol Int

2017 Jun;41(6):630-638.

(IF 2.571)

456. Liu L, Zuo Z, Lu S, Liu A, Liu X.

Naringin attenuates diabetic retinopathy by inhibiting inflammation, oxidative stress and NF-κB activation in vivo and in vitro.

Iran J Basic Med Sci

2017 Jul;20(7):813-821.

(IF 2.146)

457. Maryam A, Mehmood T, Zhang H, Li Y, Khan M, Ma T.

Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress.

SCI REP-UK

2017 Jul 24;7(1):6242.

(IF 3.998)

458. Fan L, Luo J, Li X, Chen M, Shu W, Qu X.

Activation of Na+/H+ exchanger other than formation of transmembrane pore underlies the cytotoxicity of nematocyst venom from Chrysaora helvola Brandt jellyfish.

Toxicon

2017 Jul;133:162-168.

(IF 2.201)

459. Yang W, Hong L, Xu X, Wang Q, Huang J, Jiang L.

LncRNA GAS5 suppresses the tumorigenesis of cervical cancer by downregulating miR-196a and miR-205.

TUMOR BIOL

2017 Jul;39(7):1010428317711315.

(IF 3.65)

460. Zhang Q, Hu X, Hui F, Song Q, Cui C, Wang C, Zhao Q.

Ethanol extract and its dichloromethane fraction of Alpinia oxyphylla Miquel exhibited hepatoprotective effects against CCl4-induced oxidative damage in vitro and in vivo with the involvement of Nrf2.

Biomed Pharmacother

2017 Jul;91:812-822.

(IF 4.545)

461. Gao Y, Ma L, Luo CL, Wang T, Zhang MY, Shen X, Meng HH, Ji MM, Wang ZF, Chen XP, Tao LY.

IL-33 Exerts Neuroprotective Effect in Mice Intracerebral Hemorrhage Model Through Suppressing Inflammation/Apoptotic/Autophagic Pathway.

Mol Neurobiol

2017 Jul;54(5):3879-3892.

(IF 4.5)

462. Jiang LB, Liu HX, Zhou YL, Sheng SR, Xu HZ, Xue EX.

An ultrastructural study of chondroptosis: programmed cell death in degenerative intervertebral discs in vivo.

J Anat

2017 Jul;231(1):129-139.

(IF 2.013)

463. Liu H, Zhong H, Yin Y, Jiang Z.

Genistein has beneficial effects on hepatic steatosis in high fat-high sucrose diet-treated rats.

Biomed Pharmacother

2017 Jul;91:964-969.

(IF 4.545)

464. Ma Y, Fu S, Lu L, Wang X.

Role of androgen receptor on cyclic mechanical stretch-regulated proliferation of C2C12 myoblasts and its upstream signals: IGF-1-mediated PI3K/Akt and MAPKs pathways.

Mol Cell Endocrinol

2017 Jul 15;450:83-93.

(IF 3.871)

465. Chang H, Li X, Cai Q, Li C, Tian L, Chen J, Xing X, Gan Y, Ouyang W, Yang Z.

The PI3K/Akt/mTOR pathway is involved in CVB3-induced autophagy of HeLa cells.

Int J Mol Med

2017 Jul;40(1):182-192.

(IF 3.098)

466. Xie X, Feng J, Kang Z, Zhang S, Zhang L, Zhang Y, Li X, Tang Y.

Taxifolin protects RPE cells against oxidative stress-induced apoptosis.

Mol Vis

2017 Jul 27;23:520-528. eCollection 2017.

(IF 2.202)

467. Shen M, Zhou L, Zhou P, Zhou W, Lin X.

Lymphotoxin β receptor activation promotes mRNA expression of RelA and pro-inflammatory cytokines TNFα and IL-1β in bladder cancer cells.

Mol Med Rep

2017 Jul;16(1):937-942.

(IF 2.1)

468. Liu Z, Li C, Meng X, Bai Y, Qi J, Wang J, Zhou Q, Zhang W, Zhang X.

Hypoxia-inducible factor-lα mediates aggrecan and collagen Π expression via NOTCH1 signaling in nucleus pulposus cells during intervertebral disc degeneration.

BIOCHEM BIOPH RES CO

2017 Jul 1;488(3):554-561.

(IF 2.985)

469. Luo J, Tao Y, Liang X, Chen Y, Zhang L, Jiang F, Liu S, Ye Z, Li Z, Shi W.

Flow control effect of necrostatin-1 on cell death of the NRK-52E renal tubular epithelial cell line.

Mol Med Rep

2017 Jul;16(1):57-62.

(IF 2.1)

470. Zhang J, Li G, Chen Y, Fang L, Guan C, Bai F, Ma M, Lyu J, Meng QH.

Metformin Inhibits Tumorigenesis and Tumor Growth of Breast Cancer Cells by Upregulating miR-200c but Downregulating AKT2 Expression.

J Cancer

2017 Jul 2;8(10):1849-1864.

(IF 3.565)

471. Li X, Ma M, Zhang X, Deng L, Wang Y, Bian Z, Cai S, Peng B, Yang J, Chen Y.

Ethanol extract of gardenia fruit alleviates renal interstitial fibrosis induced by unilateral ureteral obstruction in rats.

Exp Ther Med

2017 Aug;14(2):1381-1388.

(IF 1.785)

472. Mei B, Li H, Zhu J, Yang J, Yang Z, Wen Z, Li X, Shen H, Shen M, Chen G.

Neuroprotection of Botch in experimental intracerebral hemorrhage in rats.

ONCOTARGET

2017 Aug 24;8(56):95346-95360.

(IF 5.168)

473. Tian C, Yuan Z, Xu D, Ding P, Wang T, Zhang L, Jiang Z.

Inhibition of glycolysis by a novel EGFR/HER2 inhibitor KU004 suppresses the growth of HER2+ cancer.

Exp Cell Res

2017 Aug 15;357(2):211-221.

(IF 3.383)

474. Cui C, Shi X.

miR-187 inhibits tumor growth and invasion by directly targeting MAPK12 in osteosarcoma.

Exp Ther Med

2017 Aug;14(2):1045-1050.

(IF 1.785)

475. Wang J, He W, Guo L, Zhang Y, Li H, Han S, Shen D.

The ACE2-Ang (1-7)-Mas receptor axis attenuates cardiac remodeling and fibrosis in post-myocardial infarction.

Mol Med Rep

2017 Aug;16(2):1973-1981.

(IF 2.1)

476. Sun CL, Chen L, Xu J, Qu W, Guan L, Liu WY, Akihisa T, Feng F, Zhang J.

Melanogenesis-Inhibitory and Antioxidant Activities of Phenolics from Periploca forrestii.

Chem Biodivers

2017 Aug;14(8).

(IF 2.039)

477. Li Z, Gu J, Zhu Q, Liu J, Lu H, Lu Y, Wang X.

Obese donor mice splenocytes aggravated the pathogenesis of acute graft-versus-host disease via regulating differentiation of Tregs and CD4+ T cell induced-type I inflammation.

ONCOTARGET

2017 Aug 24;8(43):74880-74896.

(IF 5.168)

478. He P, Wang W, Sanogo B, Zeng X, Sun X, Lv Z, Yuan D, Duan L, Wu Z.

Molluscicidal activity and mechanism of toxicity of a novel salicylanilide ester derivative against Biomphalaria species.

PARASITE VECTOR

2017 Aug 10;10(1):383.

(IF 2.824)

479. Tang H, Gao Y, Zhang Q, Nie K, Zhu R, Gao L, Feng S, Wang L, Zhao J, Huang Z, Zhang Y, Wang L.

Chronic cerebral hypoperfusion independently exacerbates cognitive impairment within the pathopoiesis of Parkinson's disease via microvascular pathologys.

Behav Brain Res

2017 Aug 30;333:286-294.

(IF 2.977)

480. Zhang Y, Cui W, Zhai Q, Zhang T, Wen X.

N-acetylcysteine ameliorates repetitive/stereotypic behavior due to its antioxidant properties without activation of the canonical Wnt pathway in a valproic acid-induced rat model of autism.

Mol Med Rep

2017 Aug;16(2):2233-2240.

(IF 2.1)

481. Zhang P, Chen Z, Ning K, Jin J, Han X.

Inhibition of B7-H3 reverses oxaliplatin resistance in human colorectal cancer cells.

BIOCHEM BIOPH RES CO

2017 Aug 26;490(3):1132-1138.

(IF 2.985)

482. Zhang W, Zhang J.

Dexmedetomidine preconditioning protects against lung injury induced by ischemia-reperfusion through inhibition of autophagy.

Exp Ther Med

2017 Aug;14(2):973-980.

(IF 1.785)

483. Wang S, Liu B, Zhang J, Sun W, Dai C, Sun W, Li Q.

Centromere protein U is a potential target for gene therapy of human bladder cancer.

Oncol Rep

2017 Aug;38(2):735-744.

(IF 3.417)

484. Fu S, Xu H, Gu M, Liu C, Wan X, Chen Y, Chen Q, Zhou J, Wang Z.

Lack of adiponectin and adiponectin receptor 1 contributes to benign prostatic hyperplasia.

ONCOTARGET

2017 Aug 3;8(51):88537-88551.

(IF 5.168)

485. Che J, Shen WZ, Deng Y, Dai YH, Liao YD, Yuan XL, Zhang P.

Effects of lentivirus-mediated silencing of Periostin on tumor microenvironment and bone metastasis via the integrin-signaling pathway in lung cancer.

Life Sci

2017 Aug 1;182:10-21.

(IF 3.647)

486. Wen Z, Mei B, Li H, Dou Y, Tian X, Shen M, Chen G.

P2X7 Participates in Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via MAPKs Signaling Pathways.

Neurochem Res

2017 Aug;42(8):2372-2383.

(IF 3.038)

487. Liu H, Shen W, Zhang C, Cui Y, Li J, Zhang T, Chen W, Wang D.

Diffusion kurtosis imaging evaluating epithelial-mesenchymal transition in colorectal carcinoma xenografts model: a preliminary study.

SCI REP-UK

2017 Sep 12;7(1):11424.

(IF 3.998)

488. Zhao X, Zhang C, Hua M, Wang R, Zhong C, Yu J, Han F, He N, Zhao Y, Liu G, Zheng N, Ji C, Ma D.

NLRP3 inflammasome activation plays a carcinogenic role through effector cytokine IL-18 in lymphoma.

ONCOTARGET

2017 Sep 18;8(65):108571-108583.

(IF 5.168)

489. Li S, Wang H, Wang X, Wang Y, Feng J.

Betaine affects muscle lipid metabolism via regulating the fatty acid uptake and oxidation in finishing pig.

J ANIM SCI BIOTECHNO

2017 Sep 1;8:72.

(IF 4.167)

490. Sui X, Zhang C, Zhou J, Cao S, Xu C, Tang F, Zhi X, Chen B, Wang S, Yin L.

Resveratrol inhibits Extranodal NK/T cell lymphoma through activation of DNA damage response pathway.

J EXP CLIN CANC RES

2017 Sep 26;36(1):133.

(IF 7.068)

491. Liu N, Zheng M, Li S, Bai H, Liu Z, Hou CH, Zhang S, Pu J.

Genetic Mechanisms Contribute to the Development of Heart Failure in Patients with Atrioventricular Block and Right Ventricular Apical Pacing.

SCI REP-UK

2017 Sep 6;7(1):10676.

(IF 3.998)

492. Xiao W, Zhao S, Shen F, Liang J, Chen J.

Overexpression of CD147 is associated with poor prognosis, tumor cell migration and ERK signaling pathway activation in hepatocellular carcinoma.

Exp Ther Med

2017 Sep;14(3):2637-2642.

(IF 1.785)

493. Zhang B, Liu C, Yang N, Wang X.

A comparative study of changes of autophagy in rat models of CLP versus LPS induced sepsis.

Exp Ther Med

2017 Sep;14(3):2194-2200.

(IF 1.785)

494. Yang C, Guo WB, Zhang WS, Bian J, Yang JK, Zhou QZ, Chen MK, Peng W, Qi T, Wang CY, Liu CD.

Comprehensive proteomics analysis of exosomes derived from human seminal plasma.

Andrology

2017 Sep;5(5):1007-1015.

(IF 3.106)

495. Lu W, Kang J, Hu K, Tang S, Zhou X, Xu L, Li Y, Yu S.

The role of the Nox4-derived ROS-mediated RhoA/Rho kinase pathway in rat hypertension induced by chronic intermittent hypoxia.

Sleep Breath

2017 Sep;21(3):667-677.

(IF 2.162)

496. Shi L, Lin Q, Li X, Nie Y, Sun S, Deng X, Wang L, Lu J, Tang Y, Luo F.

Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-γ activation.

Mol Nutr Food Res

2017 Sep;61(9).

(IF 5.309)

497. Xue R, Yang J, Wu J, Meng Q, Hao J.

Coenzyme Q10 inhibits the activation of pancreatic stellate cells through PI3K/AKT/mTOR signaling pathway.

ONCOTARGET

2017 Sep 23;8(54):92300-92311.

(IF 5.168)

498. Li JJ, Wu XY, Chen JL, Chen GR, Xu J, Gu Y, Song HP.

Antiplatelet drug ticagrelor delays gastric ulcer healing in rats.

Exp Ther Med

2017 Oct;14(4):3774-3779.

(IF 1.785)

499. Wang X, Lin B, Nie L, Li P.

microRNA-20b contributes to high glucose-induced podocyte apoptosis by targeting SIRT7.

Mol Med Rep

2017 Oct;16(4):5667-5674.

(IF 2.1)

500. Zhou DY, Qin J, Huang J, Wang F, Xu GP, Lv YT, Zhang JB, Shen LM.

Zoledronic acid inhibits infiltration of tumor-associated macrophages and angiogenesis following transcatheter arterial chemoembolization in rat hepatocellular carcinoma models.

Oncol Lett

2017 Oct;14(4):4078-4084.

(IF 2.311)

501. Wang C, Hou W, Guo X, Li J, Hu T, Qiu M, Liu S, Mo X, Liu X.

Two-phase electrospinning to incorporate growth factors loaded chitosan nanoparticles into electrospun fibrous scaffolds for bioactivity retention and cartilage regeneration.

MAT SCI ENG C-MATER

2017 Oct 1;79:507-515.

(IF 5.88)

502. Wang Z, Yi X, Du L, Wang H, Tang J, Wang M, Qi C, Li H, Lai Y, Xia W, Tang A.

A study of Epstein-Barr virus infection in the Chinese tree shrew(Tupaia belangeri chinensis).

Virol J

2017 Oct 6;14(1):193.

(IF 2.579)

503. Sun G, Yang W, Zhang Y, Zhao M.

Esculentoside A ameliorates cecal ligation and puncture-induced acute kidney injury in rats.

EXP ANIM TOKYO

2017 Oct 30;66(4):303-312.

(IF 1.574)

504. Liu J, Yu L, Chen C, Zhou J, Gong X, Li D, Hou D, Song Y, Shao C.

The Expression of Dectin-1, Irak1 and Rip2 During the Host Response to Aspergillus fumigatus.

Mycopathologia

2017 Oct 23.

(IF 2.452)

505. Pan YJ, Wei LL, Wu XJ, Huo FC, Mou J, Pei DS.

MiR-106a-5p inhibits the cell migration and invasion of renal cell carcinoma through targeting PAK5.

Cell Death Dis

2017 Oct 26;8(10):e3155.

(IF 6.304)

506. Ye X, Wang H, Kan J, Li J, Huang T, Xiong G, Hu Z.

A novel 17β-hydroxysteroid dehydrogenase in Rhodococcus sp. P14 for transforming 17β-estradiol to estrone.

CHEM-BIOL INTERACT

2017 Oct 1;276:105-112.

(IF 3.723)

507. Li SW, Guo Y, He Y, Sun X, Zhao HJ, Wang Y, Wang YJ, Xing MW.

Assessment of arsenic trioxide toxicity on cock muscular tissue: alterations of oxidative damage parameters, inflammatory cytokines and heat shock proteins.

Ecotoxicology

2017 Oct;26(8):1078-1088.

(IF 2.535)

508. Li S, Wang Y, Zhao H, He Y, Li J, Jiang G, Xing M.

NF-κB-mediated inflammation correlates with calcium overload under arsenic trioxide-induced myocardial damage in Gallus gallus.

Chemosphere

2017 Oct;185:618-627.

(IF 5.778)

509. Li Z, Lu H, Gu J, Liu J, Zhu Q, Lu Y, Wang X.

Chitinase 3-Like-1-Deficient Splenocytes Deteriorated the Pathogenesis of Acute Graft-Versus-Host Disease via Regulating Differentiation of Tfh Cells.

Inflammation

2017 Oct;40(5):1576-1588.

(IF 3.212)

510. Wang Y, Zhao H, Shao Y, Liu J, Li J, Xing M.

Copper or/and arsenic induce oxidative stress-cascaded, nuclear factor kappa B-dependent inflammation and immune imbalance, trigging heat shock response in the kidney of chicken.

ONCOTARGET

2017 Oct 3;8(58):98103-98116.

(IF 5.168)

511. Li Q, Ge YL, Li M, Fang XZ, Yuan YP, Liang L, Huang SQ.

miR-127 contributes to ventilator-induced lung injury.

Mol Med Rep

2017 Oct;16(4):4119-4126.

(IF 2.1)

512. Liu D, Miao H, Zhao Y, Kang X, Shang S, Xiang W, Shi R, Hou A, Wang R, Zhao K, Liu Y, Ma Y, Luo H, Miao H, He F.

NF-κB potentiates tumor growth by suppressing a novel target LPTS.

Cell Commun Signal

2017 Oct 10;15(1):39.

(IF 4.344)

513. Ji Y, Teng L, Zhang R, Sun J, Guo Y.

NRG-1β exerts neuroprotective effects against ischemia reperfusion-induced injury in rats through the JNK signaling pathway.

Neuroscience

2017 Oct 24;362:13-24.

(IF 3.056)

514. Zhou X, Li Y, Li C.

Autophagy plays a positive role in zinc-induced apoptosis in intestinal porcine epithelial cells.

Toxicol In Vitro

2017 Oct;44:392-402.

(IF 2.959)

515. Meng X, Zhao Y, Wang J, Gao Z, Geng Q, Liu X.

Regulatory roles of miRNA-758 and matrix extracellular phosphoglycoprotein in cervical cancer.

Exp Ther Med

2017 Oct;14(4):2789-2794.

(IF 1.785)

516. Zhang J, Song N, Zang D, Yu J, Li J, Di W, Guo R, Zhao W, Wang H.

c-Myc promotes tumor proliferation and anti‑apoptosis by repressing p21 in rhabdomyosarcomas.

Mol Med Rep

2017 Oct;16(4):4089-4094.

(IF 2.1)

517. Kong M, Wu Y, Liu Y.

The impact of HuD protein on the intestinal nervous system in the terminal rectum of animal models of congenital anorectal malformation.

Mol Med Rep

2017 Oct;16(4):4797-4802.

(IF 2.1)

518. Wang X, Yu Y, Li M, Yu Y, Liu G, Xie Y, Liu Y, Yang X, Zou Y, Ge J, Chen R.

Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells.

Exp Mol Pathol

2017 Oct;103(2):210-217.

(IF 2.28)

519. Wu M, Wu Y, Qian H, Tao Y, Pang J, Wang Y, Chen Y.

Type II cGMP‑dependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells.

Mol Med Rep

2017 Oct;16(4):5729-5737.

(IF 2.1)

520. Zhai F, Song N, Ma J, Gong W, Tian H, Li X, Jiang C, Wang H.

FGF18 inhibits MC3T3‑E1 cell osteogenic differentiation via the ERK signaling pathway.

Mol Med Rep

2017 Oct;16(4):4127-4132.

(IF 2.1)

521. Mehmood T, Maryam A, Tian X, Khan M, Ma T.

Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.

J Cancer

2017 Oct 17;8(18):3707-3717.

(IF 3.565)

522. Zhu SM, Rao T, Yang X, Ning JZ, Yu WM, Ruan Y, Yuan R, Li CL, Jiang K, Hu W, Li HY, Cheng F.

Autophagy may play an important role in varicocele.

Mol Med Rep

2017 Oct;16(4):5471-5479.

(IF 2.1)

523. Yang W, Huang L, Gao J, Wen S, Tai Y, Chen M, Huang Z, Liu R, Tang C, Li J.

Betaine attenuates chronic alcohol‑induced fatty liver by broadly regulating hepatic lipid metabolism.

Mol Med Rep

2017 Oct;16(4):5225-5234.

(IF 2.1)

524. Li J, Liu B, Cai M, Lin X, Lou S.

Glucose metabolic alterations in hippocampus of diabetes mellitus rats and the regulation of aerobic exercise.

Behav Brain Res

2017 Nov 4. pii: S0166-4328(17)31309-8.

(IF 2.977)

525. Meng L, Huo X, Feng M, Fang Y, Han B, Hu H, Wu F, Li J.

Proteomics Reveals the Molecular Underpinnings of Stronger Learning and Memory in Eastern Compared to Western Bees.

Mol Cell Proteomics

2017 Nov 29. pii: mcp.RA117.000159.

(IF 4.87)

526. Han X, Li H, Zhang Y, Qin J, Yang Q, Wang L, Yuan M, Xia C.

Brain lipid-binding protein promotes proliferation and modulates cell cycle in C6 rat glioma cells.

Int J Oncol

2017 Nov;51(5):1439-1448.

(IF 3.899)

527. Li J, Zhang L, Xia Q, Fu J, Zhou Z, Lin F.

Hedgehog signaling inhibitor GANT61 induces endoplasmic reticulum stress-mediated protective autophagy in hepatic stellate cells.

BIOCHEM BIOPH RES CO

2017 Nov 4;493(1):487-493.

(IF 2.985)

528. Lin J, Chen Z, Huang Z, Chen F, Ye Z, Lin S, Wang W.

Upregulation of T-cadherin suppresses cell proliferation, migration and invasion of gastric cancer in vitro.

Exp Ther Med

2017 Nov;14(5):4194-4200.

(IF 1.785)

529. Wang YL, Shao X, Wang F, Zeng L, Hu L, Cui SQ, Hou G, Huang DN.

Intron-specific shRNA-mediated downregulation of survivin and promotion of apoptosis in HeLa cells.

Oncol Lett

2017 Nov;14(5):5927-5933.

(IF 2.311)

530. Huang C, Li N, Yuan S, Ji X, Ma M, Rao K, Wang Z.

Aryl- and alkyl-phosphorus-containing flame retardants induced mitochondrial impairment and cell death in Chinese hamster ovary (CHO-k1) cells.

Environ Pollut

2017 Nov;230:775-786.

(IF 6.792)

531. Wang H, Zhu L, Feng X, Zhang H, Luo Q, Chen F.

Oridonin induces G2/M cell cycle arrest and apoptosis in human oral squamous cell carcinoma.

Eur J Pharmacol

2017 Nov 15;815:282-289.

(IF 3.263)

532. Huo R, Zeng B, Zeng L, Cheng K, Li B, Luo Y, Wang H, Zhou C, Fang L, Li W, Niu R, Wei H, Xie P.

Microbiota Modulate Anxiety-Like Behavior and Endocrine Abnormalities in Hypothalamic-Pituitary-Adrenal Axis.

FRONT CELL INFECT MI

2017 Nov 30;7:489.

(IF 4.123)

533. Chen R, Xu L, Fan Q, Li M, Wang J, Wu L, Li W, Duan J, Chen Z.

Hierarchical pulmonary target nanoparticles via inhaled administration for anticancer drug delivery.

Drug Deliv

2017 Nov;24(1):1191-1203.

(IF 4.902)

534. Kang M, Shi J, Peng N, He S.

MicroRNA-211 promotes non-small-cell lung cancer proliferation and invasion by targeting MxA.

ONCOTARGETS THER

2017 Nov 28;10:5667-5675.

(IF 3.337)

535. Wang B, Lian YJ, Su WJ, Peng W, Dong X, Liu LL, Gong H, Zhang T, Jiang CL, Wang YX.

HMGB1 mediates depressive behavior induced by chronic stress through activating the kynurenine pathway.

Brain Behav Immun

2017 Nov 28. pii: S0889-1591(17)30518-4.

(IF 6.633)

536. Zhang W, Liu Y, Wu M, Zhu X, Wang T, He K, Li P, Wu X.

PI3K inhibition protects mice from NAFLD by down-regulating CMKLR1 and NLRP3 in Kupffer cells.

J Physiol Biochem

2017 Nov;73(4):583-594.

(IF 2.952)

537. Zhang B, Shang P, Tao Z, Qiangba Y, Wang Z, Zhang H.

Effect of a single nucleotide polymorphism in the growth hormone secretagogue receptor (GHSR) gene on growth rate in pigs.

Gene

2017 Nov 15;634:68-73.

(IF 2.984)

538. Yang YS, Yuan Y, Hu WP, Shang QX, Chen LQ.

The role of mitochondrial folate enzyme MTHFD1L in esophageal squamous cell carcinoma.

SCAND J GASTROENTERO

2017 Nov 24:1-8.

(IF 2.13)

539. Guo J, Guo S, Wang Y, Yu Y.

Promoting potential of adipose derived stem cells on peripheral nerve regeneration.

Mol Med Rep

2017 Nov;16(5):7297-7304.

(IF 2.1)

540. Qiao L, Liu X, Tang Y, Zhao Z, Zhang J, Feng Y.

Down regulation of the long non-coding RNA PCAT-1 induced growth arrest and apoptosis of colorectal cancer cells.

Life Sci

2017 Nov 1;188:37-44.

(IF 3.647)

541. Zhang B, Xu L, Zhuo N, Shen J.

Resveratrol protects against mitochondrial dysfunction through autophagy activation in human nucleus pulposus cells.

BIOCHEM BIOPH RES CO

2017 Nov 4;493(1):373-381.

(IF 2.985)

542. Zou L, Li X, Wu N, Jia P, Liu C, Jia D.

Palmitate induces myocardial lipotoxic injury via the endoplasmic reticulum stress‑mediated apoptosis pathway.

Mol Med Rep

2017 Nov;16(5):6934-6939.

(IF 2.1)

543. Huang Z, Yi X, Chen Y, Hou X, Wang X, Zhu P, Zhao K, Wu S, Fu N, Liu B.

Pretreatment of Pam3CSK4 attenuates inflammatory responses caused by systemic infection of methicillin-resistant Staphylococcus aureus in mice.

Biomed Pharmacother

2017 Nov;95:1684-1692.

(IF 4.545)

544. Zhao Y, He L, Zhang Y, Zhao J, Liu Z, Xing F, Liu M, Feng Z, Li W, Zhang J.

Estrogen receptor alpha and beta regulate actin polymerization and spatial memory through an SRC-1/mTORC2-dependent pathway in the hippocampus of female mice.

J STEROID BIOCHEM

2017 Nov;174:96-113.

(IF 3.813)

545. Gong P, Deng F, Zhang W, Ji J, Liu J, Sun Y, Hu J.

Tectorigenin attenuates the MPP+-induced SH-SY5Y cell damage, indicating a potential beneficial role in Parkinson's disease by oxidative stress inhibition.

Exp Ther Med

2017 Nov;14(5):4431-4437.

(IF 1.785)

546. Wu X, Liang M, Yang Z, Su M, Yang B.

Effect of acute exposure to PFOA on mouse liver cells in vivo and in vitro.

ENVIRON SCI POLLUT R

2017 Nov;24(31):24201-24206.

(IF 3.056)

547. Guo M, Zhao X, Yuan X, Li P.

Elevated microRNA-34a contributes to trophoblast cell apoptosis in preeclampsia by targeting BCL-2.

J Hum Hypertens

2017 Dec;31(12):815-820.

(IF 2.26)

548. Li S, Zhao H, Wang Y, Shao Y, Li J, Liu J, Xing M.

The inflammatory responses in Cu-mediated elemental imbalance is associated with mitochondrial fission and intrinsic apoptosis in Gallus gallus heart.

Chemosphere

2017 Dec;189:489-497.

(IF 5.778)

549. Fu X, Xie W, Song X, Wu K, Xiao L, Liu Y, Zhang L.

Aberrant expression of deubiquitylating enzyme USP9X predicts poor prognosis in gastric cancer.

CLIN RES HEPATOL GAS

2017 Dec;41(6):687-692.

(IF 2.718)

550. Zhang W, Wei R, Zhang L, Tan Y, Qian C.

Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation.

Neuroscience

2017 Dec 16;366:95-104.

(IF 3.056)

551. Zhao T, Bai J, Zou Q, Chen F, Xie Y.

Insulin in combination with cisplatin induces the apoptosis of ovarian cancer cells via p53 and JNK activation.

Mol Med Rep

2017 Dec;16(6):9095-9101.

(IF 2.1)

552. Ren A, Fu G, Qiu Y, Cui H.

Leflunomide inhibits proliferation and tumorigenesis of oral squamous cell carcinoma.

Mol Med Rep

2017 Dec;16(6):9125-9130.

(IF 2.1)

553. Gu YP, Yang XM, Duan ZH, Luo P, Shang JH, Xiao W, Tao YX, Zhang DY, Zhang YB, Liu HZ.

Inhibition of chemotherapy-induced apoptosis of testicular cells by squid ink polysaccharide.

Exp Ther Med

2017 Dec;14(6):5889-5895.

(IF 1.785)

554. Ye W, Zhang C, Xu N, Sun Y, Ma L, Shen B, Zhou D, Zhu C.

Carbonic anhydrase II confers resistance to deltamethrin in Culex pipiens pallens.

ARCH INSECT BIOCHEM

2017 Dec;96(4).

(IF 1.536)

555. Zheng F, Yang Y, Lu S, Yang Q, Li Y, Xu X, Zhang Y, Liu F, Tian X, Wang X.

CD36 Deficiency Suppresses Epileptic Seizures.

Neuroscience

2017 Dec 26;367:110-120.

(IF 3.056)

556. Yao L, Wang J, Tian BY, Xu TH, Sheng ZT.

Activation of the Nrf2-ARE Signaling Pathway Prevents Hyperphosphatemia-Induced Vascular Calcification by Inducing Autophagy in Renal Vascular Smooth Muscle Cells.

J Cell Biochem

2017 Dec;118(12):4708-4715.

(IF 4.237)

557. Zhang H, Nan W, Song X, Wang S, Si H, Li G.

Knockdown of HIF-1α inhibits the proliferation and migration of outer root sheath cells exposed to hypoxia in vitro: An involvement of Shh pathway.

Life Sci

2017 Dec 15;191:82-89.

(IF 3.647)

558. Li R, Luo X, Zhu Y, Zhao L, Li L, Peng Q, Ma M, Gao Y.

ATM signals to AMPK to promote autophagy and positively regulate DNA damage in response to cadmium-induced ROS in mouse spermatocytes.

Environ Pollut

2017 Dec;231(Pt 2):1560-1568.

(IF 6.792)

559. Zhang D, Xu XL, Li F, Sun HC, Cui YQ, Liu S, Xu PY.

Upregulation of the checkpoint protein CHFR is associated with tumor suppression in pancreatic cancers.

Oncol Lett

2017 Dec;14(6):8042-8050.

(IF 2.311)

560. Zhou J, Zhu YF, Chen XY, Han B, Li F, Chen JY, Peng XL, Luo LP, Chen W, Yu XP.

Black rice-derived anthocyanins inhibit HER-2-positive breast cancer epithelial-mesenchymal transition-mediated metastasis in vitro by suppressing FAK signaling.

Int J Mol Med

2017 Dec;40(6):1649-1656.

(IF 3.098)

561. Liu S, Yi F, Cheng W, Qu X, Wang C.

Molecular mechanisms in vascular injury induced by hypertension: Expression and role of microRNA-34a.

Exp Ther Med

2017 Dec;14(6):5497-5502.

(IF 1.785)

562. Li X, Wu Z, Zhang Y, Xu Y, Han G, Zhao P.

Activation of Autophagy Contributes to Sevoflurane-Induced Neurotoxicity in Fetal Rats.

Front Mol Neurosci

2017 Dec 22;10:432.

(IF 4.057)

563. Zhang WJ, Wang HH, Lv YD, Liu CC, Sun WY, Tian LJ.

Downregulation of Egr-1 Expression Level via GluN2B Underlies the Antidepressant Effects of Ketamine in a Chronic Unpredictable Stress Animal Model of Depression.

Neuroscience

2017 Dec 30;372:38-45.

(IF 3.056)

564. Lang L, Zhang Z, Jing W, Hwang JS, Lee SC, Wang L.

Identification of a novel toll gene (Shtoll3) from the freshwater crab Sinopotamon henanense and its expression pattern changes in response to cadmium followed by Aeromonas hydrophila infection.

FISH SHELLFISH IMMUN

2017 Dec;71:177-190.

(IF 3.298)

565. Jiang KL, Zhong L, Yang XQ, Ma PP, Wang H, Zhu XY, Liu BZ.

NLS-RARα is a novel transcriptional factor.

Oncol Lett

2017 Dec;14(6):7091-7098.

(IF 2.311)

566. Zhao X, Xing F, Cong Y, Zhuang Y, Han M, Wu Z, Yu S, Wei H, Wang X, Chen G.

Antimony trichloride induces a loss of cell viability via reactive oxygen species-dependent autophagy in A549 cells.

INT J BIOCHEM CELL B

2017 Dec;93:32-40.

(IF 3.673)

567. Li X, Wu N, Zou L, Jia D.

Protective effect of celastrol on myocardial ischemia-reperfusion injury.

Anatol J Cardiol

2017 Dec;18(6):384-390.

(IF 1.223)

568. Wang N, Yang L, Zhang H, Lu X, Wang J, Cao Y, Chen L, Wang X, Cong L, Li J, Wang N, Liu Z, Wang L.

MicroRNA-9a-5p Alleviates Ischemia Injury After Focal Cerebral Ischemia of the Rat by Targeting ATG5-Mediated Autophagy.

CELL PHYSIOL BIOCHEM

2017 Dec 22;45(1):78-87.

(IF 5.5)

569. Guo W, Lian S, Zhen L, Zang S, Chen Y, Lang L, Xu B, Guo J, Ji H, Wang J, Fu S, Zhang L, Yang H

The Favored Mechanism for Coping with Acute Cold Stress: Upregulation of miR-210 in Rats.

CELL PHYSIOL BIOCHEM.

2018;46(5):2090-2102.

(IF 5.5)

570. He L, Meng Y, Zhang Z, Liu Y, Wang X

Downregulation of basic fibroblast growth factor increases cisplatin sensitivity in A549 non-small cell lung cancer cells.

J Cancer Res Ther.

2018;14(7):1519-1524.

(IF 1.326)

571. Chen Y, Zhao J, Li D, Hao J, He P, Wang H, Zhang M

TRIM56 Suppresses Multiple Myeloma Progression by Activating TLR3/TRIF Signaling.

Yonsei Med J.

2018 Jan;59(1):43-50.

(IF 1.914)

572. Li H, Yang Q, Han X, Tan X, Qin J, Jin G

Low-dose DHA-induced astrocyte proliferation can be attenuated by insufficient expression of BLBP in vitro.

PROSTAG OTH LIPID M.

2018 Jan;134:114-122.

(IF 2.283)

573. Jiang LB, Cao L, Ma YQ, Chen Q, Liang Y, Yuan FL, Li XL, Dong J, Chen N

TIGAR mediates the inhibitory role of hypoxia on ROS production and apoptosis in rat nucleus pulposus cells.

OSTEOARTHR CARTILAGE.

2018 Jan;26(1):138-148.

(IF 4.793)

574. Tao P, Wen H, Yang B, Zhang A, Wu X, Li Q

miR-144 inhibits growth and metastasis of cervical cancer cells by targeting VEGFA and VEGFC.

Exp Ther Med.

2018 Jan;15(1):562-568.

(IF 1.785)

575. Maryam A, Mehmood T, Yan Q, Li Y, Khan M, Ma T

Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.

Oxid Med Cell Longev.

2018 Jan 11;2018:3853409.

(IF 5.076)

576. Wang J, Zhai W, Yu Z, Sun L, Li H, Shen H, Li X, Liu C, Chen G.

Neuroprotection Exerted by Netrin-1 and Kinesin Motor KIF1A in Secondary Brain Injury following Experimental Intracerebral Hemorrhage in Rats.

Front Cell Neurosci

2018 Jan 11;11:432.

(IF 3.921)

577. Dong J, Qu Y, Li J, Cui L, Wang Y, Lin J, Wang H.

Cortisol inhibits NF-κB and MAPK pathways in LPS activated bovine endometrial epithelial cells.

Int Immunopharmacol

2018 Jan 20;56:71-77.

(IF 3.943)

578. Cao B, Yang S, Li W, Chen H, Chen Y, Liu Y, Liu B.

GMZ-1 is a podophyllotoxin derivative that suppresses growth and induces apoptosis in adriamycin-resistant K562/A02 cells through modulation of MDR1 expression.

Mol Med Rep

2018 Jan;17(1):474-478.

(IF 2.1)

579. Li S, Wang T, Zhai L, Ge K, Zhao J, Cong W, Guo Y.

Picroside II Exerts a Neuroprotective Effect by Inhibiting mPTP Permeability and EndoG Release after Cerebral Ischemia/Reperfusion Injury in Rats.

J Mol Neurosci

2018 Jan;64(1):144-155.

(IF 2.678)

580. Peng X, He J, Zhao J, Wu Y, Shi X, Du L, Nong M, Zong S, Zeng G

Polygonatum Sibiricum Polysaccharide Promotes Osteoblastic Differentiation Through the ERK/GSK-3β/β-Catenin Signaling Pathway In Vitro.

REJUV RES.

2018 Feb;21(1):44-52.

(IF 3.811)

581. Xiang P, He RW, Liu RY, Li K, Gao P, Cui XY, Li H, Liu Y, Ma LQ

Cellular responses of normal (HL-7702) and cancerous (HepG2) hepatic cells to dust extract exposure.

Chemosphere.

2018 Feb;193:1189-1197.

(IF 5.778)

582. Wang Z, Li C, Jiang M, Chen J, Yang M, Pu J.

Filamin A (FLNA) regulates autophagy of bladder carcinoma cell and affects its proliferation, invasion and metastasis.

Int Urol Nephrol

2018 Feb;50(2):263-273.

(IF 1.843)

583. Niu M, Ma F, Qian J, Li J, Wang T, Gao Y, Jin J.

N‑cadherin attenuates nucleus pulposus cell senescence under high‑magnitude compression.

Mol Med Rep

2018 Feb;17(2):2879-2884.

(IF 2.1)

584. Li Y, Hong L, Liu C, Min J, Hong S, Hu M, Zhao Y, Yang Q, Tang J, He S.

Effect of puerarin on collagen metabolism of fibroblasts in pelvic tissue of women with pelvic organ prolapse.

Mol Med Rep

2018 Feb;17(2):2705-2711.

(IF 2.1)

585. Chang G, Liu J, Qin S, Jiang Y, Zhang P, Yu H, Lu K, Zhang N, Cao L, Wang Y, Li Y, Zhang D

Cardioprotection by exenatide: A novel mechanism via improving mitochondrial function involving the GLP-1 receptor/cAMP/PKA pathway.

Int J Mol Med.

2018 Mar;41(3):1693-1703.

(IF 3.098)

586. Li Y, Ye Y, Chen H

Astragaloside IV inhibits cell migration and viability of hepatocellular carcinoma cells via suppressing long noncoding RNA ATB.

Biomed Pharmacother.

2018 Mar;99:134-141.

(IF 4.545)

587. Ma L, Feng L, Ding X, Li Y

Effect of TLR4 on the growth of SiHa human cervical cancer cells via the MyD88-TRAF6-TAK1 and NF-κB-cyclin D1-STAT3 signaling pathways.

Oncol Lett.

2018 Mar;15(3):3965-3970.

(IF 2.311)

588. Chen ZW, Miu HF, Wang HP, Wu ZN, Wang WJ, Ling YJ, Xu XH, Sun HJ, Jiang X

Pterostilbene protects against uraemia serum-induced endothelial cell damage via activation of Keap1/Nrf2/HO-1 signaling.

Int Urol Nephrol.

2018 Mar;50(3):559-570.

(IF 1.843)

589. Wang W, Qing X, Wang B, Ma K, Wei Y, Shao Z

Tauroursodeoxycholic Acid Protects Nucleus Pulposus Cells from Compression-Induced Apoptosis and Necroptosis via Inhibiting Endoplasmic Reticulum Stress.

EVID-BASED COMPL ALT.

2018 Mar 12;2018:6719460.

(IF 1.813)

590. Sun L, Dong Y, Zhao J, Yin Y, Tong B, Zheng Y, Xin H.

NPPB modulates apoptosis, proliferation, migration and extracellular matrix synthesis of conjunctival fibroblasts by inhibiting PI3K/AKT signaling.

Int J Mol Med

2018 Mar;41(3):1331-1338.

(IF 3.098)

591. Yu C, Lixia Y, Ruiwei G, Yankun S, Jinshan Y

The Role of FAK in the Secretion of MMP9 after CD147 Stimulation in Macrophages.

Int Heart J.

2018 Mar 30;59(2):394-398.

(IF 1.906)

592. Deng Y, Ma W.

Metformin inhibits HaCaT cell viability via the miR-21/PTEN/Akt signaling pathway.

Mol Med Rep

2018 Mar;17(3):4062-4066. doi: 10.3892/mmr.2017.8364. Epub 2017 Dec 27.

(IF 2.1)

593. Wu J, Du W, Wang X, Wei L, Pan Y, Wu X, Zhang J, Pei D

Ras-related protein Rap2c promotes the migration and invasion of human osteosarcoma cells.

Oncol Lett.

2018 Apr;15(4):5352-5358.

(IF 2.311)

594. Fu H, Li X, Tan J

NIPAAm-MMA nanoparticle-encapsulated visnagin ameliorates myocardial ischemia/reperfusion injury through the promotion of autophagy and the inhibition of apoptosis.

Oncol Lett.

2018 Apr;15(4):4827-4836.

(IF 2.311)

595. Hu YH, Chen XM, Yang P, Ding WF

Characterization and functional assay of a fatty acyl-CoA reductase gene in the scale insect, Ericerus pela Chavannes (Hemiptera: Coccoidae).

ARCH INSECT BIOCHEM.

2018 Apr;97(4).

(IF 1.536)

596. Zhu H, Huang Y, Su H, Ma Y, Tao Y, Liao DJ, Liu Y, Feng Z

Identification of a novel human estrogen receptor-α splice variant able to enhance malignant biological behaviors of breast cancer cells.

Oncol Lett.

2018 Apr;15(4):5339-5344.

(IF 2.311)

597. Liu L, Wu W, Li J, Jiao WH, Liu LY, Tang J, Liu L, Sun F, Han BN, Lin HW

Two sesquiterpene aminoquinones protect against oxidative injury in HaCaT keratinocytes via activation of AMPKα/ERK-Nrf2/ARE/HO-1 signaling.

Biomed Pharmacother.

2018 Apr;100:417-425.

(IF 4.545)

598. Zhang H, Pang Y, Ma C, Li J, Wang H, Shao Z

ClC5 Decreases the Sensitivity of Multiple Myeloma Cells to Bortezomib via Promoting Prosurvival Autophagy.

Oncol Res.

2018 Apr 10;26(3):421-429.

(IF 4.949)

599. Chen ZJ, Ma F, Sun XM, Zhao XS, Luo R

Renoprotective Effect of a Chinese Herbal Formula, Qidan Dihuang Decoction, on Streptozotocin-Induced Diabetes in Rat.

EVID-BASED COMPL ALT.

2018 Apr 12;2018:7321086.

(IF 1.813)

600. Huang WJ, Wang Y, Liu S, Yang J, Guo SX, Wang L, Wang H, Fan YF.

Silencing circular RNA hsa_circ_0000977 suppresses pancreatic ductal adenocarcinoma progression by stimulating miR-874-3p and inhibiting PLK1 expression.

Cancer Lett.

422:70-80.

(IF 7.36)

601. Xinyu Zhang, Lei Han, Huifang Zong, Kai Ding, Yuan Yuan, Jingyi Bai, Yuexian Zhou, Baohong Zhang, Jianwei Zhu

Enhanced Production of anti-PD1 Antibody in CHO Cells Through Transient Co-Transfection With Anti-Apoptotic Genes Bcl-x L and Mcl-1

Bioprocess Biosyst Eng.

doi: 10.1007/s00449-018-1898-z.

602. Cai J, Jiang Y, Zhang M, Zhao H, Li H, Li K, Zhang X, Qiao T

Protective effects of mitochondrion-targeted peptide SS-31 against hind limb ischemia-reperfusion injury.

J Physiol Biochem.

2018 May;74(2):335-343.

(IF 2.952)

603. Qiao H, Zhou Y, Qin X, Cheng J, He Y, Jiang Y

NADPH Oxidase Signaling Pathway Mediates Mesenchymal Stem Cell-Induced Inhibition of Hepatic Stellate Cell Activation.

Stem Cells Int.

2018 May 10;2018:1239143.

(IF 3.869)

604. Wang M, Huang Y, He M, Peng WJ, Tian DY

Effects of hepatitis E virus infection on interferon production via ISG15.

WORLD J GASTROENTERO.

2018 May 28;24(20):2173-2180.

(IF 3.665)

605. Jia P, Liu C, Wu N, Jia D, Sun Y

Agomelatine protects against myocardial ischemia reperfusion injury by inhibiting mitochondrial permeability transition pore opening.

Am J Transl Res

2018 May 15;10(5):1310-1323. eCollection 2018.

(IF 3.375)

606. Chen S, Lv X, Hu B, Zhao L, Li S, Li Z, Qing X, Liu H, Xu J, Shao Z

Critical contribution of RIPK1 mediated mitochondrial dysfunction and oxidative stress to compression-induced rat nucleus pulposus cells necroptosis and apoptosis.

Apoptosis.

2018 Jun;23(5-6):299-313.

(IF 4.543)

607. Liu ZC, Wang ZL, Huang CY, Fu ZJ, Liu Y, Wei ZC, Liu SG, Ma C, Shen JL, Duan DD

Duhuo Jisheng Decoction inhibits SDF-1-induced inflammation and matrix degradation in human degenerative nucleus pulposus cells in vitro through the CXCR4/NF-κB pathway.

Acta Pharmacol Sin.

2018 Jun;39(6):912-922.

(IF 5.064)

608. Wang Y, Jiang S, Xiao J, Liang Q, Tang M

Sparstolonin B improves neurological outcomes following intracerebral hemorrhage in mice.

Exp Ther Med.

2018 Jun;15(6):5436-5442.

(IF 1.785)

609. Xiao Y, Li B, Liu J

MicroRNA‑148a inhibition protects against ovariectomy‑induced osteoporosis through PI3K/AKT signaling by estrogen receptor α.

Mol Med Rep.

2018 Jun;17(6):7789-7796.

(IF 2.1)

610. Li Y, Gong Q, Guo W, Kan X, Xu D, Ma H, Fu S, Liu J

Farrerol Relieve Lipopolysaccharide (LPS)-Induced Mastitis by Inhibiting AKT/NF-κB p65, ERK1/2 and P38 Signaling Pathway.

Int J Mol Sci.

2018 Jun 14;19(6). pii: E1770.

(IF 4.556)

611. Wang Y, Wang S, Liu J, Lu Y, Li D

Licoricidin enhances gemcitabine-induced cytotoxicity in osteosarcoma cells by suppressing the Akt and NF-κB signal pathways.

CHEM-BIOL INTERACT.

2018 Jun 25;290:44-51.

(IF 3.723)

612. Jin C, Liu X, Tan L, Cui Z, Yang X, Zheng Y, Yeung KWK, Chu PK, Wu S

Ag/AgBr-loaded mesoporous silica for rapid sterilization and promotion of wound healing.

BIOMATER SCI-UK.

2018 Jun 25;6(7):1735-1744.

(IF 6.183)

613. Lu YT, Li LZ, Yang YL, Yin X, Liu Q, Zhang L, Liu K, Liu B, Li J, Qi LW

Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling.

Cell Death Dis.

2018 Jun 4;9(6):672.

(IF 6.304)

614. Xing FZ, Zhao YG, Zhang YY, He L, Zhao JK, Liu MY, Liu Y, Zhang JQ.

Nuclear and membrane estrogen receptor antagonists induce similar mTORC2 activation-reversible changes in synaptic protein expression and actin polymerization in the mouse hippocampus.

CNS Neurosci Ther

2018 Jun;24(6):495-507.

(IF 4.074)

615. Li S, Cao H, Shen D, Jia Q, Chen C, Xing SL

Quercetin protects against ox‑LDL‑induced injury via regulation of ABCAl, LXR‑α and PCSK9 in RAW264.7 macrophages.

Mol Med Rep.

2018 Jul;18(1):799-806.

(IF 2.1)

616. Pan J, Huang C, Chen G, Cai Z, Zhang Z

MicroRNA-451 blockade promotes osteoblastic differentiation and skeletal anabolic effects by promoting YWHAZ-mediated RUNX2 protein stabilization.

Medchemcomm.

2018 Jul 10;9(8):1359-1368.

(IF 2.807)

617. Li Z, Chen S, Ma K, Lv X, Lin H, Hu B, He R, Shao Z

CsA attenuates compression-induced nucleus pulposus mesenchymal stem cells apoptosis via alleviating mitochondrial dysfunction and oxidative stress.

Life Sci.

2018 Jul 15;205:26-37.

(IF 3.647)

618. Zhou D, Duan B, Xu Y, Ma L, Shen B, Sun Y, Zhu C

NYD-OP7/PLC regulatory signaling pathway regulates deltamethrin resistance in Culex pipiens pallens (Diptera: Culicidae).

PARASITE VECTOR.

2018 Jul 16;11(1):419.

(IF 2.824)

619. Huang C, Gan D, Fan C, Wen C, Li A, Li Q, Zhao J, Wang Z, Zhu L, Lu D

The Secretion from Neural Stem Cells Pretreated with Lycopene Protects against tert-Butyl Hydroperoxide-Induced Neuron Oxidative Damage.

Oxid Med Cell Longev.

2018 Jul 22;2018:5490218.

(IF 5.076)

620. Li L, Wan G, Han B, Zhang Z

Echinacoside alleviated LPS-induced cell apoptosis and inflammation in rat intestine epithelial cells by inhibiting the mTOR/STAT3 pathway.

Biomed Pharmacother.

2018 Aug;104:622-628.

(IF 4.545)

621. Xu H, Xie J, Lei Y, Cui Q, Jin M

[Anti-inflammatory effects of penehyclidine hydrochloride on acute respiratory distress syndrome in rats].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue.

2018 Aug;30(8):764-767.

622. Xiu G, Sui X, Wang Y, Zhang Z

FOXM1 regulates radiosensitivity of lung cancer cell partly by upregulating KIF20A.

Eur J Pharmacol.

2018 Aug 15;833:79-85.

(IF 3.263)

623. Wang YD, Sun XJ, Yang WJ, Li J, Yin JJ

Magnolol exerts anticancer activity in hepatocellular carcinoma cells through regulating endoplasmic reticulum stress-mediated apoptotic signaling.

ONCOTARGETS THER.

2018 Aug 28;11:5219-5226.

(IF 3.337)

624. Huixian Xu, Jing Xie, Yanna Lei, Qingsong Cui, Minggen Jin

[Anti-inflammatory Effects of Penehyclidine Hydrochloride on Acute Respiratory Distress Syndrome in Rats]

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue.

doi: 10.3760/cma.j.issn.2095-4352.2018.08.010.

625. Chen Q, Pan Z, Zhao M, Wang Q, Qiao C, Miao L, Ding X.

High cholesterol in lipid rafts reduces the sensitivity to EGFR-TKI therapy in non-small cell lung cancer.

J Cell Physiol

2018 Sep;233(9):6722-6732.

(IF 5.546)

626. Huang X, Wang Z, Li D, Huang Z, Dong X, Li C, Lan J

Study of microRNAs targeted Dvl2 on the osteoblasts differentiation of rat BMSCs in hyperlipidemia environment.

J Cell Physiol.

2018 Sep;233(9):6758-6766.

(IF 5.546)

627. Zhu H, Zheng T, Yu J, Zhou L, Wang L

LncRNA XIST accelerates cervical cancer progression via upregulating Fus through competitively binding with miR-200a.

Biomed Pharmacother.

2018 Sep;105:789-797.

(IF 4.545)

628. Pei G, Li B, Ma A

Suppression of Hiwi inhibits the growth and epithelial-mesenchymal transition of cervical cancer cells.

Oncol Lett.

2018 Sep;16(3):3874-3880.

(IF 2.311)

629. Zhou Y, Liu H, Song J, Cao L, Tang L, Qi C

Sinomenine alleviates dextran sulfate sodium‑induced colitis via the Nrf2/NQO‑1 signaling pathway.

Mol Med Rep.

2018 Oct;18(4):3691-3698.

(IF 2.1)

630. Zhang X, Yang Y, Feng Z

Suppression of microRNA-495 alleviates high-glucose-induced retinal ganglion cell apoptosis by regulating Notch/PTEN/Akt signaling.

Biomed Pharmacother.

2018 Oct;106:923-929.

(IF 4.545)

631. Liu Y, Ren L, Liu W, Xiao Z

MiR-21 regulates the apoptosis of keloid fibroblasts by caspase-8 and the mitochondria-mediated apoptotic signaling pathway via targeting FasL.

Biochem Cell Biol.

2018 Oct;96(5):548-555.

(IF 2.46)

632. Zhang XW, Wang S, Tu PF, Zeng KW

Sesquiterpene lactone from Artemisia argyi induces gastric carcinoma cell apoptosis via activating NADPH oxidase/reactive oxygen species/mitochondrial pathway.

Eur J Pharmacol.

2018 Oct 15;837:164-170.

(IF 3.263)

633. Lu C, Chen X, Wang Q, Xu X, Xu B

TNFα promotes glioblastoma A172 cell mitochondrial apoptosis via augmenting mitochondrial fission and repression of MAPK-ERK-YAP signaling pathways.

ONCOTARGETS THER.

2018 Oct 18;11:7213-7227.

(IF 3.337)

634. Wang Y, Shen J, Chen Y, Liu H, Zhou H, Bai Z, Hu Z, Guo X

PINK1 protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy.

BIOCHEM BIOPH RES CO.

2018 Oct 2;504(2):406-414.

(IF 2.985)

635. Liu Q, Hu Y, Zhang M, Yan Y, Yu H, Ge L

microRNA-451 protects neurons against ischemia/reperfusion injury-induced cell death by targeting CELF2.

Neuropsychiatr Dis Treat.

2018 Oct 23;14:2773-2782.

636. Liu F, Wang Z, Liu F, Xu J, Liu Q, Yin K, Lan J

MicroRNA-29a-3p enhances dental implant osseointegration of hyperlipidemic rats via suppressing dishevelled 2 and frizzled 4.

Cell Biosci.

2018 Oct 26;8:55.

(IF 5.026)

637. Wang Y, Chen Y, Chen Y, Zhou B, Shan X, Yang G

Eriodictyol inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes.

Biomed Pharmacother.

2018 Nov;107:1128-1134.

(IF 4.545)

638. Luo J, Song J, Zhang H, Zhang F, Liu H, Li L, Zhang Z, Chen L, Zhang M, Lin D, Lin M, Zhou R

Melatonin mediated Foxp3-downregulation decreases cytokines production via the TLR2 and TLR4 pathways in H. pylori infected mice.

Int Immunopharmacol.

2018 Nov;64:116-122.

(IF 3.943)

639. Yao S, Yan W

Overexpression of Mst1 reduces gastric cancer cell viability by repressing the AMPK-Sirt3 pathway and activating mitochondrial fission.

ONCOTARGETS THER.

2018 Nov 29;11:8465-8479.

(IF 3.337)

640. Li Z, Wang Y, Hu R, Xu R, Xu W

LncRNA B4GALT1-AS1 recruits HuR to promote osteosarcoma cells stemness and migration via enhancing YAP transcriptional activity.

CELL PROLIFERAT.

2018 Dec;51(6):e12504.

(IF 5.753)

641. Huang H, Tang J, Zhang L, Bu Y, Zhang X

miR-874 regulates multiple-drug resistance in gastric cancer by targeting ATG16L1.

Int J Oncol.

2018 Dec;53(6):2769-2779.

(IF 3.899)

642. Wang Y, Hai B, Ai L, Cao Y, Li R, Li H, Li Y

Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress.

Iran J Basic Med Sci.

2018 Dec;21(12):1238-1244.

(IF 2.146)

643. Yue Q, Zhao C, Wang Y, Zhao L, Zhu Q, Li G, Wu N, Jia D, Ma C

Downregulation of growth arrest‑specific transcript 5 alleviates palmitic acid‑induced myocardial inflammatory injury through the miR‑26a/HMGB1/NF‑κB axis.

Mol Med Rep.

2018 Dec;18(6):5742-5750.

(IF 2.1)

644. Cheng C, Xie Z, Li Y, Wang J, Qin C, Zhang Y

PTBP1 knockdown overcomes the resistance to vincristine and oxaliplatin in drug-resistant colon cancer cells through regulation of glycolysis.

Biomed Pharmacother.

2018 Dec;108:194-200.

(IF 4.545)

645. Zheng Z, Zhou X, Cai Y, Chen E, Zhang X, Wang O, Wang Q, Liu H

TEKT4 Promotes Papillary Thyroid Cancer Cell Proliferation, Colony Formation, and Metastasis through Activating PI3K/Akt Pathway.

Endocr Pathol.

2018 Dec;29(4):310-316.

(IF 3.168)

646. Yuan Z, Li Y, Zhao D, Zhang K, Wang F, Wang C, Wen Y

High efficiency 3D nanofiber sponge for bilirubin removal used in hemoperfusion.

COLLOID SURFACE B.

2018 Dec 1;172:161-169.

(IF 4.389)

647. Li X, Ning L, Zhao X, Wan S

MicroRNA-543 promotes ovariectomy-induced osteoporosis through inhibition of AKT/p38 MAPK signaling pathway by targeting YAF2.

J Cell Biochem.

2018 Dec 2.

(IF 4.237)

648. Shen X, Gao X, Li H, Gu Y, Wang J

TIMP-3 Increases the Chemosensitivity of Laryngeal Carcinoma to Cisplatin via Facilitating Mitochondria-Dependent Apoptosis.

Oncol Res.

2018 Dec 27;27(1):73-80.

(IF 4.949)

649. Ruixi Hu, Xiaodong Zhu, Chao Chen, Ruijun Xu, Yifan Li, Wei Xu

RNA-binding Protein PUM2 Suppresses Osteosarcoma Progression via Partly and Competitively Binding to STARD13 3'UTR With miRNAs

CELL PROLIFERAT.

doi: 10.1111/cpr.12508.

(IF 5.753)

650. Wu N, Zhang X, Du S, Chen D, Che R

Upregulation of miR-335 ameliorates myocardial ischemia reperfusion injury via targeting hypoxia inducible factor 1-alpha subunit inhibitor.

Am J Transl Res

2018 Dec 15;10(12):4082-4094. eCollection 2018.

(IF 3.375)

651. Liu Z, Li H, Fan S, Lin H, Lian W

STAT3-induced upregulation of long noncoding RNA HNF1A-AS1 promotes the progression of oral squamous cell carcinoma via activating Notch signaling pathway.

Cancer Biol Ther.

20(4):444-453.

(IF 3.659)

652. Chang P, Zhang M, Zhang X, Li G, Hu H, Wu J, Wang X, Yang Z, Zhang J, Chen W, Ren M, Li X, Zhu M, Chen B, Yu J

B-type natriuretic peptide attenuates endoplasmic reticulum stress in H9c2 cardiomyocytes underwent hypoxia/reoxygenation injury under high glucose/high fat conditions.

Peptides.

111:103-111.

(IF 2.843)

653. Wei Z, Sun W, Tran NT, Gong Y, Ma H, Zheng H, Zhang Y, Li S

Two novel serine proteases from Scylla paramamosain involved in the synthesis of anti-lipopolysaccharide factors and activation of prophenoloxidase system.

FISH SHELLFISH IMMUN.

84:322-332.

(IF 3.298)

654. Miao J, Huang Z, Liu S, Li X, Jia P, Guo Y, Wu N, Jia D

Hydroxytyrosol protects against myocardial ischemia reperfusion injury by inhibiting mitochondrial permeability transition pore opening.

Exp Ther Med.

17(1):671-678.

(IF 1.785)

655. Jun-Sheng Ni, Hao Zheng, Zhi-Ping Huang, Yong-Gang Hong, Yang-Liu Ou, Yuan-Ping Tao, Meng-Chao Wang, Zhen-Guang Wang, Yuan Yang, Wei-Ping Zhou

MicroRNA-197-3p Acts as a Prognostic Marker and Inhibits Cell Invasion in Hepatocellular Carcinoma

Oncol Lett.

doi: 10.3892/ol.2018.9848.

(IF 2.311)

656. Li W, Jiang LJ, Zhou XJ, Lu XZ, Liu LF, Wang S

Association of the invasiveness of colon cancer with the expression of C/EBPα.

Oncol Lett.

17(2):1974-1979.

(IF 2.311)

657. Guo W, Liu B, Hu G, Kan X, Li Y, Gong Q, Xu D, Ma H, Cao Y, Huang B, Fu S, Liu J

Vanillin protects the blood-milk barrier and inhibits the inflammatory response in LPS-induced mastitis in mice.

TOXICOL APPL PHARM .

365:9-18.

(IF 3.616)

658. Liang X, Wu K, Liu M, Yang B

Adverse impact of carbon tetrachloride on metabolic function in mice.

J Cell Biochem.

(IF 4.237)

659. Liu B, Ji J, Feng Q, Luo X, Yan X, Ni Y, He Y, Mao Z, Liu J

Monosialoganglioside protects against bupivacaine-induced neurotoxicity caused by endoplasmic reticulum stress in rats.

DRUG DES DEV THER.

13:707-718.

(IF 3.216)

660. Wang Z, Shi Z, Zhang L, Zhang H, Zhang Y

Profilin 1, negatively regulated by microRNA-19a-3p, serves as a tumor suppressor in human hepatocellular carcinoma.

Pathol Res Pract.

2019 Mar;215(3):499-505.

(IF 2.05)

661. Dong M, Xie Y, Xu Y

miR-7-5p regulates the proliferation and migration of colorectal cancer cells by negatively regulating the expression of Krüppel-like factor 4.

Oncol Lett.

17(3):3241-3246.

(IF 2.311)

662. Du ZD, Yu S, Qi Y, Qu TF, He L, Wei W, Liu K, Gong SS

NADPH oxidase inhibitor apocynin decreases mitochondrial dysfunction and apoptosis in the ventral cochlear nucleus of D-galactose-induced aging model in rats.

Neurochem Int.

124:31-40.

(IF 3.881)

663. Yi J, Mei L, Li X, Zheng W, Li Y, Zhao Z

Effects of continuous and intermittent parathyroid hormone administration on midpalatal suture expansion in rats.

Arch Oral Biol.

99:161-168.

(IF 1.931)

664. Zhou J, Shi M, Li M, Cheng L, Yang J, Huang X

Sirtuin 3 inhibition induces mitochondrial stress in tongue cancer by targeting mitochondrial fission and the JNK-Fis1 biological axis.

CELL STRESS CHAPERON.

24(2):369-383.

(IF 2.892)

665. Bai Y, Wang W, Zhang Y, Zhang F, Zhang H

lncRNA MIAT suppression alleviates corneal angiogenesis through regulating miR-1246/ACE.

Cell Cycle.

18(6-7):661-669.

(IF 3.699)

666. Li JM, Liu LL, Su WJ, Wang B, Zhang T, Zhang Y, Jiang CL

Ketamine may exert antidepressant effects via suppressing NLRP3 inflammasome to upregulate AMPA receptors.

Neuropharmacology.

146:149-153.

(IF 4.431)

667. Gao X, Ming J, Liu S, Lai B, Fang F, Cang J

Sevoflurane enhanced the clearance of Aβ1-40 in hippocampus under surgery via up-regulating AQP-4 expression in astrocyte.

Life Sci.

221:143-151.

(IF 3.647)

668. Liu G, An L, Zhang H, Du P, Sheng Y

Activation of CXCL6/CXCR1/2 Axis Promotes the Growth and Metastasis of Osteosarcoma Cells in vitro and in vivo.

Front Pharmacol.

10:307.

(IF 4.225)

669. Di X, He G, Chen H, Zhu C, Qin Q, Yan J, Zhang X, Sun X

High-mobility group box 1 protein modulated proliferation and radioresistance in esophageal squamous cell carcinoma.

EUR J GASTROEN HEPAT.

34(4):728-735.

(IF 2.251)

670. Tan Z, Kang T, Zhang X, Tong Y, Chen S

Nerve growth factor prevents arsenic-induced toxicity in PC12 cells through the AKT/GSK-3β/NFAT pathway.

J Cell Physiol.

234(4):4726-4738.

(IF 5.546)

671. Zhuang J, Wang Y, Qu F, Wu Y, Zhao D, Xu C

Gasdermin-d Played a Critical Role in the Cyclic Stretch-Induced Inflammatory Reaction in Human Periodontal Ligament Cells.

Inflammation.

2019 Apr;42(2):548-558.

(IF 3.212)

672. Wang A, Wang J, Wu J, Deng X, Zou Y

Suramin protects hepatocytes from LPS-induced apoptosis by regulating mitochondrial stress and inactivating the JNK-Mst1 signaling pathway.

J Physiol Sci.

69(3):489-502.

(IF 2.955)

673. Wang Q, Wang J, Niu S, Wang S, Liu Y, Wang X

MicroRNA-664 targets paired box protein 6 to inhibit the oncogenicity of pancreatic ductal adenocarcinoma.

Int J Oncol.

54(5):1884-1896.

(IF 3.899)

674. Wang P, Liu X, Kong C, Liu X, Teng Z, Ma Y, Yong L, Liang C, He G, Lu S

Potential role of the IL17RC gene in the thoracic ossification of the posterior longitudinal ligament.

Int J Mol Med.

43(5):2005-2014.

(IF 3.098)

675. Song F, Wei M, Wang J, Liu Y, Guo M, Li X, Luo J, Zhou J, Wang M, Guo D, Chen L, Sun G

Hepatitis B virus-regulated growth of liver cancer cells occurs through the microRNA-340-5p-activating transcription factor 7-heat shock protein A member 1B axis.

Cancer Sci.

110(5):1633-1643.

(IF 4.966)

676. Liu X, Zhao P, Wang X, Wang L, Zhu Y, Gao W

Triptolide Induces Glioma Cell Autophagy and Apoptosis via Upregulating the ROS/JNK and Downregulating the Akt/mTOR Signaling Pathways.

Front Oncol.

9:387.

(IF 4.848)

677. Jia P, Wu N, Jia D, Sun Y

Downregulation of MALAT1 alleviates saturated fatty acid-induced myocardial inflammatory injury via the miR-26a/HMGB1/TLR4/NF-κB axis.

DIABET METAB SYND OB.

12:655-665.

(IF 2.842)

678. Jue Jiang, Juan Wang, Xin He, Wenqi Ma, Lei Sun, Qi Zhou, Miao Li, Shanshan Yu

High Expression of SPAG5 Sustains the Malignant Growth and Invasion of Breast Cancer Cells Through the Activation of Wnt/β-catenin Signalling

CLIN EXP PHARMACOL P .

doi: 10.1111/1440-1681.13082.

(IF 2.092)

679. Huang C, Wen C, Yang M, Gan D, Fan C, Li A, Li Q, Zhao J, Zhu L, Lu D

Lycopene protects against t-BHP-induced neuronal oxidative damage and apoptosis via activation of the PI3K/Akt pathway.

Mol Biol Rep.

46(3):3387-3397.

(IF 1.402)

680. Li YL, Rao MJ, Zhang NY, Wu LW, Lin NM, Zhang C

BAY 87-2243 sensitizes hepatocellular carcinoma Hep3B cells to histone deacetylase inhibitors treatment via GSK-3β activation.

Exp Ther Med.

17(6):4547-4553.

(IF 1.785)

681. Bai J, Yao B, Wang L, Sun L, Chen T, Liu R, Yin G, Xu Q, Yang W

lncRNA A1BG-AS1 suppresses proliferation and invasion of hepatocellular carcinoma cells by targeting miR-216a-5p.

J Cell Biochem.

120(6):10310-10322.

(IF 4.237)

682. Liu B, Lu Y, Wang Y, Ge L, Zhai N, Han J

A protocol for isolation and identification and comparative characterization of primary osteoblasts from mouse and rat calvaria.

Cell Tissue Bank.

20(2):173-182.

(IF 1.149)

683. Xu RY, Xu XW, Deng YZ, Ma ZX, Li XR, Zhao L, Qiu LJ, Liu HY, Chen HP

Resveratrol attenuates myocardial hypoxia/reoxygenation-induced cell apoptosis through DJ-1-mediated SIRT1-p53 pathway.

BIOCHEM BIOPH RES CO.

514(2):401-406.

(IF 2.985)

684. Jiang L, Zhu Z, Wen Y, Ye S, Su C, Zhang R, Shao W

Facile Construction of Functionalized GO Nanocomposites with Enhanced Antibacterial Activity.

Nanomaterials (Basel).

9(7). pii: E913.

685. Wang Y, Ai L, Hai B, Cao Y, Li R, Li H, Li Y

Tempol alleviates chronic intermittent hypoxia-induced pancreatic injury through repressing inflammation and apoptosis.

Physiol Res.

68(3):445-455.

(IF 1.655)

686. Yuan B, Wu W, Zhang H, Gu H, Guo D, Jiang J, Wang X

Adenomatous polyposis coli as a predictor of environmental chemical-induced transgenerational effects related to male infertility.

J BIOCHEM MOL TOXIC.

33(7):e22331.

(IF 3.606)

687. Wu Y, Zou F, Lu Y, Li X, Li F, Feng X, Sun X, Liu Y

SETD7 promotes TNF-α-induced proliferation and migration of airway smooth muscle cells in vitro through enhancing NF-κB/CD38 signaling.

Int Immunopharmacol.

72:459-466.

(IF 3.943)

688. Liu Y, Su H, Ma C, Ji D, Zheng X, Wang P, Zheng S, Wang L, Wang Z, Xu D

IQGAP1 mediates podocyte injury in diabetic kidney disease by regulating nephrin endocytosis.

Cell Signal.

59:13-23.

(IF 3.968)

689. Deng N, Lei D, Huang J, Yang Z, Fan C, Wang S

Circular RNA expression profiling identifies hsa_circ_0011460 as a novel molecule in severe preeclampsia.

Pregnancy Hypertens.

17:216-225.

(IF 2.095)

690. Chen M, Wang F, Cao JJ, Han X, Lu WW, Ji X, Chen WH, Lu WQ, Liu AL

(-)-Epigallocatechin-3-gallate attenuates the toxicity of methylmercury in Caenorhabditis elegans by activating SKN-1.

CHEM-BIOL INTERACT.

307:125-135.

(IF 3.723)

691. Zhang Y, Liu L, Sun D, He Y, Jiang Y, Cheng KW, Chen F

DHA protects against monosodium urate-induced inflammation through modulation of oxidative stress.

Food Funct.

10(7):4010-4021.

(IF 4.171)

692. Du ZD, Wei W, Yu S, Song QL, Liu K, Gong SS

NADPH Oxidase 2-Mediated Insult in the Auditory Cortex of Zucker Diabetic Fatty Rats.

Neural Plast.

2019:3591605.

(IF 3.093)

693. Zhou YT, Qiu JJ, Wang Y, Liu PC, Lv Q, Du ZG

Sperm Protein Antigen 17 Expression Correlates With Lymph Node Metastasis and Worse Overall Survival in Patients With Breast Cancer.

Front Oncol.

9:710.

(IF 4.848)

694. Wu Y, Zhuang J, Zhao D, Xu C

Interaction between caspase-3 and caspase-5 in the stretch-induced programmed cell death in the human periodontal ligament cells.

J Cell Physiol.

234(8):13571-13581.

(IF 5.546)

695. Li Z, Chen S, Chen S, Huang D, Ma K, Shao Z

Moderate activation of Wnt/β-catenin signaling promotes the survival of rat nucleus pulposus cells via regulating apoptosis, autophagy, and senescence.

J Cell Biochem.

120(8):12519-12533.

(IF 4.237)

696. Du J, Liu J, Zhen J, Yang ST, Zheng EL, Leng JY

Astragaloside IV protects cardiomyocytes from hypoxia-induced injury by down-regulation of lncRNA GAS5.

Biomed Pharmacother.

116:109028.

(IF 4.545)

697. Chen X, Han K, Lin G, Liu C, Wang S, Shi X, Hu Z, Wu C, Xu X, Hu C

Ctenopharyngodon Idella STAT3 alleviates autophagy by up-regulating BCL-2 expression.

FISH SHELLFISH IMMUN.

91:194-201.

(IF 3.298)

698. Hao P, Kang B, Li Y, Hao W, Ma F

UBE2T promotes proliferation and regulates PI3K/Akt signaling in renal cell carcinoma.

Mol Med Rep.

20(2):1212-1220.

(IF 2.1)

699. Xu Y, Yu L, Hao C, Wang Y, Zhu C, Ji W, Li Y, Li G, Chen Z, Yan Y

Plasma soluble B7-H3 levels for severity evaluation in pediatric patients with Mycoplasma pneumoniae pneumonia.

Int Immunopharmacol.

73:163-171.

(IF 3.943)

700. Wu B, Miao X, Ye J, Pu X

The Protective Effects of Protease Inhibitor MG-132 on Sepsis-Induced Acute Lung Rats and Its Possible Mechanisms.

MED SCI MONITOR.

25:5690-5699.

(IF 1.918)

701. Zhang Y, Liu Y, Bi X, Hu C, Ding F, Ding W

Therapeutic Approaches in Mitochondrial Dysfunction, Inflammation, and Autophagy in Uremic Cachexia: Role of Aerobic Exercise.

MEDIAT INFLAMM.

2019:2789014.

(IF 3.758)

702. Zhao G, Zhang L, Qian D, Sun Y, Liu W

miR-495-3p inhibits the cell proliferation, invasion and migration of osteosarcoma by targeting C1q/TNF-related protein 3.

ONCOTARGETS THER.

12:6133-6143.

(IF 3.337)

703. Fei D, Zhao H, Wang Y, Liu J, Mu M, Guo M, Yang X, Xing M.

The disturbance of autophagy and apoptosis in the gizzard caused by copper and/or arsenic are related to mitochondrial kinetics.

Chemosphere.

231:1-9.

(IF 5.778)

704. Song J, Ma SJ, Luo JH, Liu H, Li L, Zhang ZG, Chen LS, Zhou RX

Downregulation of AKT and MDM2, Melatonin Induces Apoptosis in AGS and MGC803 Cells.

ANAT REC.

302(9):1544-1551.

(IF 1.634)

705. Wang HL, Liu YC, Long MP, Zheng C, Yang JH

Blocking ROR1 enhances the roles of erlotinib in lung adenocarcinoma cell lines.

Oncol Lett.

18(3):2977-2984.

(IF 2.311)

706. Cao S, Li L, Geng X, Ma Y, Huang X, Kang X

The upregulation of miR-101 promotes vascular endothelial cell apoptosis and suppresses cell migration in acute coronary syndrome by targeting CDH5.

INT J CLIN EXP PATHO.

12(9):3320-3328. eCollection 2019.

(IF 0.252)

707. Xu B, Lang L, Li S, Yuan J, Wang J, Yang H, Lian S

Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure.

Animals (Basel).

9(9). pii: E682.

708. Tong G, Wang Y, Xu C, Xu Y, Ye X, Zhou L, Zhu G, Zhou Z, Huang J

Long non-coding RNA FOXD3-AS1 aggravates ischemia/reperfusion injury of cardiomyocytes through promoting autophagy.

Am J Transl Res.

11(9):5634-5644. eCollection 2019.

(IF 3.375)

709. Zheng XY, Yang SM, Zhang R, Wang SM, Li GB, Zhou SW

Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes.

DRUG DES DEV THER.

13:3171-3180.

(IF 3.216)

710. Yao Y, Ma Y, Zhong N, Pei J

The Inverted U-Curve Association of Fluoride and Osteoclast Formation in Mice.

Biol Trace Elem Res.

191(2):419-425.

(IF 2.639)

711. Zuo H, Wang S, Feng J, Liu X

BRD4 contributes to high-glucose-induced podocyte injury by modulating Keap1/Nrf2/ARE signaling.

Biochimie.

165:100-107.

(IF 3.413)

712. Yang X, Sun L, Wang L, Yao B, Mo H, Yang W

LncRNA SNHG7 accelerates the proliferation, migration and invasion of hepatocellular carcinoma cells via regulating miR-122-5p and RPL4.

Biomed Pharmacother.

118:109386.

(IF 4.545)

713. Peng J, Zhang L, Meng Q, Zhang F, Mao X, Liu J, Chen Y, Zou H, Shi B, Wu R, Huang B, Huang Y, Tan J, Feng C, Zhang X

Adverse impact of ambient PM2.5 on expression and trafficking of surfactant protein A through reactive oxygen species damage to lamellar bodies.

Toxicol Lett.

315:47-54.

(IF 3.569)

714. Li L, Hua L, Fan H, He Y, Xu W, Zhang L, Yang J, Deng F, Zeng F

Interplay of PKD3 with SREBP1 Promotes Cell Growth via Upregulating Lipogenesis in Prostate Cancer Cells.

J Cancer.

10(25):6395-6404.

(IF 3.565)

715. Yan L, Liu G, Cao H, Zhang H, Shao F

Hsa_circ_0035483 sponges hsa-miR-335 to promote the gemcitabine-resistance of human renal cancer cells by autophagy regulation.

BIOCHEM BIOPH RES CO.

519(1):172-178.

(IF 2.985)

716. Wang Y, Xu C, Xu B, Li L, Li W, Wang W, Wu M

Xiaoai Jiedu Recipe Inhibits Proliferation and Metastasis of Non-Small Cell Lung Cancer Cells by Blocking the P38 Mitogen-Activated Protein Kinase (MAPK) Pathway.

MED SCI MONITOR.

25:7538-7546.

(IF 1.918)

717. Ji G, Song X, Wang L, Li Z, Wu H, Dong H

Golgi apparatus fragmentation participates in oxidized low-density lipoprotein-induced endothelial cell injury.

J Cell Biochem.

120(11):18862-18870.

(IF 4.237)

718. Lu G, Xu L, Zhang P, Dou X, Yu J, Feng H

Betulin efficiently suppresses the process of an experimental Listeria monocytogenes infection as an antagonist against listeriolysin O.

Fitoterapia.

139:104409.

(IF 2.527)

719. Wei Y, Zhang Y, Meng Q, Cui L, Xu C

Hypoxia-induced circular RNA has_circRNA_403658 promotes bladder cancer cell growth through activation of LDHA.

Am J Transl Res.

11(11):6838-6849. eCollection 2019.

(IF 3.375)

720. Yin X, Zhang J, Li C, Zhang Z, Jin T, Song L, Zhang R, Wang W, Tao Y, Wang X

LncRNA HOXA11-AS accumulation-induced microRNA-761 downregulation regulates cell growth by targeting TRIM29 in papillary thyroid cancer.

Am J Transl Res.

11(11):6826-6837. eCollection 2019.

(IF 3.375)

721. Li LT, Wang X, Zhu WT, Qian GW, Pei DS, Zheng JN

Reciprocal Role Of DNA Methylation And Sp1 Binding In Ki-67 Gene Transcription.

Cancer Manag Res.

11:9749-9759.

(IF 2.886)

722. Chang B, Qiu H, Zhao H, Yang X, Wang Y, Ji T, Zhang Y, Quan Q, Li Y, Zeng J, Meng H, Gu Y

The Effects of Photobiomodulation on MC3T3-E1 Cells via 630 nm and 810 nm Light-Emitting Diode.

MED SCI MONITOR.

25:8744-8752.

(IF 1.918)

723. Li Y, Song Y, Wang Z, Zhang Z, Lu M, Wang Y

Long Non-coding RNA LINC01787 Drives Breast Cancer Progression via Disrupting miR-125b Generation.

Front Oncol.

9:1140.

(IF 4.848)

724. Li X, Han ZN, Liu Y, Hong L, Cui BR, Cui X

Endogenous ET-1 promotes ANP secretion through activation of COX2-L-PGDS-PPARγ signaling in hypoxic beating rat atria.

Peptides.

122:170150.

(IF 2.843)

725. Li X, Li X, Han B, Zhao Y, Li T, Zhao P, Yu X

Improvement in lipid production in Monoraphidium sp. QLY-1 by combining fulvic acid treatment and salinity stress.

BIORESOURCE TECHNOL.

294:122179.

(IF 7.539)

726. Wu N, Zhang X, Bao Y, Yu H, Jia D, Ma C

Down-regulation of GAS5 ameliorates myocardial ischaemia/reperfusion injury via the miR-335/ROCK1/AKT/GSK-3β axis.

J Cell Mol Med.

23(12):8420-8431.

(IF 4.486)

727. Yuan BY, Chen YH, Wu ZF, Zhuang Y, Chen GW, Zhang L, Zhang HG, Cheng JC, Lin Q, Zeng ZC

MicroRNA-146a-5p Attenuates Fibrosis-related Molecules in Irradiated and TGF-beta1-Treated Human Hepatic Stellate Cells by Regulating PTPRA-SRC Signaling.

Radiat Res.

192(6):621-629.

(IF 2.657)

728. Shi S, Zhang J, Liu M, Dong H, Li N

Ras-ERK signalling represses H1.4 phosphorylation at serine 36 to promote non-small-cell lung carcinoma cells growth and migration.

ARTIF CELL NANOMED B.

47(1):2343-2351.

(IF 3.343)

729. Zhou C, Liu Q, Zhao W, Yang L, Huang Z, Yang Z

Nrdp1 increases neuron apoptosis via downregulation of Bruce following intracerebral haemorrhage.

J INFLAMM-LOND.

16:24.

(IF 2.8)

730. Bin Xu, Li-Min Lang, Shuai Lian, Jing-Ru Guo, Jian-Fa Wang, Juxiong Liu, Huan-Min Yang, Shi-Ze Li

Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure

Brain Res.

doi: 10.1016/j.brainres.2019.146495.

(IF 2.733)

731. Guannan Zhang, Xingyu Zhang, Yongqiang Yang, Ruifang Chi, Jing Shi, Ruiqiang Hang, Xiaobo Huang, Xiaohong Yao, Paul K Chu, Xiangyu Zhang

Dual light-induced in situ antibacterial activities of biocompatibleTiO 2/MoS 2/PDA/RGD nanorod arrays on titanium

Biomater Sci.

doi: 10.1039/c9bm01507h.

732. Liqun Tang, Xiaoqin Yu, Yangyang Zheng, Ning Zhou

Inhibiting SLC26A4 reverses cardiac hypertrophy in H9C2 cells and in rats

PeerJ.

doi: 10.7717/peerj.8253.

(IF 2.379)

733. Fei Liu, Xinrong Tao, Gang Pang, Diqing Wu, Yuting Hu, Song Xue, Jing Liu, Bing Li, Li Zhou, Qiang Liu, Yong-Mei Zhang

Maternal Nicotine Exposure During Gestation and Lactation Period Affects Behavior and Hippocampal Neurogenesis in Mouse Offspring

Front Pharmacol.

doi: 10.3389/fphar.2019.01569.

(IF 4.225)

734. Mao-Xu Ge, Hong-Tao Liu, Na Zhang, Wei-Xiao Niu, Zhen-Ning Lu, Yun-Yang Bao, Rui Huang, Dong-Ke Yu, Rong-Guang Shao, Hong-Wei He

Costunolide represses hepatic fibrosis through WW domain-containing protein 2-mediated Notch3 degradation

Br J Pharmacol.

doi: 10.1111/bph.14873.

735. Wei Tian, Zhuo Wang, Nan-Nan Tang, Jia-Tong Li, Yu Liu, Wen-Feng Chu, Bao-Feng Yang

Ascorbic Acid Sensitizes Colorectal Carcinoma to the Cytotoxicity of Arsenic Trioxide via Promoting Reactive Oxygen Species-Dependent Apoptosis and Pyroptosis

Front Pharmacol.

doi: 10.3389/fphar.2020.00123.

(IF 4.225)

736. Xiong Zhang, Lan-Bing Zhu, Jia-Hui He, Hong-Qiu Zhang, Shu-Ya Ji, Chao-Nan Zhang, Na-Na Hou, Chen-Ping Huang, Jian-Hong Zhu

Paroxetine suppresses reactive microglia-mediated but not lipopolysaccharide-induced inflammatory responses in primary astrocytes

J Neuroinflammation.

doi: 10.1186/s12974-020-1712-0.

737. Xiaohua Pan, Jiahong Li, Xing Tu, Chengfei Wu, He Liu, Yang Luo, Xiaoliang Dong, Xiu Li, Li-Long Pan, Jia Sun

Lysine-specific demethylase-1 regulates fibroblast activation in pulmonary fibrosis via TGF-β1/Smad3 pathway

Pharmacol Res.

doi: 10.1016/j.phrs.2019.104592.

(IF 5.893)

738. Kai Kang, Jun-Bo Chuai, Bao-Dong Xie, Jian-Zhong Li, Hui Qu, Hua Wu, Shao-Hong Fang, Jin-Jin Cui, Li-Li Xiu, Jin-Cheng Han, Tian-Hui Cao, Xiao-Ping Leng, Hai Tian, Ren-Ke Li, Shu-Lin Jiang

Mesenchymal Stromal Cells from Patients with Cyanotic Congenital Heart Disease are Optimal Candidate for Cardiac Tissue Engineering

Biomaterials.

doi: 10.1016/j.biomaterials.2019.119574.

(IF 10.317)

739. Wang H, Luan H, Zhan T, Liu X, Song J, Dai H

Long non-coding RNA LINC00707 acts as a competing endogenous RNA to enhance cell proliferation in colorectal cancer.

Exp Ther Med.

19(2):1439-1447.

(IF 1.785)

740. Du ZD, Han SG, Qu TF, Guo B, Yu SK, Wei W, Feng S, Liu K, Gong SS

Age-related insult of cochlear ribbon synapses: An early-onset contributor to D-galactose-induced aging in mice.

Neurochem Int.

133:104649.

(IF 3.881)

741. Liu Y, Jiang Y, Li W, Han C, Zhou L, Hu H

MicroRNA-200c-3p inhibits proliferation and migration of renal artery endothelial cells by directly targeting ZEB2.

Exp Cell Res.

387(2):111778.

(IF 3.383)

742. Zhao Y, Su L, Li K, Zhao B.

Discovery of novel PC-PLC activity inhibitors.

Chem Biol Drug Des.

95(3):380-387.

(IF 2.548)

743. Qinghui Meng, Weihua Wu, Tiemin Pei, Junlin Xue, Peng Xiao, Liang Sun, Long Li, Desen Liang

miRNA-129/FBW7/NF-κB, a Novel Regulatory Pathway in Inflammatory Bowel Disease

MOL THER-NUCL ACIDS.

doi: 10.1016/j.omtn.2019.10.048.

(IF 7.032)

744. Xiuxiu Chen, Yiqin Tian, Haitao Zhu, Chen Bian, Min Li

Inhibition of steroid receptor coactivator-1 in the hippocampus impairs the consolidation and reconsolidation of contextual fear memory in mice

Life Sci.

doi: 10.1016/j.lfs.2020.117386.

(IF 3.647)

745. Yue Geng, Yeting Chen, Wei Sun, Yingmin Gu, Yongjie Zhang, Mei Li, Jiajun Xie, Xuesong Tian

Electroacupuncture Ameliorates Cerebral I/R-Induced Inflammation through DOR-BDNF/TrkB Pathway

Evid Based Complement Alternat Med.

doi: 10.1155/2020/3495836.

746. Huan Liu, Xiaobao Gong, Kai Yang

Overexpression of the clock gene Per2 suppresses oral squamous cell carcinoma progression by activating autophagy via the PI3K/AKT/mTOR pathway

J Cancer.

doi: 10.7150/jca.42771.

(IF 3.565)

747. Na Zhu, Jiang Li, Yongli Li, Yuwei Zhang, Qiubo Du, Peiyuan Hao, Jinying Li, Xueming Cao, Li Li

Berberine Protects Against Simulated Ischemia/Reperfusion Injury-Induced H9C2 Cardiomyocytes Apoptosis In Vitro and Myocardial Ischemia/Reperfusion-Induced Apoptosis In Vivo by Regulating the Mitophag

Front Pharmacol.

doi: 10.3389/fphar.2020.00367.

(IF 4.225)

748. Hui Wang, Xuefei Li, Hui Yang, Jun Wang, Qiqi Li, Ruijing Qu, Xianggen Wu

Nanocomplexes based polyvinylpyrrolidone K-17PF for ocular drug delivery of naringenin

Int J Pharm.

doi: 10.1016/j.ijpharm.2020.119133.

749. Gui Wu, Fei Huang, Yaoqing Chen, Yuehong Zhuang, Yunpeng Huang, Yun Xie

High Levels of BMP2 Promote Liver Cancer Growth via the Activation of Myeloid-Derived Suppressor Cells

Front Oncol.

doi: 10.3389/fonc.2020.00194.

(IF 4.848)

750. Yong He, Zhonghao Wu, Tianlan Lan, Yue Wang, Yu Tian, Xi Chen, Yan Li, Mengge Bai, Jie Liu, Xue Gong, Ke Cheng, Peng Xie

The 25(OH)D/VDR signaling may play a role in major depression

Biochem Biophys Res Commun.

doi: 10.1016/j.bbrc.2019.12.071.

751. Weiwei Li, Jiancheng Yang, Qiufeng Lyu, Gaofeng Wu, Shumei Lin, Qunhui Yang, Jianmin Hu

Taurine prevents cardiomyocyte apoptosis by inhibiting the calpain-1/cytochrome c pathway during RVH in broilers

Amino Acids.

doi: 10.1007/s00726-020-02824-5.

(IF 3.063)

752. Zhen Dong, Jie Yang, Lin Li, Li Tan, Pengfei Shi, Jiayi Zhang, Xi Zhong, Lingjun Ge, Zonghui Wu, Hongjuan Cui

FOXO3a‑SIRT6 axis suppresses aerobic glycolysis in melanoma

Int J Oncol.

doi: 10.3892/ijo.2020.4964.

(IF 3.899)

753. Lincheng Ju, Liping Shan, Bo Yin, Yongsheng Song

δ-Catenin regulates proliferation and apoptosis in renal cell carcinoma via promoting β-catenin nuclear localization and activating its downstream target genes

Cancer Med.

doi: 10.1002/cam4.2857.

754. Wang Y, Li Y, Shao P, Wang L, Bao X, Hu M

IL1β inhibits differentiation of cementoblasts via microRNA-325-3p.

J Cell Biochem.

121(3):2606-2617.

(IF 4.237)

755. Yin Du, Xiaozhen Ma, Lei Ma, Siyuan Li, Juan Zheng, Junlin Lv, Long Cui, Jianrui Lv

Inhibition of microRNA-148b-3p Alleviates Oxygen-Glucose Deprivation/Reoxygenation-Induced Apoptosis and Oxidative Stress in HT22 Hippocampal Neuron via Reinforcing Sestrin2/Nrf2 Signalling

CLIN EXP PHARMACOL P .

doi: 10.1111/1440-1681.13231.

(IF 2.092)

756. Xin Yi Chu, Shi Zhen Yang, Meng Qing Zhu, Dan Yang Zhang, Xiao Chen Shi, Bo Xia, Ye Yuan, Min Liu, Jiang Wei Wu

Isorhapontigenin Improves Diabetes in Mice via Regulating the Activity and Stability of PPARγ in Adipocytes

J Agric Food Chem.

doi: 10.1021/acs.jafc.0c00515.

757. Yang X, Zhang C, Tie H, Luo J, Wang Y, Wu Q

miR-760 exerts an antioncogenic effect in esophageal squamous cell carcinoma by negatively driving fat metabolism via targeting c-Myc.

J Cell Biochem.

121(4):2950-2961.

(IF 4.237)

758. Lu H, Sun L, Chen W, Zhou Y, Liu K, Chen J, Zhang Z, Zhang C, Tian H

Sirtuin 3 Therapy Attenuates Aging Expression, Oxidative Stress Parameters, and Neointimal Hyperplasia Formation in Vein Grafts.

Ann Vasc Surg.

64:303-317.

(IF 1.125)

759. Yifan Wu, Yang Jin, Tianyu Sun, Piaoyu Zhu, Jinlong Li, Qinglin Zhang, Xiaoke Wang, Junkang Jiang, Gang Chen, Xinyuan Zhao

p62/SQSTM1 accumulation due to degradation inhibition and transcriptional activation plays a critical role in silica nanoparticle-induced airway inflammation via NF-κB activation

J Nanobiotechnology.

doi: 10.1186/s12951-020-00634-1.

760. Hao Zhang, Yanan Chen, Yueping Chen, Peilu Jia, Shuli Ji, Jianxiong Xu, Yue Li, Tian Wang

Comparison of the effects of resveratrol and its derivative pterostilbene on hepatic oxidative stress and mitochondrial dysfunction in piglets challenged with diquat

Food Funct.

doi: 10.1039/d0fo00732c.

(IF 4.171)

761. Jiannan Li, Zhan Zhang, Jiangbo Wang, Shuang Du, Dengbing Yao, Rangjuan Cao, Shusen Cui

Protein Kinase Cα Promotes Proliferation and Migration of Schwann Cells by Activating ERK Signaling Pathway

Neuroscience.

doi: 10.1016/j.neuroscience.2020.03.007.

(IF 3.056)

762. Xiangyuan Chen, Jie Qi, Qichao Wu, Hui Jiang, Jing Wang, Wankun Chen, Anrong Mao, Minmin Zhu

High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression

Acta Biochim Biophys Sin (Shanghai).

doi: 10.1093/abbs/gmaa023.

763. Ruonan Zhang, Ting Pan, Yu Xiang, Mingming Zhang, Jiao Feng, Shuiping Liu, Ting Duan, Peng Chen, Bingtao Zhai, Xiaying Chen, Wengang Wang, Bi Chen, Xuemeng Han, Liuxi Chen, Lili Yan, Ting Jin, Ying Liu, Guohua Li, Xingxing Huang, Wenzheng Zhang, Yitian Sun, Qiujie Li, Qin Zhang, Lvjia Zhuo, Tian Xie, Qibiao Wu, Xinbing Sui

β-Elemene Reverses the Resistance of p53-Deficient Colorectal Cancer Cells to 5-Fluorouracil by Inducing Pro-death Autophagy and Cyclin D3-Dependent Cycle Arrest

Front Bioeng Biotechnol.

doi: 10.3389/fbioe.2020.00378.

764. Yun Shen, Yongchu Pan, Shuyu Guo, Lian Sun, Chi Zhang, Lin Wang

The roles of mechanosensitive ion channels and associated downstream MAPK signaling pathways in PDLC mechanotransduction

Mol Med Rep.

doi: 10.3892/mmr.2020.11006.

(IF 2.1)

765. Bi Lin, Ziyuan Jin, Xiang Chen, Li Zhao, Chengwei Weng, Baihui Chen, Yaning Tang, Lina Lin

Necrostatin‑1 protects mice from acute lung injury by suppressing necroptosis and reactive oxygen species

Mol Med Rep.

doi: 10.3892/mmr.2020.11010.

(IF 2.1)

766. Chunyan Wang, Jingwei Cao, Shurong Duan, Ran Xu, Hongli Yu, Xin Huo, Yuanyuan Qian

Effect of MicroRNA-126a-3p on Bone Marrow Mesenchymal Stem Cells Repairing Blood-brain Barrier and Nerve Injury after Intracerebral Hemorrhage

J Stroke Cerebrovasc Dis.

doi: 10.1016/j.jstrokecerebrovasdis.2020.104748.

767. Zheng-Liang Shi, Hua Zhang, Zhi-Yong Fan, Wei Ma, Yong-Zhou Song, Ming Li, Tong-Qiu Li, Shu-Xing Cao, Guo-Jun Feng

Long noncoding RNA LINC00314 facilitates osteogenic differentiation of adipose-derived stem cells through the hsa-miR-129-5p/GRM5 axis via the Wnt signaling pathway

Stem Cell Res Ther.

doi: 10.1186/s13287-020-01754-z.

(IF 5.116)

768. Hao Zhang, Yanan Chen, Yueping Chen, Shuli Ji, Peilu Jia, Yue Li, Tian Wang

Comparison of the protective effects of resveratrol and pterostilbene against intestinal damage and redox imbalance in weanling piglets

J Anim Sci Biotechnol.

doi: 10.1186/s40104-020-00460-3.

769. Yifan Ren, Jia Zhang, Mengzhou Wang, Jianbin Bi, Tao Wang, Minglong Qiu, Yi Lv, Zheng Wu, Rongqian Wu

Identification of irisin as a therapeutic agent that inhibits oxidative stress and fibrosis in a murine model of chronic pancreatitis

Biomed Pharmacother.

doi: 10.1016/j.biopha.2020.110101.

(IF 4.545)

770. Xiaohan Chang, Huijie Zhang, Qing Yang, Li Pang

LncRNA SOX2OT affects cervical cancer cell growth, migration and invasion by regulating SOX2

Cell Cycle.

doi: 10.1080/15384101.2020.1750812.

(IF 3.699)

771. Li Lv, Wenhui Zhang, Tingting Li, Lifeng Jiang, Xinyan Lu, Jie Lin

Hispidulin exhibits potent anticancer activity in vitro and in vivo through activating ER stress in non‑small‑cell lung cancer cells

Oncol Rep.

doi: 10.3892/or.2020.7568.

(IF 3.417)

772. Jun-Xiao Yang, Peng Xie, Yu-Sheng Li, Ting Wen, Xu-Cheng Yang

Osteoclast-derived miR-23a-5p-containing exosomes inhibit osteogenic differentiation by regulating Runx2

Cell Signal.

doi: 10.1016/j.cellsig.2019.109504.

(IF 3.968)

773. Jili Fu, Kija Malale Nchambi, Hao Wu, Xie Luo, Xizhou An, Dongfang Liu

Liraglutide protects pancreatic β cells from endoplasmic reticulum stress by upregulating MANF to promote autophagy turnover

Life Sci.

doi: 10.1016/j.lfs.2020.117648.

(IF 3.647)

774. Yujing Zhang, Huanfeng Bian, Yu Ma, Yuanyuan Xiao, Fang Xiao

Cr(VI)-induced overactive mitophagy contributes to mitochondrial loss and cytotoxicity in L02 hepatocytes

Biochem J.

doi: 10.1042/BCJ20200262.

(IF 4.097)

775. Shuang Chen, Mengzhen Li, Wei Jiang, Hao Zheng, Lian-Wen Qi, Shujun Jiang

The role of Neu1 in the protective effect of dipsacoside B on acetaminophen-induced liver injury

Ann Transl Med.

doi: 10.21037/atm-19-3850.

(IF 3.297)

776. Dong-Shan Zhu, Jing-Yao Dong, Yao-Yao Xu, Xin-Tong Zhang, Shi-Bo Fu, Wei Liu

Omipalisib Inhibits Esophageal Squamous Cell Carcinoma Growth Through Inactivation of Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) and ERK Signaling

Med Sci Monit.

doi: 10.12659/MSM.927106.

777. Tianqing Yan, Chang Liang, Haidi Fan, Wei Zhou, Linyan Huang, Suhua Qi, Wan Wang, Ping Ma

KAP1 silencing relieves OxLDL-induced vascular endothelial dysfunction by down-regulating LOX-1

Biosci Rep.

doi: 10.1042/BSR20200821.

778. Fudong Zhu, Xiaobo Cai, Xin Yang, Jianfeng He, Chengze Wang, Mingxiang Wang, Aili Simaiti, Wei Yang, Xinqiang Zhu, Peilin Yu

TRPM2 expression levels are associated with histological grading in patients with tongue squamous cell carcinoma

Mol Med Rep.

doi: 10.3892/mmr.2020.11417.

(IF 2.1)

779. Jingle Jiang, Siyi Liu, Tuniyaz Jamal, Tengxin Ding, Lina Qi, Zengpeng Lv, Debing Yu, Fangxiong Shi

Effects of dietary sweeteners supplementation on growth performance, serum biochemicals, and jejunal physiological functions of broiler chickens

Poult Sci.

doi: 10.1016/j.psj.2020.03.057.

780. Lili Chen, Shue Li, Jiaming Nie, Jiajia Zhao, Shaoling Yu, Yaoxu Li, Jinfeng Peng

Bmal1 Regulates Coagulation Factor Biosynthesis in Mouse Liver in Streptococcus oralis Infection

Front Cell Infect Microbiol.

doi: 10.3389/fcimb.2020.530190.

781. Linan Guan, Chao Li, Yi Zhang, Jianying Gong, Guangyu Wang, Pei Tian, Ning Shen

Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome

Life Sci.

doi: 10.1016/j.lfs.2020.117935.

(IF 3.647)

782. Lingling Li, Dan Luo, Yating Liao, Kailan Peng, Yanhua Zeng

Mycoplasma genitalium Protein of Adhesion Induces Inflammatory Cytokines via Cyclophilin A-CD147 Activating the ERK-NF-κB Pathway in Human Urothelial Cells

Front Immunol.

doi: 10.3389/fimmu.2020.02052.

(IF 5.085)

783. Hui Wang, Feng Yang, Ruihua Xin, Dongan Cui, Jiongjie He, Shidong Zhang, Yan Sun

The gut microbiota attenuate neuroinflammation in manganese exposure by inhibiting cerebral NLRP3 inflammasome

Biomed Pharmacother.

doi: 10.1016/j.biopha.2020.110449.

(IF 4.545)

784. Kun Ma, Chuan Zhang, Wuyin Li

TGF-β is associated with poor prognosis and promotes osteosarcoma progression via PI3K/Akt pathway activation

Cell Cycle.

doi: 10.1080/15384101.2020.1805552.

(IF 3.699)

785. Li Mao, Mei-Ling Zuo, Ai-Ping Wang, Ying Tian, Li-Chen Dong, Tao-Ming Li, Da-Bin Kuang, Gui-Lin Song, Zhong-Bao Yang

Low expression of miR‑532‑3p contributes to cerebral ischemia/reperfusion oxidative stress injury by directly targeting NOX2

Mol Med Rep.

doi: 10.3892/mmr.2020.11325.

(IF 2.1)

786. Shuyu Liu, Renjun Yang, Nuoya Yin, Francesco Faiola

Effects of per- and poly-fluorinated alkyl substances on pancreatic and endocrine differentiation of human pluripotent stem cells

Chemosphere.

doi: 10.1016/j.chemosphere.2020.126709.

(IF 5.778)

787. Shengyang Jin, Chunqing Meng, Yu He, Xiaohong Wang, Qimin Zhang, Ze Wang, Wei Huang, Hong Wang

Curcumin prevents osteocyte apoptosis by inhibiting M1-type macrophage polarization in mice model of glucocorticoid-associated osteonecrosis of the femoral head

J Orthop Res.

doi: 10.1002/jor.24619.

(IF 2.728)

788. Bei-Bei Deng, Bao-Ping Jiao, Yang-Jun Liu, Yan-Rong Li, Gui-Jun Wang

BIX-01294 enhanced chemotherapy effect in gastric cancer by inducing GSDME-mediated pyroptosis

Cell Biol Int.

doi: 10.1002/cbin.11395.

(IF 2.571)

789. Ya Gao, Boting Xi, Jiani Li, Zimeng Li, Jie Xu, Mingli Zhong, Qiongmei Xu, Yuanyu Lian, Riming Wei, Liping Wang, Houkang Cao, Ling Jin, Kefeng Zhang, Jianghui Dong

Scoparone alleviates hepatic fibrosis by inhibiting the TLR-4/NF-κB pathway

J Cell Physiol.

doi: 10.1002/jcp.30083.

(IF 5.546)

790. Chao Li, Sheng Zhang, Liming Li, Qing Hu, Shen Ji

Ursodeoxycholic Acid Protects Against Arsenic Induced Hepatotoxicity by the Nrf2 Signaling Pathway

Front Pharmacol.

doi: 10.3389/fphar.2020.594496.

(IF 4.225)

791. Dianbao Zhang, Chunhe Li, Luting Zhang, Bo Li, Yu Wang, Rui Wang, Zaixing Chen, Liang Xu, Tao Liu

Cannabisin D from Sinomenium Acutum Inhibits Proliferation and Migration of Glioblastoma Cells through MAPKs Signaling

Nutr Cancer.

doi: 10.1080/01635581.2020.1836240.

(IF 2.363)

792. Lei Wang

ELF1-activated FOXD3-AS1 promotes the migration, invasion and EMT of osteosarcoma cells via sponging miR-296-5p to upregulate ZCCHC3

J Bone Oncol.

doi: 10.1016/j.jbo.2020.100335.

(IF 3.066)

793. Liu-Jun He, Dong-Lin Yang, He-Ying Chen, Jiu-Hong Huang, Ya-Jun Zhang, Hong-Xia Qin, Juan-Li Wang, Dian-Yong Tang, Zhong-Zhu Chen

A Novel Imidazopyridine Derivative Exhibits Anticancer Activity in Breast Cancer by Inhibiting Wnt/β‑catenin Signaling

Onco Targets Ther.

doi: 10.2147/OTT.S266752.

794. Lan Jiang, Yanguo Zhang, Tao Liu, Xiaoxia Wang, Huan Wang, Haifeng Song, Wenting Wang

Exosomes derived from TSG-6 modified mesenchymal stromal cells attenuate scar formation during wound healing

Biochimie.

doi: 10.1016/j.biochi.2020.08.003.

(IF 3.413)

795. Jingyi Li, Tingting Wang, Chong Li, Zhifang Wang, Peng Wang, Lili Zheng

Sema3A and HIF1α co-overexpressed iPSC-MSCs/HA scaffold facilitates the repair of calvarial defect in a mouse model

J Cell Physiol.

doi: 10.1002/jcp.29569.

(IF 5.546)

796. Shunzhong Hong, Wenjie Cai, Zicheng Huang, Yubin Wang, Xifeng Mi, Yisen Huang, Zhijin Lin, Xiangbo Chen

Ginsenoside Rg3 enhances the anticancer effect of 5‑FU in colon cancer cells via the PI3K/AKT pathway

Oncol Rep.

doi: 10.3892/or.2020.7728.

(IF 3.417)

797. Yu Fan, Tu-Run Song, Qiang Wei, Lu Yang, Tao Lin, Xiao-Bing Feng, Xian-Ding Wang, Zhong-Li Huang, Shi-Jian Feng

Modulatory effect of aquaporin 5 on estrogen-induced epithelial-mesenchymal transition in prostate epithelial cells

Chin Med J (Engl).

doi: 10.1097/CM9.0000000000001132.

798. Shi Chen, Shiyi Tan, Shang Yang, Gang Chen, Li Zhu, Zhiqian Sun, Haibin Li, Sanqiao Yao

Nicotine induces apoptosis through exacerbation of blocked alveolar macrophage autophagic degradation in silicosis

Toxicol Lett.

doi: 10.1016/j.toxlet.2020.09.019.

(IF 3.569)

799. Ge Hong, Hao Wu, Shi-Tang Ma, Zhe Su

Catechins from oolong tea improve uterine defects by inhibiting STAT3 signaling in polycystic ovary syndrome mice

Chin Med.

doi: 10.1186/s13020-020-00405-y.

800. Linfeng Sun, Xiaoding Lin, Sakorn Pornprasert, Xiaomei Lü, Bing Ran, Yan Lin

L-type calcium channel blockers decrease the iron overload-mediated oxidative stress in renal epithelial cells by reducing iron accumulation

Eur J Pharmacol.

doi: 10.1016/j.ejphar.2020.173513.

(IF 3.263)

801. Jiajia Zhai, Zeping Li, Huifeng Zhang, Louyan Ma, Zhengquan Ma, Yi Zhang, Jian Zou, Mo Li, Li Ma, Xin Wang, Xiaomiao Li

Berberine protects against diabetic retinopathy by inhibiting cell apoptosis via deactivation of the NF‑κB signaling pathway

Mol Med Rep.

doi: 10.3892/mmr.2020.11505.

(IF 2.1)

802. Li-Ping Nan, Feng Wang, Di Ran, Shi-Feng Zhou, Yang Liu, Zhen Zhang, Ze-Nan Huang, Ze-Yu Wang, Jing-Cheng Wang, Xin-Min Feng, Liang Zhang

Naringin alleviates H 2 O 2-induced apoptosis via the PI3K/Akt pathway in rat nucleus pulposus-derived mesenchymal stem cells

Connect Tissue Res.

doi: 10.1080/03008207.2019.1631299.

(IF 2.795)

803. Joy Yue Zhang, Peihuang Wu, Danyang Chen, Fen Ning, Qinsheng Lu, Xiu Qiu, Martin Hewison, Jennifer A Tamblyn, Mark D Kilby, Gendie E Lash

Vitamin D Promotes Trophoblast Cell Induced Separation of Vascular Smooth Muscle Cells in Vascular Remodeling via Induction of G-CSF

Front Cell Dev Biol.

doi: 10.3389/fcell.2020.601043.

(IF 5.201)

804. Lili Wang, Jingzhen Zhou, Yong Zhang, Tao Hu, Yongning Sun

Long Non-Coding RNA HCG11 Aggravates Osteosarcoma Carcinogenesis via Regulating the microRNA-579/MMP13 Axis

Int J Gen Med.

doi: 10.2147/IJGM.S274641.

805. Shengjun Ji, Haohao Wu, Xin Ding, Qingqing Chen, Xing Jin, Jinming Yu, Ming Yang

Increased hippocampal TrkA expression ameliorates cranial radiation‑induced neurogenesis impairment and cognitive deficit via PI3K/AKT signaling

Oncol Rep.

doi: 10.3892/or.2020.7782.

(IF 3.417)

806. Tingting Huang, Xiaoxiao Luo, Bili Wu, Ping Peng, Yuhong Dai, Guangyuan Hu, Hong Qiu, Xianglin Yuan

Pyrotinib enhances the radiosensitivity of HER2‑overexpressing gastric and breast cancer cells

Oncol Rep.

doi: 10.3892/or.2020.7820.

(IF 3.417)

807. Ye Zhi, Chunhua Lu, Ganlin Zhu, Zhijie Li, Piaoyu Zhu, Yuting Liu, Weiwei Shi, Liling Su, Junkang Jiang, Jianhua Qu, Xinyuan Zhao

Positive regulation of the CREB phosphorylation via JNK-dependent pathway prevents antimony-induced neuronal apoptosis in PC12 cell and mice brain

Neurotoxicology.

doi: 10.1016/j.neuro.2020.09.002.

(IF 3.105)

808. Hao Zha, Wei Miao, Wei Rong, Aimei Wang, Weiqi Jiang, Rui Liu, Lanqi Liu, Ying Wang

Remote ischaemic perconditioning reduces the infarct volume and improves the neurological function of acute ischaemic stroke partially through the miR-153-5p/TLR4/p65/IkBa signalling pathway

Folia Neuropathol.

doi: 10.5114/fn.2021.112127.

(IF 1.278)

809. Lixia Sun, Renzhe Cui, Huan Meng, Xiwen Liu, Xin Liu, Yan Lu, Kun Liu, Liang Jia, Yajuan Zheng

Gene Suppression of the Chloride Channel 2 Suppressed TGF-β1-Induced Proliferation, Collagen Synthesis, and Collagen Gel Contraction Mediated by Conjunctival Fibroblasts

Ophthalmic Res.

doi: 10.1159/000507632.

(IF 1.961)

810. Hongyan Xu, Jing Shao, Jiachen Fang, Baozhen Yin, Luomeng Zhang, Jiasu Zhang, Guangjun Xia

miR-381 Targets KCTD15 to Regulate Bovine Preadipocyte Differentiation In Vitro

Horm Metab Res.

doi: 10.1055/a-1276-1602.

(IF 2.562)

811. Yi Liu, Yong Zhang, Meng Zhang, Jialin Meng, Qingqing Ma, Zongyao Hao, Meijuan Zheng, Li Zhang, Xianguo Chen, Chaozhao Liang

Activated autophagy restored the impaired frequency and function of regulatory T cells in chronic prostatitis

Prostate.

doi: 10.1002/pros.24073.

(IF 3.279)

812. Yingying Wang, Yingshuang Song, Qi Zhong, Yaqin Wu, Jiabao Zhuang, Fang Qu, Chun Xu

Suppressing ROS generation by apocynin inhibited cyclic stretch-induced inflammatory reaction in HPDLCs via a caspase-1 dependent pathway

Int Immunopharmacol.

doi: 10.1016/j.intimp.2020.107129.

(IF 3.943)

813. Jiao Meng, Ting Ding, Yuhua Chen, Tianlin Long, Quanhua Xu, Wenqing Lian, Wei Liu

LncRNA-Meg3 promotes Nlrp3-mediated microglial inflammation by targeting miR-7a-5p

Int Immunopharmacol.

doi: 10.1016/j.intimp.2020.107141.

(IF 3.943)

814. Zhaofu Liao, Yilin Chen, Chuncui Duan, Kuikui Zhu, Ruijin Huang, Hui Zhao, Maik Hintze, Qin Pu, Ziqiang Yuan, Luocheng Lv, Hongyi Chen, Binglin Lai, Shanshan Feng, Xufeng Qi, Dongqing Cai

Cardiac telocytes inhibit cardiac microvascular endothelial cell apoptosis through exosomal miRNA-21-5p-targeted cdip1 silencing to improve angiogenesis following myocardial infarction

Theranostics.

doi: 10.7150/thno.47021.

(IF 8.579)

815. Xiaomin Sun, Cuilian Ye, Qin Deng, Jingyu Chen, Chunbao Guo

Contribution of glutaredoxin-1 to Fas s-glutathionylation and inflammation in ethanol-induced liver injury

Life Sci.

doi: 10.1016/j.lfs.2020.118678.

(IF 3.647)

816. Hui Li, Linlin Liu, Zhiwen Cao, Wen Li, Rui Liu, Youwen Chen, Chenxi Li, Yurong Song, Guangzhi Liu, Jinghong Hu, Zhenli Liu, Cheng Lu, Yuanyan Liu

Naringenin ameliorates homocysteine induced endothelial damage via the AMPKα/Sirt1 pathway

J Adv Res.

doi: 10.1016/j.jare.2021.01.009.

(IF 6.992)

817. Guiqin Shi, Jiaxin Shen, Fei Ren, Weikai Yang

Molecular cloning, expression, and characterization of BmSOD3 in silkworm (Bombyx mori)

Arch Insect Biochem Physiol.

doi: 10.1002/arch.21744.

818. Litao Yan, Gejun Liu, Xing Wu

The umbilical cord mesenchymal stem cell-derived exosomal lncRNA H19 improves osteochondral activity through miR-29b-3p/FoxO3 axis

Clin Transl Med.

doi: 10.1002/ctm2.255.

819. Xianxian Jia, Bo Wu, Jinhui Huang, Lin Fan, Miao Yang, Wei Xu

YAP and Wnt3a independently promote AECIIs proliferation and differentiation by increasing nuclear β‑catenin expression in experimental bronchopulmonary dysplasia

Int J Mol Med.

doi: 10.3892/ijmm.2020.4791.

(IF 3.098)

820. Heng Chen, Guoliang Sa, Lin Li, Sangang He, Tianfu Wu

In vitro and in vivo synergistic anti-tumor effect of LIN28 inhibitor and metformin in oral squamous cell carcinoma

Eur J Pharmacol.

doi: 10.1016/j.ejphar.2020.173757.

(IF 3.263)

821. Yufei Luo, Bojun Xiong, Haiping Liu, Zehong Chen, Huihui Huang, Changxi Yu, Jian Yang

Koumine Suppresses IL-1β Secretion and Attenuates Inflammation Associated With Blocking ROS/NF-κB/NLRP3 Axis in Macrophages

Front Pharmacol.

doi: 10.3389/fphar.2020.622074.

(IF 4.225)

822. Shaofang Zhang, Ying Liu, Si Sun, Junying Wang, Qifeng Li, Ruijuan Yan, Yalong Gao, Haile Liu, Shuangjie Liu, Wenting Hao, Haitao Dai, Changlong Liu, Yuanming Sun, Wei Long, Xiaoyu Mu, Xiao-Dong Zhang

Catalytic patch with redox Cr/CeO 2 nanozyme of noninvasive intervention for brain trauma

Theranostics.

doi: 10.7150/thno.51912.

(IF 8.579)

823. Jiangfeng Liao, Guirong Zeng, Wenting Fang, Weibin Huang, Xiaoman Dai, Qinyong Ye, Jing Zhang, Xiaochun Chen

Increased Notch2/NF-κB Signaling May Mediate the Depression Susceptibility: Evidence from Chronic Social Defeat Stress Mice and WKY Rats

Physiol Behav.

doi: 10.1016/j.physbeh.2020.113197.

(IF 2.826)

824. Tao Zhang, Yu Dan Zheng, Man Jiao, Ye Zhi, Shen Ya Xu, Piao Yu Zhu, Xin Yuan Zhao, Qi Yun Wu

Nuclear Factor-κB Signaling Mediates Antimony-induced Astrocyte Activation

Biomed Environ Sci.

doi: 10.3967/bes2021.005.

(IF 2.656)

825. Zonghao Tang, Renfeng Xu, Zhenghong Zhang, Congjian Shi, Yan Zhang, Hongqin Yang, Qingqiang Lin, Yiping Liu, Fengping Lin, Baorong Geng, Zhengchao Wang

HIF-1α Protects Granulosa Cells From Hypoxia-Induced Apoptosis During Follicular Development by Inducing Autophagy

Front Cell Dev Biol.

doi: 10.3389/fcell.2021.631016.

(IF 5.201)

826. Huihui Xu, Song Dun, Ying Gao, Jian Ming, Linping Hui, Xueshan Qiu

TMEM107 inhibits EMT and invasion of NSCLC through regulating the Hedgehog pathway

Thorac Cancer.

doi: 10.1111/1759-7714.13715.

(IF 2.61)

827. Yuying Wang, Lulu Sun, Guihong Yu, Xin Qi, Aotong Zhang, Zhimin Lu, Dehai Li, Jing Li

Identification of a novel non-ATP-competitive protein kinase inhibitor of PGK1 from marine nature products

Biochem Pharmacol.

doi: 10.1016/j.bcp.2020.114343.

(IF 4.96)

828. Ling Li, Yu Bai, Runyu Du, Lei Tang, Ling Li

The role of Smad4 in the regulation of insulin resistance, inflammation and cell proliferation in HTR8-Svneo cells

Cell Biochem Funct.

doi: 10.1002/cbf.3594.

(IF 2.632)

829. Jie Wu, Lulu Sun, Tingting Liu, Gang Dong

Ultrasound-Targeted Microbubble Destruction-Mediated Downregulation of EZH2 Inhibits Stemness and Epithelial-Mesenchymal Transition of Liver Cancer Stem Cells

Onco Targets Ther.

doi: 10.2147/OTT.S269589.

830. Ya Xing, Cheng Xu, Xiao Lin, Minmeng Zhao, Daoqing Gong, Long Liu, Tuoyu Geng

Complement C3 participates in the development of goose fatty liver potentially by regulating the expression of FASN and ETNK1

Anim Sci J.

doi: 10.1111/asj.13527.

(IF 1.399)

831. Ye Yuan, Gege Yan, Mingyu He, Hong Lei, Linqiang Li, Yang Wang, Xiaoqi He, Guanghui Li, Quan Wang, Yuelin Gao, Zhezhe Qu, Zhongting Mei, Zhihua Shen, Jiaying Pu, Ao Wang, Wei Zhao, Huiwei Jiang, Weijie Du, Lei Yang

ALKBH5 suppresses tumor progression via an m6A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma

Cell Death Dis.

doi: 10.1038/s41419-020-03315-x.

(IF 6.304)

832. Yage Liang, Meijia Li, Zhaoqun Liu, Yuanmei Li, Lingling Wang, Linsheng Song

The glutaminase (CgGLS-1) mediates anti-bacterial immunity by prompting cytokine synthesis and hemocyte apoptosis in Pacific oyster Crassostrea gigas

Sci Rep.

doi: 10.1038/s41598-020-80552-2.

833. Zhiling Lou, Weijia Wu, Ruiheng Chen, Jie Xia, Haochun Shi, Hanwei Ge, Jiyang Xue, Hanlei Wang, Zhiyong Lin, Maoping Chu, Qifeng Zhao

Microarray analysis reveals a potential role of lncRNA expression in remote ischemic preconditioning in myocardial ischemia-reperfusion injury

Am J Transl Res.

(IF 3.375)

834. Jing Fang, Heng Yin, Zhuangzhi Yang, Maoyun Tan, Fengyuan Wang, Kejie Chen, Zhicai Zuo, Gang Shu, Hengmin Cui, Ping Ouyang, Hongrui Guo, Zhengli Chen, Chao Huang, Yi Geng, Wentao Liu

Vitamin E protects against cadmium-induced sub-chronic liver injury associated with the inhibition of oxidative stress and activation of Nrf2 pathway

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2020.111610.

835. Qiuyuan Lu, Feifei Ren, Jiming Yan, Yinong Zhang, Mian Awais, Jian He, Jingchen Sun

Alkaline phosphatase can promote the replication of Bombyx mori cypovirus 1 by interaction with its turret protein

Virus Res.

doi: 10.1016/j.virusres.2020.198261.

(IF 2.934)

836. Qi Li, Xiaoxia Liu, Weifang Liu, Yang Zhang, Mengying Wu, Zhirui Chen, Yin Zhao, Li Zou

MALAT1 sponges miR-26a and miR-26b to regulate endothelial cell angiogenesis via PFKFB3-driven glycolysis in early-onset preeclampsia

Mol Ther Nucleic Acids.

doi: 10.1016/j.omtn.2021.01.005.

837. Lun Zhang, Shuiqing Gui, Yinghua Xu, Jiali Zeng, Jian Wang, Qingru Chen, Liqian Su, Ziyan Wang, Rui Deng, Fujiang Chu, Wenbin Liu, Xiaobao Jin, Xuemei Lu

Colon tissue-accumulating mesoporous carbon nanoparticles loaded with Musca domestica cecropin for ulcerative colitis therapy

Theranostics.

doi: 10.7150/thno.53105.

(IF 8.579)

838. Yuqian Guo, Guoxing Li, Lei Gao, Xiaocheng Cheng, Liyou Wang, Yuhong Qin, Dongying Zhang

Exaggerated renal fibrosis in lncRNA Gas5-deficient mice after unilateral ureteric obstruction

Life Sci.

doi: 10.1016/j.lfs.2020.118656.

(IF 3.647)

839. Xiao Chen, Bing Shao, Chengmin Yu, Qunmei Yao, Peibin Ma, Haijiao Li, Bin Li, Chengye Sun

Energy disorders caused by mitochondrial dysfunction contribute to α-amatoxin-induced liver function damage and liver failure

Toxicol Lett.

doi: 10.1016/j.toxlet.2020.10.003.

(IF 3.569)

840. Hongfei Ge, Chao Zhang, Yang Yang, Weixiang Chen, Jun Zhong, Xuanyu Fang, Xuheng Jiang, Liang Tan, Yongjie Zou, Rong Hu, Yujie Chen, Hua Feng

Ambroxol Upregulates Glucocerebrosidase Expression to Promote Neural Stem Cells Differentiation Into Neurons Through Wnt/β-Catenin Pathway After Ischemic Stroke

Front Mol Neurosci.

doi: 10.3389/fnmol.2020.596039.

(IF 4.057)

841. Linjie Ju, Peipei Hu, Ping Chen, Jiejie Wu, Zhuoqun Li, Zhixia Qiu, Jun Cheng, Fang Huang

Corydalis Saxicola Bunting Total Alkaloids Attenuate Walker 256-Induced Bone Pain and Osteoclastogenesis by Suppressing RANKL-Induced NF-κB and c-Fos/NFATc1 Pathways in Rats

Front Pharmacol.

doi: 10.3389/fphar.2020.609119.

(IF 4.225)

842. Chaofan Wan, Yunlong Xu, Baoyan Cen, Yucen Xia, Lin Yao, Yuanjia Zheng, Jiaying Zhao, Su He, Yongjun Chen

Neuregulin1-ErbB4 Signaling in Spinal Cord Participates in Electroacupuncture Analgesia in Inflammatory Pain

Front Neurosci.

doi: 10.3389/fnins.2021.636348.

843. Yu Jiang, Qiuju Han, Huajun Zhao, Jian Zhang

Promotion of epithelial-mesenchymal transformation by hepatocellular carcinoma-educated macrophages through Wnt2b/β-catenin/c-Myc signaling and reprogramming glycolysis

J Exp Clin Cancer Res.

doi: 10.1186/s13046-020-01808-3.

844. Jingjie Liang, Kui Li, Kaiyu Chen, Junyong Liang, Ti Qin, Jiayi He, Shuang Shi, Qiang Tan, Zhengguang Wang

Regulation of ARHGAP19 in the endometrial epithelium: a possible role in the establishment of uterine receptivity

Reprod Biol Endocrinol.

doi: 10.1186/s12958-020-00689-7.

845. Ran Du, Feng Jiang, Yanhua Yin, Jinfen Xu, Xia Li, Likuan Hu, Xiuyu Wang

Knockdown of lncRNA X inactive specific transcript (XIST) radiosensitizes non-small cell lung cancer (NSCLC) cells through regulation of miR-16-5p/WEE1 G2 checkpoint kinase (WEE1) axis

Int J Immunopathol Pharmacol.

doi: 10.1177/2058738420966087.

846. Fei Zeng, Jierong Luo, Hong Han, Wenjie Xie, Lingzhi Wang, Ronghui Han, Hao Chen, Yin Cai, Huansen Huang, Zhengyuan Xia

Allopurinol ameliorates liver injury in type 1 diabetic rats through activating Nrf2

Int J Immunopathol Pharmacol.

doi: 10.1177/20587384211031417.

847. Weiping Shi, Danhua Ling, Feiyun Zhang, Xiaohui Fu, Danping Lai, Yanzhen Zhang

Curcumin promotes osteogenic differentiation of human periodontal ligament stem cells by inducting EGR1 expression

Arch Oral Biol.

doi: 10.1016/j.archoralbio.2020.104958.

(IF 1.931)

848. Hai-Peng Li, Ji-Ting Liu, Yuan-Xiu Chen, Wen-Bin Wang, Yue Han, Qing-Ping Yao, Ying-Xin Qi

Suppressed nuclear envelope proteins activate autophagy of vascular smooth muscle cells during cyclic stretch application

Biochim Biophys Acta Mol Cell Res.

doi: 10.1016/j.bbamcr.2020.118855.

849. Yingjun Zhang, Yuanlong An, Xiangdong He, Donglei Zhang, Wei He

Esculetin protects human corneal epithelial cells from oxidative stress through Nrf-2 signaling pathway

Exp Eye Res.

doi: 10.1016/j.exer.2020.108360.

(IF 3.011)

850. Hui Liu, Ling Zhang, Xiaoling Ding, Xuezuo Sui

LINC00861 inhibits the progression of cervical cancer cells by functioning as a ceRNA for miR‑513b‑5p and regulating the PTEN/AKT/mTOR signaling pathway

Mol Med Rep.

doi: 10.3892/mmr.2020.11662.

(IF 2.1)

851. Zhuang-Fei Chen, Ze-Hai Huang, Shi-Jun Chen, Yao-Dong Jiang, Zi-Ke Qin, Shao-Bin Zheng, Tong Chen

Oncogenic potential of macrophage‑capping protein in clear cell renal cell carcinoma

Mol Med Rep.

doi: 10.3892/mmr.2020.11718.

(IF 2.1)

852. Yao Xiong, Yan Wang, Ling Ma, Ying Zhang, Xinlan Qu, Lei Huang, Xue Wen, Huimin Liu, Ming Zhang, Yuanzhen Zhang

Mixed-lineage leukaemia 1 contributes to endometrial stromal cells progesterone responsiveness during decidualization

J Cell Mol Med.

doi: 10.1111/jcmm.16030.

(IF 4.486)

853. Cheng Li, Xiao Miao, Shudong Wang, Yucheng Liu, Jian Sun, Quan Liu, Lu Cai, Yonggang Wang

Elabela may regulate SIRT3-mediated inhibition of oxidative stress through Foxo3a deacetylation preventing diabetic-induced myocardial injury

J Cell Mol Med.

doi: 10.1111/jcmm.16052.

(IF 4.486)

854. Jiyu Chen, Yanli Huang, Xiaochuan Hu, Xiaohong Bian, Sihui Nian

Gastrodin prevents homocysteine-induced human umbilical vein endothelial cells injury via PI3K/Akt/eNOS and Nrf2/ARE pathway

J Cell Mol Med.

doi: 10.1111/jcmm.16073.

(IF 4.486)

855. Jia-Hui He, Rong-Pei Liu, Yi-Man Peng, Qing Guo, Lan-Bing Zhu, Yi-Zhi Lian, Bei-Lei Hu, Hui-Hui Fan, Xiong Zhang, Jian-Hong Zhu

Differential and paradoxical roles of new-generation antidepressants in primary astrocytic inflammation

J Neuroinflammation.

doi: 10.1186/s12974-021-02097-z.

856. Youxiang Zhang, De-Hui Xiong, Yangyang Li, Guina Xu, Baoxin Zhang, Yang Liu, Shan Zhang, Qing Huang, Simin Chen, Fansheng Zeng, Jingyi Guo, Bin Li, Zhiqiang Qin, Zuping Zhang

Schistosoma japonicum Infection in Treg-Specific USP21 Knockout Mice

J Immunol Res.

doi: 10.1155/2021/6613162.

(IF 3.327)

857. Li Zhang, Yujia Cui, Yueyi Yang, Jieya Wei, Wenjing Liu, Linyi Cai, Luling Wang, Demao Zhang, Jing Xie, Lei Cheng

The virulence factor GroEL promotes gelatinase secretion from cells in the osteoblast lineage: Implication for direct crosstalk between bacteria and adult cells

Arch Oral Biol.

doi: 10.1016/j.archoralbio.2020.104991.

(IF 1.931)

858. Yang Yang, Ying Li, Jie Wang, Lei Hong, Shigang Qiao, Chen Wang, Jianzhong An

Cholinergic receptors play a role in the cardioprotective effects of anesthetic preconditioning: Roles of nitric oxide and the CaMKKβ/AMPK pathway

Exp Ther Med.

doi: 10.3892/etm.2020.9569.

(IF 1.785)

859. Ping Zhang, Yang Wang, Mengting Qin, Dandan Li, Woodvine Otieno Odhiambo, Meng Yuan, Zhuangwei Lv, Chengcheng Liu, Yunfeng Ma, Yanying Dong, Yanhong Ji

Involvement of Blnk and Foxo1 in tumor suppression in BCR‑ABL1‑transformed pro‑B cells

Oncol Rep.

doi: 10.3892/or.2020.7888.

(IF 3.417)

860. Hui Li, Jian Zhang, Yongli Fu, Yixin Zhang, Chunhui Zhang, Xiaozhu Sun, Fang Wu, Jing He

Antidiabetic compounds 8a, 8b, 8k, and 9h enhance insulin secretion: activity and mechanism

Endocrine.

doi: 10.1007/s12020-020-02537-5.

(IF 3.235)

861. Qin Huang, Meng Gong, Tuantuan Tan, Yunong Lin, Yan Bao, Cuifang Fan

Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomal MicroRNA-18b-3p Inhibits the Occurrence of Preeclampsia by Targeting LEP

Nanoscale Res Lett.

doi: 10.1186/s11671-021-03475-5.

(IF 3.581)

862. Haocheng Ao, Haichun Li, Xiujuan Zhao, Bingqian Liu, Lin Lu

TXNIP positively regulates the autophagy and apoptosis in the rat müller cell of diabetic retinopathy

Life Sci.

doi: 10.1016/j.lfs.2020.118988.

(IF 3.647)

863. Wen Zhou, Deng Xiao, Yueyang Zhao, Botao Tan, Zhimin Long, Lehua Yu, Guiqiong He

Enhanced Autolysosomal Function Ameliorates the Inflammatory Response Mediated by the NLRP3 Inflammasome in Alzheimer's Disease

Front Aging Neurosci.

doi: 10.3389/fnagi.2021.629891.

(IF 4.362)

864. Jingyun Hu, Ming Cai, Qinghui Shang, Zhaorun Li, Yu Feng, Beibei Liu, Xiangli Xue, Shujie Lou

Elevated Lactate by High-Intensity Interval Training Regulates the Hippocampal BDNF Expression and the Mitochondrial Quality Control System

Front Physiol.

doi: 10.3389/fphys.2021.629914.

(IF 3.367)

865. Jinqiu Wang, Jing Xiao, Xin Liu, YuLing Gao, Zhang Luo, Xuedong Gu, Jiamin Zhang, Di Wu, Fang Geng

Tandem mass tag-labeled quantitative proteomic analysis of tenderloins between Tibetan and Yorkshire pigs

Meat Sci.

doi: 10.1016/j.meatsci.2020.108343.

(IF 3.644)

866. Youyang Wu, Wei Zhao, Fanhao Ye, Shiwei Huang, Hao Chen, Rui Zhou, Wenbing Jiang

Tetrandrine attenuates left ventricular dysfunction in rats with myocardial infarction

Exp Ther Med.

doi: 10.3892/etm.2020.9551.

(IF 1.785)

867. Ling Zhou, Zeming Liu, Sichao Chen, Jing Qiu, Qianqian Li, Shipei Wang, Wei Zhou, Danyang Chen, Guang Yang, Liang Guo

Transcription factor EB‑mediated autophagy promotes dermal fibroblast differentiation and collagen production by regulating endoplasmic reticulum stress and autophagy‑dependent secretion

Int J Mol Med.

doi: 10.3892/ijmm.2020.4814.

(IF 3.098)

868. Shi Chen, Kun Tang, Peiwu Hu, Shiyi Tan, Shang Yang, Chang Yang, Gang Chen, Yixiao Luo, Hui Zou

Atractylenolide III alleviates the apoptosis through inhibition of autophagy by the mTOR-dependent pathway in alveolar macrophages of human silicosis

Mol Cell Biochem.

doi: 10.1007/s11010-020-03946-w.

(IF 2.795)

869. Lijing Jiang, Jindi Ni, Guofeng Shen, Zhuye Xia, Lu Zhang, Shihong Xia, Shengfu Pan, Hongping Qu, Xiang Li

Upregulation of endothelial cell-derived exosomal microRNA-125b-5p protects from sepsis-induced acute lung injury by inhibiting topoisomerase II alpha

Inflamm Res.

doi: 10.1007/s00011-020-01415-0.

(IF 3.174)

870. Jing Wang, Jia Wang, Ling Li, Li Feng, Yu-Rong Wang, Zhe Wang, Ning-Hua Tan

RA-XII, a bicyclic hexapeptidic glucoside isolated from Rubia yunnanensis Diels, exerts antitumor activity by inhibiting protective autophagy and activating Akt-mTOR pathway in colorectal cancer cells

J Ethnopharmacol.

doi: 10.1016/j.jep.2020.113438.

(IF 3.69)

871. Jing Zhang, Xinru Yu, Chaojun Zhang, Qiong Zhang, Ying Sun, Heqin Zhu, Canming Tang

Pectin lyase enhances cotton resistance to Verticillium wilt by inducing cell apoptosis of Verticillium dahliae

J Hazard Mater.

doi: 10.1016/j.jhazmat.2020.124029.

(IF 9.038)

872. Hong-Ping Li, Xiao-Yu Wang, Chao Chen, Jing-Jing Li, Chi Yu, Li-Xue Lin, Zi-E Yu, Zhi-Yuan Jin, He Zhu, Hong-Chun Xiang, Xue-Fei Hu, Jie Cao, Xiang-Hong Jing, Man Li

100 Hz Electroacupuncture Alleviated Chronic Itch and GRPR Expression Through Activation of Kappa Opioid Receptors in Spinal Dorsal Horn

Front Neurosci.

doi: 10.3389/fnins.2021.625471.

873. Guanzhong Chen, Bowen Liu, Shiqun Chen, Huanqiang Li, Jin Liu, Ziling Mai, Enzhao Chen, Chunyun Zhou, Guoli Sun, Zhaodong Guo, Li Lei, Shanyi Huang, Liyao Zhang, Min Li, Ning Tan, Hong Li, Yulin Liao, Jia Liu, Jiyan Chen, Yong Liu

Novel biomarkers for post-contrast acute kidney injury identified from long non-coding RNA expression profiles

Int J Biol Sci.

doi: 10.7150/ijbs.45294.

(IF 4.858)

874. Shan He, Hanxiang Zhang, Yang Lu, Zhaosi Zhang, Xiang Zhang, Nian Zhou, Zhenming Hu

Nampt promotes osteogenic differentiation and lipopolysaccharide-induced interleukin-6 secretion in osteoblastic MC3T3-E1 cells

Aging (Albany NY).

doi: 10.18632/aging.202434.

875. Zhitao Li, Guoao Hu, Li Zhu, Zhenglong Sun, Yun Jiang, Min-Jie Gao, Xiaobei Zhan

Study of growth, metabolism, and morphology of Akkermansia muciniphila with an in vitro advanced bionic intestinal reactor

BMC Microbiol.

doi: 10.1186/s12866-021-02111-7.

(IF 2.989)

876. Qunyi Peng, Xiongpeng Zhu, Chuntuan Li, Pengliang Xin, Yan Zheng, Shengquan Liu

APDL1-CART cells exhibit strong PD-L1-specific activity against leukemia cells

Aging (Albany NY).

doi: 10.18632/aging.202578.

877. Junwen Cheng, Chaoyang Wei, Weiqi Li, Yanbin Wang, Shihao Wang, Qingrong Huang, Yu Liu, Liang He

Structural characteristics and enhanced biological activities of partially degraded arabinogalactan from larch sawdust

Int J Biol Macromol.

doi: 10.1016/j.ijbiomac.2021.01.039.

(IF 5.162)

878. Aping Niu, Wan-Ping Bian, Shuang-Long Feng, Shi-Ya Pu, Xing-Yi Wei, Yi-Fan Yang, Li-Yan Song, De-Sheng Pei

Role of manganese superoxide dismutase (Mn-SOD) against Cr(III)-induced toxicity in bacteria

J Hazard Mater.

doi: 10.1016/j.jhazmat.2020.123604.

(IF 9.038)

879. Xiaolong Tian, Jun Ma, Yijing Wu, Pan Zhang, Qinggang Li, Hao Zhang, Changxin Wu

Functional analysis of the brain natriuretic peptide gene for high-altitude adaptation in Tibetan pigs

Gene.

doi: 10.1016/j.gene.2020.145305.

(IF 2.984)

880. Qiongmei Xu, Jie Xu, Kefeng Zhang, Mingli Zhong, Houkang Cao, Riming Wei, Ling Jin, Ya Gao

Study on the protective effect and mechanism of Dicliptera chinensis (L.) Juss (Acanthaceae) polysaccharide on immune liver injury induced by LPS

Biomed Pharmacother.

doi: 10.1016/j.biopha.2020.111159.

(IF 4.545)

881. Wanyue Huang, Menglin Liu, Bonan Xiao, Jian Zhang, Miao Song, Yanfei Li, Zheng Cao

Aflatoxin B1 disrupts blood-testis barrier integrity by reducing junction protein and promoting apoptosis in mice testes

Food Chem Toxicol.

doi: 10.1016/j.fct.2021.111972.

(IF 4.679)

882. Lina Wu, Qingzhu Wang, Feng Guo, Xiaojun Ma, Jiao Wang, Yanyan Zhao, Yushan Yan, Guijun Qin

Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress

J Cell Physiol.

doi: 10.1002/jcp.29951.

(IF 5.546)

883. Imran Rashid Rajput, Summra Yaqoob, Sun Yajing, Edmond Sanganyado, Liu Wenhua

Polybrominated diphenyl ethers exert genotoxic effects in pantropic spotted dolphin fibroblast cell lines

Environ Pollut.

doi: 10.1016/j.envpol.2020.116131.

(IF 6.792)

884. Yanfa Dai, Jingyuan Nie, Zhongqin Luo, Dongsong Nie

Expression profile analysis of a new testis-specifically expressed gene C17ORF64 and its association with cell apoptosis in MCF-7 cells

Mol Biol Rep.

doi: 10.1007/s11033-021-06191-6.

(IF 1.402)

885. Zhaohui Shi, Min Xu, Xiaodong Chen, Jian Wang, Tianfeng Zhao, Dingjun Zha

The regulatory role of SFRP5/WNT5A axis in allergic rhinitis through inhibiting JNK pathway activation and lowering mucin generation in human nasal epithelial cells

Exp Mol Pathol.

doi: 10.1016/j.yexmp.2020.104591.

(IF 2.28)

886. Jing Lu, Cheng Cheng, Zhen-Chao Cheng, Qian Wu, Han Shen, Ming-Xia Yuan, Bo Zhang, Jin-Kui Yang

The dual role of RFX6 in directing β cell development and insulin production

J Mol Endocrinol.

doi: 10.1530/JME-20-0119.

(IF 3.562)

887. Chun Wang, Jie Luo, Zhihang Chen, Mingliang Ye, Yinghui Hong, Jialiang Liu, Jiayan Nie, Qiu Zhao, Ying Chang

MiR-375 Impairs the Invasive Capabilities of Hepatoma Cells by Targeting HIF1α Under Hypoxia

Dig Dis Sci.

doi: 10.1007/s10620-020-06202-9.

888. Chen-Yang Yuan, Tian-Xing Jing, Wei Li, Xiao-Qiang Liu, Tian-Yuan Liu, Yi Liu, Meng-Ling Chen, Rui-Xu Jiang, Guo-Rui Yuan, Wei Dou, Jin-Jun Wang

NADPH-cytochrome P450 reductase mediates the susceptibility of Asian citrus psyllid Diaphorina citri to imidacloprid and thiamethoxam

Pest Manag Sci.

doi: 10.1002/ps.6143.

(IF 3.75)

889. Bin Qi, Xiaowen Zhang, Hang Yu, Yandong Bao, Nan Wu, Dalin Jia

Brazilin prevents against myocardial ischemia-reperfusion injury through the modulation of Nrf2 via the PKC signaling pathway

Ann Transl Med.

doi: 10.21037/atm-20-4414.

(IF 3.297)

890. Dongli Yue, Shasha Liu, Tengfei Zhang, Yong Wang, Guohui Qin, Xinfeng Chen, Huanyu Zhang, Dong Wang, Dong Huang, Feng Wang, Liping Wang, Song Zhao, Yi Zhang

NEDD9 promotes cancer stemness by recruiting myeloid-derived suppressor cells via CXCL8 in esophageal squamous cell carcinoma

Cancer Biol Med.

doi: 10.20892/j.issn.2095-3941.2020.0290.

(IF 5.432)

891. Xiao Feng, Enfu Huang, Yuanyuan Gao, Ya Zhang, Yun Zhou

The effects of NONRATT008453.2 on autophagy in genital tubercle fibroblasts of rats with hypospadias induced by dibutyl phthalate

Birth Defects Res.

doi: 10.1002/bdr2.1863.

(IF 1.896)

892. H Guo, Y Wang, W Jia, L Liu

MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway

Physiol Res.

doi: 10.33549/physiolres.934506.

(IF 1.655)

893. Yajie Li, Xinliu Zeng, Dingheng Lu, Minuo Yin, Meirong Shan, Ying Gao

Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis

Hum Reprod.

doi: 10.1093/humrep/deaa363.

(IF 5.733)

894. Jun Li, Cuiting Zhao, Qing Zhu, Yonghuai Wang, Guangyuan Li, Xinxin Li, Yuhong Li, Nan Wu, Chunyan Ma

Sweroside Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress and Pyroptosis Partially via Modulation of the Keap1/Nrf2 Axis

Front Cardiovasc Med.

doi: 10.3389/fcvm.2021.650368.

895. Guangqi Liu, Dan Yan, Liu Yang, Yunwei Sun, Lin Zhan, Lili Lu, Zhigang Jin, Chunxiang Zhang, Ping Long, Jinhua Chen, Qiong Yuan

The effect of miR-471-3p on macrophage polarization in the development of diabetic cardiomyopathy

Life Sci.

doi: 10.1016/j.lfs.2020.118989.

(IF 3.647)

896. Yu-Peng Wu, Zhi-Bin Ke, Wen-Cai Zheng, Ye-Hui Chen, Jun-Ming Zhu, Fei Lin, Xiao-Dong Li, Shao-Hao Chen, Hai Cai, Qing-Shui Zheng, Yong Wei, Xue-Yi Xue, Ning Xu

Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells

Cell Death Dis.

doi: 10.1038/s41419-021-03582-2.

(IF 6.304)

897. Guoshu Bi, Donglin Zhu, Yunyi Bian, Yiwei Huang, Cheng Zhan, Yong Yang, Qun Wang

Knockdown of GTF2E2 inhibits the growth and progression of lung adenocarcinoma via RPS4X in vitro and in vivo

Cancer Cell Int.

doi: 10.1186/s12935-021-01878-z.

(IF 4.175)

898. Ting Huang, Xue Li, Fei Wang, Lihong Lu, Wenting Hou, Minmin Zhu, Changhong Miao

The CREB/KMT5A complex regulates PTP1B to modulate high glucose-induced endothelial inflammatory factor levels in diabetic nephropathy

Cell Death Dis.

doi: 10.1038/s41419-021-03629-4.

(IF 6.304)

899. Sheng Li, Di Qi, Jia-Ni Li, Xin-Yu Deng, Dao-Xin Wang

Vagus nerve stimulation enhances the cholinergic anti-inflammatory pathway to reduce lung injury in acute respiratory distress syndrome via STAT3

Cell Death Discov.

doi: 10.1038/s41420-021-00431-1.

900. Zilong Deng, Wenjuan Yan, Xingzhu Dai, Ming Chen, Qian Qu, Buling Wu, Wanghong Zhao

N-Cadherin Regulates the Odontogenic Differentiation of Dental Pulp Stem Cells via β-Catenin Activity

Front Cell Dev Biol.

doi: 10.3389/fcell.2021.661116.

(IF 5.201)

901. Guoyuan Pan, Jingyan Cheng, Weimin Shen, Yao Lin, Anqi Zhu, Lingqin Jin, Qingfeng Xie, Mingjin Zhu, Chan Liu, Fengxia Tu, Xiang Chen

Intensive treadmill training promotes cognitive recovery after cerebral ischemia-reperfusion in juvenile rats

Behav Brain Res.

doi: 10.1016/j.bbr.2020.113085.

(IF 2.977)

902. Ran Li, Qing Ruan, Jia Zheng, Butian Zhang, Hongliang Yang

LINC01116 Promotes Doxorubicin Resistance in Osteosarcoma by Epigenetically Silencing miR-424-5p and Inducing Epithelial-Mesenchymal Transition

Front Pharmacol.

doi: 10.3389/fphar.2021.632206.

(IF 4.225)

903. Min Li, Kun Fan, Bohao Zheng, David Zekria, Tao Suo, Han Liu, Sheng Shen, Houbao Liu, Xiaoling Ni

Knockdown of SLC39A4 Expression Inhibits the Proliferation and Motility of Gallbladder Cancer Cells and Tumor Formation in Nude Mice

Cancer Manag Res.

doi: 10.2147/CMAR.S282269.

(IF 2.886)

904. Yumeng Chen, Xingjia Fan, Xinqing Zhao, Yaling Shen, Xiangyang Xu, Liujing Wei, Wei Wang, Dongzhi Wei

cAMP activates calcium signalling via phospholipase C to regulate cellulase production in the filamentous fungus Trichoderma reesei

Biotechnol Biofuels.

doi: 10.1186/s13068-021-01914-0.

(IF 4.815)

905. Fan Chao, Zhenyu Song, Shiyu Wang, Zhe Ma, Zhiyuan Zhuo, Ting Meng, Guoxiong Xu, Gang Chen

Novel circular RNA circSOBP governs amoeboid migration through the regulation of the miR-141-3p/MYPT1/p-MLC2 axis in prostate cancer

Clin Transl Med.

doi: 10.1002/ctm2.360.

906. Peng Zheng, Yujun Liu, Xuejiao Liu, Yuqing Huang, Feng Sun, Wenyi Wang, Hao Chen, Mehmood Jan, Cuicui Zhang, Yue Yuan, Bao-Cai Tan, Hao Du, Jumin Tu

OsPPR939, a nad5 splicing factor, is essential for plant growth and pollen development in rice

Theor Appl Genet.

doi: 10.1007/s00122-020-03742-6.

(IF 4.439)

907. Xuliang Zhang, Yucong Wang, Xu Yang, Menglin Liu, Wanyue Huang, Jian Zhang, Miao Song, Bing Shao, Yanfei Li

The nephrotoxicity of T-2 toxin in mice caused by oxidative stress-mediated apoptosis is related to Nrf2 pathway

Food Chem Toxicol.

doi: 10.1016/j.fct.2021.112027.

(IF 4.679)

908. Xiao-Yu Dong, Xing Yuan, Ren-Jun Wang

Interaction of air cold plasma with Saccharomyces cerevisiae in the multi-scale microenvironment for improved ethanol yield

Bioresour Technol.

doi: 10.1016/j.biortech.2020.124621.

909. Fang Shen, Xiang Xu, Zhengquan Yu, Haiying Li, Haitao Shen, Xiang Li, Meifen Shen, Gang Chen

Rbfox-1 contributes to CaMKIIα expression and intracerebral hemorrhage-induced secondary brain injury via blocking micro-RNA-124

J Cereb Blood Flow Metab.

doi: 10.1177/0271678X20916860.

910. Xing Li, Bing Hu, Li Wang, Qingqing Xia, Xiuqin Ni

P2X7 receptor-mediated phenotype switching of pulmonary artery smooth muscle cells in hypoxia

Mol Biol Rep.

doi: 10.1007/s11033-021-06222-2.

(IF 1.402)

911. Dan-Dan Wang, Fang Wu, Ling-Yu Zhang, Ying-Cai Zhao, Cheng-Cheng Wang, Chang-Hu Xue, Teruyoshi Yanagita, Tian-Tian Zhang, Yu-Ming Wang

Effects of dietary n-3 PUFA levels in early life on susceptibility to high-fat-diet-induced metabolic syndrome in adult mice

J Nutr Biochem.

doi: 10.1016/j.jnutbio.2020.108578.

(IF 4.873)

912. Lisha Chang, Yunhe Zhang, Min Li, Xiaojing Zhao, Dali Wang, Jian Liu, Fuling Zhou, Jiang Zhang

Nanostructured lipid carrier co-delivering paclitaxel and doxorubicin restrains the proliferation and promotes apoptosis of glioma stem cells via regulating PI3K/Akt/mTOR signaling

Nanotechnology.

doi: 10.1088/1361-6528/abd439.

(IF 3.551)

913. Xiaobao Gong, Hong Tang, Kai Yang

PER1 suppresses glycolysis and cell proliferation in oral squamous cell carcinoma via the PER1/RACK1/PI3K signaling complex

Cell Death Dis.

doi: 10.1038/s41419-021-03563-5.

(IF 6.304)

914. Fang Qu, Yingshuang Song, Yaqin Wu, Yujie Huang, Qi Zhong, Yifan Zhang, Zhen Fan, Chun Xu

The protective role of Ephrin-B2/EphB4 signaling in osteogenic differentiation under inflammatory environment

Exp Cell Res.

doi: 10.1016/j.yexcr.2021.112505.

(IF 3.383)

915. Fengming Chen, Jiayi Chen, Qinghua Chen, Lingyuan Yang, Jie Yin, Yinghui Li, Xingguo Huang

Lactobacillus delbrueckii Protected Intestinal Integrity, Alleviated Intestinal Oxidative Damage, and Activated Toll-Like Receptor-Bruton's Tyrosine Kinase-Nuclear Factor Erythroid 2-Related Factor 2

Antioxidants (Basel).

doi: 10.3390/antiox10030468.

916. Dazhuang Yi, Qunhui Wang, Yuhao Zhao, Yu Song, Hong You, Jian Wang, Renjie Liu, Zhongqiang Shi, Xuan Chen, Qi Luo

Alteration of N 6 -Methyladenosine mRNA Methylation in a Rat Model of Cerebral Ischemia-Reperfusion Injury

Front Neurosci.

doi: 10.3389/fnins.2021.605654.

917. Huiling Li, Yihan Chen, Qiaofeng Jin, Ya Wu, Cheng Deng, Yongkang Gai, Zhenxing Sun, Yuman Li, Jing Wang, Yali Yang, Qing Lv, Yongxue Zhang, Rui An, Xiaoli Lan, Li Zhang, Mingxing Xie

Noninvasive Radionuclide Molecular Imaging of the CD4-Positive T Lymphocytes in Acute Cardiac Rejection

Mol Pharm.

doi: 10.1021/acs.molpharmaceut.0c01155.

918. Xiaolei Yao, M A Ei-Samahy, Shenhua Xiao, Zhibo Wang, Fanxing Meng, Xiaodan Li, Yongjin Bao, Yanli Zhang, Ziyu Wang, Yixuan Fan, Feng Wang

CITED4 mediates proliferation, apoptosis and steroidogenesis of Hu sheep granulosa cells in vitro

Reproduction.

doi: 10.1530/REP-20-0427.

(IF 3.206)

919. Xin-Sen Zou, Lu Xie, Wen-Yan Wang, Gao-Yang Zhao, Xin-Yue Tian, Meng-Hua Chen

Pomelo peel oil alleviates cerebral NLRP3 inflammasome activation in a cardiopulmonary resuscitation rat model

Exp Ther Med.

doi: 10.3892/etm.2021.9664.

(IF 1.785)

920. Xin-Yi Liu, Xue-Jiao Chen, Miao Zhao, Zhi-Qiang Wang, Hai-Zhu Chen, Hong-Fu Li, Chen-Ji Wang, Shi-Fei Wu, Chao Peng, Yue Yin, Hong-Xia Fu, Min-Ting Lin, Long Yu, Zhi-Qi Xiong, Zhi-Ying Wu, Ning Wang

CHIP control degradation of mutant ETF:QO through ubiquitylation in late-onset multiple acyl-CoA dehydrogenase deficiency

J Inherit Metab Dis.

doi: 10.1002/jimd.12361.

(IF 4.036)

921. Xuancheng Zhang, Zhuochang Cai, Minghu Wu, Xiaoqiao Huangfu, Juehong Li, Xudong Liu

Adipose Stem Cell-Derived Exosomes Recover Impaired Matrix Metabolism of Torn Human Rotator Cuff Tendons by Maintaining Tissue Homeostasis

Am J Sports Med.

doi: 10.1177/0363546521992469.

922. Zuping Wu, Chenchen Zhou, Quan Yuan, Demao Zhang, Jing Xie, Shujuan Zou

CTGF facilitates cell-cell communication in chondrocytes via PI3K/Akt signalling pathway

Cell Prolif.

doi: 10.1111/cpr.13001.

923. Lin Li, Haiyan Gan, Huaqian Jin, Yan Fang, Yan Yang, Jianping Zhang, Xiaowei Hu, Lisheng Chu

Astragaloside IV promotes microglia/macrophages M2 polarization and enhances neurogenesis and angiogenesis through PPARγ pathway after cerebral ischemia/reperfusion injury in rats

Int Immunopharmacol.

doi: 10.1016/j.intimp.2020.107335.

(IF 3.943)

924. Xintong Jia, Bin Sun, Qiu Tu, Huaxin Qi, Lin Li, Xiuyun Liu, Lanzhen Yan, Hongjuan Dai, Qingpeng Kong, Chengwei Tang, Xudong Zhao

Smad4 deficiency substitutes Cdkn2b but not Cdkn2a downregulation in pancreatic cancer following induction of genetic events in adult mice

Pancreatology.

doi: 10.1016/j.pan.2021.01.004.

(IF 3.629)

925. Chong Wang, Ying Feng, Wen-Jing Zhou, Zhao-Jun Cheng, Mei-Yan Jiang, Yan Zhou, Xiao-Yang Fei

Screening and identification of endometrial proteins as novel potential biomarkers for repeated implantation failure

PeerJ.

doi: 10.7717/peerj.11009.

(IF 2.379)

926. Dandan Wu, Yufeng Zhu

Role of kynurenine in promoting the generation of exhausted CD8+ T cells in colorectal cancer

Am J Transl Res.

(IF 3.375)

927. Jinguo Wang, Sheng Xie, Jun Liu, Tao Li, Wanrong Wang, Ziping Xie

MicroRNA-4429 suppresses proliferation of prostate cancer cells by targeting distal-less homeobox 1 and inactivating the Wnt/β-catenin pathway

BMC Urol.

doi: 10.1186/s12894-021-00810-x.

(IF 1.592)

928. Yanfei Yang, Yabin Li, Jinli Han, Yanfen Wang

Gastrodin attenuates lithium-pilocarpine-induced epilepsy by activating AMPK-mediated PPARα in a juvenile rat model

Biosci Biotechnol Biochem.

doi: 10.1093/bbb/zbab013.

929. Wei Yuan, Liaoxun Lu, Muding Rao, Yang Huang, Chun-E Liu, Shuang Liu, Yue Zhao, Huicong Liu, Jiangli Zhu, Tianzhu Chao, Can Wu, Junyan Ren, Luxian Lv, Wenqiang Li, Shiqian Qi, Yinming Liang, Shijing Yue, Jian Gao, Zhongjian Zhang, Eryan Kong

GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice

Proc Natl Acad Sci U S A.

doi: 10.1073/pnas.2022261118.

930. Wei Zhao, Youyang Wu, Fanhao Ye, Shiwei Huang, Hao Chen, Rui Zhou, Wenbing Jiang

Tetrandrine Ameliorates Myocardial Ischemia Reperfusion Injury through miR-202-5p/TRPV2

Biomed Res Int.

doi: 10.1155/2021/8870674.

(IF 2.276)

931. Weimin Shen, Lingqin Jin, Anqi Zhu, Yao Lin, Guoyuan Pan, Shanshan Zhou, Jingyan Cheng, Jieqiong Zhang, Fengxia Tu, Chan Liu, Qingfeng Xie, Xiang Chen

Treadmill exercise enhances synaptic plasticity in the ischemic penumbra of MCAO mice by inducing the expression of Camk2a via CYFIP1 upregulation

Life Sci.

doi: 10.1016/j.lfs.2021.119033.

(IF 3.647)

932. Jiye Chen, Yongjian Zhang, Yongcheng Wang, Ping Jiang, Guofeng Zhou, Zhaoyu Li, Jinlong Yang, Xiao Li

Potential mechanisms of Guizhi decoction against hypertension based on network pharmacology and Dahl salt-sensitive rat model

Chin Med.

doi: 10.1186/s13020-021-00446-x.

933. J Y Fu, C X Jiang, M Y Wu, R Y Mei, A F Yang, H P Tao, X J Chen, J Zhang, L Huang, X F Zhao

Theabrownin Induces Cell Apoptosis and Cell Cycle Arrest of Oligodendroglioma and Astrocytoma in Different Pathways

Front Pharmacol.

doi: 10.3389/fphar.2021.664003.

(IF 4.225)

934. Peng Xiao, Yu-Kang Liu, Wei Han, Yan Hu, Bo-You Zhang, Wen-Liang Liu

Exosomal Delivery of FTO Confers Gefitinib Resistance to Recipient Cells through ABCC10 Regulation in an m6A-dependent Manner

Mol Cancer Res.

doi: 10.1158/1541-7786.MCR-20-0541.

(IF 4.63)

935. Yu Liu, Lili Zou, Peng Wang, Jingxuan Zhou, Chunling Yuan, Jun Wang

Construction of differential expression plasmids of NGF to detect its influence on PC12 cell neuronal differentiation

Exp Ther Med.

doi: 10.3892/etm.2021.9794.

(IF 1.785)

936. Yan Zhang, Xiaomei Yang, Shuang Wang, Shuang Song, Xiudong Yang

Gentiopicroside prevents alcoholic liver damage by improving mitochondrial dysfunction in the rat model

Phytother Res.

doi: 10.1002/ptr.6981.

(IF 4.087)

937. Zhan Ye, Yong-Jiang Xu, Yuanfa Liu

Influence of different dietary oil consumption on nutrient malabsorption: An animal trial using Sprague Dawley rats

J Food Biochem.

doi: 10.1111/jfbc.13695.

(IF 1.662)

938. Yong Wang, Rongfen Gao, Jinpeng Li, Shaotao Tang, Shuai Li, Qiangsong Tong, Shiwang Li

Downregulation of hsa_circ_0074854 Suppresses the Migration and Invasion in Hepatocellular Carcinoma via Interacting with HuR and via Suppressing Exosomes-Mediated Macrophage M2 Polarization

Int J Nanomedicine.

doi: 10.2147/IJN.S284560.

939. Da Zhong, Gan-Zhe Xu, Ju-Zhi Wu, Hua Liu, Ju-Yu Tang, Cheng-Gong Wang

Circ-ITCH sponges miR-214 to promote the osteogenic differentiation in osteoporosis via upregulating YAP1

Cell Death Dis.

doi: 10.1038/s41419-021-03586-y.

(IF 6.304)

940. Yu Cai, Mingtian Deng, Qifan Zhang, Zifei Liu, Liang Wang, Wenwen Sheng, Yanli Zhang, Peihua You, Ziyu Wang, Feng Wang

Effects of dietary betaine supplementation on biochemical parameters of blood and testicular oxidative stress in Hu sheep

Theriogenology.

doi: 10.1016/j.theriogenology.2021.01.006.

(IF 2.094)

941. Shanshan Xu, Xuefeng Xu, Ziming Zhang, Lingling Yan, Liyan Zhang, Lizhong Du

The role of RNA m6A methylation in the regulation of postnatal hypoxia-induced pulmonary hypertension

Respir Res.

doi: 10.1186/s12931-021-01728-6.

942. Shaozhi Hou, Yang Song, Di Sun, Shujun Zhu, Zhenhua Wang

Xanthohumol-Induced Rat Glioma C6 Cells Death by Triggering Mitochondrial Stress

Int J Mol Sci.

doi: 10.3390/ijms22094506.

(IF 4.556)

943. Xiang Wang, Srinivasan Balamurugan, Si-Fen Liu, Chang-Yang Ji, Yu-Hong Liu, Wei-Dong Yang, Liwen Jiang, Hong-Ye Li

Hydrolysis of organophosphorus by diatom purple acid phosphatase and sequential regulation of cell metabolism

J Exp Bot.

doi: 10.1093/jxb/erab026.

(IF 5.908)

944. Qun Zhao, Jian Guo, Xinran Cheng, Yingying Liao, Yun Bi, Yingxia Gong, Xudong Zhang, Yang Guo, Xianhui Wang, Wei Yu, Shu Jin, Yan Tan, Xianjun Yu

RIPK3 Suppresses the Progression of Spontaneous Intestinal Tumorigenesis

Front Oncol.

doi: 10.3389/fonc.2021.664927.

(IF 4.848)

945. Cong Han, Yue-Hua Jiang, Wei Li, Yao Liu

Astragalus membranaceus and Salvia miltiorrhiza ameliorates cyclosporin A-induced chronic nephrotoxicity through the "gut-kidney axis"

J Ethnopharmacol.

doi: 10.1016/j.jep.2020.113768.

(IF 3.69)

946. Yan Wang, Jianji Gao, Fan Wu, Caiyun Lai, Yueqi Li, Gaoqiang Zhang, Xinyue Peng, Susu Yu, Jiani Yang, Wei Wang, Wenjuan Zhang, Xingfen Yang

Biological and epigenetic alterations of mitochondria involved in cellular replicative and hydrogen peroxide-induced premature senescence of human embryonic lung fibroblasts

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2021.112204.

947. Pan Wang, Hai-Juan Sui, Xiao-Jia Li, Li-Na Bai, Jing Bi, Hong Lai

Melatonin ameliorates microvessel abnormalities in the cerebral cortex and hippocampus in a rat model of Alzheimer's disease

Neural Regen Res.

doi: 10.4103/1673-5374.295349.

(IF 3.171)

948. Yan Yang, Chen Zhang, Shu Li, Jialun Liu, Yiyu Qin, Anxing Ge

Tissue factor pathway inhibitor 2 suppresses the growth of thyroid cancer cells through by induction of apoptosis

Asia Pac J Clin Oncol.

doi: 10.1111/ajco.13298.

949. Ling Zhang, Jin Zhang, Shujing Li, Yanyan Zhang, Yun Liu, Jian Dong, Wenjun Zhao, Bo Yu, Huifang Wang, Jing Liu

Genomic amplification of long noncoding RNA HOTAIRM1 drives anaplastic thyroid cancer progression via repressing miR-144 biogenesis

RNA Biol.

doi: 10.1080/15476286.2020.1819670.

(IF 5.35)

950. Guohong Shi, Zhen Zhang

Rap2B promotes the proliferation and migration of human glioma cells via activation of the ERK pathway

Oncol Lett.

doi: 10.3892/ol.2021.12575.

(IF 2.311)

951. Bin Li, Pei-Jun Xie, Yan-Wei Hao, Yu Guo, Jun-Rong Yu, Dao-Yin Gong, Jing Guo, Jin-Hao Zeng, Yi Zhang

Yuan‑zhi‑san inhibits tau protein aggregation in an Aβ1‑40‑induced Alzheimer's disease rat model via the ubiquitin‑proteasome system

Mol Med Rep.

doi: 10.3892/mmr.2021.11918.

(IF 2.1)

952. Hao Liu, Changying Wang, Gen Liu, Yanping Li, Li Kang, Yi Sun, Yunliang Jiang

A 14 bp indel polymorphism in the promoter region is associated with different responses to porcine circovirus type 2 infection by regulating MRC1 transcription

Vet Immunol Immunopathol.

doi: 10.1016/j.vetimm.2021.110202.

953. Haoran Zhang, Shixuan Zhuo, Danni Song, Leyao Wang, Junyi Gu, Junyan Ma, Yang Gu, Minghui Ji, Meijuan Chen, Yuanyuan Guo

Icariin Inhibits Intestinal Inflammation of DSS-Induced Colitis Mice Through Modulating Intestinal Flora Abundance and Modulating p-p65/p65 Molecule

Turk J Gastroenterol.

doi: 10.5152/tjg.2021.20282.

(IF 1.111)

954. Xianjing Zheng, Haimei Liu, Maoqiang Ma, Jianbo Ji, Faliang Zhu, Longru Sun

Anti-thrombotic activity of phenolic acids obtained from Salvia miltiorrhiza f. alba in TNF-α-stimulated endothelial cells via the NF-κB/JNK/p38 MAPK signaling pathway

Arch Pharm Res.

doi: 10.1007/s12272-021-01325-7.

(IF 2.934)

955. Yaoguang Gu, Xiang Xiao, Ruirong Pan, Jiayan Zhang, Yansheng Zhao, Ying Dong, Henglin Cui

Lactobacillus plantarum dy-1 fermented barley extraction activates white adipocyte browning in high-fat diet-induced obese rats

J Food Biochem.

doi: 10.1111/jfbc.13680.

(IF 1.662)

956. Yuqi Zhou, Xiangyong Li, Min Ye

Morusin inhibits the growth of human colorectal cancer HCT116‑derived sphere‑forming cells via the inactivation of Akt pathway

Int J Mol Med.

doi: 10.3892/ijmm.2021.4884.

(IF 3.098)

957. Jun Miao, Bo Wang, Ran Shao, Yan Wang

CircUSP36 knockdown alleviates oxidized low‑density lipoprotein‑induced cell injury and inflammatory responses in human umbilical vein endothelial cells via the miR‑20a‑5p/ROCK2 axis

Int J Mol Med.

doi: 10.3892/ijmm.2021.4873.

(IF 3.098)

958. Qingling Wang, Wenjuan Wang, Aihau Zhang

TET-mediated DNA demethylation plays an important role in arsenic-induced HBE cells oxidative stress via regulating promoter methylation of OGG1 and GSTP1

Toxicol In Vitro.

doi: 10.1016/j.tiv.2020.105075.

(IF 2.959)

959. Kai Zhu, Ying Li, Yikai Xu

The FTO m 6 A demethylase inhibits the invasion and migration of prostate cancer cells by regulating total m 6 A levels

Life Sci.

doi: 10.1016/j.lfs.2021.119180.

(IF 3.647)

960. Jie Wan, Chu-Meng Shen, Yu Wang, Qing-Zi Wu, Yi-Lei Wang, Qiang Liu, Yi-Man Sun, Jun-Ping Cao, Yu-Qing Wu

Repeated exposure to propofol in the neonatal period impairs hippocampal synaptic plasticity and the recognition function of rats in adulthood

Brain Res Bull.

doi: 10.1016/j.brainresbull.2021.01.007.

(IF 3.37)

961. Dongfang Tang, Tao Huang, Qilong Tian, Julei Wang

MYC/NBS1-Mediated DNA Damage Response is Involved in the Inhibitory Effect of Hydroxysafflor Yellow A on Glioma Cells

Drug Des Devel Ther.

doi: 10.2147/DDDT.S288841.

962. Yali Chen, Mengchan Ou, Xuechao Hao, Peng Liang, Yan Liang, Yangyang Wang, Yu Li, Cheng Zhou

Sub-chronic exposure to morphine alters general anesthetic potency by differentially regulating the expression of neurotransmitter receptor subunits in mice

Brain Res Bull.

doi: 10.1016/j.brainresbull.2021.01.009.

(IF 3.37)

963. Datong Sun, Shenghui Yang, Xufeng Zhang, Sai Li, Lin Wang, Junmin Chen, Chun Qiu, Ke Xu

Forkhead box protein O3a promotes glioma cell resistance to temozolomide by regulating matrix metallopeptidase and β-catenin

Oncol Lett.

doi: 10.3892/ol.2021.12580.

(IF 2.311)

964. Yinghua Li, Jian Zhou

USP5 Promotes Uterine Corpus Endometrial Carcinoma Cell Growth and Migration via mTOR/4EBP1 Activation

Cancer Manag Res.

doi: 10.2147/CMAR.S290467.

(IF 2.886)

965. Yicheng Tian, Jian Gou, He Zhang, Jinghan Lu, Zhuangzhuang Jin, Shuangshuo Jia, Lunhao Bai

The anti-inflammatory effects of 15-HETE on osteoarthritis during treadmill exercise

Life Sci.

doi: 10.1016/j.lfs.2021.119260.

(IF 3.647)

966. Ying Xiao, Lei Xie, Qi-Ya Xu, Li Chen, Huan Chen, Guang-Yin Xu, Ping-An Zhang

Transcranial direct current stimulation relieves visceral hypersensitivity via normalizing GluN2B expression and neural activity in anterior cingulate cortex

J Neurophysiol.

doi: 10.1152/jn.00025.2021.

(IF 2.225)

967. Ziqing Wang, Wenwen Mu, Pengxiao Li, Guoyun Liu, Jie Yang

Anti-inflammatory activity of ortho-trifluoromethoxy-substituted 4-piperidione-containing mono-carbonyl curcumin derivatives in vitro and in vivo

Eur J Pharm Sci.

doi: 10.1016/j.ejps.2021.105756.

(IF 3.616)

968. Yanan Ding, Longlin Zhang, Xiaofeng Yao, Haihan Zhang, Xi He, Zhiyong Fan, Zehe Song

Honokiol Alleviates High-Fat Diet-Induced Obesity of Mice by Inhibiting Adipogenesis and Promoting White Adipose Tissue Browning

Animals (Basel).

doi: 10.3390/ani11061493.

969. Qingqing Yin, Tong Du, Chunlin Yang, Xiaoli Li, Zeyu Zhao, Rutao Liu, Bing Yang, Bin Liu

Gadd45b is a novel mediator of depression-like behaviors and neuroinflammation after cerebral ischemia

Biochem Biophys Res Commun.

doi: 10.1016/j.bbrc.2021.03.104.

970. Juanjuan Zhang, Ying Xu, Ying Zhao, Jingkun Bai, Mengge Xu, Chuanji Li, Jinyue Li, Yong Ren, Chang Xu, Yuguang Gao, Yan Sun, Xiaoying Liu

The absence of muscle segment homeobox 2 leads to the pyroptosis of ameloblasts by inducing squamous epithelial hyperplasia in the enamel organ

J Cell Mol Med.

doi: 10.1111/jcmm.16646.

(IF 4.486)

971. Yang Guo, Youbing Wu, Jiahao Shi, Hua Zhuang, Lei Ci, Qin Huang, Zhipeng Wan, Hua Yang, Mengjie Zhang, Yutong Tan, Ruilin Sun, Leon Xu, Zhugang Wang, Ruling Shen, Jian Fei

miR-29a/b1 Regulates the Luteinizing Hormone Secretion and Affects Mouse Ovulation

Front Endocrinol (Lausanne).

doi: 10.3389/fendo.2021.636220.

972. Zuotian Wu, Gaohua Wang, Lin Zhou, Limin Sun, Yumeng Xie, Ling Xiao

Neuroinflammation decreased hippocampal microtubule dynamics in the acute behavioral deficits induced by intracerebroventricular injection of lipopolysaccharide in male adult rats

Neuroreport.

doi: 10.1097/WNR.0000000000001638.

(IF 1.394)

973. Hang Deng, Liugen Zeng, Kaile Chang, Yangfeng Lv, Hailing Du, Shina Lu, Yapeng Liu, Pengcheng Zhou, Huiling Mao, Chengyu Hu

Grass carp (Ctenopharyngodon idellus) Cdc25a down-regulates IFN 1 expression by reducing TBK1 phosphorylation

Dev Comp Immunol.

doi: 10.1016/j.dci.2021.104014.

(IF 3.192)

974. Mengyuan Li, Wen Xue, Xinhua Li, Yaxiang Song, Xinying Liu, Ling Qin

Axl is related to inflammation in hemodialysis patients

Mol Immunol.

doi: 10.1016/j.molimm.2021.02.024.

(IF 3.641)

975. Wuxue Peng, Xi Liu, Changhong Tan, Wen Zhou, Jin Jiang, Xuan Zhou, Juncong Du, Lijuan Mo, Lifen Chen

Zinc-α2-glycoprotein relieved seizure-Induced neuronal glucose uptake impairment via insulin-like growth factor 1 receptor-regulated glucose transporter 3 expression

J Neurochem.

doi: 10.1111/jnc.15254.

(IF 4.066)

976. Yang Yang, Ying Xiong, Hong-Fei Li, Huai-Jia Zhao, Guang-Hui Tang, Li-Wei Meng, Jin-Jun Wang, Hong-Bo Jiang

The adipokinetic hormone signaling system regulates the sensitivity of Bactrocera dorsalis to malathion

Pestic Biochem Physiol.

doi: 10.1016/j.pestbp.2021.104808.

977. Likun Yang, Xifeng Zhang, Xiufen Liu

Long non‑coding RNA GAS5 protects against Mycoplasma pneumoniae pneumonia by regulating the microRNA‑222‑3p/TIMP3 axis

Mol Med Rep.

doi: 10.3892/mmr.2021.12019.

(IF 2.1)

978. Yan Liu, Shuting Li, Yao Liu, Xujing Lv, Qing Zhou

MicroRNA-124 facilitates lens epithelial cell apoptosis by inhibiting SPRY2 and MMP-2

Mol Med Rep.

doi: 10.3892/mmr.2021.12020.

(IF 2.1)

979. Wei Guo, Zi-Yang Tang, Zhen-Yu Cai, Wen-E Zhao, Jin Yang, Xi-Peng Wang, Juan Ji, Xin-Xin Huang, Xiu-Lan Sun

Iptakalim alleviates synaptic damages via targeting mitochondrial ATP-sensitive potassium channel in depression

FASEB J.

doi: 10.1096/fj.202100124RR.

(IF 4.966)

980. Jiefeng Geng, Haibiao Zhao, Xing Liu, Junjie Geng, Yuyuan Gao, Bingzheng He

MiR-101a-3p Attenuated Pilocarpine-Induced Epilepsy by Downregulating c-FOS

Neurochem Res.

doi: 10.1007/s11064-021-03245-w.

(IF 3.038)

981. Suoli Cheng, Xueqin Liu, Fan Gong, Xiaoling Ding, Xuebing Zhou, Cuiyun Liu, Fei Zhao, Xiaoliang Li, Jiandang Shi

Dexamethasone promotes the endoplasmic reticulum stress response of bone marrow mesenchymal stem cells by activating the PERK-Nrf2 signaling pathway

Pharmacol Res Perspect.

doi: 10.1002/prp2.791.

982. Jiayan Chen, Liping Lu, Chunlong Zhang, Xiaoming Zhu, Shulin Zhuang

Endothelial dysfunction and transcriptome aberration in mouse aortas induced by black phosphorus quantum dots and nanosheets

Nanoscale.

doi: 10.1039/d1nr01965a.

(IF 6.895)

983. Wenli Luo, Li Li, Weina Xu, Jing Zhang, Jianxiong Xu

Toxic Effects of Docosahexaenoic Acid Treatment in the Rat Liver BRL-3A Cell

Toxics.

doi: 10.3390/toxics9050112.

984. Xiao-Fei Zhang, Jian-Xiong Ma, Yuan-Lin Wang, Xin-Long Ma

Calcyclin (S100A6) Attenuates Inflammatory Response and Mediates Apoptosis of Chondrocytes in Osteoarthritis via the PI3K/AKT Pathway

Orthop Surg.

doi: 10.1111/os.12990.

(IF 1.718)

985. Aonan Pan, Yue Li, Jian Guan, Pengxia Zhang, Chunbin Zhang, Yupeng Han, Tao Zhang, Yao Cheng, Luo Sun, Shizhen Lu, Jinru Weng, Qiaosheng Ren, Shengjie Fan, Weiqun Wang, Jingtao Wang

USP18-deficiency in cervical carcinoma is crucial for the malignant behavior of tumor cells in an ERK signal-dependent manner

Oncol Lett.

doi: 10.3892/ol.2021.12682.

(IF 2.311)

986. Hui-Li Wang, Guang-Dong Xing, Yong Qian, Xue-Feng Sun, Ji-Feng Zhong, Kun-Lin Chen

Dihydromyricetin attenuates heat stress-induced apoptosis in dairy cow mammary epithelial cells through suppressing mitochondrial dysfunction

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2021.112078.

987. Jun-Hua Huang, Hua Duan, Sha Wang, Yi-Yi Wang

Estrogen 17β‑estradiol accelerates the proliferation of uterine junctional zone smooth muscle cells via the let‑7a/Lin28B axis in adenomyosis

Mol Med Rep.

doi: 10.3892/mmr.2021.11976.

(IF 2.1)

988. Zhen Lan, Zhaoyou Meng, Biyao Lian, Mengying Liu, Tao Sun, Huan Sun, Zhi Liu, Zhenxin Hu, Qiang Guo, Jiqiang Zhang

Hippocampal Aromatase Knockdown Aggravates Ovariectomy-Induced Spatial Memory Impairment, Aβ Accumulation and Neural Plasticity Deficiency in Adult Female Mice

Neurochem Res.

doi: 10.1007/s11064-021-03258-5.

(IF 3.038)

989. Ran Tian, Xin Guan, Hao Qian, Liang Wang, Zhujun Shen, Ligang Fang, Zhenyu Liu

Restoration of NRF2 attenuates myocardial ischemia reperfusion injury through mediating microRNA-29a-3p/CCNT2 axis

Biofactors.

doi: 10.1002/biof.1712.

(IF 4.734)

990. Yuhua Li, Na Wang, Zhongliang Ma, Yunwen Wang, Yuan Yuan, Zhitao Zhong, Yi Hong, Min Zhao

Lipoxin A4 protects against paraquat‑induced acute lung injury by inhibiting the TLR4/MyD88‑mediated activation of the NF‑κB and PI3K/AKT pathways

Int J Mol Med.

doi: 10.3892/ijmm.2021.4919.

(IF 3.098)

991. Huimin Lu, Yanchao Ma, Mingyuan Wang, Jin Shen, Hongya Wu, Juntao Li, Nan Gao, Yanzheng Gu, Xueguang Zhang, Guangbo Zhang, Tongguo Shi, Weichang Chen

B7-H3 confers resistance to Vγ9Vδ2 T cell-mediated cytotoxicity in human colon cancer cells via the STAT3/ULBP2 axis

Cancer Immunol Immunother.

doi: 10.1007/s00262-020-02771-w.

992. Zhicheng Zhao, Li Lu, Weidong Li

N-(3',4'-dimethoxycinnamonyl) anthranilic acid alleviates severe acute pancreatitis by inhibiting intestinal barrier dysfunction and NF-κB activation

Drug Dev Res.

doi: 10.1002/ddr.21769.

993. Li Zhou, Xinrong Tao, Gang Pang, Min Mu, Qixian Sun, Fei Liu, Yuting Hu, Huihui Tao, Bing Li, Keyi Xu

Maternal Nicotine Exposure Alters Hippocampal Microglia Polarization and Promotes Anti-inflammatory Signaling in Juvenile Offspring in Mice

Front Pharmacol.

doi: 10.3389/fphar.2021.661304.

(IF 4.225)

994. Wenfei Zhang, Liang Xiong, Jiaming Chen, Zhezhe Tian, Jiaxin Liu, Fang Chen, Man Ren, Wutai Guan, Shihai Zhang

Artemisinin Protects Porcine Mammary Epithelial Cells against Lipopolysaccharide-Induced Inflammatory Injury by Regulating the NF-κB and MAPK Signaling Pathways

Animals (Basel).

doi: 10.3390/ani11061528.

995. Li Zhang, Xiufen Chen, Mingxiu Chang, Boning Jiao

MiR-30c-5p/ATG5 Axis Regulates the Progression of Parkinson's Disease

Front Cell Neurosci.

doi: 10.3389/fncel.2021.644507.

(IF 3.921)

996. Hai-Rong Zhang, Shi-Yong Wu, Zhong-Xue Fu

LncRNA-cCSC1 promotes cell proliferation of colorectal cancer through sponging miR-124-3p and upregulating CD44

Biochem Biophys Res Commun.

doi: 10.1016/j.bbrc.2021.04.018.

997. Chao Hu, Yuzhen Li, Danting Pan, Jing Wang, Liufang Zhu, Yu Lin, Shanli Zhu, Weiqing Pan

A Schistosoma japonicum MicroRNA Exerts Antitumor Effects Through Inhibition of Both Cell Migration and Angiogenesis by Targeting PGAM1

Front Oncol.

doi: 10.3389/fonc.2021.652395.

(IF 4.848)

998. Jin Wang, Lirong Tan, Beibei Jia, Xiaofan Yu, Ruixin Yao, Nan OUYang, Xueting Yu, Xiyuan Cao, Jian Tong, Tao Chen, Rui Chen, Jianxiang Li

Downregulation of m6A Reader YTHDC2 Promotes the Proliferation and Migration of Malignant Lung Cells via CYLD/NF-κB Pathway

Int J Biol Sci.

doi: 10.7150/ijbs.58514.

(IF 4.858)

999. Chaochao Luo, Wanwan Peng, Jia Kang, Caiming Chen, Jiajia Peng, Yue Wang, Qian Tang, Hailong Xie, Yazi Li, Xinghua Pan

Glutamine Regulates Cell Growth and Casein Synthesis through the CYTHs/ARFGAP1-Arf1-mTORC1 Pathway in Bovine Mammary Epithelial Cells

J Agric Food Chem.

doi: 10.1021/acs.jafc.1c02223.

1000. Lin Ding, Zhen-Jing Xu, Hao-Hao Shi, Chang-Hu Xue, Qing-Rong Huang, Teruyoshi Yanagita, Yu-Ming Wang, Tian-Tian Zhang

Sterol sulfate alleviates atherosclerosis via mediating hepatic cholesterol metabolism in ApoE-/- mice

Food Funct.

doi: 10.1039/d0fo03266b.

(IF 4.171)

1001. Qiuling Fu, Zuyun Wei, Yuhong Chen, Jingguang Xie, Xiangyang Zhang, Tianliang He, Xinhua Chen

Development of monoclonal antibody against IgT of a perciform fish, large yellow croaker (Larimichthys crocea) and characterization of IgT+ B cells

Dev Comp Immunol.

doi: 10.1016/j.dci.2021.104027.

(IF 3.192)

1002. Xingyu Ma, Xiaoli Li, Qianqian Di, Xibao Zhao, Ruihan Zhang, Yue Xiao, Ping Sun, Haimei Tang, Jiazheng Quan, Weilie Xiao, Weilin Chen

Natural molecule Munronoid I attenuates LPS-induced acute lung injury by promoting the K48-linked ubiquitination and degradation of TAK1

Biomed Pharmacother.

doi: 10.1016/j.biopha.2021.111543.

(IF 4.545)

1003. Qirong Lu, Siyi Hu, Pu Guo, Xiaohui Zhu, Zhongchang Ren, Qinghua Wu, Xu Wang

PPAR-γ with its anti-fibrotic action could serve as an effective therapeutic target in T-2 toxin-induced cardiac fibrosis of rats

Food Chem Toxicol.

doi: 10.1016/j.fct.2021.112183.

(IF 4.679)

1004. Jiapeng Hu, Jia Wang, Chunlu Li, Yunxiao Shang

Fructose-1,6-bisphosphatase aggravates oxidative stress-induced apoptosis in asthma by suppressing the Nrf2 pathway

J Cell Mol Med.

doi: 10.1111/jcmm.16439.

(IF 4.486)

1005. Jie Ren, Zhen Ding, Puxian Fang, Shaobo Xiao, Liurong Fang

ATPase and helicase activities of porcine epidemic diarrhea virus nsp13

Vet Microbiol.

doi: 10.1016/j.vetmic.2021.109074.

(IF 3.03)

1006. Yan-Long Tang, Xiao-Bo Wang, Yue Zhou, Ya-Ping Wang, Ji-Chao Ding

Ginsenoside Rg1 induces senescence of leukemic stem cells by upregulating p16INK4a and downregulating hTERT expression

Adv Clin Exp Med.

doi: 10.17219/acem/133485.

(IF 1.514)

1007. Xiunan Kong, Xiu Wang, Yumei Qin, Jianzhong Han

Effects of sunset yellow on proliferation and differentiation of intestinal epithelial cells in murine intestinal organoids

J Appl Toxicol.

doi: 10.1002/jat.4080.

(IF 2.997)

1008. Xiaohui Xu, Yong Wu, Ke Yi, Yan Hu, Weiqun Ding, Chungen Xing

IRF1 regulates the progression of colorectal cancer via interferon‑induced proteins

Int J Mol Med.

doi: 10.3892/ijmm.2021.4937.

(IF 3.098)

1009. Haiyan Xu, Dan Song, Renfang Xu, Xiaozhou He

BAFF signaling drives interstitial transformation of mouse renal tubular epithelial cells in a Pin1-dependent manner

In Vitro Cell Dev Biol Anim.

doi: 10.1007/s11626-021-00598-y.

1010. Hengxiao Lu, Hao Wang, Peidao Sun, Jiang Wang, Shuhai Li, Tongzhen Xu

MiR-522-3p inhibits proliferation and activation by regulating the expression of SLC31A1 in T cells

Cytotechnology.

doi: 10.1007/s10616-021-00472-5.

(IF 1.777)

1011. Haifeng Yu, Shuailing Peng, Shuiyun Han, Xi Chen, Qinghua Lyu, Tao Lei

Distinct Molecular Subtypes of Diffuse Large B Cell Lymphoma Patients Treated with Rituximab-CHOP Are Associated with Different Clinical Outcomes and Molecular Mechanisms

Biomed Res Int.

doi: 10.1155/2021/5514726.

(IF 2.276)

1012. Wenjing Ma, Yong Cai, Yuntian Shen, Xin Chen, Lilei Zhang, Yanan Ji, Zehao Chen, Jianwei Zhu, Xiaoming Yang, Hualin Sun

HDAC4 Knockdown Alleviates Denervation-Induced Muscle Atrophy by Inhibiting Myogenin-Dependent Atrogene Activation

Front Cell Neurosci.

doi: 10.3389/fncel.2021.663384.

(IF 3.921)

1013. Yuhua He, Jiaqi Chen, Qiyue Zhang, Jialong Zhang, Lulai Wang, Xiaoxia Chen, Adrian J Molenaar, Xuezhao Sun

α-Chaconine Affects the Apoptosis, Mechanical Barrier Function, and Antioxidant Ability of Mouse Small Intestinal Epithelial Cells

Front Plant Sci.

doi: 10.3389/fpls.2021.673774.

(IF 4.402)

1014. Xia Wang, Yansong Ge, Mingqi Shi, Hanhan Dai, Wei Liu, Peiyuan Wang

Protein kinase N1 promotes proliferation and invasion of liver cancer

Exp Ther Med.

doi: 10.3892/etm.2021.10083.

(IF 1.785)

1015. Xiaoli Liao, Yue Li, Zhenzhu Hu, Ying Lin, Bo Zheng, Jihua Ding

Poplar acetylome profiling reveals lysine acetylation dynamics in seasonal bud dormancy release

Plant Cell Environ.

doi: 10.1111/pce.14040.

(IF 6.362)

1016. Shuo Zhou, Yanfen Ma, Jinwei Yao, An Zhao, Chukang Xie, Yuling Mi, Caiqiao Zhang

TGF-β1-induced collagen promotes chicken ovarian follicle development via an intercellular cooperative pattern

Cell Biol Int.

doi: 10.1002/cbin.11580.

(IF 2.571)

1017. Zhuang Shen, Zhen Liu, Xin Rui, Xiaohong Chen, Mei Jiang, Mingsheng Dong

Effects of fat content on the textural and in vivo buccal breakdown properties of soy yogurt

J Texture Stud.

doi: 10.1111/jtxs.12584.

(IF 1.902)

1018. Tao Li, Yingchun Wan, Ziyuan Su, Jiayu Li, Minna Han, Changyu Zhou

Mesenchymal Stem Cell-Derived Exosomal microRNA-3940-5p Inhibits Colorectal Cancer Metastasis by Targeting Integrin α6

Dig Dis Sci.

doi: 10.1007/s10620-020-06458-1.

1019. Shanshan Jia, Pin Guo, Junhua Lu, Xujun Huang, Laming Deng, Yan Jin, Lanyan Zhao, Xiaofang Fan

Curcumol Ameliorates Lung Inflammation and Airway Remodeling via Inhibiting the Abnormal Activation of the Wnt/β-Catenin Pathway in Chronic Asthmatic Mice

Drug Des Devel Ther.

doi: 10.2147/DDDT.S292642.

1020. Wei Feng

Tectorigenin attenuates cognitive impairments in mice with chronic cerebral ischemia by inhibiting the TLR4/NF-κB signaling pathway

Biosci Biotechnol Biochem.

doi: 10.1093/bbb/zbab086.

1021. Hongyan Wang, Huaiqing Gao

Protective effects of repetitive transcranial magnetic stimulation against 6-OHDA-induced Parkinson's symptoms in a mice model: the key role of miR-409-3p/PDHB axis

Int J Neurosci.

doi: 10.1080/00207454.2021.1938037.

(IF 2.107)

1022. Huiying Pan, Yi Xu, Qian Cai, Meiling Wu, Mingxing Ding

Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism

Med Sci Monit.

doi: 10.12659/MSM.931884.

1023. Zupeng Luo, Hailong Hu, Siqi Liu, Zhiwang Zhang, Yixing Li, Lei Zhou

Comprehensive analysis of the translatome reveals the relationship between the translational and transcriptional control in high fat diet-induced liver steatosis

RNA Biol.

doi: 10.1080/15476286.2020.1827193.

(IF 5.35)

1024. Ying Liang, Wen-Yu Tian, Juan-Juan Huang, Ling-Xi Gao, Xiao-Hui Fan

MicroRNA-204 plays a role as a tumor suppressor in Newcastle disease virus-induced oncolysis in lung cancer A549 cells

Oncol Lett.

doi: 10.3892/ol.2021.12743.

(IF 2.311)

1025. Jinhui Dong, Ou Xu, Jianxing Wang, Chunguang Shan, Xiumin Ren

Luteolin ameliorates inflammation and Th1/Th2 imbalance via regulating the TLR4/NF-κB pathway in allergic rhinitis rats

Immunopharmacol Immunotoxicol.

doi: 10.1080/08923973.2021.1905659.

1026. Qian Chai, Jiajing Miao, Meili Liu, Ziying Zhang, Ziang Meng, Weihua Wu

Knockdown of SGLT1 prevents the apoptosis of cardiomyocytes induced by glucose fluctuation via relieving oxidative stress and mitochondrial dysfunction

Biochem Cell Biol.

doi: 10.1139/bcb-2020-0491.

(IF 2.46)

1027. Lichuang Zhang, Hao Xu, Ziyi Cheng, Yan Wei, Ruize Sun, Ziwei Liang, Yinchun Hu, Liqin Zhao, Xiaojie Lian, Xia Li, Di Huang

Human Cancer Cell Membrane-Cloaked Fe3O4 Nanocubes for Homologous Targeting Improvement

J Phys Chem B.

doi: 10.1021/acs.jpcb.1c04383.

(IF 2.857)

1028. Wei Guo, Shan Liu, Xinting Zheng, Zhiwei Xiao, Hanrui Chen, Lingling Sun, Chi Zhang, Zhijie Wang, Lizhu Lin

Network Pharmacology/Metabolomics-Based Validation of AMPK and PI3K/AKT Signaling Pathway as a Central Role of Shengqi Fuzheng Injection Regulation of Mitochondrial Dysfunction in Cancer-Related Fatig

Oxid Med Cell Longev.

doi: 10.1155/2021/5556212.

(IF 5.076)

1029. Bo Fu, Wei Liu, Cui Zhu, Peng Li, Li Wang, Li Pan, Ke Li, Peiying Cai, Min Meng, Yiting Wang, Anqi Zhang, Wenqiang Tang, Meng An

Circular RNA circBCBM1 promotes breast cancer brain metastasis by modulating miR-125a/BRD4 axis

Int J Biol Sci.

doi: 10.7150/ijbs.58916.

(IF 4.858)

1030. Lin Zhou, Jianing Li, Jinsong Liu, Anbei Wang, Ying Liu, Hao Yu, Hongsheng Ouyang, Daxin Pang

Investigation of the lncRNA THOR in Mice Highlights the Importance of Noncoding RNAs in Mammalian Male Reproduction

Biomedicines.

doi: 10.3390/biomedicines9080859.

1031. Wanzun Lin, Yun Sun, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J Lu

VMP1, a novel prognostic biomarker, contributes to glioma development by regulating autophagy

J Neuroinflammation.

doi: 10.1186/s12974-021-02213-z.

1032. Suqin Wang, Siyu Yang, Jun Zuo, Chenlin Hu, Lirong Song, Nanqin Gan, Peng Chen

Simultaneous Removal of the Freshwater Bloom-Forming Cyanobacterium Microcystis and Cyanotoxin Microcystins via Combined Use of Algicidal Bacterial Filtrate and the Microcystin-Degrading Enzymatic Age

Microorganisms.

doi: 10.3390/microorganisms9081594.

(IF 4.152)

1033. Xiaowei Cai, Yiheng Dai, Peng Gao, Guanyu Ren, Dingcai Cheng, Bo Wang, Yi Wang, Jiang Yu, Yiheng Du, Xizhi Wang, Boxin Xue

LncRNA CCAT1 promotes prostate cancer cells proliferation, migration, and invasion through regulation of miR-490-3p/FRAT1 axis

Aging (Albany NY).

doi: 10.18632/aging.203300.

1034. Xue Kong, Juan Li, Yanru Li, Weili Duan, Qiuchen Qi, Tiantian Wang, Qifeng Yang, Lutao Du, Haiting Mao, Chuanxin Wang

A novel long non-coding RNA AC073352.1 promotes metastasis and angiogenesis via interacting with YBX1 in breast cancer

Cell Death Dis.

doi: 10.1038/s41419-021-03943-x.

(IF 6.304)

1035. Jianping Wu, Qian Xie, Yanjun Liu, Yanan Gao, Zhipeng Qu, Lian Mo, Ying Xu, Ruihuan Chen, Liyun Shi

A Small Vimentin-Binding Molecule Blocks Cancer Exosome Release and Reduces Cancer Cell Mobility

Front Pharmacol.

doi: 10.3389/fphar.2021.627394.

(IF 4.225)

1036. Lihong Lu, Ziwen Zhong, Jiahui Gu, Ke Nan, Minmin Zhu, Changhong Miao

ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy

Mol Med.

doi: 10.1186/s10020-021-00339-7.

(IF 4.096)

1037. Tianyan Jiang, Haoxiang Guo, Ya-Nan Xia, Yun Liu, Dandan Chen, Guibin Pang, Yahui Feng, Huan Yu, Yanxian Wu, Shaodian Zhang, Yangyun Wang, Yong Wang, Hairuo Wen, Leshuai W Zhang

Hepatotoxicity of copper sulfide nanoparticles towards hepatocyte spheroids using a novel multi-concave agarose chip method

Nanomedicine (Lond).

doi: 10.2217/nnm-2021-0011.

1038. Mengyue Chen, Yugang Chi, Hongwei Chen, Limei Zhao

Long non-coding RNA USP30-AS1 aggravates the malignant progression of cervical cancer by sequestering microRNA-299-3p and thereby overexpressing PTP4A1

Oncol Lett.

doi: 10.3892/ol.2021.12766.

(IF 2.311)

1039. Wenzhao Wang, Bing Han, Jianan Chen, Huichao Tian, Mingjie Sun, Yunpeng Jiang, Wei Xie

Tolerogenic dendritic cells suppress titanium particle-induced inflammation

Exp Ther Med.

doi: 10.3892/etm.2021.10144.

(IF 1.785)

1040. Shuguang Han, Feng Zhu, Xiaoxia Huang, Panpan Yan, Ke Xu, Fangfang Shen, Jiawen Sun, Zeyu Yang, Guoxi Jin, Yiqun Teng

Maternal obesity accelerated non-alcoholic fatty liver disease in offspring mice by reducing autophagy

Exp Ther Med.

doi: 10.3892/etm.2021.10148.

(IF 1.785)

1041. Pengyu Jia, Nan Wu, Huimin Yang, Yuxuan Guo, Xiaofan Guo, Yingxian Sun

Different roles of BAG3 in cardiac physiological hypertrophy and pathological remodeling

Transl Res.

doi: 10.1016/j.trsl.2021.02.004.

(IF 5.411)

1042. Wenhui Dong, Qing Dong, Hairui Ding

Ophiopogonin B induces reactive oxygen species‑dependent apoptosis through the Hippo pathway in nasopharyngeal carcinoma

Mol Med Rep.

doi: 10.3892/mmr.2021.12173.

(IF 2.1)

1043. Weiping Wang, Jingyang Liu, Mingzhu Yang, Ruiqi Qiu, Ya Li, Shasha Bian, Bingtao Hao, Bo Lei

Intravitreal Injection of an Exosome-Associated Adeno-Associated Viral Vector Enhances Retinoschisin 1 Gene Transduction in the Mouse Retina

Hum Gene Ther.

doi: 10.1089/hum.2020.328.

(IF 4.273)

1044. Jie Wei, Yan Wang, Xiangming Qi, Yonggui Wu

Enhanced Bruton's tyrosine kinase activity in the kidney of patients with IgA nephropathy

Int Urol Nephrol.

doi: 10.1007/s11255-020-02733-2.

(IF 1.843)

1045. Zuotian Wu, Lin Zhou, Limin Sun, Yumeng Xie, Ling Xiao, Huiling Wang, Gaohua Wang

Brief postpartum separation from offspring promotes resilience to lipopolysaccharide challenge-induced anxiety and depressive-like behaviors and inhibits neuroinflammation in C57BL/6J dams

Brain Behav Immun.

doi: 10.1016/j.bbi.2021.03.016.

(IF 6.633)

1046. Liyuan Cui, Feng Xu, Songcun Wang, Zhuxuan Jiang, Lu Liu, Yan Ding, Xiaoli Sun, Meirong Du

Melatonin-MT1 signal is essential for endometrial decidualization

Reproduction.

doi: 10.1530/REP-21-0159.

(IF 3.206)

1047. Ke Zhang, Xingtao Zhou, Junqiao Wang, Yujia Zhou, Wucheng Qi, Haihong Chen, Shaoping Nie, Mingyong Xie

Dendrobium officinale polysaccharide triggers mitochondrial disorder to induce colon cancer cell death via ROS-AMPK-autophagy pathway

Carbohydr Polym.

doi: 10.1016/j.carbpol.2021.118018.

1048. Yueying Li, Zhan Zhang, Ke Xu, Shuang Du, Xiaosong Gu, Rangjuan Cao, Shusen Cui

Minocycline alleviates peripheral nerve adhesion by promoting regulatory macrophage polarization via the TAK1 and its downstream pathway

Life Sci.

doi: 10.1016/j.lfs.2021.119422.

(IF 3.647)

1049. Yiwei Wang, Xiaochen Xie, Shu Li, Dongyong Zhang, Heyu Zheng, Min Zhang, Zhong Zhang

Co-overexpression of RIOK1 and AKT1 as a prognostic risk factor in glioma

J Cancer.

doi: 10.7150/jca.60596.

(IF 3.565)

1050. Peipei Liu, Shengnan Yang, Zai Wang, Huaping Dai, Chen Wang

Feasibility and Mechanism Analysis of Shenfu Injection in the Treatment of Idiopathic Pulmonary Fibrosis

Front Pharmacol.

doi: 10.3389/fphar.2021.670146.

(IF 4.225)

1051. Lu Gan, Baosheng Huang, Zhaojian Song, Yachun Zhang, Yujie Zhang, Si Chen, Liqi Tong, Zhisong Wei, Lingxiang Yu, Xiangbo Luo, Xianhua Zhang, Detian Cai, Yuchi He

Unique Glutelin Expression Patterns and Seed Endosperm Structure Facilitate Glutelin Accumulation in Polyploid Rice Seed

Rice (N Y).

doi: 10.1186/s12284-021-00500-0.

1052. Xuemei Cao, Min Mao, Junlin Diao, Yi Hou, Hong Su, Yongjun Gan, Jibin Li, Xiaoyong Tong, Chaodong Wu, Zhong Zuo, Xiaoqiu Xiao

Ectopic Overexpression of PPARγ2 in the Heart Determines Differences in Hypertrophic Cardiomyopathy After Treatment With Different Thiazolidinediones in a Mouse Model of Diabetes

Front Pharmacol.

doi: 10.3389/fphar.2021.683156.

(IF 4.225)

1053. Limei Chen, He Chen, Yanli Xing, Juan Li

ABCC1 regulates cocaine-associated memory, spine plasticity and GluA1 and GluA2 surface expression

Neuroreport.

doi: 10.1097/WNR.0000000000001657.

(IF 1.394)

1054. Luying Cui, Yang Qu, Hele Cai, Heng Wang, Junsheng Dong, Jun Li, Chen Qian, Jianji Li

Meloxicam Inhibited the Proliferation of LPS-Stimulated Bovine Endometrial Epithelial Cells Through Wnt/β-Catenin and PI3K/AKT Pathways

Front Vet Sci.

doi: 10.3389/fvets.2021.637707.

(IF 2.245)

1055. Yaqun Wang, Xiaonan Sima, Ying Ying, Yonghong Huang

Exogenous BMP9 promotes lung fibroblast HFL-1 cell activation via ALK1/Smad1/5 signaling in vitro

Exp Ther Med.

doi: 10.3892/etm.2021.10160.

(IF 1.785)

1056. Yuan Yang, Chunyan Liu, Tingting Xie, Dapeng Wang, Xiong Chen, Lu Ma, Aihua Zhang

Role of inhibiting Chk1-p53 pathway in hepatotoxicity caused by chronic arsenic exposure from coal-burning

Hum Exp Toxicol.

doi: 10.1177/0960327120988880.

(IF 2.067)

1057. Bin Zhao, Tongyao Yu, Shenghang Wang, Jingmin Che, Liangfu Zhou, Peng Shang

Static Magnetic Field (0.2-0.4 T) Stimulates the Self-Renewal Ability of Osteosarcoma Stem Cells Through Autophagic Degradation of Ferritin

Bioelectromagnetics.

doi: 10.1002/bem.22352.

(IF 2.278)

1058. Jing Chu, Jinghai Gao, Jing Wang, Lingling Li, Guoqiang Chen, Jianhong Dang, Zhifeng Wang, Zhijun Jin, Xiaojun Liu

Mechanism of hydrogen on cervical cancer suppression revealed by high‑throughput RNA sequencing

Oncol Rep.

doi: 10.3892/or.2021.8092.

(IF 3.417)

1059. Yan Tang, Chunsheng Hu

NMU Is a Poor Prognostic Biomarker in Patients with Lung Adenocarcinoma

Dis Markers.

doi: 10.1155/2021/5031479.

(IF 2.738)

1060. Xudong Tang, Qiaoru Dong, Jun Li, Fang Li, Bozena B Michniak-Kohn, Denggao Zhao, Chi-Tang Ho, Qingrong Huang

Anti-Melanogenic Mechanism of Tetrahydrocurcumin and Enhancing Its Topical Delivery Efficacy Using a Lecithin-Based Nanoemulsion

Pharmaceutics.

doi: 10.3390/pharmaceutics13081185.

(IF 4.421)

1061. Yu Bai, Qiang Du, Le Zhang, Ling Li, Lei Tang, Wei Zhang, Runyu Du, Ping Li, Ling Li

Fasudil alleviated insulin resistance through promotion of proliferation, attenuation of cell apoptosis and inflammation and regulation of RhoA/Rho kinase/insulin/nuclear factor-κB signalling pathway

J Pharm Pharmacol.

doi: 10.1093/jpp/rgab033.

(IF 2.571)

1062. Jiqiang Hu, Xuan Wang, Xiaoyun Cui, Wu Kuang, Dong Li, Jing Wang

Quercetin prevents isoprenaline-induced myocardial fibrosis by promoting autophagy via regulating miR-223-3p/FOXO3

Cell Cycle.

doi: 10.1080/15384101.2021.1932029.

(IF 3.699)

1063. Na Luo, Shiqin Liu, Xin Li, Yu Hu, Kejing Zhang

Circular RNA circHIPK3 promotes breast cancer progression via sponging MiR-326

Cell Cycle.

doi: 10.1080/15384101.2021.1939476.

(IF 3.699)

1064. Gang Wang, Qikai Sun, Hai Zhu, Yihui Bi, Haixing Zhu, Aman Xu

The stabilization of yes-associated protein by TGFβ-activated kinase 1 regulates the self-renewal and oncogenesis of gastric cancer stem cells

J Cell Mol Med.

doi: 10.1111/jcmm.16660.

(IF 4.486)

1065. Gang Ma, Weijie Dai, Juan Zhang, Qianjun Li, Biao Gu, Yaqi Song, Xiaozhong Yang

ELK1‑mediated upregulation of lncRNA LBX2‑AS1 facilitates cell proliferation and invasion via regulating miR‑491‑5p/S100A11 axis in colorectal cancer

Int J Mol Med.

doi: 10.3892/ijmm.2021.4971.

(IF 3.098)

1066. Zhuo-Min Ling, Qian Wang, Yu Ma, Peng Xue, Yun Gu, Mao-Hong Cao, Zhong-Ya Wei

Astrocyte Pannexin 1 Suppresses LPS-Induced Inflammatory Responses to Protect Neuronal SH-SY5Y Cells

Front Cell Neurosci.

doi: 10.3389/fncel.2021.710820.

(IF 3.921)

1067. Cong Wang, Hao Chen, Shi-Tang Ma, Bin-Bin Mao, Yu Chen, Hao-Nan Xu, Hao Yu

A Network Pharmacology Approach for Exploring the Mechanisms of Panax notoginseng Saponins in Ischaemic Stroke

Evid Based Complement Alternat Med.

doi: 10.1155/2021/5582782.

1068. Wensi Wu, Xiaojun Zhang, Jiaxin Zhou, Hongmei Yang, Junjun Chen, Le Zhao, Junying Zhong, Wei-Jye Lin, Zhi Wang

Clemastine Ameliorates Perioperative Neurocognitive Disorder in Aged Mice Caused by Anesthesia and Surgery

Front Pharmacol.

doi: 10.3389/fphar.2021.738590.

(IF 4.225)

1069. Haiwei Bao, Ting Chen, Junyan Zhu, Haiyang Xie, Fen Chen

CEUS-Based Radiomics Can Show Changes in Protein Levels in Liver Metastases After Incomplete Thermal Ablation

Front Oncol.

doi: 10.3389/fonc.2021.694102.

(IF 4.848)

1070. Fang Geng, Yunxiao Xie, Yi Wang, Jinqiu Wang

Depolymerization of chicken egg yolk granules induced by high-intensity ultrasound

Food Chem.

doi: 10.1016/j.foodchem.2021.129580.

(IF 6.306)

1071. Yujuan Kang, Lin Wan, Qin Wang, Yanling Yin, Jiena Liu, Lei Liu, Hao Wu, Lei Zhang, Xin Zhang, Shouping Xu, Da Pang

Long noncoding RNA SNHG1 promotes TERT expression by sponging miR-18b-5p in breast cancer

Cell Biosci.

doi: 10.1186/s13578-021-00675-5.

(IF 5.026)

1072. Zhaoqi Yuan, Zhu Zhu, Fangxing Zhu, Feixue Ding, Yinmin Wang, Xiuxia Wang, Xusong Luo, Jun Yang, Fei Liu, Di Sun

Impact of human adipose tissue-derived stem cells on dermatofibrosarcoma protuberans cells in an indirect co-culture: an in vitro study

Stem Cell Res Ther.

doi: 10.1186/s13287-021-02512-5.

(IF 5.116)

1073. Xi Cheng, Lili Qian, Bo Wang, Minjia Tan, Jing Li

SPA: A Quantitation Strategy for MS Data in Patient-derived Xenograft Models

Genomics Proteomics Bioinformatics.

doi: 10.1016/j.gpb.2019.11.016.

1074. Yujie Zhao, Yuan Chen, Jiayi Wang, Xue Zhu, Ke Wang, Yue Li, Fanfan Zhou

Ginkgolide J protects human synovial cells SW982 via suppression of p38‑dependent production of pro‑inflammatory mediators

Mol Med Rep.

doi: 10.3892/mmr.2021.12194.

(IF 2.1)

1075. Mei Tao, Danna Zheng, Xudong Liang, Diandian Wu, Kang Hu, Juan Jin, Qiang He

Tripterygium glycoside suppresses epithelial‑to‑mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway

Mol Med Rep.

doi: 10.3892/mmr.2021.12231.

(IF 2.1)

1076. Xiyi Hu, Linglian Kong, Chuanpi Xiao, Qidong Zhu, Zhigang Song

The AMPK-mTOR signaling pathway is involved in regulation of food intake in the hypothalamus of stressed chickens

Comp Biochem Physiol A Mol Integr Physiol.

doi: 10.1016/j.cbpa.2021.110979.

1077. Chun Wang, Ling Hu, Shuang Guo, Qing Yao, Xiufen Liu, Bo Zhang, Xiangwen Meng, Xiaosong Yang

Phosphocreatine attenuates doxorubicin-induced cardiotoxicity by inhibiting oxidative stress and activating TAK1 to promote myocardial survival in vivo and in vitro

Toxicology.

doi: 10.1016/j.tox.2021.152881.

(IF 4.099)

1078. Yu Guo, Huan Zhu, Xiangchen Li, Caiyun Ma, Yanan Li, Tingting Sun, Yuanyuan Wang, Chunjing Wang, Weijun Guan, Changqing Liu

RepSox effectively promotes the induced differentiation of sheep fibroblasts into adipocytes via the inhibition of the TGF‑β1/Smad pathway

Int J Mol Med.

doi: 10.3892/ijmm.2021.4981.

(IF 3.098)

1079. Cong Cong, Xiaohong Yuan, Ying Hu, Wenjing Chen, Yong Wang, Lei Tao

Sinigrin attenuates angiotensin II‑induced kidney injury by inactivating nuclear factor‑κB and extracellular signal‑regulated kinase signaling in vivo and in vitro

Int J Mol Med.

doi: 10.3892/ijmm.2021.4994.

(IF 3.098)

1080. Yanyi Li, Qifan Hu, Weishuo Li, Shijing Liu, Kaiming Li, Xiaoyu Li, Junjie Du, Zexuan Yu, Cong Wang, Can Zhang

Simultaneous blockage of contextual TGF-β by cyto-pharmaceuticals to suppress breast cancer metastasis

J Control Release.

doi: 10.1016/j.jconrel.2021.06.012.

(IF 7.727)

1081. Gen Li, Tianquan Yang, Yanling Chen, Jianping Bao, Di Wu, Xiaohan Hu, Chenxi Feng, Lixiao Xu, Mei Li, Gang Li, Meifang Jin, Yunyun Xu, Rui Zhang, Guanghui Qian, Jian Pan

USP5 Sustains the Proliferation of Glioblastoma Through Stabilization of CyclinD1

Front Pharmacol.

doi: 10.3389/fphar.2021.720307.

(IF 4.225)

1082. Nani Wang, Pingcui Xu, Renjie Wu, Xuping Wang, Yongjun Wang, Dan Shou, Yan Zhang

Timosaponin BII improved osteoporosis caused by hyperglycemia through promoting autophagy of osteoblasts via suppressing the mTOR/NFκB signaling pathway

Free Radic Biol Med.

doi: 10.1016/j.freeradbiomed.2021.05.014.

1083. Xu-Ting Song, Jia-Nan Zhang, Duo-Wei Zhao, Yu-Fei Zhai, Qi Lu, Mei-Yu Qi, Ming-Hai Lu, Shou-Long Deng, Hong-Bing Han, Xiu-Qin Yang, Yu-Chang Yao

Molecular cloning, expression, and functional features of IGF1 splice variants in sheep

Endocr Connect.

doi: 10.1530/EC-21-0181.

(IF 2.592)

1084. Panpan Zheng, Jiyu Kang, Entong Xing, Bin Zheng, Xueyao Wang, Huacheng Zhou

Lung Inflation With Hydrogen During the Cold Ischemia Phase Alleviates Lung Ischemia-Reperfusion Injury by Inhibiting Pyroptosis in Rats

Front Physiol.

doi: 10.3389/fphys.2021.699344.

(IF 3.367)

1085. Xiaoming Ma, Qiang Zhang, Yongfu La, Donghai Fu, Hiu Jiang, Pengjia Bao, Xiaoyun Wu, Min Chu, Xian Guo, Ping Yan, Chunnian Liang

Differential Abundance of Brain Mitochondrial Proteins in Yak and Cattle: A Proteomics-Based Study

Front Vet Sci.

doi: 10.3389/fvets.2021.663031.

(IF 2.245)

1086. Jingwu Zhu, Jiang Tian, Chao Yang, Junpeng Chen, Lihuang Wu, Mengni Fan, Xiaojun Cai

L-Arg-Rich Amphiphilic Dendritic Peptide as a Versatile NO Donor for NO/Photodynamic Synergistic Treatment of Bacterial Infections and Promoting Wound Healing

Small.

doi: 10.1002/smll.202101495.

(IF 11.459)

1087. Lihong Zhang, Xiaozhen Zhao, Wei Wang

Disruption of anchoring junctions in the testes of experimental varicocele rats

Exp Ther Med.

doi: 10.3892/etm.2021.10319.

(IF 1.785)

1088. Xiaoqi Zeng, Shanshan Jiang, Simin Ruan, Zhaoze Guo, Jingyun Guo, Minfeng Liu, Changsheng Ye, Jianyu Dong

MAPK4 silencing together with a PARP1 inhibitor as a combination therapy in triple‑negative breast cancer cells

Mol Med Rep.

doi: 10.3892/mmr.2021.12187.

(IF 2.1)

1089. Erpeng Liu, Lei Lv, Yonghao Zhan, Yuan Ma, Jinjin Feng, Yulin He, Yibo Wen, Yanping Zhang, Qingsong Pu, Fengping Ji, Xinghuan Yang, Jian Guo Wen

METTL3/N6-methyladenosine/ miR-21-5p promotes obstructive renal fibrosis by regulating inflammation through SPRY1/ERK/NF-κB pathway activation

J Cell Mol Med.

doi: 10.1111/jcmm.16603.

(IF 4.486)

1090. Hongyan Ma, Ying Liu, Zhengtian Li, Lu Yu, Yang Gao, Xiangmei Ye, Baoyi Yang, Hulun Li, Jinghui Shi

Propofol Protects Against Hepatic Ischemia Reperfusion Injury via Inhibiting Bnip3-Mediated Oxidative Stress

Inflammation.

doi: 10.1007/s10753-021-01416-z.

(IF 3.212)

1091. Yajie Yang, Yan Hu, Yile Zhou, Tao Liang, Haihong Tang, Huihui Ju, Qiqing Shi, Hao Fang

Lys694Arg polymorphism leads to blunted responses to LPS by interfering TLR4 with recruitment of MyD88

Innate Immun.

doi: 10.1177/1753425920927479.

1092. Ding Liu, Wanzhe Zhang

Pioglitazone Attenuates Lupus Nephritis Symptoms in Mice by Modulating miR-21-5p/TIMP3 Axis: the Key Role of the Activation of Peroxisome Proliferator-Activated Receptor-γ

Inflammation.

doi: 10.1007/s10753-021-01426-x.

(IF 3.212)

1093. Zehao Wang, Lixia Wang, Boya Shi, Xiuli Sun, Yinrong Xie, Haonan Yang, Chengting Zi, Xuanjun Wang, Jun Sheng

Demethyleneberberine promotes apoptosis and suppresses TGF-β/Smads induced EMT in the colon cancer cells HCT-116

Cell Biochem Funct.

doi: 10.1002/cbf.3638.

(IF 2.632)

1094. Yan Jiang, Caifeng Zhang, Tingli Wang

bFGF ameliorates intestinal mucosal permeability and barrier function through tight junction proteins in burn injury rats

Burns.

doi: 10.1016/j.burns.2020.11.004.

(IF 2.066)

1095. Yujie Jia, Yu Tong, Lianqiu Min, Yanrong Li, Yan Cheng

Protective effects of oridonin against cerebral ischemia/reperfusion injury by inhibiting the NLRP3 inflammasome activation

Tissue Cell.

doi: 10.1016/j.tice.2021.101514.

(IF 1.837)

1096. Zhenkui Ren, Yumei Hu, Dongfen Guo, Zhizhong Guan, Ling Chen, Jun He, Wenfeng Yu

Increased miR‑187‑3p expression after cerebral ischemia/reperfusion induces apoptosis via initiation of endoplasmic reticulum stress

Neurosci Lett.

doi: 10.1016/j.neulet.2021.135947.

(IF 2.274)

1097. Yuchen Jing, Bai Gao, Zhiyang Han, Lifang Xia, Shijie Xin

The protective effect of HOXA5 on carotid atherosclerosis occurs by modulating the vascular smooth muscle cell phenotype

Mol Cell Endocrinol.

doi: 10.1016/j.mce.2021.111366.

(IF 3.871)

1098. Chengjun Hu, Yingli Yan, Fengjie Ji, Hanlin Zhou

Maternal Obesity Increases Oxidative Stress in Placenta and It Is Associated With Intestinal Microbiota

Front Cell Infect Microbiol.

doi: 10.3389/fcimb.2021.671347.

1099. Hong Ye, Ying Meng

Honokiol regulates endoplasmic reticulum stress by promoting the activation of the sirtuin 1-mediated protein kinase B pathway and ameliorates high glucose/high fat-induced dysfunction in human umbili

Endocr J.

doi: 10.1507/endocrj.EJ20-0747.

(IF 1.952)

1100. Jun He, Zhenkui Ren, Wansong Xia, Cao Zhou, Bin Bi, Wenfeng Yu, Li Zuo

Identification of key genes and crucial pathways for major depressive disorder using peripheral blood samples and chronic unpredictable mild stress rat models

PeerJ.

doi: 10.7717/peerj.11694.

(IF 2.379)

1101. Bin Yin, Ruirui Lian, Zhen Li, Yueyue Liu, Shifa Yang, Zhongli Huang, Zengcheng Zhao, Ying Li, Chuanxi Sun, Shuqian Lin, Renzhong Wan, Guiming Li

Tea Polyphenols Enhanced the Antioxidant Capacity and Induced Hsps to Relieve Heat Stress Injury

Oxid Med Cell Longev.

doi: 10.1155/2021/9615429.

(IF 5.076)

1102. Cong Yu, Bin Wu, Jinsong Jiang, Guangwei Yang, Chao Weng, Fei Cai

Overexpressed lncRNA ROR Promotes the Biological Characteristics of ox-LDL-Induced HUVECs via the let-7b-5p/HOXA1 Axis in Atherosclerosis

Front Cardiovasc Med.

doi: 10.3389/fcvm.2021.659769.

1103. Hanrui Wang, Siying Pei, Shuqing Fang, Song Jin, Shuhua Deng, Yanan Zhao, Yao Feng

Irisin restores high glucose-induced cell injury in vascular endothelial cells by activating Notch pathway via Notch receptor 1

Biosci Biotechnol Biochem.

doi: 10.1093/bbb/zbab137.

1104. Ying Xu, Yunxia Dong, Cong Wang, Qian Jiang, Haichao Chu, Yue Tian

Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation

Neurochem Int.

doi: 10.1016/j.neuint.2021.105078.

(IF 3.881)

1105. Fengtong Liu, Yali Liu, Yuqing Du, Youshan Li

MiRNA-130a promotes inflammation to accelerate atherosclerosis via the regulation of proliferator-activated receptor γ (PPARγ) expression

Anatol J Cardiol.

doi: 10.5152/AnatolJCardiol.2021.56721.

(IF 1.223)

1106. Xin Ouyang, Zhengjia Wang, Mei Luo, Maozhou Wang, Xing Liu, Jiaxin Chen, JianGuo Feng, Jing Jia, Xiaobin Wang

Ketamine ameliorates depressive-like behaviors in mice through increasing glucose uptake regulated by the ERK/GLUT3 signaling pathway

Sci Rep.

doi: 10.1038/s41598-021-97758-7.

1107. Jiaqi Chen, Qiaoya Pan, Yang Bai, Xuepeng Chen, Yi Zhou

Hydroxychloroquine Induces Apoptosis in Cholangiocarcinoma via Reactive Oxygen Species Accumulation Induced by Autophagy Inhibition

Front Mol Biosci.

doi: 10.3389/fmolb.2021.720370.

(IF 4.188)

1108. Yingmin Qu, Jing Wang, Pengyun Huang, Xiaohong Liu, Jianping Lu, Fu-Cheng Lin

PoRal2 Is Involved in Appressorium Formation and Virulence via Pmk1 MAPK Pathways in the Rice Blast Fungus Pyricularia oryzae

Front Plant Sci.

doi: 10.3389/fpls.2021.702368.

(IF 4.402)

1109. Xiao-Yue Ge, Tian-Tian Zhu, Mao-Zhong Yao, Hong Liu, Qian Wu, Jie Qiao, Wei-Fang Zhang, Chang-Ping Hu

MicroRNA-137 Inhibited Hypoxia-Induced Proliferation of Pulmonary Artery Smooth Muscle Cells by Targeting Calpain-2

Biomed Res Int.

doi: 10.1155/2021/2202888.

(IF 2.276)

1110. Lin Cai, Jian Chen, Jianglong Lu, Qun Li, Xianbin Chen, Linlin Zhang, Jinsen Wu, Weiming Zheng, Chengde Wang, Zhipeng Su

Tumor stem-like cells isolated from MMQ cells resist to dopamine agonist treatment

Mol Cell Endocrinol.

doi: 10.1016/j.mce.2021.111396.

(IF 3.871)

1111. Yulu Tu, Dazhi Chen, Tongtong Pan, Zhengkang Chen, Jie Xu, Lanling Jin, Lina Sheng, Xiaozhi Jin, Xiaodong Wang, Xiaolin Lan, Yuli Ge, Huiling Sun, Yongping Chen

Inhibition of miR-431-5p attenuated liver apoptosis through KLF15/p53 signal pathway in S100 induced autoimmune hepatitis mice

Life Sci.

doi: 10.1016/j.lfs.2021.119698.

(IF 3.647)

1112. Ru Zhang, Shiquan Tan, Bianling Zhang, Pengcheng Hu, Ling Li

Cerium-Promoted Ginsenosides Accumulation by Regulating Endogenous Methyl Jasmonate Biosynthesis in Hairy Roots of Panax ginseng

Molecules.

doi: 10.3390/molecules26185623.

(IF 3.267)

1113. Jing Sun, Wugui Chen, Songtao Li, Sizhen Yang, Ying Zhang, Xu Hu, Hao Qiu, Jigong Wu, Shangcheng Xu, Tongwei Chu

Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway

Front Pharmacol.

doi: 10.3389/fphar.2021.751845.

(IF 4.225)

1114. Jiali Yuan, Ping Li, Honghong Pan, Qi Xu, Tiantian Xu, Yan Li, Dong Wei, Yiqun Mo, Qunwei Zhang, Jingyu Chen, Chunhui Ni

miR-770-5p inhibits the activation of pulmonary fibroblasts and silica-induced pulmonary fibrosis through targeting TGFBR1

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2021.112372.

1115. Menglin Liu, Xia Wu, Yilong Cui, Pengli Liu, Bonan Xiao, Xuliang Zhang, Jian Zhang, Zhuo Sun, Miao Song, Bing Shao, Yanfei Li

Mitophagy and apoptosis mediated by ROS participate in AlCl3-induced MC3T3-E1 cell dysfunction

Food Chem Toxicol.

doi: 10.1016/j.fct.2021.112388.

(IF 4.679)

1116. Si-Qiang Zheng, Huan-Xin Chen, Xiao-Cheng Liu, Qin Yang, Guo-Wei He

Identification of variants of ISL1 gene promoter and cellular functions in isolated ventricular septal defects

Am J Physiol Cell Physiol.

doi: 10.1152/ajpcell.00167.2021.

1117. Mengjuan Shang, Jimeng Zhang, Meilun Shen, Zhichuan Sun, Peng Gao, Jing Li, Junlin Xing, Guozhen Guo

Bright light exposure induces dynamic changes of spatial memory in nocturnal rodents

Brain Res Bull.

doi: 10.1016/j.brainresbull.2021.06.019.

(IF 3.37)

1118. Xing Ge, Yong Zuo, Jinhong Xie, Xincheng Li, Yan Li, Anand Thirupathi, Peng Yu, Guofen Gao, Changhao Zhou, Yanzhong Chang, Zhenhua Shi

A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism

Aging (Albany NY).

doi: 10.18632/aging.203544.

1119. Yao Liu, Qiong Tang, Zhili Rao, Yang Fang, Xinni Jiang, Wenjun Liu, Fei Luan, Nan Zeng

Inhibition of herpes simplex virus 1 by cepharanthine via promoting cellular autophagy through up-regulation of STING/TBK1/P62 pathway

Antiviral Res.

doi: 10.1016/j.antiviral.2021.105143.

1120. Xiaolong Song, Junhong Kong, Jun Song, Renyou Pan, Lei Wang

Angelica sinensis Polysaccharide Alleviates Myocardial Fibrosis and Oxidative Stress in the Heart of Hypertensive Rats

Comput Math Methods Med.

doi: 10.1155/2021/6710006.

1121. Huifeng Wang, Qingjun Zhou, Luqin Wan, Menglong Guo, Chen Chen, Junfa Xue, Lingling Yang, Lixin Xie

Lipidomic analysis of meibomian glands from type-1 diabetes mouse model and preliminary studies of potential mechanism

Exp Eye Res.

doi: 10.1016/j.exer.2021.108710.

(IF 3.011)

1122. Zhao Hu, Fengtong Yuan, Yutan Guo, Suping Ying, Jie Chen, Danpeng Zhu, Lu Cai, Xiaowei Wang, Wei Liu, Xiaojue Peng

OsCBL1 affects rice seedling growth by modulating nitrate and phosphate responses

Gene.

doi: 10.1016/j.gene.2021.145806.

(IF 2.984)

1123. Yunlian Zou, Jinping Zhang, Lichen Zhang, Xinmin Yan

Interferon-induced protein 16 expression in colorectal cancer and its correlation with proliferation and immune signature markers

Oncol Lett.

doi: 10.3892/ol.2021.12948.

(IF 2.311)

1124. Dong-Lin Yang, Ya-Jun Zhang, Liu-Jun He, Chun-Sheng Hu, Li-Xia Gao, Jiu-Hong Huang, Yan Tang, Jie Luo, Dian-Yong Tang, Zhong-Zhu Chen

Demethylzeylasteral (T-96) initiates extrinsic apoptosis against prostate cancer cells by inducing ROS-mediated ER stress and suppressing autophagic flux

Biol Res.

doi: 10.1186/s40659-021-00350-6.

(IF 3.092)

1125. Jing-Yu Duan, Wei Chen, Yang-Qi Zhao, Liang-Liang He, En-Chao Li, Zhong-Hui Bai, Yong-Jian Wang, Chun-Ping Zhang

Flavonoids from Hypericum patulum enhance glucose consumption and attenuate lipid accumulation in HepG2 cells

J Food Biochem.

doi: 10.1111/jfbc.13898.

(IF 1.662)

1126. Min Fei, Zheng Li, Yuanwu Cao, Chang Jiang, Haodong Lin, Zixian Chen

MicroRNA-182 improves spinal cord injury in mice by modulating apoptosis and the inflammatory response via IKKβ/NF-κB

Lab Invest.

doi: 10.1038/s41374-021-00606-5.

(IF 4.197)

1127. Yu Feng, Xu Tian, Miao Zhang, Shujie Lou

Treadmill Exercise Reverses the Change of Dendritic Morphology and Activates BNDF-mTOR Signaling Pathway in the Hippocampus and Cerebral Cortex of Ovariectomized Mice

J Mol Neurosci.

doi: 10.1007/s12031-021-01848-0.

(IF 2.678)

1128. Yuanyuan Fang, Dongjie Peng, Yuan Liang, Lili Lu, Junyan Li, Lin Zhao, Shiyan Ou, Shaojun Li, Michael Aschner, Yueming Jiang

Sodium P-aminosalicylic Acid Inhibits Manganese-Induced Neuroinflammation in BV2 Microglial Cells via NLRP3-CASP1 Inflammasome Pathway

Biol Trace Elem Res.

doi: 10.1007/s12011-020-02471-7.

(IF 2.639)

1129. Zeyu Jiang, Jiang Shen, Jie Ding, Yan Yuan, Lulu Gao, Zhuocheng Yang, Xin Zhao

USP18 mitigates lipopolysaccharide-induced oxidative stress and inflammation in human pulmonary microvascular endothelial cells through the TLR4/NF-κB/ROS signaling

Toxicol In Vitro.

doi: 10.1016/j.tiv.2021.105181.

(IF 2.959)

1130. Xuezuo Sui, Yanchun Wang, Hui Liu

hsa_circ_0101119 facilitates the progression of cervical cancer via an interaction with EIF4A3 to inhibit TCEAL6 expression

Mol Med Rep.

doi: 10.3892/mmr.2021.12293.

(IF 2.1)

1131. Su-Su Tang, Shu-Yun Xing, Xue-Jiao Zhang, Xiao-Qian Ren, Hao Hong, Yan Long

Neuroprotective effects of novel compound Tozan on cognition, neurogenesis and apoptosis in diabetes

Ann Transl Med.

doi: 10.21037/atm-21-4439.

(IF 3.297)

1132. Jianxiu Duan, Mingyuan Yin, Yaqin Shao, Jiao Zheng, Shengdan Nie

Puerarin induces platinum-resistant epithelial ovarian cancer cell apoptosis by targeting SIRT1

J Int Med Res.

doi: 10.1177/03000605211040762.

(IF 1.287)

1133. Bang Wang, Xiujuan Lv, Yufei Wang, Zhibo Wang, Qi Liu, Bin Lu, Yong Liu, Feng Gu

CRISPR/Cas9-mediated mutagenesis at microhomologous regions of human mitochondrial genome

Sci China Life Sci.

doi: 10.1007/s11427-020-1819-8.

(IF 4.611)

1134. Zhujun Zhu, Sihong Wang, Qi Cao, Gang Li

CircUBQLN1 Promotes Proliferation but Inhibits Apoptosis and Oxidative Stress of Hippocampal Neurons in Epilepsy via the miR-155-Mediated SOX7 Upregulation

J Mol Neurosci.

doi: 10.1007/s12031-021-01838-2.

(IF 2.678)

1135. Qingwei Yang, Jingcong Zhuang, Pingping Cai, Longling Li, Rong Wang, Zhongjie Chen

JKAP relates to disease risk, severity, and Th1 and Th17 differentiation in Parkinson's disease

Ann Clin Transl Neurol.

doi: 10.1002/acn3.51420.

1136. Tengda Huang, Jingsu Yu, Zupeng Luo, Lin Yu, Siqi Liu, Peng Wang, Mengting Jia, Tian Wu, Weiwei Miao, Lei Zhou, Ziyi Song, Haojie Zhang, Yixing Li

Translatome analysis reveals the regulatory role of betaine in high fat diet (HFD)-induced hepatic steatosis

Biochem Biophys Res Commun.

doi: 10.1016/j.bbrc.2021.08.058.

1137. Tingting Jin, Lei Xu, Peipei Wang, Xiaobei Hu, Runyuan Zhang, Zhiqi Wu, Wenxin Du, Weijuan Kan, Kun Li, Chang Wang, Yubo Zhou, Jia Li, Tao Liu

Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile

J Med Chem.

doi: 10.1021/acs.jmedchem.1c00994.

(IF 6.205)

1138. Zeyu Xing, Menglu Zhang, Jiaqi Liu, Gang Liu, Kexin Feng, Xiang Wang

LINC00337 induces tumor development and chemoresistance to paclitaxel of breast cancer by recruiting M2 tumor-associated macrophages

Mol Immunol.

doi: 10.1016/j.molimm.2021.07.009.

(IF 3.641)

1139. Ting-Ting Gong, Qian Guo, Xiao Li, Tie-Ning Zhang, Fang-Hua Liu, Xin-Hui He, Bei Lin, Qi-Jun Wu

Isothiocyanate Iberin inhibits cell proliferation and induces cell apoptosis in the progression of ovarian cancer by mediating ROS accumulation and GPX1 expression

Biomed Pharmacother.

doi: 10.1016/j.biopha.2021.111533.

(IF 4.545)

1140. Lan Zhan, Xiangxiu Wang, Yanjing Zhang, Guonian Zhu, Yu Ding, Xuemei Chen, Wei Jiang, Sisi Wu

Benazepril hydrochloride protects against doxorubicin cardiotoxicity by regulating the PI3K/Akt pathway

Exp Ther Med.

doi: 10.3892/etm.2021.10516.

(IF 1.785)

1141. Jing Zhu, Ning Zhu, Jian Xu

miR‑101a‑3p overexpression prevents acetylcholine‑CaCl2‑induced atrial fibrillation in rats via reduction of atrial tissue fibrosis, involving inhibition of EZH2

Mol Med Rep.

doi: 10.3892/mmr.2021.12380.

(IF 2.1)

1142. Tingjiao Liu, Qianqian Li, Shanshan Yang, Tingting Zhao, Jinghan Lin, Ting Ju, Zhaohui Wen

CNTs-CaP/chitosan-coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway

Cell Biochem Funct.

doi: 10.1002/cbf.3662.

(IF 2.632)

1143. Zhibing Qiu, Wen Chen, Yafeng Liu, Ben Jiang, Li Yin, Xin Chen

LncRNA AC061961.2 overexpression inhibited endoplasmic reticulum stress induced apoptosis in dilated cardiomyopathy rats and cardiomyocytes via activating wnt/β-catenin pathway

J Recept Signal Transduct Res.

doi: 10.1080/10799893.2020.1828915.

1144. Shuo Li, Ruirong Guo, Zhibin Peng, Bingxuan Quan, Yuhang Hu, Yiwen Wang, Yansong Wang

NPR3, transcriptionally regulated by POU2F1, inhibits osteosarcoma cell growth through blocking the PI3K/AKT pathway

Cell Signal.

doi: 10.1016/j.cellsig.2021.110074.

(IF 3.968)

1145. Qian Sun, Yan-Chun Ji, Zheng-Li Wang, Xiang She, Yu He, Qing Ai, Lu-Quan Li

Sodium Butyrate Alleviates Intestinal Inflammation in Mice with Necrotizing Enterocolitis

Mediators Inflamm.

doi: 10.1155/2021/6259381.

1146. Jinglin Zhu, Ruifei Huang, Ruijie Yang, Yue Xiao, Jiangna Yan, Chunli Zheng, Wei Xiao, Chao Huang, Yonghua Wang

Licorice extract inhibits growth of non-small cell lung cancer by down-regulating CDK4-Cyclin D1 complex and increasing CD8+ T cell infiltration

Cancer Cell Int.

doi: 10.1186/s12935-021-02223-0.

(IF 4.175)

1147. Qian Ma, Jia Wang, Haopeng Yu, Junyi Sun, Jun Sun, Jiahao Chen, Yangyinhui Yu, Peihang Fang, Qi Tian, Junjun Ding

Protocol to alter a protein's phase separation capacity to control cell fate transitions

STAR Protoc.

doi: 10.1016/j.xpro.2021.100887.

1148. Heng Yin, Zhicai Zuo, Zhuangzhi Yang, Hongrui Guo, Jing Fang, Hengmin Cui, Ping Ouyang, Xia Chen, Jian Chen, Yi Geng, Zhengli Chen, Chao Huang, Yanqiu Zhu

Nickel induces autophagy via PI3K/AKT/mTOR and AMPK pathways in mouse kidney

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2021.112583.

1149. Qi Han, Honggui Liu, Runxiang Zhang, Xuesong Yang, Jun Bao, Houjuan Xing

Selenomethionine protects against ammonia-induced apoptosis through inhibition of endoplasmic reticulum stress in pig kidneys

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2021.112596.

1150. Rong-Hui Tu, Dong-Xiao Wang, Guo-Qiang Zhong, Jian-Jun Meng, Hong Wen, Jie-Feng, Qi Bi, Yan He

New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB

Open Med (Wars).

doi: 10.1515/med-2021-0340.

1151. Yuying Zhang, Anqi Guo, Cheng Lyu, Ran Bi, Zhaozhao Wu, Wenjing Li, Peng Zhao, Yudi Niu, Jie Na, Jianzhong Jeff Xi, Yanan Du

Synthetic liver fibrotic niche extracts achieve in vitro hepatoblasts phenotype enhancement and expansion

iScience.

doi: 10.1016/j.isci.2021.103303.

1152. Hongyan Ding, Yu Li, Leihong Liu, Ning Hao, Suping Zou, Qianming Jiang, Yusheng Liang, Nana Ma, Shibing Feng, Xichun Wang, Jinjie Wu, Juan J Loor

Sirtuin 1 is involved in oleic acid-induced calf hepatocyte steatosis via alterations in lipid metabolism-related proteins

J Anim Sci.

doi: 10.1093/jas/skab250.

(IF 2.092)

1153. Yunyi Bian, Qihai Sui, Guoshu Bi, Yuansheng Zheng, Mengnan Zhao, Guangyu Yao, Liang Xue, Yi Zhang, Hong Fan

Identification and Validation of a Proliferation-Associated Score Model Predicting Survival in Lung Adenocarcinomas

Dis Markers.

doi: 10.1155/2021/3219594.

(IF 2.738)

1154. Fan Feng, Lianhong Pan, Jiaqin Wu, Lanqing Li, Haiying Xu, Li Yang, Kang Xu, Chunli Wang

Cepharanthine inhibits hepatocellular carcinoma cell growth and proliferation by regulating amino acid metabolism and suppresses tumorigenesis in vivo

Int J Biol Sci.

doi: 10.7150/ijbs.64675.

(IF 4.858)

1155. Hao Zhang, Peng Xia, Jie Liu, Zhang Chen, Weijie Ma, Yufeng Yuan

ATIC inhibits autophagy in hepatocellular cancer through the AKT/FOXO3 pathway and serves as a prognostic signature for modeling patient survival

Int J Biol Sci.

doi: 10.7150/ijbs.65669.

(IF 4.858)

1156. Xianbao Huang, Ling Qi, Wei Lu, Ziye Li, Wuping Li, Fei Li

MYCN contributes to the sensitization of acute myelogenous leukemia cells to cisplatin by targeting SRY-box transcription factor 4

Bioengineered.

doi: 10.1080/21655979.2021.1997697.

(IF 2.205)

1157. Yu Xiang, Xiaying Chen, Wengang Wang, Lijuan Zhai, Xueni Sun, Jiao Feng, Ting Duan, Mingming Zhang, Ting Pan, Lili Yan, Ting Jin, Quan Gao, Chengyong Wen, Weirui Ma, Wencheng Liu, Deqiang Wang, Qibiao Wu, Tian Xie, Xinbing Sui

Natural Product Erianin Inhibits Bladder Cancer Cell Growth by Inducing Ferroptosis via NRF2 Inactivation

Front Pharmacol.

doi: 10.3389/fphar.2021.775506.

(IF 4.225)

1158. Hui Wang, Fei Shang, Jiawei Shen, Jingyi Xu, Xiaolin Chen, Jingtian Ni, Lumin Yu, Ting Xue

LsrR, the effector of AI-2 quorum sensing, is vital for the H2O2 stress response in mammary pathogenic Escherichia coli

Vet Res.

doi: 10.1186/s13567-021-00998-8.

(IF 3.357)

1159. Qianxing Zou, Lele Yang, Ruona Shi, Yuling Qi, Xiaofei Zhang, Huayu Qi

Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis

iScience.

doi: 10.1016/j.isci.2021.103396.

1160. Liyuan Cui, Feng Xu, Zhuxuan Jiang, Songcun Wang, Xinyi Li, Yan Ding, Ying Zhang, Meirong Du

Melatonin regulates proliferation and apoptosis of endometrial stromal cells via MT1

Acta Biochim Biophys Sin (Shanghai).

doi: 10.1093/abbs/gmab108.

1161. Lihong Lu, Xue Li, Ziwen Zhong, Wenchang Zhou, Di Zhou, Minmin Zhu, Changhong Miao

KMT5A downregulation participated in High Glucose-mediated EndMT via Upregulation of ENO1 Expression in Diabetic Nephropathy

Int J Biol Sci.

doi: 10.7150/ijbs.62867.

(IF 4.858)

1162. Jiaqi Xing, Xu Peng, Anqi Li, Meilin Chen, Yuan Ding, Xinyuan Xu, Peng Yu, Jing Xie, Jianshu Li

Gellan gum/alginate-based Ca-enriched acellular bilayer hydrogel with robust interface bonding for effective osteochondral repair

Carbohydr Polym.

doi: 10.1016/j.carbpol.2021.118382.

1163. Qi Han, Huiling Chen, Likai Wang, Yang An, Xiaoxiang Hu, Yaofeng Zhao, Hao Zhang, Ran Zhang

Systemic Deficiency of GHR in Pigs leads to Hepatic Steatosis via Negative Regulation of AHR Signaling

Int J Biol Sci.

doi: 10.7150/ijbs.64894.

(IF 4.858)

1164. Cai-Xia Yang, Lu Chen, Yu-Wei Yang, Qiao Mou, Zhi-Qiang Du

Acute heat stress reduces viability but increases lactate secretion of porcine immature Sertoli cells through transcriptome reprogramming

Theriogenology.

doi: 10.1016/j.theriogenology.2021.06.024.

(IF 2.094)

1165. Huijie Wu, Jingyuan Zhou, Songda Chen, Lingyu Zhu, Mengjie Jiang, Aiqun Liu

Survival-Related lncRNA Landscape Analysis Identifies LINC01614 as an Oncogenic lncRNA in Gastric Cancer

Front Genet.

doi: 10.3389/fgene.2021.698947.

(IF 3.258)

1166. Wen-Jing Guo, Yi-Cheng Wang, Yong-Dan Ma, Zhi-Hui Cui, Li-Xue Zhang, Li Nie, Xue-Qin Zhang, Mei-Jiao Wang, Jin-Hu Zhang, Dong-Zhi Yuan, Li-Min Yue

Contribution of high-fat diet-induced PCSK9 upregulation to a mouse model of PCOS is mediated partly by SREBP2

Reproduction.

doi: 10.1530/REP-21-0164.

(IF 3.206)

1167. Liang Sun, Yingyu Chen, Ping Yi, Li Yang, Yu Yan, Kailun Zhang, Qiaoying Zeng, Aizhen Guo

Serological detection of Mycobacterium Tuberculosis complex infection in multiple hosts by One Universal ELISA

PLoS One.

doi: 10.1371/journal.pone.0257920.

(IF 2.74)

1168. Yan-Bo Kou, Xiao-Qing Yan, Qi-Yue Jing, Sheng-Han Zhang, Zhuan-Zhuan Liu, Yan-Xia Wei, Yu-Gang Wang

LIGHT (TNFSF14) inhibits glucose uptake of adipocytes by downregulating GLUT4 expression via AKT signaling pathway

Biochem Biophys Res Commun.

doi: 10.1016/j.bbrc.2021.10.061.

1169. Panghua Ding, Jiajing Liu, Qiuyi Li, Qiongqiong Lu, Junxiang Li, Rui Shi, Lei Shi, Tangyou Mao, Dongyu Ge, HaiJun Niu, Guiying Peng, Zhibin Wang

Investigation of the Active Ingredients and Mechanism of Hudi Enteric-Coated Capsules in DSS-Induced Ulcerative Colitis Mice Based on Network Pharmacology and Experimental Verification

Drug Des Devel Ther.

doi: 10.2147/DDDT.S326029.

1170. Xiangli Xue, Feng Li, Ming Cai, Jingyun Hu, Qian Wang, Shujie Lou

Interactions between Endoplasmic Reticulum Stress and Autophagy: Implications for Apoptosis and Neuroplasticity-Related Proteins in Palmitic Acid-Treated Prefrontal Cells

Neural Plast.

doi: 10.1155/2021/8851327.

(IF 3.093)

1171. Wei Tian, Yinping Sun, Yuping Cheng, Xiao Ma, Weina Du, Wenna Shi, Qisen Guo

Arsenic sulfide reverses cisplatin resistance in non-small cell lung cancer in vitro and in vivo through targeting PD-L1

Thorac Cancer.

doi: 10.1111/1759-7714.14136.

(IF 2.61)

1172. Weiwei Liu, Liqiang Shi, Qiang Wan, Yansheng Wu, Di Huang, Jiaoying Ou, Qiuyu Liu, Xin Guan, Yuzhu Yang, Xiaotian Zhang, Jiandong Gao

Huangqi Guizhi Wuwu Decoction attenuates Podocyte cytoskeletal protein damage in IgA nephropathy rats by regulating AT1R/Nephrin/c-Abl pathway

Biomed Pharmacother.

doi: 10.1016/j.biopha.2021.111907.

(IF 4.545)

1173. Qianxing Zou, Huayu Qi

Deletion of ribosomal paralogs Rpl39 and Rpl39l compromises cell proliferation via protein synthesis and mitochondrial activity

Int J Biochem Cell Biol.

doi: 10.1016/j.biocel.2021.106070.

1174. Zihao Zhang, Xinyu Zhang, Chengwei Wang, Peng Zhou, Jie Xiao, Hui Zheng, Lei Wang, Senbo Yan, Yue Zhang, Xiaoping Ji

Deacetylated Sp1 improves β-glycerophosphate-induced calcification in vascular smooth muscle cells

Exp Ther Med.

doi: 10.3892/etm.2021.10586.

(IF 1.785)

1175. Dan Li, Wenjia Lai, Qingsong Wang, Zhichu Xiang, Xiaohui Nan, Xiaoliang Yang, Qiaojun Fang

CD151 enrichment in exosomes of luminal androgen receptor breast cancer cell line contributes to cell invasion

Biochimie.

doi: 10.1016/j.biochi.2021.06.007.

(IF 3.413)

1176. Di Zhao, Bo Yang, Chen Ye, Shaoyi Zhang, Xiaoqiong Lv, Qiyi Chen

Enteral nutrition ameliorates the symptoms of Crohn's disease in mice via activating special pro-resolving mediators through innate lymphoid cells

Innate Immun.

doi: 10.1177/17534259211057038.

1177. Zhijun Jiang, Zemeng Zhu, Mingyue Zhao, Wei Wang, Haonan Li, Dexiang Liu, Fang Pan

H3K9me2 regulation of BDNF expression in the hippocampus and medial prefrontal cortex is involved in the depressive-like phenotype induced by maternal separation in male rats

Psychopharmacology (Berl).

doi: 10.1007/s00213-021-05896-7.

1178. Yahan Zhang, Qiushi Gao, Ziyi Wu, Hang Xue, Ping Zhao

Sevoflurane Postconditioning Ameliorates Neuronal Migration Disorder Through Reelin/Dab1 and Improves Long-term Cognition in Neonatal Rats After Hypoxic-Ischemic Injury

Neurotox Res.

doi: 10.1007/s12640-021-00377-3.

(IF 2.992)

1179. Zhengrong Mei, Ye Hong, Haiyi Yang, Qiongyu Sheng, Bing Situ

Huperzine A protects against traumatic brain injury through anti-oxidative effects via the Nrf2-ARE pathway

Iran J Basic Med Sci.

doi: 10.22038/IJBMS.2021.58169.12932.

(IF 2.146)

1180. Zetian Shen, Li Yin, Han Zhou, Xiaoqin Ji, Changchen Jiang, Xixu Zhu, Xia He

Combined inhibition of AURKA and HSF1 suppresses proliferation and promotes apoptosis in hepatocellular carcinoma by activating endoplasmic reticulum stress

Cell Oncol (Dordr).

doi: 10.1007/s13402-021-00617-w.

1181. Xu Fan, Xiaoming Yin, Qi Zhao, Yi Yang

Hsa_circRNA_0045861 promotes renal injury in ureteropelvic junction obstruction via the microRNA-181d-5p/sirtuin 1 signaling axis

Ann Transl Med.

doi: 10.21037/atm-21-5060.

(IF 3.297)

1182. Xiaoyang Hua, Heng Chu, Chuanxiao Wang, Xuexin Shi, Ailin Wang, Zhe Zhang

Targeting USP22 with miR‑30‑5p to inhibit the hypoxia‑induced expression of PD‑L1 in lung adenocarcinoma cells

Oncol Rep.

doi: 10.3892/or.2021.8166.

(IF 3.417)

1183. Wenjuan Xun, Qingyao Fu, Liguang Shi, Ting Cao, Hongzheng Jiang, Zhonghua Ma

Resveratrol protects intestinal integrity, alleviates intestinal inflammation and oxidative stress by modulating AhR/Nrf2 pathways in weaned piglets challenged with diquat

Int Immunopharmacol.

doi: 10.1016/j.intimp.2021.107989.

(IF 3.943)

1184. Boning Cheng, Jianhong Jin, Dianlei Liu, Tingting Shi, Xiaoqing Fu, Chuntao Liu, Shourong Liu, Rui Wu

Oridonin interferes with simple steatosis of liver cells by regulating autophagy

Tissue Cell.

doi: 10.1016/j.tice.2021.101532.

(IF 1.837)

1185. Rongjiao Shao, Xintao Wang, Tianhua Xu, Yiyang Xia, Derong Cui

The balance between AIM2-associated inflammation and autophagy: the role of CHMP2A in brain injury after cardiac arrest

J Neuroinflammation.

doi: 10.1186/s12974-021-02307-8.

1186. Ran Liang, Qi Zhao, Qing Zhu, Xin He, Mingjun Gao, Yiru Wang

Lycium barbarum polysaccharide protects ARPE‑19 cells against H2O2‑induced oxidative stress via the Nrf2/HO‑1 pathway

Mol Med Rep.

doi: 10.3892/mmr.2021.12409.

(IF 2.1)

1187. Sheng-Lin Wang, Dan-Feng Weng, Hong-Xiang Wei, Zhen Huang, Ren-Qin Lin, Kai Shi, Jian-Hua Lin

Prognostic role of the recepteur d'origine nantais (RON) expression in primary high-grade osteosarcoma

J Orthop Sci.

doi: 10.1016/j.jos.2020.08.013.

(IF 1.259)

1188. Wuyang He, Yinghong Tang, Chunqiu Li, Xiaoyue Zhang, Shunping Huang, Benxu Tan, Zhenzhou Yang

Exercise Enhanced Cardiac Function in Mice With Radiation-Induced Heart Disease via the FNDC5/Irisin-Dependent Mitochondrial Turnover Pathway

Front Physiol.

doi: 10.3389/fphys.2021.739485.

(IF 3.367)

1189. Yang Zhang, Weifang Liu, Yanqi Zhong, Qi Li, Mengying Wu, Liu Yang, Xiaoxia Liu, Li Zou

Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF- κ B/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of P

Oxid Med Cell Longev.

doi: 10.1155/2021/1806344.

(IF 5.076)

1190. Xingyi Zhao, Minpeng Ji, Xin Wen, Dan Chen, Fu Huang, Xiaoju Guan, Jing Tian, Jiajia Xie, Jingjing Shao, Jiexia Wang, Luoqi Huang, Han Lin, Leping Ye, Haolin Chen

Effects of Midazolam on the Development of Adult Leydig Cells From Stem Cells In Vitro

Front Endocrinol (Lausanne).

doi: 10.3389/fendo.2021.765251.

1191. Jing He, Zhuang Wang, Yanbo Zhao, Jin Yang, Yuanxing Zhang, Qin Liu, Dahai Yang

Feeding with poly(I:C) induced long-term immune responses against bacterial infection in turbot ( Scophthalmus maximus)

Fish Shellfish Immunol Rep.

doi: 10.1016/j.fsirep.2021.100037.

1192. Yuan Wang, Yutong Sui, Aobo Lian, Xing Han, Feilin Liu, Kuiyang Zuo, Mingsheng Liu, Wei Sun, Ziyu Wang, Zinan Liu, Fei Zou, Rifeng Lu, Minghua Jin, Haiying Du, Kan Xu, Xiaomei Liu, Jinyu Liu

PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair

Front Cell Dev Biol.

doi: 10.3389/fcell.2021.739868.

(IF 5.201)

1193. Qing Tian, Chen Cao, Weijian Qiu, Han Wu, Lijun Zhou, Zhipeng Dai, Zhenwei Li, Songfeng Chen

RIPK1 Coordinates Bone Marrow Mesenchymal Stem Cell Survival by Maintaining Mitochondrial Homeostasis via p53

Stem Cells Int.

doi: 10.1155/2021/5540149.

(IF 3.869)

1194. Yilong Cui, Miao Song, Bonan Xiao, Menglin Liu, Pengli Liu, Yanfei Han, Bing Shao, Yanfei Li

ROS-mediated mitophagy and apoptosis are involved in aluminum-induced femoral impairment in mice

Chem Biol Interact.

doi: 10.1016/j.cbi.2021.109663.

1195. Zhongjuan Xu, Junjun Cao, Zhe Zhao, Yong Qiao, Xingzhi Liu, Junjie Zhong, Bin Wang, Guangli Suo

A functional extracellular matrix biomaterial enriched with VEGFA and bFGF as vehicle of human umbilical cord mesenchymal stem cells in skin wound healing

Biomed Mater.

doi: 10.1088/1748-605X/ac37b0.

(IF 3.174)

1196. Bingyu Li, Chaofan Hou, Xian Ju, Yong Feng, Zhi-Qiang Ye, Yunzhu Xiao, Mingyao Gu, Chunxiang Fu, Chaoliang Wei, Conghui You

Gain of Spontaneous clpX Mutations Boosting Motility via Adaption to Environments in Escherichia coli

Front Bioeng Biotechnol.

doi: 10.3389/fbioe.2021.772397.

1197. Ye-Hui Liao, Mo-Xian Chen, Shao-Chun Chen, Kai-Xuan Luo, Bin Wang, Yao Liu, Li-Juan Ao

Effects of Noninvasive Low-Intensity Focus Ultrasound Neuromodulation on Spinal Cord Neurocircuits In Vivo

Evid Based Complement Alternat Med.

doi: 10.1155/2021/8534466.

1198. Zhipeng Yan, Ni Zeng, Jieting Li, Tao Liao, Guoxin Ni

Cardiac Effects of Treadmill Running at Different Intensities in a Rat Model

Front Physiol.

doi: 10.3389/fphys.2021.774681.

(IF 3.367)

1199. Hongrui Guo, Heng Yin, Zhicai Zuo, Zhuangzhi Yang, Yue Yang, Ling Wei, Hengmin Cui, Huidan Deng, Xia Chen, Jian Chen, Yanqiu Zhu, Ping Ouyang, Yi Geng, Zongjun Du, Huaqiao Tang, Fengyuan Wang, Jing Fang

Oxidative stress-mediated apoptosis and autophagy involved in Ni-induced nephrotoxicity in the mice

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2021.112954.

1200. Na Sun, Lina Yu, Yibo Gao, Longfei Ma, Jinxuan Ren, Ying Liu, Dave Schwinn Gao, Chen Xie, Ying Wu, Lieju Wang, Juncong Hong, Min Yan

MeCP2 Epigenetic Silencing of Oprm1 Gene in Primary Sensory Neurons Under Neuropathic Pain Conditions

Front Neurosci.

doi: 10.3389/fnins.2021.743207.

1201. Xueyang Jiang, Chang Liu, Manxing Zou, Huanfang Xie, Tailiang Lin, Weiping Lyu, Jian Xu, Yuan Li, Feng Feng, Haopeng Sun, Wenyuan Liu

Discovery of 2-(cyclopropanecarboxamido)-N-(5-((1-(4-fluorobenzyl)piperidin-4-yl)methoxy)pyridin-3-yl)isonicotinamide as a potent dual AChE/GSK3β inhibitor for the treatment of Alzheimer's disease: Si

Eur J Med Chem.

doi: 10.1016/j.ejmech.2021.113663.

(IF 5.572)

1202. Liping Zhang, Yilin Liu, Sanrong Wang, Lu Long, Qianwen Zang, Jingxi Ma, Lehua Yu, Gongwei Jia

Vagus nerve stimulation mediates microglia M1/2 polarization via inhibition of TLR4 pathway after ischemic stroke

Biochem Biophys Res Commun.

doi: 10.1016/j.bbrc.2021.09.004.

1203. Yanyu Li, Guomei Su, Yu Zhong, Zhilin Xiong, Tong Huang, Jingyun Quan, Jiewen Huang, Xiaoxia Wen, Chaole Luo, Weilin Zheng, Jinfeng Chen, Junfen Cheng, Weimin Yao, Tianwen Lai

HB-EGF-induced IL-8 secretion from airway epithelium leads to lung fibroblast proliferation and migration

BMC Pulm Med.

doi: 10.1186/s12890-021-01726-w.

(IF 2.813)

1204. Yi Wang, Shengwen Wang, Weiwei Zhang, Jiayi Liu, Zhuo Yang, Chunhua Liu

Notch1 participates in the activation of autophagy in the hippocampus of type I diabetic mice

Neurochem Int.

doi: 10.1016/j.neuint.2021.105156.

(IF 3.881)

1205. Jian Luo, Qiang He, Jin-Zhi Xu, Chen Xu, Yin-Ze Han, Hai-Long Gao, Xian-Zhi Meng, Guo-Qing Pan, Tian Li, Ze-Yang Zhou

Microsporidia infection upregulates host energy metabolism but maintains ATP homeostasis

J Invertebr Pathol.

doi: 10.1016/j.jip.2021.107596.

(IF 2.074)

1206. Suna Zheng, Tianchi Zhuang, Yajun Tang, Ruihan Wu, Ting Xu, Tian Leng, Yao Wang, Zheng Lin, Minghui Ji

Leonurine protects against ulcerative colitis by alleviating inflammation and modulating intestinal microflora in mouse models

Exp Ther Med.

doi: 10.3892/etm.2021.10633.

(IF 1.785)

1207. Xinlu Li, Geng Lin, Tongtong Liu, Ning Zhao, He Xu, Huaqin Wang, Wei Zheng

Postnatal development of BAG3 expression in mouse cerebral cortex and hippocampus

Brain Struct Funct.

doi: 10.1007/s00429-021-02356-y.

(IF 3.298)

1208. Xueling Guo, Yan Deng, Linghui Zhan, Jin Shang, Huiguo Liu

O‑GlcNAcylation contributes to intermittent hypoxia‑associated vascular dysfunction via modulation of MAPKs but not CaMKII pathways

Mol Med Rep.

doi: 10.3892/mmr.2021.12384.

(IF 2.1)

1209. Chaohua Lv, Qingsong Wan, Chengxiang Shen, Hongsheng Wu, Bin Zhou, Weiwei Wang

Long non‑coding RNA ZSCAN16‑AS1 promotes the malignant properties of hepatocellular carcinoma by decoying microRNA‑451a and consequently increasing ATF2 expression

Mol Med Rep.

doi: 10.3892/mmr.2021.12420.

(IF 2.1)

1210. Weidang Xie, Wei Huang, Shumin Cai, Hui Chen, Weijun Fu, Zhongqing Chen, Yanan Liu

NF‑κB/IκBα signaling pathways are essential for resistance to heat stress‑induced ROS production in pulmonary microvascular endothelial cells

Mol Med Rep.

doi: 10.3892/mmr.2021.12454.

(IF 2.1)

1211. Pengli Liu, Yilong Cui, Menglin Liu, Bonan Xiao, Jian Zhang, Wanyue Huang, Xuliang Zhang, Miao Song, Yanfei Li

Protective effect of mitophagy against aluminum-induced MC3T3-E1 cells dysfunction

Chemosphere.

doi: 10.1016/j.chemosphere.2021.131086.

(IF 5.778)

1212. Juanjuan Qiu, Li Xu, Xiaohong Zeng, Zhenru Wu, Yu Wang, Yao Wang, Jiqiao Yang, Hao Wu, Yanyan Xie, Faqing Liang, Qing Lv, Zhenggui Du

NUSAP1 promotes the metastasis of breast cancer cells via the AMPK/PPARγ signaling pathway

Ann Transl Med.

doi: 10.21037/atm-21-5517.

(IF 3.297)

1213. Lingdi Nie, Liwen Jiang, John P Quinn, Blair D Grubb, Minyan Wang

TRPA1-Mediated Src Family Kinases Activity Facilitates Cortical Spreading Depression Susceptibility and Trigeminovascular System Sensitization

Int J Mol Sci.

doi: 10.3390/ijms222212273.

(IF 4.556)

1214. Nan Gao, Xiujing Dou, Ting Yin, Yang Yang, Di Yan, Ziwen Ma, Chongpeng Bi, Anshan Shan

Tryptophan Promotes Intestinal Immune Defense through Calcium-Sensing Receptor (CaSR)-Dependent Metabolic Pathways

J Agric Food Chem.

doi: 10.1021/acs.jafc.1c05820.

1215. Qi Shao, Junjie Huang, Jingui Li

Intracellular Replication Inhibitory Effects of Tea Tree Oil on Vesicular Stomatitis Virus and Anti-inflammatory Activities in Vero Cells

Front Vet Sci.

doi: 10.3389/fvets.2021.759812.

(IF 2.245)

1216. Tianhan Li, Juhui Qiu, Tingting Jia, Yinming Liang, Kun Zhang, Wenhua Yan, Zhengjun Hou, Shiwei Yang, Lushan Liu, Wenhao Xiong, Yaokai Chen, Guixue Wang

G3BP2 regulates oscillatory shear stress-induced endothelial dysfunction

Genes Dis.

doi: 10.1016/j.gendis.2021.11.003.

1217. Yan Huang, Yanping Dai, Min Li, Lulu Guo, Chulin Cao, Yuting Huang, Rui Ma, Shengyue Qiu, Xiaoyi Su, Kai Zhong, Yina Huang, Hong Gao, Qian Bu

Exposure to cadmium induces neuroinflammation and impairs ciliogenesis in hESC-derived 3D cerebral organoids

Sci Total Environ.

doi: 10.1016/j.scitotenv.2021.149043.

(IF 6.551)

1218. Zi Lv, Li-Ling Xiong, Xian Qin, Hua Zhang, Xin Luo, Wei Peng, Mark D Kilby, Richard Saffery, Philip N Baker, Hong-Bo Qi

Role of GRK2 in Trophoblast Necroptosis and Spiral Artery Remodeling: Implications for Preeclampsia Pathogenesis

Front Cell Dev Biol.

doi: 10.3389/fcell.2021.694261.

(IF 5.201)

1219. Xunxun Wu, Lian Liu, Qiuling Zheng, Haiping Hao, Hui Ye, Ping Li, Hua Yang

Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2

Acta Pharm Sin B.

doi: 10.1016/j.apsb.2021.03.021.

(IF 7.097)

1220. Mingdong Si, Meng Wu, Yingying Huo, Aiying Li, Shengjiang Guan, Donglai Ma, Zhihong Ma

Gentianella acuta mitigates cardiovascular damage and inflammation in diet-induced hypercholesterolaemic rats

Exp Ther Med.

doi: 10.3892/etm.2021.10694.

(IF 1.785)

1221. Yan Zhou, Shuai Chen, Wenxian Gu, Xiao Sun, Linxiao Wang, Liming Tang

Sinomenine hydrochloride ameliorates dextran sulfate sodium-induced colitis in mice by modulating the gut microbiota composition whilst suppressing the activation of the NLRP3 inflammasome

Exp Ther Med.

doi: 10.3892/etm.2021.10722.

(IF 1.785)

1222. Qiu Renfeng, Chen Shuxiao, Gao Peixian, Luo Kun, Feng Xuedong, Yuan Hai, Wu Xuejun, Li Gang

ADAM10 attenuates the development of abdominal aortic aneurysms in a mouse model

Mol Med Rep.

doi: 10.3892/mmr.2021.12414.

(IF 2.1)

1223. Junjun Wei, Liangliang Chen, Duidui Wang, Li Tang, Zhenhua Xie, Weifeng Chen, Shuwei Zhang, Guobin Weng

Upregulation of RIP3 promotes necroptosis via a ROS‑dependent NF‑κB pathway to induce chronic inflammation in HK‑2 cells

Mol Med Rep.

doi: 10.3892/mmr.2021.12423.

(IF 2.1)

1224. Meng Yang, Binbin Yang, Danqi Deng

Targeting of EIF4EBP1 by miR-99a-3p affects the functions of B lymphocytes via autophagy and aggravates SLE disease progression

J Cell Mol Med.

doi: 10.1111/jcmm.16991.

(IF 4.486)

1225. Shengfu Wang, Chunyan Wang, Xiao Wang, Xiang Wang, Lina Huang, Jiajie Kuai, Wei Wei, Xiaorong Lu, Shangxue Yan

Antitumor efficacy of CHMFL-KIT-110 solid dispersion in mouse xenograft models of human gastrointestinal stromal tumors

Cancer Chemother Pharmacol.

doi: 10.1007/s00280-021-04332-z.

1226. Jie Liu, Wei Ma, Cheng-Hao Zang, Guo-Dong Wang, Si-Jia Zhang, Hong-Jie Wu, Ke-Wei Zhu, Xiang-Lin Xiang, Chun-Yan Li, Kuang-Pin Liu, Jian-Hui Guo, Li-Yan Li

Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-κB signaling pathway

Ann Transl Med.

doi: 10.21037/atm-21-5752.

(IF 3.297)

1227. Lei Yu, Yuxi Chen, Shaohui Yuan, Yang Cao, Zhenggang Bi

Peiminine Induces G0/G1-Phase Arrest, Apoptosis, and Autophagy via the ROS/JNK Signaling Pathway in Human Osteosarcoma Cells in Vitro and in Vivo

Front Pharmacol.

doi: 10.3389/fphar.2021.770846.

(IF 4.225)

1228. Meixue Chen, Jing Li, Jinfeng Wang, Yuan Le, Chunfeng Liu

SMYD1 alleviates septic myocardial injury by inhibiting endoplasmic reticulum stress

Biosci Biotechnol Biochem.

doi: 10.1093/bbb/zbab167.

1229. Qiong Li, Lei Huang

MiR-148a-3p Regulates the Invasion and Odontoblastic Differentiation of Human Dental Pulp Stem Cells via the Wnt1/ β-Catenin Pathway

Int J Stem Cells.

doi: 10.15283/ijsc20118.

(IF 1.94)

1230. Congrui Jiao, Jiahong Zou, Zhenwei Chen, Feifei Zheng, Zhen Xu, Yu-Hung Lin, Qingchao Wang

Dietary Glutamine Inclusion Regulates Immune and Antioxidant System, as Well as Programmed Cell Death in Fish to Protect against Flavobacterium columnare Infection

Antioxidants (Basel).

doi: 10.3390/antiox11010044.

1231. Zhen Liu, Yaqiong Wang, Yifei Liu, Qiuqin Zhang, Wei Li, Mingsheng Dong, Xin Rui

The Conformational Structural Change of Soy Glycinin via Lactic Acid Bacteria Fermentation Reduced Immunoglobulin E Reactivity

Foods.

doi: 10.3390/foods10122969.

(IF 4.092)

1232. Xingyu Deng, Xiabin Chen, Fang Geng, Xin Tang, Zhenzhen Li, Jie Zhang, Yikai Wang, Fangqian Wang, Na Zheng, Peng Wang, Xiaohua Yu, Shurong Hou, Wei Zhang

Precision 3D printed meniscus scaffolds to facilitate hMSCs proliferation and chondrogenic differentiation for tissue regeneration

J Nanobiotechnology.

doi: 10.1186/s12951-021-01141-7.

1233. Long Miao, Juan Zhang, Lihong Yin, Yuepu Pu

TMT-Based Quantitative Proteomics Reveals Cochlear Protein Profile Alterations in Mice with Noise-Induced Hearing Loss

Int J Environ Res Public Health.

doi: 10.3390/ijerph19010382.

1234. Yichen Guo, Yawen Cheng, Jiaqi An, Yi Qi, Guogang Luo

Neuropeptide changes in an improved migraine model with repeat stimulations

Transl Neurosci.

doi: 10.1515/tnsci-2020-0201.

(IF 1.373)

1235. Yao Liu, Li Chen, Wenjun Liu, Dan Li, Jiuseng Zeng, Qiong Tang, Yuexin Zhang, Fei Luan, Nan Zeng

Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways

Front Microbiol.

doi: 10.3389/fmicb.2021.795756.

(IF 4.235)

1236. Cong Wang, Hao Chen, Hui-Hui Jiang, Bin-Bin Mao, Hao Yu

Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses

Front Neurosci.

doi: 10.3389/fnins.2021.772401.

1237. Hongjian Dai, Zengpeng Lv, Zhenwu Huang, Nanwei Ye, Simeng Li, Jingle Jiang, Ying Cheng, Fangxiong Shi

Dietary hawthorn-leaves flavonoids improves ovarian function and liver lipid metabolism in aged breeder hens

Poult Sci.

doi: 10.1016/j.psj.2021.101499.

1238. Shengyang Jin, Liang Yang, Chunqing Meng, Yu He, Kaige Ma, Wei Huang, Hong Wang

Sequential Epiphyseal Cartilage Changes of Femoral Heads in C57BL/6 Female Mice Treated with Excessive Glucocorticoids

Cartilage.

doi: 10.1177/1947603520978574.

(IF 3.857)

1239. Lili Zhang, Shilun Li, Juan Li, Yukun Li

LncRNA ORLNC1 Promotes Bone Marrow Mesenchyml Stem Cell Pyroptosis Induced by Advanced Glycation End Production by Targeting miR-200b-3p/Foxo3 Pathway

Stem Cell Rev Rep.

doi: 10.1007/s12015-021-10247-2.

(IF 5.316)

1240. Changquan Guo, Juan Dong, Yanfen Ma, Shuo Zhou, Weidong Zeng, Guang Liu, Caiqiao Zhang

LIF and bFGF enhanced chicken primordial follicle activation by Wnt/β-catenin pathway

Theriogenology.

doi: 10.1016/j.theriogenology.2021.09.008.

(IF 2.094)

1241. Xiaodan Li, Xiaolei Yao, Haiqiang Xie, Guomin Zhang, Mingtian Deng, Kaiping Deng, Xiaoxiao Gao, Yongjin Bao, Kang Li, Feng Wang

PPP2R2A affects embryonic implantation by regulating the proliferation and apoptosis of Hu sheep endometrial stromal cells

Theriogenology.

doi: 10.1016/j.theriogenology.2021.09.026.

(IF 2.094)

1242. Huihui Li, Jun Li, Xianjing Zhang, Jiaomeng Li, Cong Xi, Wenqiong Wang, Youli Lu, Lijiang Xuan

Euphornin L promotes lipid clearance by dual regulation of LDLR and PCSK9

Exp Ther Med.

doi: 10.3892/etm.2021.10817.

(IF 1.785)

1243. Xiao Lin, Ya Xing, Yihui Zhang, Biao Dong, Minmeng Zhao, Jian Wang, Tuoyu Geng, Daoqing Gong, Yun Zheng, Long Liu

Glucose participates in the formation of goose fatty liver by regulating the expression of miRNA-33/CROT

Anim Sci J.

doi: 10.1111/asj.13674.

(IF 1.399)

1244. Ting Xie, Xiaodong Chen, Wenyi Chen, Sien Huang, Xinye Peng, Lingmei Tian, Xuejie Wu, Yan Huang

Curcumin is a Potential Adjuvant to Alleviates Diabetic Retinal Injury via Reducing Oxidative Stress and Maintaining Nrf2 Pathway Homeostasis

Front Pharmacol.

doi: 10.3389/fphar.2021.796565.

(IF 4.225)

1245. Zhang'an Dai, Lin Cai, Yingyu Chen, Silu Wang, Qian Zhang, Chengde Wang, Ming Tu, Zhangzhang Zhu, Qun Li, Xianghe Lu

Brusatol Inhibits Proliferation and Invasion of Glioblastoma by Down-Regulating the Expression of ECM1

Front Pharmacol.

doi: 10.3389/fphar.2021.775680.

(IF 4.225)

1246. Junfang Li, Xiaoling Hu, Tian Luo, Yingmei Lu, Yiyue Feng, Honghua Zhang, Dan Liu, Xiaohong Fan, Yuqing Wang, Liming Jiang, Yuying Wang, Xiangyong Hao, Tao Shi, Zhen Wang

N-2-(phenylamino) benzamide derivatives as novel anti-glioblastoma agents: Synthesis and biological evaluation

Eur J Med Chem.

doi: 10.1016/j.ejmech.2021.113817.

(IF 5.572)

1247. Yue Wang, Rong Jin, Jiebiao Chen, Jinping Cao, Jianbo Xiao, Xian Li, Chongde Sun

Tangeretin maintains antioxidant activity by reducing CUL3 mediated NRF2 ubiquitination

Food Chem.

doi: 10.1016/j.foodchem.2021.130470.

(IF 6.306)

1248. Xiao-Jun Cao, Rui Wu, He-Ya Qian, Xiang Chen, Hong-Yan Zhu, Guang-Yin Xu, Ye-Zi Sun, Ping-An Zhang

Metformin attenuates diabetic neuropathic pain via AMPK/NF-κB signaling pathway in dorsal root ganglion of diabetic rats

Brain Res.

doi: 10.1016/j.brainres.2021.147663.

(IF 2.733)

1249. Dan Jiang, Ping Li, Yan Yin, Guangxi Ren, Chunsheng Liu

Molecular cloning and functional characterization of UGTs from Glycyrrhiza uralensis flavonoid pathway

Int J Biol Macromol.

doi: 10.1016/j.ijbiomac.2021.09.136.

(IF 5.162)

1250. Yinghui Wang, Yihang Xie, Boxuan Sun, Yuwei Guo, Ling Song, Dawit Eman Mohammednur, Chunyan Zhao

The degradation of Rap1GAP via E6AP-mediated ubiquitin-proteasome pathway is associated with HPV16/18-infection in cervical cancer cells

Infect Agent Cancer.

doi: 10.1186/s13027-021-00409-9.

1251. Lin Liu, Yongwu Yang, Rui Fang, Weining Zhu, Jingxue Wu, Xiaoyun Li, Jay V Patankar, Wei Li

Giardia duodenalis and Its Secreted PPIB Trigger Inflammasome Activation and Pyroptosis in Macrophages through TLR4-Induced ROS Signaling and A20-Mediated NLRP3 Deubiquitination

Cells.

doi: 10.3390/cells10123425.

(IF 4.366)

1252. Ziqing Wang, Wenwen Mu, Zhaotang Gong, Guoyun Liu, Jie Yang

Meta-substituted piperlongumine derivatives attenuate inflammation in both RAW264.7 macrophages and a mouse model of colitis

Bioorg Chem.

doi: 10.1016/j.bioorg.2021.105465.

(IF 4.831)

1253. Zhuo Li, Zhiwen Lian, Jianchao Ma, Li Zhang, Xingji Lian, Shuangxin Liu, Jianteng Xie, Zhonglin Feng, Ting Lin, Hong Zhang, Xinling Liang

Integrin β3 overexpression contributes to podocyte injury through inhibiting RhoA/YAP signaling pathway

Bioengineered.

doi: 10.1080/21655979.2021.1906097.

(IF 2.205)

1254. Yan Li, Xiaoxiao Xu, Liyan Wang, Xuemei Li, Running Liu, Li Zhang, Yali Xu

REDD1 (regulated in development and DNA damage-1)/autophagy inhibition ameliorates fine particulate matter (PM2.5) -induced inflammation and apoptosis in BEAS-2B cells

Bioengineered.

doi: 10.1080/21655979.2021.1917227.

(IF 2.205)

1255. Hui Liu, Zuofei Chi, Hong Jin, Wei Yang

MicroRNA miR-188-5p as a mediator of long non-coding RNA MALAT1 regulates cell proliferation and apoptosis in multiple myeloma

Bioengineered.

doi: 10.1080/21655979.2021.1920325.

(IF 2.205)

1256. Mengyao Mu, Hongjing Zhao, Yu Wang, Menghao Guo, Xiaopan Nie, Yachen Liu, Mingwei Xing

Interferon-beta, interferon-gamma and their fusion interferon of Siberian tigers (Panthera tigris altaica) in China are involved in positive-feedback regulation of interferon production

Dev Comp Immunol.

doi: 10.1016/j.dci.2021.104211.

(IF 3.192)

1257. Xin Wu, Zongqi Wang, Haiying Li, Xueshun Xie, Jiang Wu, Haitao Shen, Xiang Li, Zhong Wang, Gang Chen

Loss of monocarboxylate transporter 1 aggravates white matter injury after experimental subarachnoid hemorrhage in rats

Front Med.

doi: 10.1007/s11684-021-0879-9.

1258. Qi Jia, Weifeng Tian, Binbin Li, Wen Chen, Wenjie Zhang, Yang Xie, Na Cheng, Qi Chen, Jianru Xiao, Yiwang Zhang, Jian Yang, Shu Wang

Transient Receptor Potential channels, TRPV1 and TRPA1 in melanocytes synergize UV-dependent and UV-independent melanogenesis

Br J Pharmacol.

doi: 10.1111/bph.15643.

1259. Yi Zhou, Zhi Tan, Hao Huang, Yonglian Zeng, Shilian Chen, Jie Wei, Guozhen Huang, Chaosi Qian, Guandou Yuan, Songqing He

Baicalein pre-treatment alleviates hepatic ischemia/reperfusion injury in mice by regulating the Nrf2/ARE pathway

Exp Ther Med.

doi: 10.3892/etm.2021.10816.

(IF 1.785)

1260. Yuanyang Li, Yufan Zhang, Xiangzhong Zhou, Xianghong Lei, Xinhang Li, Liping Wei

Dynamic observation of 5-fluorouracil-induced myocardial injury and mitochondrial autophagy in aging rats

Exp Ther Med.

doi: 10.3892/etm.2021.10886.

(IF 1.785)

1261. Tong-Zhuang Wang, Guo-Wei Zuo, Ling Yao, Chun-Lin Yuan, Hai-Fei Li, Ying Lai, Zhi-Wei Chen, Jun Zhang, Ya-Qian Jin, Johji Yamahara, Jian-Wei Wang

Ursolic acid ameliorates adipose tissue insulin resistance in aged rats via activating the Akt-glucose transporter 4 signaling pathway and inhibiting inflammation

Exp Ther Med.

doi: 10.3892/etm.2021.10901.

(IF 1.785)

1262. Yuying Fan, Xiaoli Ren, Yingxue Wang, Enshuang Xu, Shuang Wang, Ruidong Ge, Yun Liu

Metformin inhibits the proliferation of canine mammary gland tumor cells through the AMPK/AKT/mTOR signaling pathway in vitro

Oncol Lett.

doi: 10.3892/ol.2021.13113.

(IF 2.311)

1263. Yali Guan, Pengfei Li, Yingshuo Liu, Lan Guo, Qingwen Wu, Yuefa Cheng

Protective multi‑target effects of DL‑3‑n‑butylphthalide combined with 3‑methyl‑1‑phenyl‑2‑pyrazolin‑5‑one in mice with ischemic stroke

Mol Med Rep.

doi: 10.3892/mmr.2021.12490.

(IF 2.1)

1264. Bugao Guan, Guangrun Li, Benhai Wan, Xiang Guo, Desong Huang, Jun Ma, Ping Gong, Jinbao Guo, Yanzhi Bu

RNA-binding protein RBM38 inhibits colorectal cancer progression by partly and competitively binding to PTEN 3'UTR with miR-92a-3p

Environ Toxicol.

doi: 10.1002/tox.23356.

(IF 3.118)

1265. Xiuge Gao, Chunlei Ji, Junqi Wang, Xinhao Song, Runan Zuo, Jingjing Zhang, Xiaorong Chen, Hui Ji, Lin Peng, Dawei Guo, Shanxiang Jiang

Maduramicin induces cardiotoxicity via Rac1 signaling-independent methuosis in H9c2 cells

J Appl Toxicol.

doi: 10.1002/jat.4175.

(IF 2.997)

1266. Yang Xie, Feng Wang, Jun Yu, Jing Zhang, Yuting Liu, Mengying Li, Jian Qi

Silencing of MBD2 and EZH2 inhibits the proliferation of colorectal carcinoma cells by rescuing the expression of SFRP

Oncol Rep.

doi: 10.3892/or.2021.8201.

(IF 3.417)

1267. Wenjing Niu, Haibo Wang, Bo Wang, Xueying Mao, Min Du

Resveratrol improves muscle regeneration in obese mice through enhancing mitochondrial biogenesis

J Nutr Biochem.

doi: 10.1016/j.jnutbio.2021.108804.

(IF 4.873)

1268. Gang Zhao, Xiaobao Shi, Zhanbo Sun, Pengfei Zhao, Zaiming Lu

PAQR4 promotes the development of hepatocellular carcinoma by activating PI3K/AKT pathway

Acta Biochim Biophys Sin (Shanghai).

doi: 10.1093/abbs/gmab143.

1269. Bo Li, Xianyi Liu, Guogang Wu, Jiawen Liu, Shouliang Cai, Fuxin Wang, Chunyu Yang, Jisheng Liu

MicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2

Bioengineered.

doi: 10.1080/21655979.2021.1996505.

(IF 2.205)

1270. Huijie Fan, Yanrong Li, Mengying Sun, Wushuai Xiao, Lijuan Song, Qing Wang, Bo Zhang, Jiezhong Yu, Xiaoming Jin, Cungen Ma, Zhi Chai

Hyperoside Reduces Rotenone-induced Neuronal Injury by Suppressing Autophagy

Neurochem Res.

doi: 10.1007/s11064-021-03404-z.

(IF 3.038)

1271. Jianyun Cao, Xuebing Qiu, Yun Gao, Liangliang Cai

Puerarin promotes the osteogenic differentiation of rat dental follicle cells by promoting the activation of the nitric oxide pathway

Tissue Cell.

doi: 10.1016/j.tice.2021.101601.

(IF 1.837)

1272. Qi Zhang, Fan Zhu, Yuyin Luo, Jun Liao, Jiancheng Cao, Tao Xue

Platelet miR-107 Participates in Clopidogrel Resistance after PCI Treatment by Regulating P2Y12

Acta Haematol.

doi: 10.1159/000517811.

1273. Li Wang, Yan Zhao, Shuang Yao, Hongfei Lou, Luo Zhang

Vitamin D Improves the Effect of Glucocorticoids on Attenuating Lipopolysaccharide-Induced IL-6 Production via TLR4/NF-κB Pathway in Human Respiratory Epithelial Cells

Int Arch Allergy Immunol.

doi: 10.1159/000524855.

1274. Han Li, Jun-Xian Xu, Tiao-Chun Cheng, Li-Jun Tian, Jin-Feng Lin, Xi Luo, Zhao-Lian Bian, Xu-Dong Han

Inhibition of Phosphoinositide 3-Kinase Gamma Protects Endothelial Cells via the Akt Signaling Pathway in Sepsis-Induced Acute Kidney Injury

Kidney Blood Press Res.

doi: 10.1159/000526916.

1275. Zefeng Wang, Qianfei Cui, Ling Shi, Meiling Zhang, Peng Song, Dongzhu Duan, Wenjing Guo

Network Pharmacology-based Prediction and Verification of Shikonin for Treating Colorectal Cancer

Recent Pat Anticancer Drug Discov.

doi: 10.2174/1574892817666211224142100.

1276. Chunyan Li, Yuehua Zhu, Yuanyuan Wu, Meiyuan Fu, Yiling Wu, Yuehong Wu, Yinger Qiu, Hui Zhang, Mingxing Ding

Oridonin Alleviates LPS-Induced Depression by Inhibiting NLRP3 Inflammasome via Activation of Autophagy

Front Med (Lausanne).

doi: 10.3389/fmed.2021.813047.

1277. Leyi Zhang, Chenglong Lu, Li Kang, Yingji Li, Wenjing Tang, Dengfa Zhao, Shengyuan Yu, Ruozhuo Liu

Temporal characteristics of astrocytic activation in the TNC in a mice model of pain induced by recurrent dural infusion of inflammatory soup

J Headache Pain.

doi: 10.1186/s10194-021-01382-9.

(IF 4.797)

1278. Peiyan Zhao, Xiaodan Sun, Hui Li, Yan Liu, Yanan Cui, Lin Tian, Ying Cheng

c-Myc Targets HDAC3 to Suppress NKG2DL Expression and Innate Immune Response in N-Type SCLC through Histone Deacetylation

Cancers (Basel).

doi: 10.3390/cancers14030457.

1279. Qiao Mou, Yu-Wei Yang, Lu Chen, Ting Fang, Yu-Chang Yao, Zhi-Qiang Du, Cai-Xia Yang

Melatonin mitigates Chloroquine-induced defects in porcine immature Sertoli cells

Theriogenology.

doi: 10.1016/j.theriogenology.2021.10.005.

(IF 2.094)

1280. Rongchen Shi, Kun Zhao, Teng Wang, Jing Yuan, Dapeng Zhang, Wei Xiang, Jin Qian, Na Luo, Yong Zhou, Bo Tang, Chuan Li, Hongming Miao

5-aza-2'-deoxycytidine potentiates anti-tumor immunity in colorectal peritoneal metastasis by modulating ABC A9-mediated cholesterol accumulation in macrophages

Theranostics.

doi: 10.7150/thno.66420.

(IF 8.579)

1281. Qiushi Feng, Panpan Yang, He Wang, Congshan Li, Tomoka Hasegawa, Zhaopeng Liu, Minqi Li

ID09, A Newly-Designed Tubulin Inhibitor, Regulating the Proliferation, Migration, EMT Process and Apoptosis of Oral Squamous Cell Carcinoma

Int J Biol Sci.

doi: 10.7150/ijbs.65824.

(IF 4.858)

1282. Haiyang Zhao, Tingting Zhao, Jihong Yang, Qianqian Huang, Hua Wu, Yueyun Pan, Hui Wang, Yun Qian

Epimedium protects against dyszoospermia in mice with Pex3 knockout by exerting antioxidant effects and regulating the expression level of P16

Cell Death Dis.

doi: 10.1038/s41419-021-04435-8.

(IF 6.304)

1283. Chenxi Shi, Jiaqi Wang, Ruichen Zhang, Muhammad Ishfaq, Ying Li, Ruihui Zhang, Chuanbiao Si, Rui Li, Changwen Li, Fangping Liu

Dihydromyricetin alleviates Escherichia coli lipopolysaccharide-induced hepatic injury in chickens by inhibiting the NLRP3 inflammasome

Vet Res.

doi: 10.1186/s13567-022-01024-1.

(IF 3.357)

1284. Xin-Yi Wu, Ya-Jun Chen, Chang-An Liu, Jun-Hua Gong, Xue-Song Xu

STING Induces Liver Ischemia-Reperfusion Injury by Promoting Calcium-Dependent Caspase 1-GSDMD Processing in Macrophages

Oxid Med Cell Longev.

doi: 10.1155/2022/8123157.

(IF 5.076)

1285. Mo Zhu, Baofei Jiang, Hao Zuo, Xiaopeng Wang, Hengfa Ge, Ziming Huang

LIM-Domain-Binding Protein 1 Mediates Cell Proliferation and Drug Resistance in Colorectal Cancer

Front Surg.

doi: 10.3389/fsurg.2021.790380.

1286. Xiaobin Fang, Mengmeng Li, Weiyi Zhang, Jingyi Li, Tao Zhu

Thrombin induces pro-inflammatory and anti-inflammatory cytokines secretion from human mast cell line (HMC-1) via protease-activated receptors

Mol Immunol.

doi: 10.1016/j.molimm.2021.11.012.

(IF 3.641)

1287. Dongmin Xu, Li Li, Leilei Tang, Ming Guo, Jie Yang

Perfluorooctane sulfonate induces heart toxicity involving cardiac apoptosis and inflammation in rats

Exp Ther Med.

doi: 10.3892/etm.2021.10936.

(IF 1.785)

1288. Fuxin Zhao, Wei Chen, Hui Zhou, Peter S Reinach, Yuhan Wang, Suh-Hang H Juo, Zhenglin Yang, Anquan Xue, Yi Shi, Chung-Ling Liang, Changqing Zeng, Jia Qu, Xiangtian Zhou

PDE4B Proposed as a High Myopia Susceptibility Gene in Chinese Population

Front Genet.

doi: 10.3389/fgene.2021.775797.

(IF 3.258)

1289. Fenglian Yan, Dalei Cheng, Haiyan Wang, Min Gao, Junfeng Zhang, Hongyan Cheng, Changying Wang, Hui Zhang, Huabao Xiong

Corilagin Ameliorates Con A-Induced Hepatic Injury by Restricting M1 Macrophage Polarization

Front Immunol.

doi: 10.3389/fimmu.2021.807509.

(IF 5.085)

1290. Shuhua Zhang, Jianqun Xu, Huan Cao, Mi Jiang, Jun Xiong

KB-68A7.1 Inhibits Hepatocellular Carcinoma Development Through Binding to NSD1 and Suppressing Wnt/β-Catenin Signalling

Front Oncol.

doi: 10.3389/fonc.2021.808291.

(IF 4.848)

1291. Wancai Que, Zhaoyang Wu, Maohua Chen, Binqing Zhang, Chuihuai You, Hailing Lin, Zhichang Zhao, Maobai Liu, Hongqiang Qiu, Yu Cheng

Molecular Mechanism of Gelsemium elegans (Gardner and Champ.) Benth. Against Neuropathic Pain Based on Network Pharmacology and Experimental Evidence

Front Pharmacol.

doi: 10.3389/fphar.2021.792932.

(IF 4.225)

1292. Shuo Zhang, Peng Wang, Binwu Hu, Weijian Liu, Xiao Lv, Songfeng Chen, Zengwu Shao

HSP90 Inhibitor 17-AAG Attenuates Nucleus Pulposus Inflammation and Catabolism Induced by M1-Polarized Macrophages

Front Cell Dev Biol.

doi: 10.3389/fcell.2021.796974.

(IF 5.201)

1293. Qi Li, Jun Mo, Baichen Xiong, Qinghong Liao, Ying Chen, Yuanyuan Wang, Shuaishuai Xing, Siyu He, Weiping Lyu, Ning Zhang, Haopeng Sun

Discovery of Resorcinol-Based Polycyclic Structures as Tyrosinase Inhibitors for Treatment of Parkinson's Disease

ACS Chem Neurosci.

doi: 10.1021/acschemneuro.1c00560.

(IF 4.486)

1294. San-Qiao Yang, Yi-Yun Tang, Dan Zeng, Qing Tian, Hai-Jun Wei, Chun-Yan Wang, Ping Zhang, Yong-Jun Chen, Wei Zou, Xiao-Qing Tang

Sodium hydrosulfide reverses β2-microglobulin-induced depressive-like behaviors of male Sprague-Dawley rats: Involving improvement of synaptic plasticity and enhancement of Warburg effect in hippocamp

Behav Brain Res.

doi: 10.1016/j.bbr.2021.113562.

(IF 2.977)

1295. Xuling Zhang, Tao Huang, Lubo Lang, Ling Yu

Effects of lysophosphatidic acid receptor 5 on NLRC4 inflammasome in brain tissues of transient cerebral ischemia/reperfusion rat

Hum Exp Toxicol.

doi: 10.1177/09603271221078870.

(IF 2.067)

1296. Li Wu, Jing Li, Fang Zhao, Yi Xiang

MiR-340-5p inhibits Müller cell activation and pro-inflammatory cytokine production by targeting BMP4 in experimental diabetic retinopathy

Cytokine.

doi: 10.1016/j.cyto.2021.155745.

(IF 2.952)

1297. Zhaoming Sun, Lixiang Song, Jiazhen Li

Knockdown of small nucleolar RNA host gene 10 (SNHG10) alleviates the injury of human neuroblastoma cells via the miR-1277-5p/insulin substrate receptor 2 axis

Bioengineered.

doi: 10.1080/21655979.2021.2012623.

(IF 2.205)

1298. Ping Liu, Xiaoji Cong, Shengjie Liao, Xinglong Jia, Xiaomin Wang, Wei Dai, Linhui Zhai, Lei Zhao, Jing Ji, Duan Ni, Zhiwei Liu, Yulu Chen, Lulu Pan, Wei Liu, Jian Zhang, Min Huang, Bin Liu, Minjia Tan

Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis

Cell Death Differ.

doi: 10.1038/s41418-021-00827-7.

(IF 10.717)

1299. Wu Jiang, Wei Zou, Min Hu, Qing Tian, Fan Xiao, Min Li, Ping Zhang, Yong-Jun Chen, Jia-Mei Jiang

Hydrogen sulphide attenuates neuronal apoptosis of substantia nigra by re-establishing autophagic flux via promoting leptin signalling in a 6-hydroxydopamine rat model of Parkinson's disease

Clin Exp Pharmacol Physiol.

doi: 10.1111/1440-1681.13587.

1300. Lijie Chen, Xing Niu, Xue Qiao, Sai Liu, Hongmei Ma, Xueqing Shi, Xuemei He, Ming Zhong

Characterization of Interplay Between Autophagy and Ferroptosis and Their Synergistical Roles on Manipulating Immunological Tumor Microenvironment in Squamous Cell Carcinomas

Front Immunol.

doi: 10.3389/fimmu.2021.739039.

(IF 5.085)

1301. Ling-Yun Hao, Ming Zhang, Yang Tao, Hengjun Xu, Qiaoqiao Liu, Kehui Yang, Runa Wei, Huimin Zhou, Tong Jin, Xiao-Dan Liu, Zhouya Xue, Wen Shen, Jun-Li Cao, Zhiqiang Pan

miRNA-22 Upregulates Mtf1 in Dorsal Horn Neurons and Is Essential for Inflammatory Pain

Oxid Med Cell Longev.

doi: 10.1155/2022/8622388.

(IF 5.076)

1302. Kai Qu, Caihong Wang, Lu Huang, Xian Qin, Kun Zhang, Yuan Zhong, Qingfeng Ma, Wenhua Yan, Tianhan Li, Qin Peng, Yi Wang, Hans Gregersen, Chaojun Tang, Juhui Qiu, Guixue Wang

TET1s deficiency exacerbates oscillatory shear flow-induced atherosclerosis

Int J Biol Sci.

doi: 10.7150/ijbs.69281.

(IF 4.858)

1303. Yanbo Kou, Xingping Zheng, Liyuan Meng, Mengnan Liu, Shihong Xu, Qiyue Jing, Shenghan Zhang, Hanying Wang, Jinzhi Han, Zhuanzhuan Liu, Yanxia Wei, Yugang Wang

The HVEM-BTLA Immune Checkpoint Restrains Murine Chronic Cholestatic Liver Injury by Regulating the Gut Microbiota

Front Immunol.

doi: 10.3389/fimmu.2022.773341.

(IF 5.085)

1304. Mengge Bai, Heming Yu, Chong Chen, Xingzhe Xu, Yong He, Yue Wang, Yu Tian, Zhonghao Wu, Tianlan Lan, Yan Li, Xiangyu Chen, Zhi Chen, Libo Zhao, Liang Fang, Deyu Yang, Ke Cheng, Peng Xie

Pigment epithelium-derived factor may induce antidepressant phenotypes in mice by the prefrontal cortex

Neurosci Lett.

doi: 10.1016/j.neulet.2021.136423.

(IF 2.274)

1305. Xiangze Li, Zhan Su, Kaiying Shen, Qi Wang, Chencheng Xu, Fuqiang Wang, Yuchi Zhang, Dapeng Jiang

Eugenol-Preconditioned Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Antioxidant Capacity of Tendon Stem Cells In Vitro and In Vivo

Oxid Med Cell Longev.

doi: 10.1155/2022/3945195.

(IF 5.076)

1306. Mengmeng Duan, Yang Liu, Daimo Guo, Shiyi Kan, Zhixing Niu, Xiaohua Pu, Mingru Bai, Demao Zhang, Wei Du, Jing Xie

TGF-β2 increases cell-cell communication in chondrocytes via p-Smad3 signalling

Biochim Biophys Acta Mol Cell Res.

doi: 10.1016/j.bbamcr.2021.119175.

1307. Hongbin Peng, Pingjiang Ge

Long non‑coding RNA HCG18 facilitates the progression of laryngeal and hypopharyngeal squamous cell carcinoma by upregulating FGFR1 via miR‑133b

Mol Med Rep.

doi: 10.3892/mmr.2021.12562.

(IF 2.1)

1308. Jingwen Chen, Xin Wu, Yanyi Wang, Yunfeng Pan, Yan Ren, Yusaku Nakabeppu, Yimei Fan, Yaping Wang

Mutyh deficiency downregulates mitochondrial fusion proteins and causes cardiac dysfunction via α-ketoglutaric acid reduction with oxidative stress

Free Radic Res.

doi: 10.1080/10715762.2022.2036336.

1309. Juntao Li, Linqing Sun, Yanjun Chen, Jinghan Zhu, Jin Shen, Jiayu Wang, Yanzheng Gu, Guangbo Zhang, Mingyuan Wang, Tongguo Shi, Weichang Chen

Gastric cancer-derived exosomal miR-135b-5p impairs the function of Vγ9Vδ2 T cells by targeting specificity protein 1

Cancer Immunol Immunother.

doi: 10.1007/s00262-021-02991-8.

1310. Mei Yang, Liangliang Ju, Changlian Li, Han Cheng, Na Li, Qi Zhang, Shu Sun, Liu Ding, Xinmiao Sui, Chao Zhang, Mingwei Yang, Jiyu Cao, Rui Ding

MiR-582-3p participates in the regulation of biological behaviors of A549 cells by ambient PM2.5 exposure

Environ Sci Pollut Res Int.

doi: 10.1007/s11356-021-16801-2.

1311. Yu-Hang Zhang, Wen-Yu Wang, Xiao-Cong Pang, Zhi Wang, Cheng-Zhuo Wang, Hang Zhou, Bo Zheng, Yi-Min Cui

Thymosin-α1 binds with ACE and downregulates the expression of ACE2 in human respiratory epithelia

Front Biosci (Landmark Ed).

doi: 10.31083/j.fbl2702048.

1312. Yankun Zhang, Min Sun, Lifen Gao, Xiaohong Liang, Chunhong Ma, Jinghui Lu, Xuetian Yue

ZHX2 inhibits thyroid cancer metastasis through transcriptional inhibition of S100A14

Cancer Cell Int.

doi: 10.1186/s12935-022-02499-w.

(IF 4.175)

1313. Tingting Cheng, Cheng Wang, Qianqian Lu, Yuru Cao, Weiwei Yu, Wenzhen Li, Ben Liu, Xue Gao, Junhong Lü, Xiaohong Pan

Metformin inhibits the tumor-promoting effect of low-dose resveratrol, and enhances the anti-tumor activity of high-dose resveratrol by increasing its reducibility in triple negative breast cancer

Free Radic Biol Med.

doi: 10.1016/j.freeradbiomed.2022.01.010.

1314. Gang Yu, Wanjing Chen, Xianghua Li, Liang Yu, Yanyan Xu, Qiang Ruan, Yawei He, Yong Wang

TWIST1-EP300 Expedites Gastric Cancer Cell Resistance to Apatinib by Activating the Expression of COL1A2

Anal Cell Pathol (Amst).

doi: 10.1155/2022/5374262.

1315. Meng Zhao, Houting Lv, Na Yang, Guang-Hua Peng

Rapamycin Improved Retinal Function and Morphology in a Mouse Model of Retinal Degeneration

Front Neurosci.

doi: 10.3389/fnins.2022.846584.

1316. Haibo Ruan, Zhenzhen Dai, Jinyu Yan, Xiaoxi Long, Yi Chen, Youlin Yang, Qian Yang, Jun Zhu, Meiyun Zheng, Xiahui Zhang

ZBTB24 (Zinc Finger and BTB Domain Containing 24) prevents recurrent spontaneous abortion by promoting trophoblast proliferation, differentiation and migration

Bioengineered.

doi: 10.1080/21655979.2021.2019655.

(IF 2.205)

1317. Mingyi Li, Chenxia Li, Huarong Zheng, Zhen Zhou, Wenjian Yang, Yu Gong, Xia Wu, Leyu Li

CircRNA_0001795 sponges miRNA-339-5p to regulate yes-associated protein 1 expression and attenuate osteoporosis progression

Bioengineered.

doi: 10.1080/21655979.2021.2022074.

(IF 2.205)

1318. Kaixiang Xu, Wanyun Zhu, Anyong Xu, Zhe Xiong, Di Zou, Heng Zhao, Deling Jiao, Yubo Qing, Muhammad Ameen Jamal, Hong-Jiang Wei, Hong-Ye Zhao

Inhibition of FOXO1‑mediated autophagy promotes paclitaxel‑induced apoptosis of MDA‑MB‑231 cells

Mol Med Rep.

doi: 10.3892/mmr.2022.12588.

(IF 2.1)

1319. Xinglin Li, Xiaoyun Chen, Jiebing Gao, Jianzhong Xian, Zhijun Li, Lei Bi, Min Yang, Shuai Yang, Hongjun Jin, Hong Shan

Loss-of-function Mutations K11E or E271K Lead to Novel Tumor Suppression, Implicate Nucleolar Helicase DDX24 Oncogenicity

Int J Med Sci.

doi: 10.7150/ijms.67840.

(IF 2.523)

1320. Nanwei Ye, Zengpeng Lv, Zhenwu Huang, Ying Cheng, Quanwei Wei, Fangxiong Shi

Dietary folic acid supplementation improves semen quality and spermatogenesis through altering autophagy and histone methylation in the testis of aged broiler breeder roosters

Theriogenology.

doi: 10.1016/j.theriogenology.2021.12.032.

(IF 2.094)

1321. Caiyun Yu, Dong Wang, Yichun Tong, Qiming Li, Weiren Yang, Tian Wang, Zaibin Yang

Trans-Anethole Alleviates Subclinical Necro-Haemorrhagic Enteritis-Induced Intestinal Barrier Dysfunction and Intestinal Inflammation in Broilers

Front Microbiol.

doi: 10.3389/fmicb.2022.831882.

(IF 4.235)

1322. Yue Tian, Zhifa Zhang, Zijing Zhang, Xiaofeng Dai

Hsa_circRNA_0040462: a sensor of cells' response to CAP treatment with double-edged roles on breast cancer malignancy

Int J Med Sci.

doi: 10.7150/ijms.66940.

(IF 2.523)

1323. Yun Li, Hui Xiong

Correlation of LAGE3 with unfavorable prognosis and promoting tumor development in HCC via PI3K/AKT/mTOR and Ras/RAF/MAPK pathways

BMC Cancer.

doi: 10.1186/s12885-022-09398-3.

(IF 3.15)

1324. Yufei Huang, Xiaoya Chu, Yafei Zhang, Sheng Yang, Yonghong Shi, Qiusheng Chen

Transformation of Mitochondrial Architecture and Dynamics in the Chinese Soft-Shelled Turtle ( Pelodiscus sinensis) During Hibernation

Microsc Microanal.

doi: 10.1017/S1431927622000484.

(IF 3.414)

1325. Jianguo Chen, Tianyu Huang, Ruiquan Liu, Chenyu Wang, Haiyue Jiang, Hengyun Sun

Congenital microtia patients: the genetically engineered exosomes released from porous gelatin methacryloyl hydrogel for downstream small RNA profiling, functional modulation of microtia chondrocytes

J Nanobiotechnology.

doi: 10.1186/s12951-022-01352-6.

1326. Yan-Ran Sheng, Wen-Ting Hu, Hui-Hui Shen, Chun-Yan Wei, Yu-Kai Liu, Xiao-Qian Ma, Ming-Qing Li, Xiao-Yong Zhu

An imbalance of the IL-33/ST2-AXL-efferocytosis axis induces pregnancy loss through metabolic reprogramming of decidual macrophages

Cell Mol Life Sci.

doi: 10.1007/s00018-022-04197-2.

(IF 6.496)

1327. Meifang Yan, Junjian Li, Li Yan, Xue Li, Jie-Guang Chen

Transcription factor Foxp1 is essential for the induction of choroidal neovascularization

Eye Vis (Lond).

doi: 10.1186/s40662-022-00281-7.

1328. Xiaomi Ding, Jing Zhou, Li Zhao, Mingyue Chen, Shenglin Wang, Ming Zhang, Xiaodong Zhang, Guohui Jiang

Intestinal Flora Composition Determines Microglia Activation and Improves Epileptic Episode Progress

Front Cell Infect Microbiol.

doi: 10.3389/fcimb.2022.835217.

1329. Fengfeng Li, Man Jiang, Minghui Ma, Xuyang Chen, Yidan Zhang, Yixin Zhang, Yuanyuan Yu, Yunfeng Cui, Jiahui Chen, Hui Zhao, Zhijie Sun, Deli Dong

Anthelmintics nitazoxanide protects against experimental hyperlipidemia and hepatic steatosis in hamsters and mice

Acta Pharm Sin B.

doi: 10.1016/j.apsb.2021.09.009.

(IF 7.097)

1330. Yongsheng Yu, Xiaochun Xue, Wendong Tang, Li Su, Lei Zhang, Yuefan Zhang

Cytosolic DNA‒Mediated STING-Dependent Inflammation Contributes to the Progression of Psoriasis

J Invest Dermatol.

doi: 10.1016/j.jid.2021.08.430.

(IF 7.143)

1331. Chen Wang, Yihui He, Zhijie You, Xin Chen

TMSB10 Promotes Progression of Clear Cell Renal Cell Carcinoma via JUN Transcription Regulation

Ann Clin Lab Sci.

(IF 0.927)

1332. Yue Yin, Yuanpan Yin, Hao Yang, Zhuanggui Chen, Jun Zheng, Bo Peng

Vibrio alginolyticus Survives From Ofloxacin Stress by Metabolic Adjustment

Front Microbiol.

doi: 10.3389/fmicb.2022.818923.

(IF 4.235)

1333. Qiwei Du, Zuguo Yuan, Xiaoling Huang, Yuqing Huang, Jie Zhang, Rongguo Li

miR-26b-5p suppresses chemoresistance in breast cancer by targeting serglycin

Anticancer Drugs.

doi: 10.1097/CAD.0000000000001268.

1334. Xiao Hu, Qiongzhen Zeng, Ji Xiao, Shurong Qin, Yuan Wang, Tianhao Shan, Di Hu, Yexuan Zhu, Kaisheng Liu, Kai Zheng, Yifei Wang, Zhe Ren

Herpes Simplex Virus 1 Induces Microglia Gasdermin D-Dependent Pyroptosis Through Activating the NLR Family Pyrin Domain Containing 3 Inflammasome

Front Microbiol.

doi: 10.3389/fmicb.2022.838808.

(IF 4.235)

1335. Ruonan Zhai, Yuan Liu, Jiahao Tong, Ying Yu, Lin Yang, Yong Gu, Jianying Niu

Empagliflozin Ameliorates Preeclampsia and Reduces Postpartum Susceptibility to Adriamycin in a Mouse Model Induced by Angiotensin Receptor Agonistic Autoantibodies

Front Pharmacol.

doi: 10.3389/fphar.2022.826792.

(IF 4.225)

1336. Yue-Tao Chen, Ke-Xin Yang, Zhen-Yuan Dai, Huan Yi, Xuan-Xian Peng, Hui Li, Zhuang-Gui Chen

Repressed Central Carbon Metabolism and Its Effect on Related Metabolic Pathways in Cefoperazone/Sulbactam-Resistant Pseudomonas aeruginosa

Front Microbiol.

doi: 10.3389/fmicb.2022.847634.

(IF 4.235)

1337. Zhang Bin-Bin, Zha Xi Da-Wa, Li Chao, Zhang Lan-Tao, Wu Tao, Lu Chuan, Liu Chao-Zheng, Li De-Chun, Feng Chang, Wei Shu-Qing, Dong Zu-Nan, Pei Xian-Wei, Zhi-Xia Zhang, Li Ke-Wen

M2 macrophagy-derived exosomal miRNA-26a-5p induces osteogenic differentiation of bone mesenchymal stem cells

J Orthop Surg Res.

doi: 10.1186/s13018-022-03029-0.

(IF 1.777)

1338. Langen Zhuang, Xiaoxu Ge, Xiaolei Hu, Qingqing Yang, Xiaoyan Pei, Guoxi Jin

miR-543 regulates high glucose-induced fibrosis and autophagy in diabetic nephropathy by targeting TSPAN8

BMC Nephrol.

doi: 10.1186/s12882-022-02716-8.

(IF 1.913)

1339. Rui Dong, Yuqiang Han, Linhao Jiang, Shuai Liu, Fujun Zhang, Liangyu Peng, Zimo Wang, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu

Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice

J Neuroinflammation.

doi: 10.1186/s12974-022-02424-y.

1340. Haikun Song, Cen Wang, Chenggang Zhu, Ziying Wang, Huiya Yang, Peng Wu, Xiaotian Cui, Juan Botas, Yongjun Dang, Yu Ding, Yiyan Fei, Boxun Lu

Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide

Proc Natl Acad Sci U S A.

doi: 10.1073/pnas.2114303119.

1341. Lai Wang, Lijun Zhu, Zuguo Zheng, Lingchang Meng, Hanling Liu, Keke Wang, Jun Chen, Ping Li, Hua Yang

Mevalonate pathway orchestrates insulin signaling via RAB14 geranylgeranylation-mediated phosphorylation of AKT to regulate hepatic glucose metabolism

Metabolism.

doi: 10.1016/j.metabol.2021.155120.

(IF 6.159)

1342. Shenggui Lu, Xinmiao Wu, Shuai Xin, Jing Zhang, Hanying Lin, Yu Miao, Yixin Li

Knockdown of circ_0001679 alleviates lipopolysaccharide-induced MLE-12 lung cell injury by regulating the miR-338-3p/ mitogen-activated protein kinase 1 axis

Bioengineered.

doi: 10.1080/21655979.2022.2034564.

(IF 2.205)

1343. Zi-Yi Chen, Jie Li, Shu-Di Zhu, Zhi-Di Li, Jia-Lin Yu, Jie Wu, Chong Zhang, Ling-Hui Zeng

Harmine reinforces the effects of regorafenib on suppressing cell proliferation and inducing apoptosis in liver cancer cells

Exp Ther Med.

doi: 10.3892/etm.2022.11132.

(IF 1.785)

1344. Guoying Guan, Jinjiao Xie, Yamei Dai, Hui Han

TFPI2 suppresses the interaction of TGF-β2 pathway regulators to promote endothelial-mesenchymal transition in diabetic nephropathy

J Biol Chem.

doi: 10.1016/j.jbc.2022.101725.

(IF 4.238)

1345. Lexin He, Shixiang Zhou, Weihong Li, Qi Wang, Zhenhua Qi, Pingkun Zhou, Zhidong Wang, Jing Chen, Yaqiong Li, Zhongwu Lin

BPIFA2 as a Novel Early Biomarker to Identify Fatal Radiation Injury After Radiation Exposure

Dose Response.

doi: 10.1177/15593258221086478.

1346. Chengkuan Sun, Guangzhi Wu, Zhan Zhang, Rangjuan Cao, Shusen Cui

Protein Tyrosine Phosphatase Receptor Type D Regulates Neuropathic Pain After Nerve Injury via the STING-IFN-I Pathway

Front Mol Neurosci.

doi: 10.3389/fnmol.2022.859166.

(IF 4.057)

1347. Caiyun Yu, Yichun Tong, Qiming Li, Tian Wang, Zaibin Yang

Trans-anethole Ameliorates Intestinal Injury Through Activation of Nrf2 Signaling Pathway in Subclinical Necrotic Enteritis-Induced Broilers

Front Vet Sci.

doi: 10.3389/fvets.2022.877066.

(IF 2.245)

1348. Jiandong Li, Wenda Cen, Chenhao Tong, Luna Wang, Weiguang Zhang, Shiqing Deng, Jianhua Yu, Baochun Lu

Fangchinoline induces gallbladder cancer cell apoptosis by suppressing PI3K/Akt/XIAP axis

PLoS One.

doi: 10.1371/journal.pone.0266738.

(IF 2.74)

1349. Sha-Sha Yi, Jun-Jie Zou, Long Meng, Hou-Minji Chen, Zhong-Qiu Hong, Xiu-Fang Liu, Umar Farooq, Mo-Xian Chen, Zheng-Rong Lin, Wei Zhou, Li-Juan Ao, Xi-Quan Hu, Li-Li Niu

Ultrasound Stimulation of Prefrontal Cortex Improves Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice

Front Psychiatry.

doi: 10.3389/fpsyt.2022.864481.

(IF 2.849)

1350. Guizhu Feng, Lin Wei, Helong Che, Yan Shen, Kai Mi, Hui Bian, Hailong Yang, Jing Wu, Lixian Mu

Cathelicidin-NV from Nanorana ventripunctata effectively protects HaCaT cells, ameliorating ultraviolet B-induced skin photoaging

Peptides.

doi: 10.1016/j.peptides.2021.170712.

(IF 2.843)

1351. Yixin Yang, Hong Tang, Jiawen Zheng, Kai Yang

The PER1/HIF-1alpha negative feedback loop promotes ferroptosis and inhibits tumor progression in oral squamous cell carcinoma

Transl Oncol.

doi: 10.1016/j.tranon.2022.101360.

(IF 3.558)

1352. Yuting Gu, Yilan Shen, Wei Chen, Haidong He, Yulei Ma, Xiaobin Mei, Dianwen Ju, Hongrui Liu

Protective effects of interleukin-22 on oxalate-induced crystalline renal injury via alleviating mitochondrial damage and inflammatory response

Appl Microbiol Biotechnol.

doi: 10.1007/s00253-022-11876-4.

1353. Lin Tan, Weiming Qu, Dajun Wu, Minji Liu, Qiongjia Ai, Hongsai Hu, Qian Wang, Weishun Chen, Hongbing Zhou

The interferon regulatory factor 6 promotes cisplatin sensitivity in colorectal cancer

Bioengineered.

doi: 10.1080/21655979.2022.2062103.

(IF 2.205)

1354. Bo Wang, Yuyang Zhang, Shunmiao Fang, Hui Wang

Role of circRNA circ_0000080 in myocardial hypoxia injury

Bioengineered.

doi: 10.1080/21655979.2022.2066752.

(IF 2.205)

1355. Xuesong Yang, Guangyun Luo, Lan Fu, Hong Huang, Lifen Wang, Lihua Yin, Xuelian Zhang, Tingting Wang, Xuan Ma, Tianyu Feng, Jianzhou Ye

Intervention Mechanism of Hunag-Lian Jie-Du Decoction on Canonical Wnt/ β-Catenin Signaling Pathway in Psoriasis Mouse Model

Evid Based Complement Alternat Med.

doi: 10.1155/2022/3193572.

1356. Shali Yu, Zhijie Li, Qin Zhang, Rui Wang, Zixuan Zhao, Wenjie Ding, Fengxu Wang, Chuan Sun, Juan Tang, Xiaoke Wang, Hongbing Zhang, Rongrong Huang, Qiyun Wu, Junkang Jiang, Xinyuan Zhao

GPX4 degradation via chaperone-mediated autophagy contributes to antimony-triggered neuronal ferroptosis

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2022.113413.

1357. Shengqiang Pei, Chuansheng Xu, Jianqiu Pei, Ruifeng Bai, Rui Peng, Tiewei Li, Junjie Zhang, Xiangfeng Cong, Jerold Chun, Fang Wang, Xi Chen

Lysophosphatidic Acid Receptor 3 Suppress Neutrophil Extracellular Traps Production and Thrombosis During Sepsis

Front Immunol.

doi: 10.3389/fimmu.2022.844781.

(IF 5.085)

1358. Jieru Han, Wenhao Li, Guangyu Shi, Yunlei Huang, Xutao Sun, Na Sun, Deyou Jiang

Atractylenolide III Improves Mitochondrial Function and Protects Against Ulcerative Colitis by Activating AMPK/SIRT1/PGC-1 α

Mediators Inflamm.

doi: 10.1155/2022/9129984.

1359. Yingbin Lin, Xiaoman Dai, Jing Zhang, Xiaochun Chen

Metformin alleviates the depression-like behaviors of elderly apoE4 mice via improving glucose metabolism and mitochondrial biogenesis

Behav Brain Res.

doi: 10.1016/j.bbr.2022.113772.

(IF 2.977)

1360. Rui Yu, Mi Tian, Ping He, Jie Chen, Zixia Zhao, Yongzhe Zhang, Beiru Zhang

Suppression of LMCD1 ameliorates renal fibrosis by blocking the activation of ERK pathway

Biochim Biophys Acta Mol Cell Res.

doi: 10.1016/j.bbamcr.2021.119200.

1361. Hai-Liang Qi, Zheng-Yi Chen, Yu-Huan Qin, Ya-Zhai Li

Curcumin ameliorates H2O2-induced inflammatory response in chondrocytes by inducing autophagy activation

Exp Ther Med.

doi: 10.3892/etm.2022.11198.

(IF 1.785)

1362. Chong Zhang, Lin-Wen Wu, Zhi-Di Li, Man-Man Zhang, Jie Wu, Fei-Hua Du, Ling-Hui Zeng, Yang-Ling Li

DYRK1A suppression attenuates HIF‑1α accumulation and enhances the anti‑liver cancer effects of regorafenib and sorafenib under hypoxic conditions

Int J Oncol.

doi: 10.3892/ijo.2022.5335.

(IF 3.899)

1363. Huanhuan Wang, Yao Chen, Xudan Liu, Ruo Zhang, Xiaotong Wang, Qianhui Zhang, Yuting Wei, Fang Fang, Ye Yuan, Qianqian Zhou, Yinqiao Dong, Sainan Shi, Xiaojing Jiang, Xin Li

TNF-α derived from arsenite-induced microglia activation mediated neuronal necroptosis

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2022.113468.

1364. Dichao Hu, Lili Tian, Xueyun Li, Yirui Chen, Zheqing Xu, Ren-Shan Ge, Yiyan Wang

Tetramethyl bisphenol a inhibits leydig cell function in late puberty by inducing ferroptosis

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2022.113515.

1365. Yue Yang, Zhuangzhuang Jin, Jianghua Luo, Delong Zhang, Peng Shen, Dianbin Zheng, Donghao Liu, Lunhao Bai

Primary Repair for Treating Acute Proximal Anterior Cruciate Ligament Tears: A Histological Analysis and Prospective Clinical Trial

Front Bioeng Biotechnol.

doi: 10.3389/fbioe.2022.913900.

1366. Ming Xin, Qi Gao, Xindong Xiang, Juanjuan Xu, Yuhan Jiao, Xuan Li, Xianzhen Zhang, Xiuqin Jia

Autophagy Inhibition Enhances the Anti-Tumor Activity of Methylseleninic Acid in Cisplatin-Resistance Human Lung Adenocarcinoma Cells

Front Pharmacol.

doi: 10.3389/fphar.2022.890974.

(IF 4.225)

1367. Ting Geng, Yifan Sun, Lin Cheng, Yuming Cao, Ming Zhang, Zhidan Hong, Ling Ma, Yuanzhen Zhang

Downregulation of LHCGR Attenuates COX-2 Expression and Induces Luteinized Unruptured Follicle Syndrome in Endometriosis

Front Endocrinol (Lausanne).

doi: 10.3389/fendo.2022.853563.

1368. Haiheng Peng, Yifeng Yu, Huiyun Gu, Baiwen Qi, Aixi Yu

MicroRNA-483-5p inhibits osteogenic differentiation of human bone marrow mesenchymal stem cells by targeting the RPL31-mediated RAS/MEK/ERK signaling pathway

Cell Signal.

doi: 10.1016/j.cellsig.2022.110298.

(IF 3.968)

1369. Yue Zhuo, Shujun Li, Wei Hu, Yu Zhang, Yufan Shi, Faxue Zhang, Jian Zhang, Juan Wang, Meijuan Liao, Jiahao Chen, Huiling Qian, Dejia Li, Chengcao Sun

Targeting SNORA38B attenuates tumorigenesis and sensitizes immune checkpoint blockade in non-small cell lung cancer by remodeling the tumor microenvironment via regulation of GAB2/AKT/mTOR signaling p

J Immunother Cancer.

doi: 10.1136/jitc-2021-004113.

(IF 9.913)

1370. Changgui Wu, Shaohua Chen, Yang Liu, Bo Kong, Wei Yan, Tao Jiang, Hao Tian, Zhaoyi Liu, Qi Shi, Yongjun Wang, Qianqian Liang, Xiaobing Xi, Hao Xu

Cynarin suppresses gouty arthritis induced by monosodium urate crystals

Bioengineered.

doi: 10.1080/21655979.2022.2072055.

(IF 2.205)

1371. Qilai Cheng, Shanshan Zhang, Bing Zhong, Zhixi Chen, Fang Peng

Asiatic acid re-sensitizes multidrug-resistant A549/DDP cells to cisplatin by down regulating long non-coding RNA metastasis associated lung adenocarcinoma transcript 1/β-catenin signaling

Bioengineered.

doi: 10.1080/21655979.2022.2079302.

(IF 2.205)

1372. Zheng-Nan Ren, Jun Yang, Meng-Ya Zhang, Yi-Wen Huang, Dong-Xiao Song, Xun Sun, Li-Long Pan, Jia Sun

A novel resveratrol analog upregulates sirtuin 1 and inhibits inflammatory cell infiltration in acute pancreatitis

Acta Pharmacol Sin.

doi: 10.1038/s41401-021-00744-y.

(IF 5.064)

1373. Xiao Xu, Hao-Ran Shen, Min Yu, Mei-Rong Du, Xue-Lian Li

MicroRNA let-7i inhibits granulosa-luteal cell proliferation and oestradiol biosynthesis by directly targeting IMP2

Reprod Biomed Online.

doi: 10.1016/j.rbmo.2022.01.016.

(IF 3.218)

1374. Manyun Dai, Wan Peng, Ting Zhang, Qi Zhao, Xiaofang Ma, Yan Cheng, Chunyan Wang, Fei Li

Metabolomics reveals the role of PPARα in Tripterygium Wilfordii-induced liver injury

J Ethnopharmacol.

doi: 10.1016/j.jep.2022.115090.

(IF 3.69)

1375. Xusheng Zhang, Mengting Wang, Bingyan Feng, Qiuyu Zhang, Jia Tong, Mingyong Wang, Chengbiao Lu, Shiyong Peng

Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia

Int J Mol Sci.

doi: 10.3390/ijms23105586.

(IF 4.556)

1376. Yudan Gong, Xinze Li, Liuyi Xie

Circ_0001897 regulates high glucose-induced angiogenesis and inflammation in retinal microvascular endothelial cells through miR-29c-3p/transforming growth factor beta 2 axis

Bioengineered.

doi: 10.1080/21655979.2022.2070997.

(IF 2.205)

1377. Jia-Hui Sun, Ming Huang, Zhou Fang, Tian-Xiao Li, Ting-Ting Wu, Yi Chen, Da-Ping Quan, Ying-Ying Xu, Yu-Ming Wang, Yi Yang, Jian-Long Zou

Nerve bundle formation during the promotion of peripheral nerve regeneration: collagen VI-neural cell adhesion molecule 1 interaction

Neural Regen Res.

doi: 10.4103/1673-5374.324861.

(IF 3.171)

1378. Huixing Zhou, Fulei Zhang, Yahan Wu, Hongyu Liu, Ran Duan, Yuanyuan Liu, Yan Wang, Xiaoyu He, Yuemei Zhang, Xiue Ma, Yi Guan, Yi Liu, Dandan Liang, Liping Zhou, Yi-Han Chen

LRP5 regulates cardiomyocyte proliferation and neonatal heart regeneration by the AKT/P21 pathway

J Cell Mol Med.

doi: 10.1111/jcmm.17311.

(IF 4.486)

1379. Qingyong Li, Jun Peng, Yuelian Luo, Jiaxin Zhou, Tailin Li, Lin Cao, Shuling Peng, Zhiyi Zuo, Zhi Wang

Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer's disease-like mice

J Neuroinflammation.

doi: 10.1186/s12974-022-02521-y.

1380. Junfeng Yan, Xia Zhang, Caixian Xiao, Junlu Yi, Qian Chen, Tingliang Gong, Xin Xie, Wenqiang Tao

Effect of Yisui Multipurpose Soup's Amelioration on D-Galactose-Induced Neuronal Cells

Evid Based Complement Alternat Med.

doi: 10.1155/2022/3372350.

1381. Xia Li, Shuyi Qian, Feng Huang, Kaimin Li, Yu Song, Jiqian Liu, Yujie Guo, Chunhui Zhang, Christophe Blecker

The Investigation of Protein Profile and Meat Quality in Bovine Longissimus thoracic Frozen under Different Temperatures by Data-Independent Acquisition (DIA) Strategy

Foods.

doi: 10.3390/foods11121791.

(IF 4.092)

1382. Yongfang Zhang, Yan Gao, Fan Yang, Xiuying Wu, Zhiyin Tang, Hongtao Liu

Neuroglobin alleviates the neurotoxicity of sevoflurane to fetal rats by inhibiting neuroinflammation and affecting microglial polarization

Brain Res Bull.

doi: 10.1016/j.brainresbull.2022.03.006.

(IF 3.37)

1383. Yanhui Cui, Xueqin Wang, Fengyu Lin, Wen Li, Yuhao Zhao, Fei Zhu, Hang Yang, Mingjun Rao, Yi Li, Huaying Liang, Minhui Dai, Ben Liu, Lingli Chen, Duoduo Han, Rongli Lu, Wenzhong Peng, Yan Zhang, Chao Song, Yanwei Luo, Pinhua Pan

MiR-29a-3p Improves Acute Lung Injury by Reducing Alveolar Epithelial Cell PANoptosis

Aging Dis.

doi: 10.14336/AD.2021.1023.

(IF 5.402)

1384. Shunyun Xie, Feng Xu, Yue Lu, Yixian Zhang, Xinyang Li, Mengyuan Yu, Wenpeng Cui

Elabela Attenuates the TGF-β1-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells in Patients Receiving Peritoneal Dialysis

Front Pharmacol.

doi: 10.3389/fphar.2022.890881.

(IF 4.225)

1385. Xuqing Cao, Xiaojin La, Biwei Zhang, Zhigang Wang, Yinghong Li, Yanping Bo, Hong Chang, Xiujuan Gao, Chunyu Tian, Chenxi Wu, Ji-An Li

Sanghuang Tongxie Formula Ameliorates Insulin Resistance in Drosophila Through Regulating PI3K/Akt Signaling

Front Pharmacol.

doi: 10.3389/fphar.2022.874180.

(IF 4.225)

1386. Jin Qiu, Qianqian Fan, Sainan Xu, Dongmei Wang, Juntong Chen, Sainan Wang, Tianhui Hu, Xinran Ma, Yiyun Cheng, Lingyan Xu

A fluorinated peptide with high serum- and lipid-tolerence for the delivery of siRNA drugs to treat obesity and metabolic dysfunction

Biomaterials.

doi: 10.1016/j.biomaterials.2022.121541.

(IF 10.317)

1387. Yan Zhang, Dandan Xu, Youjun Zhang, Qingjun Wu, Wen Xie, Zhaojiang Guo, Shaoli Wang

Frequencies and mechanisms of pesticide resistance in Tetranychus urticae field populations in China

Insect Sci.

doi: 10.1111/1744-7917.12957.

(IF 2.791)

1388. Yuhuan Cui, Meihong Liu, Li Zuo, Haiyan Wang, Jian Liu

Fraxetin protects rat brains from the cerebral stroke via promoting angiogenesis and activating PI3K/Akt pathway

Immunopharmacol Immunotoxicol.

doi: 10.1080/08923973.2022.2052893.

1389. Nan Huang, Yaxun Wei, Yi Cheng, Xiaolong Wang, Qi Wang, Dong Chen, Wenjing Li

Iron metabolism protein transferrin receptor 1 involves in cervical cancer progression by affecting gene expression and alternative splicing in HeLa cells

Genes Genomics.

doi: 10.1007/s13258-021-01205-w.

1390. Jinhui Bai, Hongyan Xu, Jiachen Fang, Congcong Zhang, Jixuan Song, Xinxin Zhang, Beibei Hao, Baozhen Yin, Guangjun Xia

miR-15a regulates the preadipocyte differentiation by targeting ABAT gene in Yanbian yellow cattle

Anim Biotechnol.

doi: 10.1080/10495398.2022.2088552.

(IF 1.487)

1391. Zhuo-Na Han, Xiao-Xue Lin, Yue-Ying Wang, Ran Ding, Lan Hong, Xun Cui

Cholecystokinin Octapeptide Promotes ANP Secretion through Activation of NOX4-PGC-1 α-PPAR α/PPAR γ Signaling in Isolated Beating Rat Atria

Oxid Med Cell Longev.

doi: 10.1155/2022/5905374.

(IF 5.076)

1392. Kai Xu, Xiang Liu, Bin Wen, Yazhou Liu, Wei Zhang, Xiaolin Hu, Ling Chen, Weijian Hang, Juan Chen

GSK-J4, a Specific Histone Lysine Demethylase 6A Inhibitor, Ameliorates Lipotoxicity to Cardiomyocytes via Preserving H3K27 Methylation and Reducing Ferroptosis

Front Cardiovasc Med.

doi: 10.3389/fcvm.2022.907747.

1393. Yong Fang, Jun Yin, Yaxing Shen, Hao Wang, Han Tang, Xiaosang Chen

CircCDR1 sponges miR-1290 to regulate cell proliferation, migration, invasion, and apoptosis in esophageal squamous cell cancer

Cell Cycle.

doi: 10.1080/15384101.2022.2050645.

(IF 3.699)

1394. Changwei Li, Minglong Qiu, Leilei Chang, Jin Qi, Lianfang Zhang, Bernhard Ryffel, Lianfu Deng

The osteoprotective role of USP26 in coordinating bone formation and resorption

Cell Death Differ.

doi: 10.1038/s41418-021-00904-x.

(IF 10.717)

1395. Gang Zhang, Song-Lin Liu, Wen-Ting Yi, Yu-Ping Dong, Yin-Xu Wan

Long noncoding RNA ZFPM2-AS1 regulates renal cell carcinoma progression via miR-130a-3p/ESCO2

Kaohsiung J Med Sci.

doi: 10.1002/kjm2.12527.

(IF 1.737)

1396. Qiuping Guo, Lingyu Zhang, Yunju Yin, Saiming Gong, Yuhuan Yang, Sisi Chen, Mengmeng Han, Yehui Duan

Taurine Attenuates Oxidized Fish Oil-Induced Oxidative Stress and Lipid Metabolism Disorder in Mice

Antioxidants (Basel).

doi: 10.3390/antiox11071391.

1397. Haijun Cai, Hui Guo, Yixuan Deng, Jinhai Jiang, Siyuan Liu, Wenge He, Huagang Jian

RRM2 regulates osteogenesis of mouse embryo fibroblasts via the Wnt/β‑catenin signaling pathway

Exp Ther Med.

doi: 10.3892/etm.2022.11542.

(IF 1.785)

1398. Danjun Wang, Jianying Zhang, Linhan Cai, Xiaofeng Dai

Cold Atmospheric Plasma Conveys Selectivity Against Hepatocellular Carcinoma Cells via Triggering EGFR(Tyr1068)-Mediated Autophagy

Front Oncol.

doi: 10.3389/fonc.2022.895106.

(IF 4.848)

1399. Wan Wang, Tianqing Yan, Xinjian Guo, Heng Cai, Chang Liang, Linyan Huang, Yanling Wang, Ping Ma, Suhua Qi

KAP1 phosphorylation promotes the survival of neural stem cells after ischemia/reperfusion by maintaining the stability of PCNA

Stem Cell Res Ther.

doi: 10.1186/s13287-022-02962-5.

(IF 5.116)

1400. Zhi-Bin Ke, Qi You, Jia-Yin Chen, Jiang-Bo Sun, Yu-Ting Xue, Rui-Bin Zhuang, Qing-Shui Zheng, Ye-Hui Chen, Yong Wei, Xiong-Lin Sun, Xue-Yi Xue, Ning Xu

A radiation resistance related index for biochemical recurrence and tumor immune environment in prostate cancer patients

Comput Biol Med.

doi: 10.1016/j.compbiomed.2022.105711.

(IF 3.434)

1401. Zhuangzhuang Jin, Bohan Chang, Yingliang Wei, Yue Yang, He Zhang, Jiabao Liu, Longhuan Piao, Lunhao Bai

Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK/PINK1/Parkin-mediated mitophagy

Biomed Pharmacother.

doi: 10.1016/j.biopha.2022.113092.

(IF 4.545)

1402. Xianxiang Chen, Mingyue Shen, Jun Yang, Qiang Yu, Yi Chen, Xin Wang, Hanyu Lu, Xin Tao, Haizhen Li, Jianhua Xie

RNA-seq based elucidation of mechanism underlying Mesona chinensis Benth polysaccharide protected H2O2-induced oxidative damage in L02 cells

Food Res Int.

doi: 10.1016/j.foodres.2022.111383.

(IF 4.972)

1403. Jinghui Zhang, Nana Qiao, Jiwen Wang, Baomin Li

Nuclear translocation of GluA2/ GAPDH promotes neurotoxicity after pilocarpine-induced epilepsy

Epilepsy Res.

doi: 10.1016/j.eplepsyres.2022.106945.

(IF 2.208)

1404. Lu Zheng, Yi Wang, Bin Shao, Huijuan Zhou, Xing Li, Cai Zhang, Ning Sun, Jing Shi

Multiple Mild Stimulations Reduce Membrane Distribution of CX3CR1 Promoted by Annexin a1 in Microglia to Attenuate Excessive Dendritic Spine Pruning and Cognitive Deficits Caused by a Transient Ischem

Neurosci Bull.

doi: 10.1007/s12264-022-00847-4.

(IF 4.326)

1405. Xiaoxue Lu, Qiaolin Xu, Yanan Tong, Zhujun Zhang, Guodong Dun, Yuyang Feng, Jie Tang, Dan Han, Yilan Mao, Ling Deng, Xiaoyi He, Qian Li, Yang Xiang, FengChao Wang, Dongzhu Zeng, Bin Tang, Xuhu Mao

Long non-coding RNA EVADR induced by Fusobacterium nucleatum infection promotes colorectal cancer metastasis

Cell Rep.

doi: 10.1016/j.celrep.2022.111127.

(IF 8.109)

1406. Fengqi Qiu, Qi Yang, Wenjia Sun, Kexin Ruan, Nan Jiang, Jianya Zhou

EZH2 inhibition activates dsRNA-interferon axis stress and promotes response to PD-1 checkpoint blockade in NSCLC

J Cancer.

doi: 10.7150/jca.73291.

(IF 3.565)

1407. Cong Chen, Shuhong Liu, Gaozhen Cao, Yang Hu, Run Wang, Min Wu, Mingya Liu, Kai Hang Yiu

Cardioprotective Effect of Paeonol on Chronic Heart Failure Induced by Doxorubicin via Regulating the miR-21-5p/S-Phase Kinase-Associated Protein 2 Axis

Front Cardiovasc Med.

doi: 10.3389/fcvm.2022.695004.

1408. Fangfang Hu, Yan Ren, Zunyun Wang, Hui Zhou, Yumei Luo, Minghua Wang, Faqing Tian, Jian Zheng, Juan Du, Gang Pang

Bioinformatics analysis of KLF2 as a potential prognostic factor in ccRCC and association with epithelial-mesenchymal transition

Exp Ther Med.

doi: 10.3892/etm.2022.11498.

(IF 1.785)

1409. Hai-Juan Bao, Xi Chen, Xin Liu, Wu Wu, Qian-Hui Li, Jing-Yuan Xian, Yang Zhao, Shuo Chen

Box C/D snoRNA SNORD89 influences the occurrence and development of endometrial cancer through 2'-O-methylation modification of Bim

Cell Death Discov.

doi: 10.1038/s41420-022-01102-5.

1410. Yong Zeng, Rui He, Yong Liu, Ting Luo, Qing Li, Yu He, Miao Fang, Taiping Wang

HDAC1 regulates inflammation and osteogenic differentiation of ankylosing spondylitis fibroblasts through the Wnt-Smad signaling pathway

J Orthop Surg Res.

doi: 10.1186/s13018-022-03224-z.

(IF 1.777)

1411. Chunyue Liu, Zixing Fu, Shanshan Wu, Xiaosong Wang, Shengrong Zhang, Chu Chu, Yuan Hong, Wenbo Wu, Shengqi Chen, Yueqing Jiang, Yang Wu, Yongbo Song, Yan Liu, Xing Guo

Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease

EMBO Mol Med.

doi: 10.15252/emmm.202215851.

(IF 8.821)

1412. Yuanzheng Lu, Chenyu Zhang, Jie Chen, Qiuping Zou, Bo Li, Hongyan Wei, Mary P Chang, Xiaoxing Liao, Chunlin Hu

Hypothermia preconditioning improves cardiac contractility after cardiopulmonary resuscitation through AMPK-activated mitophagy

Exp Biol Med (Maywood).

doi: 10.1177/15353702221081546.

1413. Xiuchen Xuan, Peizhu Tan, Ximei Zhang, Hui Huang, Yanze Li, Yu Jiang, Aimiao Yu, Yuanyuan Zhao, Kuo Wang, Baozhu Tang, Shuye Qu, Yunyan Jiang, Jiaran Xu, Xu Gao, Lingyun Zhou

Long-term low-dose alcohol intake promotes white adipose tissue browning and reduces obesity in mice

Food Funct.

doi: 10.1039/d2fo00743f.

(IF 4.171)

1414. Di Zhu, Chenglin Jia, Tongkai Cai, Jiacheng Li, Xia Feng, Nan Chen, Cheng Zhao, Yuzhen Wang, Yongbing Cao, Yemin Cao

Ruan Jian Qing Mai Recipe Inhibits the Inflammatory Response in Acute Lower Limb Ischemic Mice through the JAK2/STAT3 Pathway

Evid Based Complement Alternat Med.

doi: 10.1155/2022/2481022.

1415. Qian Ren, Caixia Yi, Jun Pan, Xin Sun, Xiao Huang

Smart Fe3O4@ZnO Core-Shell Nanophotosensitizers Potential for Combined Chemo and Photodynamic Skin Cancer Therapy Controlled by UVA Radiation

Int J Nanomedicine.

doi: 10.2147/IJN.S372377.

1416. Yaqing Li, Chujie Qu, Hao Song, Tian Li, Jiaxin Zheng, Liyang Wu, Nao Yan, Linling Xu, Changhua Qu, Junjian Zhang

Enriched environment priors to TET1 hippocampal administration for regulating psychiatric behaviors via glial reactivity in chronic cerebral hypoperfusion models

J Affect Disord.

doi: 10.1016/j.jad.2022.04.087.

1417. Xiuqin Jia, Ming Xin, Juanjuan Xu, Xindong Xiang, Xuan Li, Yuhan Jiao, Lulin Wang, Jingjing Jiang, Feng Pang, Xianzhen Zhang, Jian Zhang

Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma

Cell Death Dis.

doi: 10.1038/s41419-022-05201-0.

(IF 6.304)

1418. Beibei Zhang, Jing Li, Xianlong Zong, Jianling Wang, Lianlian Xin, Haiyao Song, Wenxue Zhang, Stephane Koda, Hui Hua, Bo Zhang, Qian Yu, Kui-Yang Zheng, Chao Yan

FXR deficiency in hepatocytes disrupts the bile acid homeostasis and inhibits autophagy to promote liver injury in Schistosoma japonicum-infected mice

PLoS Negl Trop Dis.

doi: 10.1371/journal.pntd.0010651.

1419. Yanli Li, Shilian Tan, Yuanying Shen, Le Guo

miR‑146a‑5p negatively regulates the IL‑1β‑stimulated inflammatory response via downregulation of the IRAK1/TRAF6 signaling pathway in human intestinal epithelial cells

Exp Ther Med.

doi: 10.3892/etm.2022.11552.

(IF 1.785)

1420. Xiaojin Liu, Hao Lv, Haibin Shen

Vitamin D enhances the sensitivity of breast cancer cells to the combination therapy of photodynamic therapy and paclitaxel

Tissue Cell.

doi: 10.1016/j.tice.2022.101815.

(IF 1.837)

1421. Dan Qin, Shenghui Liu, Yuanyuan Lu, Yi Yan, Jing Zhang, Shiyao Cao, Mi Chen, Ning Chen, Wendong Huang, Liqiang Wang, Xiangmei Chen, Lisheng Zhang

Lgr5 + cell fate regulation by coordination of metabolic nuclear receptors during liver repair

Theranostics.

doi: 10.7150/thno.74194.

(IF 8.579)

1422. Shenghang Wang, Ting Huyan, Chenge Lou, Peng Shang, Hao Zhang

12 T high static magnetic field suppresses osteosarcoma cells proliferation by regulating intracellular ROS and iron status

Exp Cell Res.

doi: 10.1016/j.yexcr.2022.113223.

(IF 3.383)

1423. Ying He, Yang Zhang, Junli Zhang, Xiaoyu Hu

The Key Molecular Mechanisms of Sini Decoction Plus Ginseng Soup to Rescue Acute Liver Failure: Regulating PPARα to Reduce Hepatocyte Necroptosis?

J Inflamm Res.

doi: 10.2147/JIR.S373903.

1424. Lu Li, Pishun Li, Jiale Chen, Li Li, Yunfan Shen, Yangzixuan Zhu, Jiayi Liu, Lu Lv, Song Mao, Fang Chen, Guang Hu, Kai Yuan

Rif1 interacts with non-canonical polycomb repressive complex PRC1.6 to regulate mouse embryonic stem cells fate potential

Cell Regen.

doi: 10.1186/s13619-022-00124-9.

1425. Su-Fang Kuang, Xia Li, Ding-Yun Feng, Wen-Bin Wu, Hui Li, Bo Peng, Xuan-Xian Peng, Zhuang-Gui Chen, Tian-Tuo Zhang

Nitrite Promotes ROS Production to Potentiate Cefoperazone-Sulbactam-Mediated Elimination to Lab-Evolved and Clinical-Evolved Pseudomonas aeruginosa

Microbiol Spectr.

doi: 10.1128/spectrum.02327-21.

(IF 5.465)

1426. Shishuai Meng, Kai Kang, Dongsheng Fei, Songlin Yang, Shangha Pan, Kaijiang Yu, Mingyan Zhao

MicroRNA-363-3p/sphingosine-1-phosphate receptor 1 axis inhibits sepsis-induced acute lung injury via the inactivation of nuclear factor kappa-B ligand signaling

Exp Anim.

doi: 10.1538/expanim.21-0160.

1427. Lan Zhou, Shupei Tang, Fang Li, Yonghui Wu, Sirui Li, Liwei Cui, Jing Luo, Lu Yang, Zhicheng Ren, Ji Zhang, Denglu Zhou, Jun Jiang, Xiaochao Yang, Xinyuan Zhou, Yuzhang Wu

Ceria nanoparticles prophylactic used for renal ischemia-reperfusion injury treatment by attenuating oxidative stress and inflammatory response

Biomaterials.

doi: 10.1016/j.biomaterials.2022.121686.

(IF 10.317)

1428. Ruyi Yang, Fazhang Chen, Haizhen Xu, Zhanfang Guo, Changxia Cao, Hongyan Zhang, Changrong Zhang

Exploring the Mechanism of Realgar against Esophageal Cancer Based on Ferroptosis Induced by ROS-ASK1-p38 MAPK Signaling Pathway

Evid Based Complement Alternat Med.

doi: 10.1155/2022/3698772.

1429. Qiu Tu, Xiuyun Liu, Xiaoqing Yao, Ruixue Li, Gaojing Liu, Honglv Jiang, Kaiqin Li, Qiongfang Chen, Xiaoyan Huang, Qing Chang, Guoqiang Xu, Hong Zhu, Peng Shi, Bo Zhao

RETSAT associates with DDX39B to promote fork restarting and resistance to gemcitabine based chemotherapy in pancreatic ductal adenocarcinoma

J Exp Clin Cancer Res.

doi: 10.1186/s13046-022-02490-3.

1430. Juan Wang, Guo-Dong Dai

Comparative Effects of Brominated Flame Retardants BDE-209, TBBPA, and HBCD on Neurotoxicity in Mice

Chem Res Toxicol.

doi: 10.1021/acs.chemrestox.2c00126.

(IF 3.184)

1431. Kepeng Ou, Youjian Li, Yiling Long, Yafei Luo, Dianyong Tang, Zhongzhu Chen

Inhibition of MORC2 Mediates HDAC4 to Promote Cellular Senescence through p53/p21 Signaling Axis

Molecules.

doi: 10.3390/molecules27196247.

(IF 3.267)

1432. Ye Tian, Gang Xu, Hong Gao, Hong-Yan Xie, Yu-Lin Leng, Xiao-Xu Fu, Chun-Guang Xie

The Mitigatory Effect of Shen-Qi Compound on the Diabetic Thoracic Aortic Complications through Inhibiting the Inflammatory Microenvironment by miR-223-3p/RBP-J/IRF8 Axis

Evid Based Complement Alternat Med.

doi: 10.1155/2022/6686931.

1433. Chengzhao Li, Jun Dang, Yue Lv, Yan Fang, Chengjun Ma, Qilan Wang, Gang Li

The Isolation and Preparation of Samwinol from Dracocephalum heterophyllum and Prevention on Aβ25-35-Induced Neuroinflammation in PC-12 Cells

Int J Mol Sci.

doi: 10.3390/ijms231911572.

(IF 4.556)

1434. Huige Zhang, Zixi Gao, Fei He, Jingfeng Lan, Hailong Chai, Shiqian Zhang, Xianwei Zuo, Hongli Chen, Xingguo Chen

Generation of 3'-OH terminal-triggered encoding of multicolor fluorescence for simultaneous detection of different DNA glycosylases

Anal Bioanal Chem.

doi: 10.1007/s00216-022-04267-1.

(IF 3.637)

1435. Wen Zhang, Jingwen Liu, Yiming Li, Fujiang Guo

A bavachinin analog, D36, induces cell death by targeting both autophagy and apoptosis pathway in acute myeloid leukemia cells

Cancer Chemother Pharmacol.

doi: 10.1007/s00280-022-04462-y.

1436. Shuo Chen, Danyuan Huang, Li Zhu, Yukun Jiang, Yuzhe Guan, Shujuan Zou, Yuyu Li

Contribution of diabetes mellitus to periodontal inflammation during orthodontic tooth movement

Oral Dis.

doi: 10.1111/odi.14365.

(IF 2.613)

1437. Jing Zuo, Tian-Hao Zhang, Liang Xiong, Lu Huang, Cheng Peng, Qin-Mei Zhou, Ou Dai

Two Pairs of 7,7'-Cyclolignan Enantiomers with Anti-Inflammatory Activities from Perilla frutescens

Molecules.

doi: 10.3390/molecules27186102.

(IF 3.267)

1438. Yin Tang, Ke Wei, Ling Liu, Jingyue Ma, Siqi Wu, Wenjing Tang

Activation of PPAR γ Protects Obese Mice from Acute Lung Injury by Inhibiting Endoplasmic Reticulum Stress and Promoting Mitochondrial Biogenesis

PPAR Res.

doi: 10.1155/2022/7888937.

(IF 2.953)

1439. Na Qu, Ruizhe Wang, Yiming Meng, Ning Liu, Jingbo Zhai, Fengping Shan

Methionine enkephalin inhibited cervical carcinoma via apoptosis promotion and reduction of myeloid derived suppressor cell infiltrated in tumor

Int Immunopharmacol.

doi: 10.1016/j.intimp.2022.108933.

(IF 3.943)

1440. Xinxin Shao, Shenghua Zhan, Qiuying Quan, Yu Shen, Siji Chen, Xueguang Zhang, Rui Li, Mi Liu, Lei Cao

Clinical significance of B7-H3 and HER2 co-expression and therapeutic value of combination treatment in gastric cancer

Int Immunopharmacol.

doi: 10.1016/j.intimp.2022.108988.

(IF 3.943)

1441. Shilin Yin, Zhiwei Zhang, Hong Tang, Kai Yang

The biological clock gene PER1 affects the development of oral squamous cell carcinoma by altering the circadian rhythms of cell proliferation and apoptosis

Chronobiol Int.

doi: 10.1080/07420528.2022.2082302.

(IF 2.486)

1442. Lin Cai, Ze-Rui Wu, Lei Cao, Jia-Dong Xu, Jiang-Long Lu, Cheng-de Wang, Jing-Hao Jin, Zhe-Bao Wu, Zhi-Peng Su

ACT001 inhibits pituitary tumor growth by inducing autophagic cell death via MEK4/MAPK pathway

Acta Pharmacol Sin.

doi: 10.1038/s41401-021-00856-5.

(IF 5.064)

1443. Kailing Pan, Bin Hu, Lude Wang, Jianlie Yuan, Wenxia Xu

STUB1-SMYD2 Axis Regulates Drug Resistance in Glioma cells

J Mol Neurosci.

doi: 10.1007/s12031-022-02051-5.

(IF 2.678)

1444. Hang Zeng, Chenxi Tang, Bingru Lin, Mengli Yu, Xinyu Wang, Jinghua Wang, Shenghui Chen, Chaohui Yu

The regulation effect of GLUT9/SLC2A9 on intrahepatic uric acid level and metabolic associated fatty liver disease

Hepatol Int.

doi: 10.1007/s12072-022-10371-2.

(IF 5.102)

1445. Min-Hua Cui, Lei Chen, Qian Zhang, Lan-Ying Liu, Hui Pan, He Liu, Ai-Jie Wang

Understanding the effects of sludge characteristics on the biosorption of triclosan

Sci Total Environ.

doi: 10.1016/j.scitotenv.2022.156665.

(IF 6.551)

1446. Tian Xiao, Liping Yang, Pu Chen, Xiaohua Duan

Para‑hydroxybenzaldehyde against transient focal cerebral ischemia in rats via mitochondrial preservation

Exp Ther Med.

doi: 10.3892/etm.2022.11652.

(IF 1.785)

1447. Jiexin Zhang, Caiwen Ou, Minsheng Chen

Curcumin attenuates cadmium-induced atherosclerosis by regulating trimethylamine-N-oxide synthesis and macrophage polarization through remodeling the gut microbiota

Ecotoxicol Environ Saf.

doi: 10.1016/j.ecoenv.2022.114057.

1448. Fangwei Yang, Yixuan Li, Yunfei Xie, Weirong Yao, Fazheng Ren

Diethyl phosphate disrupts hypothalamus-pituitary-adrenal axis endocrine hormones via nuclear receptors GR and Nur77: Integration of evidences from in vivo, in vitro and in silico approaches

Sci Total Environ.

doi: 10.1016/j.scitotenv.2022.157015.

(IF 6.551)

1449. Sihui Li, Xing Luo, Zhangbin Liao, Mengqing Liang, Houguo Xu, Kangsen Mai, Yanjiao Zhang

Effects of Lysophosphatidylcholine on Intestinal Health of Turbot Fed High-Lipid Diets

Nutrients.

doi: 10.3390/nu14204398.

(IF 4.546)

1450. Zhongye Jiang, Jianmin Cao, Hao Su, Hui Cao, Zeyuan Sun, Haoze Jiang, Yanjun Fan

Exercise serum regulates uric acid transporters in normal rat kidney cells

Sci Rep.

doi: 10.1038/s41598-022-22570-w.

1451. Qian Wang, Han-Yang Li, Zhuo-Min Ling, Gang Chen, Zhong-Ya Wei

Inhibition of Schwann cell pannexin 1 attenuates neuropathic pain through the suppression of inflammatory responses

J Neuroinflammation.

doi: 10.1186/s12974-022-02603-x.

1452. Xiaobo Zhang, Rui Gao, Zhen Zhou, Jiayi Sun, Xuehua Tang, Jialiang Li, Xin Zhou, Tao Shen

Uncovering the mechanism of Huanglian-Wuzhuyu herb pair in treating nonalcoholic steatohepatitis based on network pharmacology and experimental validation

J Ethnopharmacol.

doi: 10.1016/j.jep.2022.115405.

(IF 3.69)

1453. Jianqing Zhang, Xiaoxia Yan, Qinghao Jin, Jing Chen, Lin Yang, Wenlong Wei, Hua Qu, Changliang Yao, Jinjun Hou, Likun Gong, Wanying Wu, De-An Guo

Novel triterpenoids from Alisma plantago-aquatica with influence on LDL uptake in HepG2 cells by inhibiting PCSK9

Phytomedicine.

doi: 10.1016/j.phymed.2022.154342.

(IF 4.268)

1454. Yan-Mei Zhang, Khas Erdene, Ya-Bo Zhao, Chang-Qing Li, Li Wang, Feng Tian, Chang-Jin Ao, Hai Jin

Role of white adipose tissue browning in cold seasonal acclimation in grazing Mongolian sheep (Ovisaries)

J Therm Biol.

doi: 10.1016/j.jtherbio.2022.103333.

(IF 2.361)

1455. Shuying Dai, Yi Liu, Fangmin Zhao, Haibing Wang, Tianyu Shao, Zeting Xu, Liumei Shou, Shuyi Chen, Gao-Chen-Xi Zhang, Qijin Shu

Aqueous extract of Taxus chinensis var. mairei targeting CD47 enhanced antitumor effects in non-small cell lung cancer

Biomed Pharmacother.

doi: 10.1016/j.biopha.2022.113628.

(IF 4.545)

1456. Shaowei Wang, Bingru Zhang, Yingna Zhai, Yunbing Tang, Yuzhen Lou, Yang Zhu, Yiyan Wang, Ren-Shan Ge, Huitao Li

Structure-activity relationship analysis of perfluoroalkyl carbonic acids on human and rat placental 3β-hydroxysteroid dehydrogenase activity

Toxicology.

doi: 10.1016/j.tox.2022.153334.

(IF 4.099)

1457. Kou Liu, Xiang Gao, Chengyang Hu, Yanchao Gui, Siyu Gui, Qinyu Ni, Liming Tao, Zhengxuan Jiang

Capsaicin ameliorates diabetic retinopathy by inhibiting poldip2-induced oxidative stress

Redox Biol.

doi: 10.1016/j.redox.2022.102460.

(IF 9.986)

1458. Jie Man, Hongsheng Wang, Xiaowen Qian, Lian Chen, Yangyang Ma, Maoxiang Qian, Xiaowen Zhai

TCF3 protein was highly expressed in pediatric Burkitt lymphoma and predicts poor prognosis: a single-center study

Leuk Lymphoma.

doi: 10.1080/10428194.2022.2076852.

1459. Lifang Ye, Jieqiong Song, Yijun Zheng, Ming Zhong, Jun Liu, Duming Zhu, Shuling Hu

New mechanism for mesenchymal stem cell microvesicle to restore lung permeability: intracellular S1P signaling pathway independent of S1P receptor-1

Stem Cell Res Ther.

doi: 10.1186/s13287-022-03177-4.

(IF 5.116)

1460. Gang Rui, Li-Yuan Liu, Ling Guo, Yi-Zhe Xue, Pan-Pan Lai, Peng Gao, Jun-Ling Xing, Jing Li, Gui-Rong Ding

Effects of 5.8 GHz microwave on hippocampal synaptic plasticity of rats

Int J Environ Health Res.

doi: 10.1080/09603123.2021.1952165.

1461. Qian Hu, Jiaqi Yao, Xiajia Wu, Juan Li, Guixiang Li, Wenfu Tang, Jingping Liu, Meihua Wan

Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation

Acta Pharm Sin B.

doi: 10.1016/j.apsb.2021.10.008.

(IF 7.097)

1462. Wei Zhou, Wen-Hui Wu, Zi-Lin Si, Hui-Ling Liu, Hanyu Wang, Hong Jiang, Ya-Fang Liu, Raphael N Alolga, Cheng Chen, Shi-Jia Liu, Xue-Yan Bian, Jin-Jun Shan, Jing Li, Ning-Hua Tan, Zhi-Hao Zhang

The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice

Nat Commun.

doi: 10.1038/s41467-022-33824-6.

(IF 12.121)

1463. Chuanli Hou, Wangqian Sha, Yujuan Li, Maojin Yao, Jiaoyan Ren

A modified xanthine oxidase cell model for screening of antihyperuricemic functional compounds

Food Funct.

doi: 10.1039/d2fo00297c.

(IF 4.171)

1464. Yanting Yu, Zhiyun Ren, Anni Xie, Yutao Jia, Ying Xue, Ping Wang, Daxi Ji, Xiaoyan Wang

Assessment of Urinary Exosomal NHE3 as a Biomarker of Acute Kidney Injury

Diagnostics (Basel).

doi: 10.3390/diagnostics12112634.

1465. Shunchi Zhang, Yanrou Bei, Yueling Huang, Yimin Huang, Lianjie Hou, Xi-Long Zheng, Yiming Xu, Shaoguo Wu, Xiaoyan Dai

Induction of ferroptosis promotes vascular smooth muscle cell phenotypic switching and aggravates neointimal hyperplasia in mice

Mol Med.

doi: 10.1186/s10020-022-00549-7.

(IF 4.096)

1466. Wei-Xiao Niu, Yun-Yang Bao, Na Zhang, Zhen-Ning Lu, Mao-Xu Ge, Yi-Ming Li, Yi Li, Ming-Hua Chen, Hong-Wei He

Dehydromevalonolactone ameliorates liver fibrosis and inflammation by repressing activation of NLRP3 inflammasome

Bioorg Chem.

doi: 10.1016/j.bioorg.2022.105971.

(IF 4.831)

1467. Heng Sun, Wenjie Han, Juyi Wen, Xue Ma

IL4I1 and tryptophan metabolites enhance AHR signals to facilitate colorectal cancer progression and immunosuppression

Am J Transl Res.

(IF 3.375)

1468. Dan Zhang, Ying Su, Peng Sun, Xingzhi Liu, Lin Zhang, Xuwei Ling, Yuhui Fan, Kang Wu, Qin Shi, Jisheng Liu

A TGF-loading hydrogel scaffold capable of promoting chondrogenic differentiation for repairing rabbit nasal septum cartilage defect

Front Bioeng Biotechnol.

doi: 10.3389/fbioe.2022.1057904.

1469. Lingdi Nie, Kai Sun, Ziyang Gong, Haoyang Li, John P Quinn, Minyan Wang

Src Family Kinases Facilitate the Crosstalk between CGRP and Cytokines in Sensitizing Trigeminal Ganglion via Transmitting CGRP Receptor/PKA Pathway

Cells.

doi: 10.3390/cells11213498.

(IF 4.366)

1470. Ying Du, Gang Geng, Chunquan Zhao, Tian Gao, Bin Wei

LncRNA MEG3 promotes cisplatin sensitivity of cervical cancer cells by regulating the miR-21/PTEN axis

BMC Cancer.

doi: 10.1186/s12885-022-10188-0.

(IF 3.15)

1471. Qi Hao, Lulu Wang, Minghui Zhang, Zhe Wang, Meng Li, Xuejun Gao

Taurine stimulates protein synthesis and proliferation of C2C12 myoblast cells through the PI3K-ARID4B-mTOR pathway

Br J Nutr.

doi: 10.1017/S0007114521004918.

1472. Bingke Ma, Xingyue Shan, Juehua Yu, Tailin Zhu, Ren Li, Hui Lv, Haidi Cheng, Tiantian Zhang, Lihua Wang, Feiyang Wei, Bo Meng, Xiaobing Yuan, Bing Mei, Xiao-Yong Zhang, Wei-Guang Li, Fei Li

Social deficits via dysregulated Rac1-dependent excitability control of prefrontal cortical neurons and increased GABA/glutamate ratios

Cell Rep.

doi: 10.1016/j.celrep.2022.111722.

(IF 8.109)

1473. Raoqiong Wang, Mengnan Liu, Guilin Ren, Gang Luo, Zhichuan Wang, Zhengxin Ge, Qingrong Pu, Wei Ren, Sijin Yang

Zhilong Huoxue Tongyu Capsules' Effects on ischemic stroke: An assessment using fecal 16S rRNA gene sequencing and untargeted serum metabolomics

Front Pharmacol.

doi: 10.3389/fphar.2022.1052110.

(IF 4.225)

1474. Can Yang, Zhiyuan Feng, Hong Deng, Lu Dai, Ling He, Linlin Yin, Jing Zhao

CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut-brain axis

BMC Neurosci.

doi: 10.1186/s12868-022-00749-1.

(IF 2.811)

1475. Xue-Ting Li, Jia-Wei Song, Zhen-Zhou Zhang, Mi-Wen Zhang, Li-Rong Liang, Ran Miao, Ying Liu, Yi-Hang Chen, Xiao-Yan Liu, Jiu-Chang Zhong

Sirtuin 7 mitigates renal ferroptosis, fibrosis and injury in hypertensive mice by facilitating the KLF15/Nrf2 signaling

Free Radic Biol Med.

doi: 10.1016/j.freeradbiomed.2022.10.320.

1476. Dongyan Zhang, Hong Zhu, Xin Yu, Liyin Wang, Yingying Wen, Liyue Zhang, Jianping Tong, Ye Shen

Blue light attenuates TGF-β2-induced epithelial-mesenchymal transition in human lens epithelial cells via autophagy impairment

BMC Ophthalmol.

doi: 10.1186/s12886-022-02691-6.

(IF 1.413)

1477. Yingchun Wang, Yuzhen Wang, Lu Ding, Xiaolei Ren, Bo Wang, Liyuan Wang, Songbo Zhao, Xuetian Yue, Zhuanchang Wu, Chunyang Li, Xiaohong Liang, Chunhong Ma, Lifen Gao

Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages

Cell Rep.

doi: 10.1016/j.celrep.2022.111738.

(IF 8.109)

1478. Zhuo Zhang, Xu Zhang, Xin Wu, Yan Zhang, Jie Lu, Dan Li

Sirt1 attenuates astrocyte activation via modulating Dnajb1 and chaperone-mediated autophagy after closed head injury

Cereb Cortex.

doi: 10.1093/cercor/bhac007.

(IF 5.043)

1479. Haoyu Guo, Lutong Wang, Wei Wu, Mingke Guo, Lingkai Yang, Zhenhao Zhang, Li Cao, Feifei Pu, Xin Huang, Zengwu Shao

Engineered biomimetic nanoreactor for synergistic photodynamic-chemotherapy against hypoxic tumor

J Control Release.

doi: 10.1016/j.jconrel.2022.09.020.

(IF 7.727)

1480. Ling Li, Yu Bai, Runyu Du, Lei Tang, Ling Li

Orphan nuclear receptor NUR77 relieves insulin resistance in HTR-8/SVneo trophoblast cells through activation of autophagy and insulin signaling

J Physiol Biochem.

doi: 10.1007/s13105-022-00901-9.

(IF 2.952)

1481. Tong Pei, Guanyue Su, Jie Yang, Wenbo Gao, Xinrui Yang, Yaojia Zhang, Jie Ren, Yang Shen, Xiaoheng Liu

Fluid Shear Stress Regulates Osteogenic Differentiation via AnnexinA6-Mediated Autophagy in MC3T3-E1 Cells

Int J Mol Sci.

doi: 10.3390/ijms232415702.

(IF 4.556)

1482. Hong Wang, Yingzhen Lai, Zeyu Xie, Yanyin Lin, Yihuang Cai, Zhiqiang Xu, Jiang Chen

Graphene Oxide-Modified Concentric Microgrooved Titanium Surfaces for the Dual Effects of Osteogenesis and Antiosteoclastogenesis

ACS Appl Mater Interfaces.

doi: 10.1021/acsami.2c14271.

1483. Yanru Chen, Wei Wang, Lingyu Fang, Zhenyang Zhang, Shishan Deng

Identification of PTK2 as an adverse prognostic biomarker in breast cancer by integrated bioinformatics and experimental analyses

Front Mol Biosci.

doi: 10.3389/fmolb.2022.984564.

(IF 4.188)

1484. Panpan Yang, Congshan Li, Qin Zhou, Xiaoqi Zhang, Yuying Kou, Qiushi Feng, He Wang, Rongjian Su, Tomoka Hasegawa, Hongrui Liu, Minqi Li

Notum leads to potential pro-survival of OSCC through crosstalk between Shh and Wnt/β-catenin signaling via p-GSK3β

Int J Biochem Cell Biol.

doi: 10.1016/j.biocel.2022.106316.

1485. Shenghan Su, Qingrui Zhao, Lingfeng Dan, Yuqing Lin, Xuebei Li, Yunjin Zhang, Chunxiao Yang, Yimeng Dong, Xiaohan Li, Romano Regazzi, Changhao Sun, Xia Chu, Huimin Lu

Inhibition of miR-146a-5p and miR-8114 in Insulin-Secreting Cells Contributes to the Protection of Melatonin against Stearic Acid-Induced Cellular Senescence by Targeting Mafa

Endocrinol Metab (Seoul).

doi: 10.3803/EnM.2022.1565.

1486. Jiajia Xu, Yangyang Li, Huan Zhu, Wenyu Wu, Yumeng Liu, Yu Guo, Weijun Guan, Changqing Liu, Caiyun Ma

Therapeutic function of a novel rat induced pluripotent stem cell line in a 6‑OHDA‑induced rat model of Parkinson's disease

Int J Mol Med.

doi: 10.3892/ijmm.2022.5196.

(IF 3.098)

1487. Liqun Wang, Wentao Zhang, Ruiyan Cen, Chenda Yue, Tianzhen Xiao, Yumeng Deng, Lingfei Li, Kedai Sun, Xia Lei

ALA-PDT regulates macrophage M1 polarization via ERK/MAPK-NLRP3 pathway to promote the early inflammatory response

Lasers Surg Med.

doi: 10.1002/lsm.23618.

1488. Kun Wang, Muyun Wang, Ximing Liao, Shaoyong Gao, Jing Hua, Xiaodong Wu, Qian Guo, Wujian Xu, Jiaxing Sun, Yanan He, Qiang Li, Wei Gao

Locally organised and activated Fth1hi neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner

Nat Commun.

doi: 10.1038/s41467-022-35492-y.

(IF 12.121)

1489. Yan-Ting Wu, Li-Shan Zhong, Chen Huang, Yu-Ying Guo, Fu-Jun Jin, Yu-Ze Hu, Zi-Bo Zhao, Zhe Ren, Yi-Fei Wang

β-Caryophyllene Acts as a Ferroptosis Inhibitor to Ameliorate Experimental Colitis

Int J Mol Sci.

doi: 10.3390/ijms232416055.

(IF 4.556)

1490. Xiaowei Song, Wenyan Cao, Zexu Wang, Feng Li, Ji Xiao, Qiongzhen Zeng, Yuan Wang, Shan Li, Cuifang Ye, Yifei Wang, Kai Zheng

Nicotinamide n-Oxide Attenuates HSV-1-Induced Microglial Inflammation through Sirtuin-1/NF-κB Signaling

Int J Mol Sci.

doi: 10.3390/ijms232416085.

(IF 4.556)

1491. Haijuan Bao, Wu Wu, Ying Li, Zhihong Zong, Shuo Chen

WNT6 participates in the occurrence and development of ovarian cancer by upregulating/activating the typical Wnt pathway and Notch1 signaling pathway

Gene.

doi: 10.1016/j.gene.2022.146871.

(IF 2.984)

1492. Wei Wu, Haoyu Guo, Doudou Jing, Zhenhao Zhang, Zhicai Zhang, Feifei Pu, Wenbo Yang, Xin Jin, Xin Huang, Zengwu Shao

Targeted Delivery of PD-L1-Derived Phosphorylation-Mimicking Peptides by Engineered Biomimetic Nanovesicles to Enhance Osteosarcoma Treatment

Adv Healthc Mater.

doi: 10.1002/adhm.202200955.

(IF 7.367)

1493. Jilong Zhou, Hainan He, Jing-Jing Zhang, Xin Liu, Wang Yao, Chengyu Li, Tian Xu, Shu-Yuan Yin, Dan-Ya Wu, Cheng-Li Dou, Qiao Li, Jiani Xiang, Wen-Jing Xiong, Li-Yan Wang, Jun-Ming Tang, Zhouyiyuan Xue, Xia Zhang, Yi-Liang Miao

ATG7-mediated autophagy facilitates embryonic stem cell exit from naive pluripotency and marks commitment to differentiation

Autophagy.

doi: 10.1080/15548627.2022.2055285.

(IF 9.77)

1494. Dan-Lin Zheng, Qing-Rui Wu, Peng Zeng, Sui-Min Li, Yong-Jiang Cai, Shu-Zhen Chen, Xue-Shan Luo, Su-Juan Kuang, Fang Rao, Ying-Yu Lai, Meng-Yuan Zhou, Fei-Long Wu, Hui Yang, Chun-Yu Deng

Advanced glycation end products induce senescence of atrial myocytes and increase susceptibility of atrial fibrillation in diabetic mice

Aging Cell.

doi: 10.1111/acel.13734.

(IF 7.238)

1495. Mengdi Gao, Xue Li, Mao Yang, WanRu Feng, Yan Lin, Tao He

TNFAIP3 mediates FGFR1 activation-induced breast cancer angiogenesis by promoting VEGFA expression and secretion

Clin Transl Oncol.

doi: 10.1007/s12094-022-02918-4.

(IF 2.737)

1496. Yi Wen, Lingxiu Fan, Lili Pang, Tingting Zhao, Ruonan Li, Ying Zhang, Liye Zhang, Wei Yang

NeiyiKangfu tablets control the progression of endometriosis through inhibiting RAF/MEK/ERK signal pathway by targeting RKIP

Gynecol Endocrinol.

doi: 10.1080/09513590.2022.2162495.

(IF 1.571)

1497. Li L, Xiao L, Hou Y, He Q, Zhu J, Li Y, Wu J, Zhao J, Yu S, Zhao Y.

Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing MitochondrialBiogenesis through the AMPK/PGC-1α Pathway in Rats.

1498. Jianguo Ai, Feng Zhao, Xiaowen Zhou

HMGA1 Aggravates Oxidative Stress Injury and Inflammatory Responses in IL-1β-Induced Primary Chondrocytes through the JMJD3/ZEB1 Axis

Int Arch Allergy Immunol.

doi: 10.1159/000526680.

1499. Lichun Guan, Ziqin Yu, Zhimei Che, Hang Zhang, Yong Yu, Dicheng Yang, Dewei Qian, Ruizhen Chen, Min Yu

Experimental diabetes exacerbates autophagic flux impairment during myocardial I/R injury through calpain-mediated cleavage of Atg5/LAMP2

J Cell Mol Med.

doi: 10.1111/jcmm.17642.

(IF 4.486)

1500. Yulin Huang, Jing Hao, Xuli Yang, Li Xu, Yue Liu, Yu'e Sun, Xiaoping Gu, Wei Zhang, Zhengliang Ma

Pretreatment of the ROS Inhibitor Phenyl-N-tert-butylnitrone Alleviates Sleep Deprivation-Induced Hyperalgesia by Suppressing Microglia Activation and NLRP3 Inflammasome Activity in the Spinal Dorsal

Neurochem Res.

doi: 10.1007/s11064-022-03751-5.

(IF 3.038)

1501. Mei Wang, Yingying Guo, Meiyin Wan, Zheng Chen, Julia Li Zhong

TAZ Reduces UVA-mediated Photoaging through Regulates Cell Proliferation in Skin Fibroblasts

Photochem Photobiol.

doi: 10.1111/php.13654.

(IF 2.721)

1502. Lijun Ling, Anqi Ren, Yan Lu, Yunyi Zhang, Haiyan Zhu, Peng Tu, Hong Li, Daofeng Chen

The synergistic effect and mechanisms of flavonoids and polysaccharides from Houttuynia cordata on H1N1-induced pneumonia in mice

J Ethnopharmacol.

doi: 10.1016/j.jep.2022.115761.

(IF 3.69)

1503. Denghui Shi, Wei Su, Yingchun Mu

Quantitative proteomics study on the changes of egg white of yellow preserved primary chicken eggs soaked in alkali solution

Food Res Int.

doi: 10.1016/j.foodres.2022.112346.

(IF 4.972)

1504. Jian Chai, Yongqiang Lei, Xindong Xiang, Jing Ye, Hang Zhao, Lili Yi

High expression of caspase-8 as a predictive factor of poor prognosis in patients with esophageal cancer

Cancer Med.

doi: 10.1002/cam4.5496.

1505. Chuansheng Yang, Meijiao Wang, Renfeng Huang, Linyang Ou, Min Li, Wanming Wu, Ruiwen Lei

Circ_0108942 Regulates the Progression of Breast Cancer by Regulating the MiR-1178-3p/TMED3 Axis

Clin Breast Cancer.

doi: 10.1016/j.clbc.2022.12.014.

(IF 2.647)

1506. Chang-Feng Song, Yu-Heng Hu, Zhi-Guo Mang, Zeng Ye, Hai-di Chen, De-Sheng Jing, Gui-Xiong Fan, Shun-Rong Ji, Xian-Jun Yu, Xiao-Wu Xu, Yi Qin

Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway

Acta Pharmacol Sin.

doi: 10.1038/s41401-022-01006-1.

(IF 5.064)

1507. Wei Wang, Yuqing Xiong, Haomiao Zhao, Rongli Xu

CircEXOC5 facilitates cell pyroptosis via epigenetic suppression of Nrf2 in septic acute lung injury

Mol Cell Biochem.

doi: 10.1007/s11010-022-04521-1.

(IF 2.795)

1508. Hongyan Liao, Jiagui Huang, Jie Liu, Huimin Zhu, Yue Chen, Xuemei Li, Jun Wen, Qin Yang

Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway

Mol Biol Rep.

doi: 10.1007/s11033-022-08167-6.

(IF 1.402)

1509. Xiao Lin, Zidi Jin, Shuo Li, Mingde Zheng, Ya Xing, Xikui Liu, Mengqing Lv, Minmeng Zhao, Tuoyu Geng, Daoqing Gong, Debiao Zhao, Long Liu

Preliminary Study on Expression and Function of the Chicken W Chromosome Gene MIER3 in Embryonic Gonads

Int J Mol Sci.

doi: 10.3390/ijms24108891.

(IF 4.556)

1510. L Xu, J Han, Z Yang, Y Yang, J Chen, X Wu, Q Wang, Y Hong

[LRG1 inhibits hepatic macrophage activation by enhancing TGF-β1 signaling to alleviate MAFLD in mice]

Nan Fang Yi Ke Da Xue Xue Bao.

doi: 10.12122/j.issn.1673-4254.2023.07.13.

1511. Li-Ping Shen, Wei Li, Ling-Zhu Pei, Jun Yin, Shu-Tao Xie, Hong-Zhao Li, Chao Yan, Jian-Jun Wang, Qipeng Zhang, Xiao-Yang Zhang, Jing-Ning Zhu

Oxytocin Receptor in Cerebellar Purkinje Cells Does Not Engage in Autism-Related Behaviors

Cerebellum.

doi: 10.1007/s12311-022-01466-5.

(IF 3.129)

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蛋白质定量BCA法原理/实验流程/优缺点-钟鼎生物

~~蛋白质定量BCA法原理/实验流程/优缺点-钟鼎生物~~

~~BCA法原理/优缺点/实验流程~~

~~◎当前位置：首页>>技术服务>>重组蛋白表达服务>>BCA法实验指南~~

~~BCA法（bicinchoninic acid）是一种常用的测蛋白质浓度的方法，本文介绍了BCA法蛋白质定量的原理,优缺点,以及BCA的实验流程。~~

~~1.BCA法原理~~

BCA法基于双缩脲原理，碱性条件下蛋白质将Cu2+还原成Cu+，BCA鳌合Cu+作为显色剂，产生蓝紫色并在562nm有吸收峰，单价Cu+与蛋白质呈剂量相关性。可以根据待测蛋白在562nm处的吸光度计算待测蛋白浓度。

~~2.BCA法优缺点分析~~

优点

缺点

①.灵敏度高，检测浓度下限达到25μg/ml，最小检测蛋白量达到0.5μg；②.不易受一般浓度去污剂的干扰，抗干扰能力强。③.在20-2000μg/ml浓度范围内有良好的线性关系。

~~①.可受螯合剂，高浓度还原剂的影响。~~

~~3.BCA法实验流程~~

~~①标准曲线的绘制：取一块酶标板，按下表加入试剂。~~

孔号

~~蛋白标准溶液（μL）~~

~~去离子水（μL）~~

~~对应蛋白含量（μg）~~

~~0.5~~

~~1.0~~

~~2.0~~

~~4.0~~

~~6.0~~

~~8.0~~

~~10.0~~

~~②根据样品数量，按50体积BCA试剂A加1体积BCA试剂B（50：1）配制适量BCA工作液，充分混匀。~~

~~③各孔加入200μL BCA工作液。~~

~~④把酶标板放在振荡器上振荡30s，37℃放置30min，然后在562nm下比色测定。以蛋白含量（μg）为横坐标，吸光值为纵坐标，绘出标准曲线。~~

⑤稀释待测样品至合适浓度，使样品稀释液总体积为20μL，加入BCA工作液200μL，充分混匀，37℃放置30min后，以标准曲线0号管做参比，在562nm波长下比色，记录吸光值。

~~⑥根据所测样品的吸光值，利用计算公式计算出蛋白样品的实际浓度（单位：μg/μL）。~~

~~相关服务~~

~~7个工作日交付~~

~~原核表达服务~~

~~无甲醇诱导体系~~

~~酵母表达服务~~

~~sf9、sf21、 High5~~

~~昆虫表达服务~~

~~CHO、HEK293~~

~~哺乳表达服务~~

~~猜您想看：~~

~~Lowry法:Folin-酚试剂法实验原理、实验方法以及实验要点分析~~

~~Bradford法：考马斯亮蓝染色法原理、优缺点分析、实验流程以及注意事项~~

~~瞬蓝SDS-PAGE染色液：5分钟出结果，无毒，无味，无需脱色~~

~~技术咨询~~

~~BCA法相关~~

~~•sds-page介绍~~

~~•瞬蓝染色剂~~

~~•原核蛋白表达FAQ~~

~~BCA法相关服务目录~~

~~抗体偶联与修饰服务~~

~~抗体应用检测技术服务~~

~~蛋白纯化服务~~

~~原核蛋白表达服务~~

~~乳酸球菌蛋白表达服务~~

~~杆状病毒-昆虫细胞蛋白表达服务~~

~~哺乳动物细胞蛋白表达服务~~

~~BCA法相关文档下载~~

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~~1.蛋白表达服务~~

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